Characterization of the activation pathway of phosphoramidate triester prodrugs of stavudine and zidovudine

Molecular Pharmacology

Volumn 56, Issue 4, 1999, Pages 693-704

  Saboulard, Didier ^a   Naesens, Lieve ^a   Cahard, Dominique ^b   Salgado, Antonio ^b   Pathirana, Ranjith ^b   Velazquez, Sonsoles ^b   Mcguigan, Christopher ^b   De Clercq, Erik ^a   Balzarini, Jan ^a  

^a REGA INSTITUTE FOR MEDICAL RESEARCH   (Belgium)

^b CARDIFF UNIVERSITY   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ALKALINE PHOSPHATASE; CARBOXYLESTERASE; CREATINE KINASE; DRUG METABOLITE; DRUG METABOLIZING ENZYME; PHOSPHODIESTERASE; PHOSPHORAMIDIC ACID DERIVATIVE; PRODRUG; STAVUDINE; ZIDOVUDINE;

ANIMAL TISSUE; ANTIVIRAL ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG ACTIVATION; DRUG DEGRADATION; DRUG STABILITY; DRUG STRUCTURE; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS; INCUBATION TIME; LIVER CYTOSOL; MALE; NONHUMAN; PHOSPHORYLATION; PRIORITY JOURNAL; RAT; REACTION ANALYSIS; STRUCTURE ACTIVITY RELATION;

AMINO ACIDS; ANIMALS; ANTI-HIV AGENTS; BIOTRANSFORMATION; DRUG DESIGN; ESTERASES; ESTERS; HIV; HUMANS; LIVER; MALE; MICE; NUCLEOSIDES; PRODRUGS; RATS; RATS, WISTAR; REVERSE TRANSCRIPTASE INHIBITORS; STAVUDINE; THYMINE NUCLEOTIDES; TUMOR CELLS, CULTURED; ZIDOVUDINE;

EID: 0032834955     PISSN: 0026895X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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