Synthesis and in vitro evaluation of novel morpholinyl- and methylpiperazinylacyloxyalkyl prodrugs of 2-(6-methoxy,2-naphthyl)propionic acid (naproxen) for topical drug delivery

Journal of Medicinal Chemistry

Volumn 43, Issue 8, 2000, Pages 1489-1494

  Rautio, Jarkko ^a   Nevalainen, Tapio ^a   Taipale, Hannu ^a   Vepsäläinen, Jouko ^a,b   Gynther, Jukka ^a,b   Laine, Krista ^a   Järvinen, Tomi ^a,b  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b Finncovery Ltd   (Finland)

Author keywords

[No Author keywords available]

Indexed keywords

NAPROXEN;

ARTICLE; DRUG PENETRATION; DRUG SOLUBILITY; DRUG SYNTHESIS; HUMAN; HUMAN TISSUE; LIPOPHILICITY; PARTITION COEFFICIENT; PH; TOPICAL DRUG ADMINISTRATION;

ADMINISTRATION, TOPICAL; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; HUMANS; NAPROXEN; PERMEABILITY; PIPERAZINES; PRODRUGS; SKIN ABSORPTION; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 0034692169     PISSN: 00222623     EISSN: None     Source Type: Journal    
DOI: 10.1021/jm991149s     Document Type: Article

References (34)

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