Applications of the Caco-2 model in the design and development of orally active drugs: Elucidation of biochemical and physical barriers posed by the intestinal epithelium

Advanced Drug Delivery Reviews

Volumn 23, Issue 1-3, 1997, Pages 77-98

  Gan, Liang Shang L ^a,c   Thakker, Dhiren R ^b  

^a GLAXOSMITHKLINE   (United States)

^b UNIVERSITY OF NORTH CAROLINA   (United States)

^c DUPONT COMPANY   (United States)

Author keywords

active transport; Caco 2 cells; CYP1A; CYP3A; cytochrome P 450; drug discovery and development; drug interactions; glutath ione S transferase; intestinal epithelium; MDR P glycoprotein; mucosal toxicity; oral absorption; paracellular; phase I enzymes; phase II enzymes; sulfotransferase; transcellular; UDP glucuronosyltransferase

Indexed keywords

CELLS; DRUG INTERACTIONS; DRUG THERAPY; ENZYMES; METABOLISM; PROTEINS; TOXICITY;

ACTIVE TRANSPORT; BIOAVAILABILITY; CACO 2 CELLS; GLUCURONOSYLTRANSFERASE; GLUTATHIONE S TRANSFERASE; GLYCOPROTEIN; INTESTINAL EPITHELIUM; ORAL ABSORPTION; ORALLY ACTIVE DRUGS; SULFOTRANSFERASE;

DRUG PRODUCTS;

ALPHA 1 ADRENERGIC RECEPTOR BLOCKING AGENT; ANGIOTENSIN II ANTAGONIST; BENZODIAZEPINE DERIVATIVE; CHLORPROMAZINE; CHOLECYSTOKININ A RECEPTOR ANTAGONIST; CYCLODEXTRIN; CYCLOSPORIN A; CYTOCHROME P450 ISOENZYME; DODECYL SULFATE SODIUM; DRUG METABOLIZING ENZYME; GLYCOPROTEIN P; GLYCYLSARCOSINE; HYDROXYPROPYLMETHYLCELLULOSE; MACROGOL; MANNITOL; MATRIX METALLOPROTEINASE INHIBITOR; ONDANSETRON; PHOSPHATIDYLCHOLINE; PHOSPHOLIPASE A2 INHIBITOR; PROGESTERONE; PROPYLENE GLYCOL; RANITIDINE; TESTOSTERONE; UNINDEXED DRUG;

BIOCHEMISTRY; CELL STRAIN CACO 2; DIFFUSION; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG DESIGN; DRUG DEVELOPMENT; DRUG FORMULATION; DRUG METABOLISM; DRUG TRANSPORT; HUMAN; HUMAN CELL; INTESTINE EPITHELIUM; MEMBRANE TRANSPORT; MODEL; MOLECULAR WEIGHT; MORPHOLOGY; PERMEABILITY BARRIER; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; REVIEW;

EID: 0031022120     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(96)00427-9     Document Type: Review

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