Modeling the metabolic competency of glutathione S-transferases using genetically modified cell lines

Toxicology

Volumn 181-182, Issue , 2002, Pages 265-269

  Townsend, Alan J ^a   Kabler, Sandra L ^a   Doehmer, Johannes ^b   Morrow, Charles S ^a  

^a WAKE FOREST SCHOOL OF MEDICINE   (United States)

^b TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Carcinogen detoxification; Cytochrome P 450; Glutathione S transferase; Multidrug resistance protein; Polycyclic hydrocarbons; Transfection

Indexed keywords

4 NITROQUINOLINE 1 OXIDE; ADENOSINE TRIPHOSPHATE; CARCINOGEN; CARRIER PROTEIN; CYTOCHROME P450 1A1; DNA; GLUTATHIONE TRANSFERASE; ISOENZYME;

ALKYLATION; ARTICLE; CELL LINE; CHEMOPROPHYLAXIS; CONTROLLED STUDY; CYTOTOXICITY; DETOXIFICATION; DNA DAMAGE; DNA MODIFICATION; HUMAN; HUMAN CELL; PRIORITY JOURNAL; PROTEIN EXPRESSION;

7,8-DIHYDRO-7,8-DIHYDROXYBENZO(A)PYRENE 9,10-OXIDE; ANIMALS; BENZO(A)PYRENE; CELL LINE; CELL SURVIVAL; CYTOCHROME P-450 CYP1A1; ENZYME ACTIVATION; GLUTATHIONE TRANSFERASE; HUMANS; ISOENZYMES; RATS; TRANSFECTION;

EID: 17944392598     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0300-483X(02)00294-9     Document Type: Article

References (13)

1. Burke M.D., Thompson S., Elcombe C.R., Halpert J., Haaparanta T., Mayer R.T. Biochem. Pharm. 34:1985;3337-3345.
2. Doehmer J., Buters J.T., Luch A., Soballa V., Baird W.M., Morisson H., Stegeman J.J., Townsend A.J., Greenlee W.F., Glatt H.R., Seidel A., Jacob J., Greim H. Drug Metab. Rev. 31:1999;423-435.
3. Dogra S., Doehmer J., Glatt H., Molders H., Siegert P., Freidberg T., Seidel A., Oesch F. Mol. Pharm. 37:1990;608-613.
4. Fields W.R., Li Y., Townsend A.J. Carcinogenesis. 15:1994;1155-1160.
5. Hayes J.D., Pulford D.J. Crit. Rev. Biochem. Mol. Biol. 30:1995;445-600.
6. Morrow C.S., Diah S., Smitherman P.K., Schneider E., Townsend A.J. Carcinogenesis. 19:1998;109-115.
7. Morrow C.S., Smitherman P.K., Townsend A.J. Mol. Carcinog. 29:2000;170-178.
8. Paumi C.M., Ledford B.G., Smitherman P.K., Townsend A.J., Morrow C.S. J. Biol. Chem. 276:2001;7952-7956.
9. Schmalix W.A., Maser H., Kiefer F., Reen R., Wiebel F.J., Gonzalez F., Seidel A., Glatt H., Greim H., Doehmer J. Euro. J. Pharmacol. 248:1993;251-261.
10. Sundberg K., Johansson A.S., Stenberg G., Widersten M., Seidel A., Mannervik B., Jernström B. Carcinogenesis. 19:1998;433-436.
11. Townsend A.J., Goldsmith M.E., Pickett C.B., Cowan K.H. J. Biol. Chem. 264:1989;21582-21590.
12. Townsend A.J., Fields W.R., Haynes R.L., Karper A.J., Li Y., Doehmer J., Morrow C.S. Chem. Biol. Interact. 111-112:1998;389-407.
13. Wattenberg L.W. Cancer Res. 43:1983;2448s-2453s.