Novel prodrug approach for tertiary amines: Synthesis and preliminary evaluation of N-phosphonooxymethyl prodrugs

Journal of Medicinal Chemistry

Volumn 42, Issue 16, 1999, Pages 3094-3100

  Krise, Jeffrey P ^a   Zygmunt, Jan ^a   Georg, Gunda I ^a   Stella, Valentino J ^a  

^a UNIVERSITY OF KANSAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; AMIODARONE; ANTIARRHYTHMIC AGENT; CALCIUM CHANNEL BLOCKING AGENT; CINNARIZINE; LOXAPINE; NEUROLEPTIC AGENT; PRODRUG; QUINUCLIDINE DERIVATIVE; TERTIARY AMINE;

ANIMAL EXPERIMENT; ARTICLE; DEPHOSPHORYLATION; DOG; DRUG METABOLISM; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; INTRAVENOUS DRUG ADMINISTRATION; NONHUMAN;

ALKALINE PHOSPHATASE; AMINES; ANIMALS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CINNARIZINE; DOGS; HUMANS; INJECTIONS, INTRAVENOUS; KINETICS; LOXAPINE; MALE; PLACENTA; PRODRUGS; QUINUCLIDINES; SOLUBILITY;

EID: 0033549849     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm980539w     Document Type: Article

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