Refining in vitro neurotoxicity testing - The development of blood-brain barrier models

Alternatives to Laboratory Animals

Volumn 31, Issue 3, 2003, Pages 273-276

  Tähti, Hanna ^a   Nevala, Heidi ^b   Toimela, Tarja ^a  

^a UNIVERSITY OF TAMPERE MEDICAL SCHOOL   (Finland)

^b UNIVERSITY OF JYVÄSKYLÄ   (Finland)

Author keywords

Blood brain barrier; Co culture techniques; In vitro

Indexed keywords

ASTROCYTE; BLOOD BRAIN BARRIER; BRAIN CAPILLARY; CELL FUNCTION; CENTRAL NERVOUS SYSTEM; CONFERENCE PAPER; ENDOTHELIUM CELL; HUMAN; IN VITRO STUDY; MODEL; NERVE CELL CULTURE; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; SCREENING; TOXICITY TESTING; TOXICOKINETICS;

EID: 0041695321     PISSN: 02611929     EISSN: None     Source Type: Journal    
DOI: 10.1177/026119290303100309     Document Type: Conference Paper

References (18)

1. Panula, P., Joo, F. & Rechardt, L. (1978). Evidence for the presence of viable endothelial cells in cultures derived from dissociated rat brain. Experientia 34, 95-97.
2. Janzer, R.C. & Raff, M.C. (1987). Astrocytes induce blood-brain barrier properties in endothelial cells. Nature, London 325, 253-257.
3. Tao-Cheng, J-H., Nagy, Z. & Brightman, M.W. (1987). Tight junctions of brain endothelium in vitro are enhanced by astroglia. Journal of Neuroscience 7, 3293-3299.
4. Gaillard, P.J., Voorwinden, L.H., Nielsen, J.L., Ivanov, A., Atsumi, R., Engman, H., Ringbom, C., de Boer, A.G. & Breimer, D.D. (2001). Establishment and functional characterization of in vitro model of the blood-brain barrier, comprising a co-culture of brain capillary endothelial cells and astrocytes. European Journal of Pharmaceutical Sciences 12, 215-222.
5. Rubin, L.L., Hall, D.E., Porter, S., Barbu, K., Cannon, C., Horner, H.C., Janatpour, M., Liaw, C.W., Manning, K., Morales, J., Tanner, I., Tomaselli, K.J. & Bard, F. (1991). A cell culture model of the blood-brain barrier. Journal of Cell Biology 115, 1725-1735.
6. Ghazanfari, F.A. & Stewart, R.R. (2001). Characteristics of endothelial cells derived from blood-brain barrier and astrocytes in culture. Brain Research 890, 49-65.
7. Garberg, P. (1998). In vitro models of the blood-brain barrier. ATLA 26, 821-847.
8. Yang, J., Lysette, A.M., Sumner, D., Stevens, J.T., Eldridge, J.T.C., Strandhoy, J.W. & Aschner, M. (2001). Transendothelial permeability of chlorpyrifos in RBE4 monolayers is modulated by astrocyte-conditioned medium. Molecular Brain Research 97, 43-50.
9. Harry, G.J., Billingsley, M., Bruinink, A., Campbell, I.L., Classen, W., Dorman, D.C., Galli, C., Ray, D., Smith, R.A. & Tilson, H.A. (1998). In vitro techniques for the assessment of neurotoxicity. Environmental Health Perspectives 106, Suppl. 1, 1-35.
10. Tähti, H., Mäenpää, H., Salminen, L. & Toimela, T. (1999). Retinal pigment epithelial cell cultures as a tool for evaluating retinal toxicity in vitro. ATLA 27, 417-424.
11. Mäenpää, H., Mannerström, M., Toimela, T., Salminen, L., Saransari, P. & Tähti, H. (2002). Glutamate uptake is inhibited by tamoxifen and toremifene in cultured retinal pigment epithelial cells. Pharmacology and Toxicology 91, 116-122.
12. Abbruscato, T.J. & Davis, T.P. (1999). Protein expression of brain endothelial cell E-cadherin after hypoxia/aglycemia: influence of astrocyte contact. Brain Research 842, 277-286.
13. Eisenblätter, T. & Galla, H-J. (2002). A new multidrug resistance protein at the blood-brain barrier. Biochemical and Biophysical Research Communications 293, 1273-1278.
14. Megard, I., Garrigues, A., Orlowski, S., Jorajuria, S., Clayette, P., Ezan, E. & Mabondzo, A. (2002). A co-culture-based model of human blood-brain barrier: application to active transport of indinavir and in vivo-in vitro correlation. Brain Research 927, 153-167.
15. Hurst, R.D. (2001). Nitric oxide-induced inhibition of glyceraldehyde-3-phosphate dehydrogenase may mediate reduced endothelial cell monolayer integrity in an in vitro model blood-brain barrier. Brain Research 894, 181-188.
16. Tähti, H., Vaalavirta, L. & Toimela, T. (1995). In vitro methods as a tool in neurotoxicity studies. ATLA 23, 491-496.
17. Clemedson, C. & Ekwall, B. (1999). Overview of the final MEIC results. I. The in vitro-in vivo evaluation. Toxicology in Vitro 13, 1-7.
18. Clemedson, C., Nordin-Andersson, M., Bjerregaard, H.F., Clausen, J., Forsby, A., Gustafsson, H., Hansson, U., Isomaa, B., Jorgensen, C., Kolman, A., Kotova, N., Krause, G., Kristen, U., Kurppa, K., Romert, L. & Scheers, E. (2002). Development of an in vitro test battery for the estimation of acute human systemic toxicity: an outline of the EDIT project. ATLA 30, 313-321.