Cyclodextrin solubilization of benzodiazepines: Formulation of midazolam nasal spray

International Journal of Pharmaceutics

Volumn 212, Issue 1, 2001, Pages 29-40

  Loftsson, T ^a   Guamundsdottir H ^a   Sigurjonsdottir J F ^a   Sigurasson, H H ^a   Sigfusson S D ^a   Masson M ^a   Stefansson E ^a  

^a UNIVERSITY OF ICELAND   (Iceland)

Author keywords

Benzodiazepines; Complexation; Cyclodextrin; Ionization; Solubility

Indexed keywords

ALPRAZOLAM; BENZODIAZEPINE DERIVATIVE; BETA CYCLODEXTRIN SULFOBUTYL ETHER; CYCLODEXTRIN; HYDROXYPROPYLMETHYLCELLULOSE; MIDAZOLAM; MIDAZOLAM MALEATE; TRIAZOLAM;

ANALYTIC METHOD; AREA UNDER THE CURVE; ARTICLE; BLOOD SAMPLING; CHEMICAL REACTION; COMPLEX FORMATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG BLOOD LEVEL; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; DRUG SOLUBILITY; DRUG STABILITY; DRUG STRUCTURE; FEMALE; HUMAN; HUMAN EXPERIMENT; IONIZATION; MALE; NORMAL HUMAN; PH; PRIORITY JOURNAL;

ADMINISTRATION, INTRANASAL; ADULT; ANIMALS; ANTI-ANXIETY AGENTS; CHEMISTRY, PHARMACEUTICAL; CYCLODEXTRINS; FEMALE; HUMANS; HYDROGEN-ION CONCENTRATION; MALE; MIDAZOLAM; SOLUBILITY;

EID: 0035808275     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(00)00580-9     Document Type: Article

References (27)

1. Solubilization of diazepam
2. Measurment of pH
3. Pharmacokinetic and pharmacodynamic response after intranasal administration of diazepam to rabbits
4. Pharmacokinetics of midazolam given as an intranasal spray to adult surgical patients
5. Parenteral safety and applications of 2-hydroxypropyl β-cyclodextrin
6. Complexation-use of cyclodextrins to improve pharmaceutical properties of intramuscular formulations
7. The potential use of cyclodextrins in parenteral formulations
8. Pharmacokinetics and pharmacodynamics of midazolam after intranasal administration
9. Kinetics and equilibrium of the reversible alprazolam ring-opening reaction
10. Chemical structure and properties of midazolam compared with other benzodiazepines
11. Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines I: Chlordiazepoxide and demoxepam
12. Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines II: Oxazepam and diazepam
13. Kinetics and mechanisms of hydrolysis of 1,4-benzodiazepines III: Nitrazepam
14. Phase-solubility techniques
15. Midazolam: The first water-soluble benzodiazepine. Pharmacology, pharmacokinetics and efficacy in insomnia and anaesthesia
16. Interactions of b-cyclodextrin with Solutol® HS and their influence on diazepam solubilization
17. The behavior of 1,4-benzodiazepine drugs in aqueous media. II. Kinetics and mechanism of the acid-base equilibrium reaction of oxazolam
18. The behavior of 1,4-benzodiazepine drugs in acidic media. V. Kinetics of hydrolysis of haloxazolam in aqueous solution
19. Increasing the cyclodextrin complexation of drugs and drug bioavailability through addition of water-soluble polymers
20. Cyclodextrin solubilization of ETH-615, a zwitterionic drug
21. The effect of water-soluble polymers on drug-cyclodextrin complexation
22. Methods to enhance the complexation efficiency of cyclodextrins
23. Cyclodextrins as permeation enhancers: Some theoretical evaluations and in vitro testing
24. 2O
25. Quinazolines and 1,4-benzodiazepines. Synthesis and reactions of imidazo [1,5-a][1,4]benzodiazepines
26. Cosolvent use in injectable formulations
27. Solubilization by cosolvents. I: Organic solutes in propylene glycol-water mixtures