New water-soluble prodrugs of HIV protease inhibitors based on O→N intramolecular acyl migration

Bioorganic and Medicinal Chemistry

Volumn 10, Issue 12, 2002, Pages 4155-4167

  Hamada, Yoshio ^a   Ohtake, Jun ^a   Sohma, Youhei ^a   Kimura, Tooru ^a   Hayashi, Yoshio ^a   Kiso, Yoshiaki ^a  

^a KYOTO PHARMACEUTICAL UNIVERSITY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

3 [O [N [N METHYL N [(2 ISOPROPYL 4 THIAZOLYL)METHYL]AMINO]CARBONYL]VALYL]OXY 5 [N [(TERT BUTYLOXY)CARBONYL]AMINO] 2 [N [(5 THIAZOLY)METHOXY]CARBONYL]AMINO 1,6 DIPHENYL 3 HYDROXYHEXANE; 5 [N (TERT BUTYLOXYCARBONYL)AMINO] 2 [N [(5 THIAZOLYL)METHOXY]CARBONYLAMINO] 1,6 DIPHENYL 3 HYDROXYHEXANE; 5 AMINO 3 [O [N [N METHYL N [(2 ISOPROPYL 4 THIAZOLYL)METHYL]AMINO]CARBONYL]VALYL]OXY 2 [N [(5 THIAZOLYL)METHOXY]CARBONYL]AMINO 1,6 DIPHENYL 3 HYDROXYHEXANE; ALLOPHENYLNORSTATINE; CHLORIDE; KNI 279; KYNOSTATIN 272; PRODRUG; PROTEINASE INHIBITOR; RITONAVIR; SODIUM CHLORIDE; STATINE DERIVATIVE; TIMONACIC; UNCLASSIFIED DRUG; WATER;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ARTICLE; COMPARATIVE STUDY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; HUMAN IMMUNODEFICIENCY VIRUS 1; PH; PROTEINASE INHIBITION; SOLUBILITY; STOMACH JUICE; TEMPERATURE;

ACYLATION; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG STABILITY; HALF-LIFE; HIV PROTEASE INHIBITORS; HUMANS; HYDROGEN-ION CONCENTRATION; OLIGOPEPTIDES; PRODRUGS; SOLUBILITY; STRUCTURE-ACTIVITY RELATIONSHIP;

HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 0036973331     PISSN: 09680896     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0968-0896(02)00322-X     Document Type: Article

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