Integrated decision-tree testing strategies for acute systemic toxicity and toxicokinetics with respect to the requirements of the EU REACH legislation

Alternatives to Laboratory Animals

Volumn 36, Issue 1, 2008, Pages 45-63

  Combes, Robert ^a   Grindon, Christina ^a   Cronin, Mark T D ^b   Roberts, David W ^b   Garrod, John F ^c  

^a RUSSELL AND BURCH HOUSE   (United Kingdom)

^b LIVERPOOL JOHN MOORES UNIVERSITY   (United Kingdom)

^c DEFRA   (United Kingdom)

Author keywords

Acute toxicity; Animal testing; Decision trees; Defra; In silico models; In vitro testing; Integrated testing strategies; REACH; Risk assessment; Three Rs; Toxicokinetics

Indexed keywords

CHEMICAL AGENT; ORGANOPHOSPHATE PESTICIDE;

ABSORPTION; ACUTE TOXICITY; ANIMAL TESTING ALTERNATIVE; BIOTRANSFORMATION; COMPUTER MODEL; CYTOTOXICITY; DECISION MAKING; EXCRETION; IN VITRO STUDY; IN VIVO STUDY; LAW; METABOLISM; NOTE; PREDICTION; PRIORITY JOURNAL; QUANTITATIVE STRUCTURE ACTIVITY RELATION; RISK ASSESSMENT; SCREENING; TARGET ORGAN; TECHNIQUE; TOXICOKINETICS;

ANIMALIA;

EID: 41149150770     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290803600107     Document Type: Note

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