Overview of the final MEIC results: II. The in vitro--in vivo evaluation, including the selection of a practical battery of cell tests for prediction of acute lethal blood concentrations in humans

Toxicology in Vitro

Volumn 13, Issue 4-5, 1999, Pages 665-673

  Ekwall, B ^a  

^a CTLU   (Sweden)

Author keywords

Acute systemic toxicity; Alternatives; Basal cytotoxicity; Battery selection; Cell tests; Evaluation; Human toxicity; lethal concentrations; Lethal dose; Validation

Indexed keywords

ACETYLCHOLINESTERASE; ATROPINE; COPPER; CYANIDE; DIGOXIN; ETHYLENE; GLYCOL; LEAD; METHANOL; NICOTINE; OXALIC ACID; PARACETAMOL; PARAQUAT; PHENOL;

ACUTE TOXICITY; CONFERENCE PAPER; CYTOTOXICITY; DIAGNOSTIC TEST; HUMAN; HUMAN CELL; IN VITRO STUDY; LETHAL DOSE; NONHUMAN; PREDICTION; VALIDATION PROCESS;

EID: 0032839104     PISSN: 08872333     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0887-2333(99)00061-2     Document Type: Conference Paper

References (11)

1. Bondesson I., Ekwall B., Hellberg S., Romert L., Stenberg K., Walum E. MEIC - A new international multicenter project to evaluate the relevance to human toxicity of in vitro cytotoxicity tests. Cell Biology and Toxicology. 5:1989;331-347.
2. Clemedson C., Barile F.A., Chesné C., Cottin M., Curren R., Ferro M., Gómez-Lechón M-J., Imai K., Janus J., Kemp R.B., Kerszman G., Kjellstrand P., Lavrijsen K., Logemann P., McFarlane-Abdulla E., Roguet R., Segner H., Thuvander A., Walum E., Ekwall B. MEIC Evaluation of Acute Systemic Toxicity. Part VII. Prediction of human toxicity by results from testing of the first 30 reference chemicals with 27 further in vitro assays. ATLA. 27:(Suppl. 1)):1999.
3. Clemedson C., Ekwall B. Overview of the final MEIC results: I. The In Vitro-In Vitro Evaluation. Toxicology in Vitro. 13:1989;657-663.
4. Ekwall B. (1983) Screening of toxic compounds in mammalian cell cultures. In Annals of the New York Academy of Sciences, Vol. 407, Cellular Systems for Toxicity Testing. Edited by G. M. Williams, V. C. Dunkel and V. A. Ray, pp. 64-77. New York Academy of Sciences, New York.
5. Ekwall B. (1995) The basal cytotoxicity concept. In Alternative Methods in Toxicology and the Life Sciences, Vol. 11, The World Congress on Alternatives and Animal Use in the Life Sciences; Education, Research, Testing. Edited by A. M. Goldberg and L. F. M. van Zupthen, pp. 721-725. Mary Ann Liebert, New York.
6. Ekwall B. and Ekwall Ba. (1997) The MEMO database. Available at the CTLU website (http://www.ctlu.se). CTLU, Stånga.
7. Ekwall B., Barile F.A., Castano A., Clemedson C., Clothier R.H., Dierickx P., Ekwall Ba, Ferro M., Fiskesjö G., Garza-Ocanas L., Gómez-Lechón M-J., Gülden M., Hall T., Isomaa B., Kahru A., Kerszman G., Kristen U., Kunimoto M., Kärenlampi S., Lewan L., Loukianov A., Ohno T., Persoone G., Romert L., Sawyer T.W., Segner H., Shrivastava R., Stammati A., Tanaka N., Valentino M., Walum E., Zucco F. MEIC Evaluation of Acute Systemic Toxicity. Part VI. Prediction of human toxicity by rodent LD50 values and results from 61 in vitro tests. ATLA. 26:(Suppl. 2):1998;617-658.
8. Ekwall B., Bondesson I., Castell J.V., Gómez-Lechón M.J., Hellberg S., Högberg J., Jover R., Ponsoda X., Romert L., Stenberg K., Walum E. Cytotoxicity evaluation of the first ten MEIC chemicals: acute lethal toxicity in man predicted by cytotoxicity in five cellular assays and by oral LD50 tests in rodents. ATLA. 17:1989;83-100.
9. Ekwall B., Clemedson C., Crafoord B., Ekwall Ba, Hallander S., Walum E., Bondesson I. MEIC evaluation of acute systemic toxicity. Part V. Rodent and human toxicity data for the 50 reference chemicals. ATLA. 26:(Suppl. 2):1998;571-616.
10. Ekwall B., Ekwall Ba, Sjöström M. MEIC evaluation of acute systemic toxicity. Part VIII. Multivariate PLS evaluation, including the selection of a battery of cell line tests with good prediction of human acute lethal blood concentrations for 50 chemicals. ATLA. 27:(Suppl. 1):1999.
11. Hellberg S., Eriksson L., Jonsson J., Lindgren F., Sjöström M., Wold S. Analogy models for prediction of human toxicity. ATLA. 18:1990;103-116.