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Volumn 76, Issue 1-3, 1997, Pages 1-27

Drug targeting via retrometabolic approaches

Author keywords

Brain targeting; Eye targeting; Molecular packaging; Peptide delivery; Soft blockers; Soft anticholinergics

Indexed keywords

ATENOLOL; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CETYLPYRIDINIUM SALT; CHLORAMBUCIL; CHLORPHENOTANE; CHOLINERGIC RECEPTOR BLOCKING AGENT; CHOLINESTERASE INHIBITOR; CORTICOSTEROID; CROMOGLYCATE DISODIUM; ENKEPHALIN[2 DEXTRO ALANINE 5 DEXTRO LEUCINE]; ESTRADIOL; HOMATROPINE METHYL BROMIDE; HYDROCORTISONE; LOTEPREDNOL ETABONATE; METHYLSCOPOLAMINE; METOPROLOL; NALOXONE; OXIME; PROSTAGLANDIN E1; PROTIRELIN DERIVATIVE;

EID: 0031278026     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(97)00098-3     Document Type: Review
Times cited : (66)

References (113)
  • 1
    • 0014337792 scopus 로고
    • The metabolism in vivo of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in the chick by embryonic injection and dietary ingestion
    • Abou-Donia, M. B. and Menzel, D. B. (1968) The metabolism in vivo of 1,1,1-trichloro-2,2-bis(p-chlorophenyl)ethane (DDT), 1,1-dichloro-2,2-bis(p-chlorophenyl)ethane (DDD) and 1,1-dichloro-2,2-bis(p-chlorophenyl)ethylene (DDE) in the chick by embryonic injection and dietary ingestion. Biochem. Pharmacol. 17: 2143-2161.
    • (1968) Biochem. Pharmacol. , vol.17 , pp. 2143-2161
    • Abou-Donia, M.B.1    Menzel, D.B.2
  • 3
    • 0010546381 scopus 로고
    • U.S. Patent 4061722, December 6
    • Bodor, N. (1977) U.S. Patent 4061722, December 6.
    • (1977)
    • Bodor, N.1
  • 4
    • 0002334089 scopus 로고
    • Soft drugs: Strategies for design of safer drugs
    • Noordwijkerhout, The Netherlands, Ruisman, J. A. K. (ed.) Elsevier, Amsterdam
    • Bodor, N. (1982a) Soft drugs: strategies for design of safer drugs. In: Strategy in Drug Research, Proceedings of the 2nd IUPAC-IUPHAR Symposium on Research, Noordwijkerhout, The Netherlands, pp. 137-164, Ruisman, J. A. K. (ed.) Elsevier, Amsterdam.
    • (1982) Strategy in Drug Research, Proceedings of the 2nd IUPAC-IUPHAR Symposium on Research , pp. 137-164
    • Bodor, N.1
  • 5
    • 0002622795 scopus 로고
    • Designing safer drugs based on the soft drug approach
    • Bodor, N. (1982b) Designing safer drugs based on the soft drug approach. Trends Pharmacol. Sci. 3: 53-56.
    • (1982) Trends Pharmacol. Sci. , vol.3 , pp. 53-56
    • Bodor, N.1
  • 6
    • 0010615439 scopus 로고
    • Soft drugs: Strategies for design of safer drugs
    • November 26-27, 1981, Briot, M., Cautreels, W. and Roncucci, R. (eds.) CLIN MIDY, Montpellier
    • Bodor, N. (1983) Soft drugs: strategies for design of safer drugs. In: Metabolisme et Conception Medicaments: Quo Vadis? Proceedings of Symposium at Montpellier, France, November 26-27, 1981, pp. 217-251, Briot, M., Cautreels, W. and Roncucci, R. (eds.) CLIN MIDY, Montpellier.
    • (1983) Metabolisme et Conception Medicaments: Quo Vadis? Proceedings of Symposium at Montpellier, France , pp. 217-251
    • Bodor, N.1
  • 7
    • 0021294113 scopus 로고
    • The soft drug approach
    • Bodor, N. (1984a) The soft drug approach. Chemtech 14(1): 28-38.
    • (1984) Chemtech , vol.14 , Issue.1 , pp. 28-38
    • Bodor, N.1
  • 8
    • 0021210779 scopus 로고
    • Soft drugs: Principles and methods for the design of safe drugs
    • Bodor, N. (1984b) Soft drugs: principles and methods for the design of safe drugs. Med. Res. Rev. 3: 449-469.
    • (1984) Med. Res. Rev. , vol.3 , pp. 449-469
    • Bodor, N.1
  • 9
    • 0000120844 scopus 로고
    • Novel approaches to the design of safer drugs: Soft drugs and site-specific chemical delivery systems
    • Testa, B. (ed.) Academic Press, London
    • Bodor, N. (1984c) Novel approaches to the design of safer drugs: soft drugs and site-specific chemical delivery systems. In: Advances in Drug Research, Vol. 13, pp. 255-331, Testa, B. (ed.) Academic Press, London.
    • (1984) Advances in Drug Research , vol.13 , pp. 255-331
    • Bodor, N.1
  • 10
    • 0010577935 scopus 로고
    • Novel approaches to the design of safer drugs by site-specific chemical delivery systems
    • Tipnis, H. P. (ed.) MSR Foundation, Bombay
    • Bodor, N. (1985) Novel approaches to the design of safer drugs by site-specific chemical delivery systems. In: Advances in Drug Delivery Systems, pp. 111-127, Tipnis, H. P. (ed.) MSR Foundation, Bombay.
    • (1985) Advances in Drug Delivery Systems , pp. 111-127
    • Bodor, N.1
  • 11
    • 0023632674 scopus 로고
    • Redox drug delivery systems for targeting drugs to the brain
    • Bodor, N. (1987) Redox drug delivery systems for targeting drugs to the brain. Ann. NY Acad. Sci. 507: 289-306.
    • (1987) Ann. NY Acad. Sci. , vol.507 , pp. 289-306
    • Bodor, N.1
  • 12
    • 0002050603 scopus 로고
    • The application of soft drug approaches to the design of safer corticosteroids
    • Christophers, E., Kligman, A. M., Schöpf, E. and Stougton, R. B. (eds.) Raven Press Ltd., New York
    • Bodor, N. (1988) The application of soft drug approaches to the design of safer corticosteroids. In: Topical Corricosteroid Therapy: A Novel Approach to Safer Drugs, pp. 13-25, Christophers, E., Kligman, A. M., Schöpf, E. and Stougton, R. B. (eds.) Raven Press Ltd., New York.
    • (1988) Topical Corricosteroid Therapy: A Novel Approach to Safer Drugs , pp. 13-25
    • Bodor, N.1
  • 14
    • 0001189322 scopus 로고
    • Soft drugs
    • Dulbecco, R. (ed.) Academic Press, San Diego
    • Bodor, N. (1991) Soft drugs. In: Encyclopedia of Human Biology, Vol. 7, pp. 101-117, Dulbecco, R. (ed.) Academic Press, San Diego.
    • (1991) Encyclopedia of Human Biology , vol.7 , pp. 101-117
    • Bodor, N.1
  • 15
    • 0001793393 scopus 로고
    • New methods of drug targeting
    • Sarel, S., Mechoulam, R. and Agranar, I. (eds.) Blackwell Scientific Publications, Oxford
    • Bodor, N. (1992) New methods of drug targeting. In: Trends in Medicinal Chemistry '90, pp 15-44, Sarel, S., Mechoulam, R. and Agranar, I. (eds.) Blackwell Scientific Publications, Oxford.
    • (1992) Trends in Medicinal Chemistry '90 , pp. 15-44
    • Bodor, N.1
  • 17
    • 0028457169 scopus 로고
    • Drug targeting and retrometabolic drug design approaches
    • Bodor, N. (1994) Drug targeting and retrometabolic drug design approaches. Adv. Drug Delivery Rev. 14: 157-166.
    • (1994) Adv. Drug Delivery Rev. , vol.14 , pp. 157-166
    • Bodor, N.1
  • 18
    • 0002292012 scopus 로고
    • Design of biologically safer chemicals
    • Bodor, N. (1995a) Design of biologically safer chemicals. Chemtech 25(10): 22-32.
    • (1995) Chemtech , vol.25 , Issue.10 , pp. 22-32
    • Bodor, N.1
  • 19
    • 0029347474 scopus 로고
    • Retrometabolic drug design concepts in ophthalmic target-specific drug delivery
    • Bodor, N. (1995b) Retrometabolic drug design concepts in ophthalmic target-specific drug delivery. Adv. Drug Delivery Rev. 16: 21-18.
    • (1995) Adv. Drug Delivery Rev. , vol.16 , pp. 21-118
    • Bodor, N.1
  • 21
    • 0028991721 scopus 로고
    • Targeting drugs to the brain by sequential metabolism
    • Rapaka, R. and Sorer, H. (eds.) NIDA, Rockville
    • Bodor, N. (1995d) Targeting drugs to the brain by sequential metabolism. In: NIDA Research Monograph Series, Vol. 147, Discovery of Novel Opioid Medications, pp. 1-32, Rapaka, R. and Sorer, H. (eds.) NIDA, Rockville.
    • (1995) NIDA Research Monograph Series, Vol. 147, Discovery of Novel Opioid Medications , vol.147 , pp. 1-32
    • Bodor, N.1
  • 22
    • 0020314516 scopus 로고
    • Problems of delivery of drugs to the brain
    • Bodor, N. and Brewster, M. E. (1983) Problems of delivery of drugs to the brain. Pharmacol. Ther. 19: 337-386.
    • (1983) Pharmacol. Ther. , vol.19 , pp. 337-386
    • Bodor, N.1    Brewster, M.E.2
  • 24
    • 0001590002 scopus 로고    scopus 로고
    • Molecular size based approach to estimate partition properties for organic solutes
    • Bodor, N. and Buchwald, P. (1997) Molecular size based approach to estimate partition properties for organic solutes. J. Phys. Chem. B 101: 3404-3412.
    • (1997) J. Phys. Chem. B , vol.101 , pp. 3404-3412
    • Bodor, N.1    Buchwald, P.2
  • 25
    • 0020657167 scopus 로고
    • Improved delivery through biological membranes. 11. A redox chemical drug-delivery system and its use for brain specific delivery of phenylethylamme
    • Bodor, N. and Farag, H. H. (1983) Improved delivery through biological membranes. 11. A redox chemical drug-delivery system and its use for brain specific delivery of phenylethylamme. J. Med. Chem. 26: 313-318.
    • (1983) J. Med. Chem. , vol.26 , pp. 313-318
    • Bodor, N.1    Farag, H.H.2
  • 26
    • 0010545309 scopus 로고
    • U.S. Patent 4262765, April 28
    • Bodor, N. and Freiberg, E. (1981) U.S. Patent 4262765, April 28.
    • (1981)
    • Bodor, N.1    Freiberg, E.2
  • 27
    • 0026590304 scopus 로고
    • An extended version of a novel method for the estimation of partition coefficients
    • Bodor, N. and Huang, M.-J. (1992a) An extended version of a novel method for the estimation of partition coefficients. J. Pharm. Sci. 81: 272-281.
    • (1992) J. Pharm. Sci. , vol.81 , pp. 272-281
    • Bodor, N.1    Huang, M.-J.2
  • 28
    • 0027078680 scopus 로고
    • A new method for the estimation of the aqueous solubility of organic compounds
    • Bodor, N. and Huang, M.-J. (1992b) A new method for the estimation of the aqueous solubility of organic compounds. J. Pharm. Sci. 81: 954-960.
    • (1992) J. Pharm. Sci. , vol.81 , pp. 954-960
    • Bodor, N.1    Huang, M.-J.2
  • 30
    • 0000138305 scopus 로고    scopus 로고
    • Computational approaches to the design of safer drugs and their molecular properties
    • Leszczynski, J. (ed.) World Scientific, Singapore
    • Bodor, N. and Huang, M.-J. (1996) Computational approaches to the design of safer drugs and their molecular properties. In: Computational Chemistry: Reviews of Current Trends, Vol. 1, pp. 219-266, Leszczynski, J. (ed.) World Scientific, Singapore.
    • (1996) Computational Chemistry: Reviews of Current Trends , vol.1 , pp. 219-266
    • Bodor, N.1    Huang, M.-J.2
  • 31
    • 0018908788 scopus 로고
    • Soft drugs. 2. Soft alkylating compounds as potential antitumor agents
    • Bodor, N. and Kaminski, J. J. (1980) Soft drugs. 2. Soft alkylating compounds as potential antitumor agents. J. Med. Chem. 23: 566-569.
    • (1980) J. Med. Chem. , vol.23 , pp. 566-569
    • Bodor, N.1    Kaminski, J.J.2
  • 32
    • 77956854345 scopus 로고
    • Prodrugs and site-specific chemical delivery systems
    • Bodor, N. and Kaminski, J. J. (1987) Prodrugs and site-specific chemical delivery systems. Annu. Rep. Med. Chem. 22: 303-313.
    • (1987) Annu. Rep. Med. Chem. , vol.22 , pp. 303-313
    • Bodor, N.1    Kaminski, J.J.2
  • 33
    • 0010581842 scopus 로고
    • Japan Patent 21201, February 10
    • Bodor, N. and Oshiro, Y. (1983) Japan Patent 21201, February 10.
    • (1983)
    • Bodor, N.1    Oshiro, Y.2
  • 34
    • 0025170708 scopus 로고
    • Site- and stereospecific ocular drug delivery by sequential enzymatic bioactivation
    • Bodor, N. and Prokai, L. (1990) Site- and stereospecific ocular drug delivery by sequential enzymatic bioactivation. Pharm. Res. 7: 723-725.
    • (1990) Pharm. Res. , vol.7 , pp. 723-725
    • Bodor, N.1    Prokai, L.2
  • 35
    • 0002739535 scopus 로고
    • Molecular packaging: Peptide delivery to the central nervous system by sequential metabolism
    • Taylor, M. and Amidon, C. (eds.) American Chemical Society, Washington, DC
    • Bodor, N. and Prokai, L. (1995) Molecular packaging: peptide delivery to the central nervous system by sequential metabolism. In: Peptide-Based Drug Design: Controlling Transport and Metabolism, pp. 317-337, Taylor, M. and Amidon, C. (eds.) American Chemical Society, Washington, DC.
    • (1995) Peptide-Based Drug Design: Controlling Transport and Metabolism , pp. 317-337
    • Bodor, N.1    Prokai, L.2
  • 36
    • 0020332724 scopus 로고
    • Soft drugs. V. Thiazolidine-type derivatives of progesterone and testosterone
    • Bodor, N. and Sloan, K. B. (1982) Soft drugs. V. Thiazolidine-type derivatives of progesterone and testosterone. J. Pharm. Sci. 71: 514-520.
    • (1982) J. Pharm. Sci. , vol.71 , pp. 514-520
    • Bodor, N.1    Sloan, K.B.2
  • 37
    • 0021206496 scopus 로고
    • Formation of adrenaline in the irisciliary body from adrenalone diesters
    • Bodor, N. and Visor, G. (1984) Formation of adrenaline in the irisciliary body from adrenalone diesters. Exp. Eye Res. 38: 621-626.
    • (1984) Exp. Eye Res. , vol.38 , pp. 621-626
    • Bodor, N.1    Visor, G.2
  • 38
    • 33745609384 scopus 로고
    • Soft drugs. 1. Labile quaternary ammonium salts as soft antimicrobials
    • Bodor, N., Kaminski, J. J. and Selk, S. (1980a) Soft drugs. 1. Labile quaternary ammonium salts as soft antimicrobials. J. Med. Chem. 23: 469-474.
    • (1980) J. Med. Chem. , vol.23 , pp. 469-474
    • Bodor, N.1    Kaminski, J.J.2    Selk, S.3
  • 40
    • 0019843193 scopus 로고
    • Site-specific, sustained release of drugs to the brain
    • Bodor, N., Farag, H. H. and Brewster, M. E. (1981) Site-specific, sustained release of drugs to the brain. Science 214: 1370-1372.
    • (1981) Science , vol.214 , pp. 1370-1372
    • Bodor, N.1    Farag, H.H.2    Brewster, M.E.3
  • 41
    • 0019990671 scopus 로고
    • Soft drugs. 4. 3-Spirothiazolidines of hydrocortisone and its derivatives
    • Bodor, N., Sloan, K. B., Little, R. J., Selk, S. H. and Caldwell, L. (1982) Soft drugs. 4. 3-Spirothiazolidines of hydrocortisone and its derivatives. Int. J. Pharm. 10: 307-321.
    • (1982) Int. J. Pharm. , vol.10 , pp. 307-321
    • Bodor, N.1    Sloan, K.B.2    Little, R.J.3    Selk, S.H.4    Caldwell, L.5
  • 42
    • 0021258295 scopus 로고
    • Soft drugs. VI: The application of the inactive metabolite approach for design of soft β-blockers
    • Bodor, N., Oshiro, Y., Loftsson, T., Katovich, M. and Caldwell, W. (1984) Soft drugs. VI: the application of the inactive metabolite approach for design of soft β-blockers. Pharm. Res. 3: 120-125.
    • (1984) Pharm. Res. , vol.3 , pp. 120-125
    • Bodor, N.1    Oshiro, Y.2    Loftsson, T.3    Katovich, M.4    Caldwell, W.5
  • 43
    • 0023153469 scopus 로고
    • Improved delivery through biological membranes. XXII. Synthesis and distribution of brain-selective estrogen delivery systems
    • Bodor, N., McComack, J. and Brewster, M. E. (1987) Improved delivery through biological membranes. XXII. Synthesis and distribution of brain-selective estrogen delivery systems. Int. J. Pharm. 35: 47-59.
    • (1987) Int. J. Pharm. , vol.35 , pp. 47-59
    • Bodor, N.1    McComack, J.2    Brewster, M.E.3
  • 44
    • 0023719851 scopus 로고
    • Soft drugs. 7. β-Blockers for systemic and ophthalmic use
    • Bodor, N., El-Koussi, A., Kano, M. and Khalifa, M. (1988a) Soft drugs. 7. β-Blockers for systemic and ophthalmic use. J. Med. Chem. 31: 1651-1656.
    • (1988) J. Med. Chem. , vol.31 , pp. 1651-1656
    • Bodor, N.1    El-Koussi, A.2    Kano, M.3    Khalifa, M.4
  • 45
    • 0023853652 scopus 로고
    • Improved delivery through biological membranes. 26. Design, synthesis, and pharmacological activity of a novel chemical delivery system for β-adrenergic blocking agents
    • Bodor, N., El-Koussi, A., Kano, M. and Nakamuro, T. (1988b) Improved delivery through biological membranes. 26. Design, synthesis, and pharmacological activity of a novel chemical delivery system for β-adrenergic blocking agents. J. Med. Chem. 31: 100-106.
    • (1988) J. Med. Chem. , vol.31 , pp. 100-106
    • Bodor, N.1    El-Koussi, A.2    Kano, M.3    Nakamuro, T.4
  • 46
    • 0024656378 scopus 로고
    • A new method for the estimation of partition coefficient
    • Bodor, N., Gabanyi, Z. and Wong, C.-K. (1989) A new method for the estimation of partition coefficient. J. Am. Chem. Soc. 111: 3783-3786.
    • (1989) J. Am. Chem. Soc. , vol.111 , pp. 3783-3786
    • Bodor, N.1    Gabanyi, Z.2    Wong, C.-K.3
  • 47
    • 0010608884 scopus 로고
    • Soft drugs. 9. The ultra-short duration of the muscarinolytic activity of a new short-acting "soft" mydriatic agent
    • Bodor, N., El-Koussi, A. and Hammer, R. (1990) Soft drugs. 9. The ultra-short duration of the muscarinolytic activity of a new short-acting "soft" mydriatic agent. J. Biopharm. Sci 1: 215-223.
    • (1990) J. Biopharm. Sci , vol.1 , pp. 215-223
    • Bodor, N.1    El-Koussi, A.2    Hammer, R.3
  • 48
    • 0026352974 scopus 로고
    • Neural network studies. 1. Estimation of the aqueous solubility of organic compounds
    • Bodor, N., Harget, A. and Huang, M.-J. (1991) Neural network studies. 1. Estimation of the aqueous solubility of organic compounds. J. Am. Chem. Soc. 113: 9480-9483.
    • (1991) J. Am. Chem. Soc. , vol.113 , pp. 9480-9483
    • Bodor, N.1    Harget, A.2    Huang, M.-J.3
  • 49
    • 0026638362 scopus 로고
    • A comparison of intraocular pressure elevating activity of loteprednol etabonate and dexamethasone in rabbits
    • Bodor, N., Bodor, N. and Wu, W.-M. (1992a) A comparison of intraocular pressure elevating activity of loteprednol etabonate and dexamethasone in rabbits. Curr. Eye Res. 11: 525-530.
    • (1992) Curr. Eye Res. , vol.11 , pp. 525-530
    • Bodor, N.1    Bodor, N.2    Wu, W.-M.3
  • 50
    • 0026783425 scopus 로고
    • A strategy for delivering peptides into the central nervous system by sequential metabolism
    • Budor, N., Prokai, L., Wu, W.-M., Farag, H. H., Jonnalagadda, S., Kawamura, M. and Simpkins, J. (1992b) A strategy for delivering peptides into the central nervous system by sequential metabolism. Science 257: 1698-1700.
    • (1992) Science , vol.257 , pp. 1698-1700
    • Budor, N.1    Prokai, L.2    Wu, W.-M.3    Farag, H.H.4    Jonnalagadda, S.5    Kawamura, M.6    Simpkins, J.7
  • 51
    • 0010608885 scopus 로고    scopus 로고
    • Computer assisted design of new drugs based on retrometabolic concepts
    • Bodor, N., Buchwald, P. and Huang, M.-J. (1997a) Computer assisted design of new drugs based on retrometabolic concepts. SAR QSAR Environ. Res., 13: 389-403.
    • (1997) SAR QSAR Environ. Res. , vol.13 , pp. 389-403
    • Bodor, N.1    Buchwald, P.2    Huang, M.-J.3
  • 52
    • 0031416266 scopus 로고    scopus 로고
    • Ocular-specific delivery of timolol by sequential bioactivation of its oxime and methoxime analogs
    • in press
    • Bodor, N., Farag, H. H., Somogyi, G., Wu, W.-M., Barros, M. D. C. and Prokai, L. (1997b) Ocular-specific delivery of timolol by sequential bioactivation of its oxime and methoxime analogs. J Ocul. Pharmacol., in press.
    • (1997) J Ocul. Pharmacol.
    • Bodor, N.1    Farag, H.H.2    Somogyi, G.3    Wu, W.-M.4    Barros, M.D.C.5    Prokai, L.6
  • 53
    • 0028457106 scopus 로고
    • Improved brain delivery of antiviral agents through the use of redox targeting
    • Brewster, M. E. and Bodor, N. (1994) Improved brain delivery of antiviral agents through the use of redox targeting. Adv. Drug Delivery Rev. 14: 177-197.
    • (1994) Adv. Drug Delivery Rev. , vol.14 , pp. 177-197
    • Brewster, M.E.1    Bodor, N.2
  • 54
    • 0022996140 scopus 로고
    • Improved delivery through biological membranes. XXIV. Synthesis, in vitro studies, and in vivo characterization of brain-specific and sustained progestin delivers systems
    • Brewster, M. E., Estes, K. S. and Bodor, N. (1986) Improved delivery through biological membranes. XXIV. Synthesis, in vitro studies, and in vivo characterization of brain-specific and sustained progestin delivers systems. Pharm. Res. 3: 278-085.
    • (1986) Pharm. Res. , vol.3 , pp. 278-1085
    • Brewster, M.E.1    Estes, K.S.2    Bodor, N.3
  • 55
    • 0023845773 scopus 로고
    • Improved delivery through biological membranes. XXXII. Synthesis and biological activity of brain-targeted delivery systems for various estradiol derivatives
    • Brewster, M. E., Estes, K. S. and Bodor, N. (1988) Improved delivery through biological membranes. XXXII. Synthesis and biological activity of brain-targeted delivery systems for various estradiol derivatives. J. Med. Chem. 31: 244-249.
    • (1988) J. Med. Chem. , vol.31 , pp. 244-249
    • Brewster, M.E.1    Estes, K.S.2    Bodor, N.3
  • 56
    • 0027404655 scopus 로고
    • Peptidases, peptides, and the mammalian blood-brain barrier
    • Brownlees, J. and Williams, C. H. (1993) Peptidases, peptides, and the mammalian blood-brain barrier. J. Neurochem. 60: 793-803.
    • (1993) J. Neurochem. , vol.60 , pp. 793-803
    • Brownlees, J.1    Williams, C.H.2
  • 57
    • 0010614090 scopus 로고    scopus 로고
    • Octanol-water partition of nonzwitterionic peptides: Predictive power of a molecular size based model
    • in press
    • Buchwald, P. and Bodor, N. (1997) Octanol-water partition of nonzwitterionic peptides: predictive power of a molecular size based model. Proteins, in press.
    • (1997) Proteins
    • Buchwald, P.1    Bodor, N.2
  • 59
  • 60
    • 0026052024 scopus 로고
    • Regioselective O-alkylation of cortienic acid and synthesis of a new class of glua corticoids containing a 17α-alkoxy, a 17α-(1′-alkoxyethyloxy), a 17α-alkoxymethyloxy, or a 17α-methylthiomethyloxy function
    • Druzgala, P. and Bodor, N. (1991) Regioselective O-alkylation of cortienic acid and synthesis of a new class of glua corticoids containing a 17α-alkoxy, a 17α-(1′-alkoxyethyloxy), a 17α-alkoxymethyloxy, or a 17α-methylthiomethyloxy function. Steroids 56: 490-494.
    • (1991) Steroids , vol.56 , pp. 490-494
    • Druzgala, P.1    Bodor, N.2
  • 61
    • 0026100181 scopus 로고
    • Soft drugs. 10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: Loteprednol etahonate
    • Druzgala, P., Hochhaus, G. and Bodor, N. (1991) Soft drugs. 10. Blanching activity and receptor binding affinity of a new type of glucocorticoid: loteprednol etahonate. J. Steroid Biochem. 38: 149-154.
    • (1991) J. Steroid Biochem. , vol.38 , pp. 149-154
    • Druzgala, P.1    Hochhaus, G.2    Bodor, N.3
  • 62
    • 0024337492 scopus 로고
    • Formation of propanolol in the iris-ciliary body from its propranolol ketoxime precursor - A potential antiglaucoma drug
    • El-Koussi, A. and Bodor, N. (1989) Formation of propanolol in the iris-ciliary body from its propranolol ketoxime precursor - a potential antiglaucoma drug. Int. J. Pharm. 53: 189-194.
    • (1989) Int. J. Pharm. , vol.53 , pp. 189-194
    • El-Koussi, A.1    Bodor, N.2
  • 63
    • 0030882954 scopus 로고    scopus 로고
    • Ocular-specific chemical delivery system of betaxolol for safe local treatment of glaucoma
    • in press
    • Farag, H. H., Wu, W.-M., Barros, M. D. C., Somogyi, G., Prokai, L. and Bodor, N. (1997) Ocular-specific chemical delivery system of betaxolol for safe local treatment of glaucoma. Drug Des. Discov., in press.
    • (1997) Drug Des. Discov.
    • Farag, H.H.1    Wu, W.-M.2    Barros, M.D.C.3    Somogyi, G.4    Prokai, L.5    Bodor, N.6
  • 64
    • 0017222253 scopus 로고
    • Determination of bufuralol and its metabolites in plasma by mass fragmentography and by gas chromatograpby with electron capture detection
    • Francis, R. J., East, P. B., McLaren, S. J. and Larman, J. (1976) Determination of bufuralol and its metabolites in plasma by mass fragmentography and by gas chromatograpby with electron capture detection. Biomed. Mass Spectrom. 3: 281-285.
    • (1976) Biomed. Mass Spectrom. , vol.3 , pp. 281-285
    • Francis, R.J.1    East, P.B.2    McLaren, S.J.3    Larman, J.4
  • 65
    • 0023134539 scopus 로고
    • Site-specific drug delivery
    • Friend, D. R. and Pangburn, S. (1987) Site-specific drug delivery. Med. Res. Rev. 7: 53-106.
    • (1987) Med. Res. Rev. , vol.7 , pp. 53-106
    • Friend, D.R.1    Pangburn, S.2
  • 66
    • 0014519356 scopus 로고
    • Acute toxicity of pesticides
    • Gaines, T. B. (1969) Acute toxicity of pesticides. Toxicol. Appl. Pharmacol. 14: 515-534.
    • (1969) Toxicol. Appl. Pharmacol. , vol.14 , pp. 515-534
    • Gaines, T.B.1
  • 67
    • 0021940136 scopus 로고
    • Potential and limitations of drug targeting: An overview
    • Gardner, C. R. (1985) Potential and limitations of drug targeting: an overview. Biomaterials 6: 153-160.
    • (1985) Biomaterials , vol.6 , pp. 153-160
    • Gardner, C.R.1
  • 68
    • 0024353657 scopus 로고
    • A prodrug of zidovudine with enhanced efficacy against human immunodeficiency virus
    • Gogu, S. R., Aggarwal, S. K., Rangan, S. R. S. and Agrawal, K. C. (1989) A prodrug of zidovudine with enhanced efficacy against human immunodeficiency virus. Biochem. Biophys. Res. Commun. 160: 656-661.
    • (1989) Biochem. Biophys. Res. Commun. , vol.160 , pp. 656-661
    • Gogu, S.R.1    Aggarwal, S.K.2    Rangan, S.R.S.3    Agrawal, K.C.4
  • 69
    • 0018143071 scopus 로고
    • Intrinsic sympathomimetic activity of β-adrenoceptor blocking drugs at cardiac and vascular β-adrenoceptors
    • Hamilton, T. C. and Chapman, V. (1978) Intrinsic sympathomimetic activity of β-adrenoceptor blocking drugs at cardiac and vascular β-adrenoceptors. Life Sci. 23: 813-820.
    • (1978) Life Sci. , vol.23 , pp. 813-820
    • Hamilton, T.C.1    Chapman, V.2
  • 75
    • 0028177263 scopus 로고    scopus 로고
    • The κ-opioid receptor expressed on the mouse lymphoma cell line R1.1 contains a sulfhydryl group at the binding site
    • Joseph, D. B. and Bidlak, J. M. (1996) The κ-opioid receptor expressed on the mouse lymphoma cell line R1.1 contains a sulfhydryl group at the binding site. Eur. J. Pharmacol. 267: 1-6.
    • (1996) Eur. J. Pharmacol. , vol.267 , pp. 1-6
    • Joseph, D.B.1    Bidlak, J.M.2
  • 76
    • 0017273398 scopus 로고
    • N-Halo derivatives. III: Stabilization of nitrogen chlorine bond in N-chloroamino acid derivatives
    • Kaminski, J. J., Bodor, N. and Higuchi, T. (1976a) N-Halo derivatives. III: Stabilization of nitrogen chlorine bond in N-chloroamino acid derivatives. J. Pharm. Sci. 65: 553-557.
    • (1976) J. Pharm. Sci. , vol.65 , pp. 553-557
    • Kaminski, J.J.1    Bodor, N.2    Higuchi, T.3
  • 77
    • 0017030686 scopus 로고
    • N-Halo derivatives. IV: Synthesis of low chlorine potential soft-N-chloramine systems
    • Kaminski, J. J., Bodor, N. and Higuchi, T. (1976b) N-Halo derivatives. IV: Synthesis of low chlorine potential soft-N-chloramine systems. J. Pharm. Sci. 65: 1733-1737.
    • (1976) J. Pharm. Sci. , vol.65 , pp. 1733-1737
    • Kaminski, J.J.1    Bodor, N.2    Higuchi, T.3
  • 78
    • 0025164412 scopus 로고
    • Design and synthesis of an opiod receptor probe: Mode of binding of S-activated (-)-6β-sulfhydryldihydromorphine with the SH group in the μ-opioid receptor
    • Kanematsu, K., Naito, R., Shimohigashi, Y., Ohno, M., Ogasawara, T., Kurono, M. and Yagi, K. (1990) Design and synthesis of an opiod receptor probe: mode of binding of S-activated (-)-6β-sulfhydryldihydromorphine with the SH group in the μ-opioid receptor. Chem. Pharm. Bull. 38: 1438-1440.
    • (1990) Chem. Pharm. Bull. , vol.38 , pp. 1438-1440
    • Kanematsu, K.1    Naito, R.2    Shimohigashi, Y.3    Ohno, M.4    Ogasawara, T.5    Kurono, M.6    Yagi, K.7
  • 79
    • 0017722468 scopus 로고
    • Carcinogenicity of DDT (dichlorodiphenyltrichloroethane) in pure inbred Swiss mice
    • Kashyap, S. K., Nigam, S. K., Karnik, A. B., Gupta, R. C. and Chatterjee, S. K. (1979) Carcinogenicity of DDT (dichlorodiphenyltrichloroethane) in pure inbred Swiss mice. Int. J. Cancer 19: 725-729.
    • (1979) Int. J. Cancer , vol.19 , pp. 725-729
    • Kashyap, S.K.1    Nigam, S.K.2    Karnik, A.B.3    Gupta, R.C.4    Chatterjee, S.K.5
  • 81
    • 0030572635 scopus 로고    scopus 로고
    • Synthesis and evaluation of a brain-targeted catechol derivative as a potential NGF-inducer
    • Kourounakis, A., Bodor, N. and Smipkins, J. (1996) Synthesis and evaluation of a brain-targeted catechol derivative as a potential NGF-inducer. Int. J. Pharm. 141: 239-250.
    • (1996) Int. J. Pharm. , vol.141 , pp. 239-250
    • Kourounakis, A.1    Bodor, N.2    Smipkins, J.3
  • 82
    • 0031027656 scopus 로고    scopus 로고
    • Synthesis and evaluation of a brain-targeted chemical delivery system for the neurotrophomodutator 4-methylcatechol
    • Kourounakis, A., Bodor, N. and Simpkins, J. (1997) Synthesis and evaluation of a brain-targeted chemical delivery system for the neurotrophomodutator 4-methylcatechol. J. Pharm. Pharmacol. 49: 1-9.
    • (1997) J. Pharm. Pharmacol. , vol.49 , pp. 1-9
    • Kourounakis, A.1    Bodor, N.2    Simpkins, J.3
  • 83
    • 0027489426 scopus 로고
    • Soft drugs-12. Design, synthesis, stability and evaluation of soft anticholinergics
    • Kumar, G. N., Hammer, R. H. and Bodor, N. (1993a) Soft drugs-12. Design, synthesis, stability and evaluation of soft anticholinergics. Drug Des. Discov. 10: 11-21.
    • (1993) Drug Des. Discov. , vol.10 , pp. 11-21
    • Kumar, G.N.1    Hammer, R.H.2    Bodor, N.3
  • 84
    • 0027369980 scopus 로고
    • Soft drugs. 13. Design and evaluation of phenylsuccinic analogs of scopolamine as soft anticholinergics
    • Kumar, G. N., Hammer, R. H. and Bodor, N. (1993b) Soft drugs. 13. Design and evaluation of phenylsuccinic analogs of scopolamine as soft anticholinergics. Drug Des. Discov. 10: 1-9.
    • (1993) Drug Des. Discov. , vol.10 , pp. 1-9
    • Kumar, G.N.1    Hammer, R.H.2    Bodor, N.3
  • 85
    • 0027700255 scopus 로고
    • Soft drugs. 16. Design, evaluation and transdermal penetration of novel soft anticholinergics based on methatropine
    • Kumar, G. N., Hammer, R. H. and Bodor, N. (1993c) Soft drugs. 16. Design, evaluation and transdermal penetration of novel soft anticholinergics based on methatropine. Bioorg. Med. Chem. 1: 327-332.
    • (1993) Bioorg. Med. Chem. , vol.1 , pp. 327-332
    • Kumar, G.N.1    Hammer, R.H.2    Bodor, N.3
  • 86
    • 0027270915 scopus 로고
    • Soft drugs. 15. Mydriatic activity of phenylsuccinic analogs of methscopolamine and transcorneal penetration of short acting mydriatics
    • Kumar, G. N., Hammer, R. H., Wu, W.-M. and Bodor, N. (1993d) Soft drugs. 15. Mydriatic activity of phenylsuccinic analogs of methscopolamine and transcorneal penetration of short acting mydriatics. Curr. Eye Res. 12: 501-506.
    • (1993) Curr. Eye Res. , vol.12 , pp. 501-506
    • Kumar, G.N.1    Hammer, R.H.2    Wu, W.-M.3    Bodor, N.4
  • 87
    • 0001934054 scopus 로고
    • Improved delivery through biological membranes. XXXIII. Brain enhanced delivery of azidothymidine AZT
    • Little, R., Bailey, D., Brewster, M. E., Estes, K., Clemmons, R., Saab, A. and Bodor, N. (1990) Improved delivery through biological membranes. XXXIII. Brain enhanced delivery of azidothymidine AZT. J. Biopharm. Sci. 1: 1-13.
    • (1990) J. Biopharm. Sci. , vol.1 , pp. 1-13
    • Little, R.1    Bailey, D.2    Brewster, M.E.3    Estes, K.4    Clemmons, R.5    Saab, A.6    Bodor, N.7
  • 88
    • 0022401863 scopus 로고
    • β-Adrenoceptor activity of the stereoisomers of the bufuralol alcohol and ketone metabolites
    • Machin, P. J., Hurst, D. N. and Osbond, J. M. (1985) β-Adrenoceptor activity of the stereoisomers of the bufuralol alcohol and ketone metabolites. J. Med. Chem. 28: 1648-1651.
    • (1985) J. Med. Chem. , vol.28 , pp. 1648-1651
    • Machin, P.J.1    Hurst, D.N.2    Osbond, J.M.3
  • 89
    • 0026711121 scopus 로고
    • Drug targeting systems for antiviral agents: Options and limitations
    • Meijer, D. K. F., Jansen, R. W. and Molema, G. (1992) Drug targeting systems for antiviral agents: options and limitations. Antiviral Res. 18: 215-258.
    • (1992) Antiviral Res. , vol.18 , pp. 215-258
    • Meijer, D.K.F.1    Jansen, R.W.2    Molema, G.3
  • 90
    • 0010545001 scopus 로고    scopus 로고
    • note
    • ONO Pharmaceutical Co. (1990) FPO Patent 386901, December 12, Japan.
  • 91
    • 0024500236 scopus 로고
    • A dihydropyridine carrier system for sustained delivery of 1′,3′-dideoxynucleosides to the brain
    • Palomino, E., Kessel, D. and Horwitz, J. P. (1989) A dihydropyridine carrier system for sustained delivery of 1′,3′-dideoxynucleosides to the brain. J. Med. Chem. 32: 622-625.
    • (1989) J. Med. Chem. , vol.32 , pp. 622-625
    • Palomino, E.1    Kessel, D.2    Horwitz, J.P.3
  • 92
    • 0028966770 scopus 로고
    • 1 a site-activated ocular β-blocker, in dogs
    • 1 a site-activated ocular β-blocker, in dogs. Life Sci. 56: 1207-1216.
    • (1995) Life Sci. , vol.56 , pp. 1207-1216
    • Polgar, P.1    Bodor, N.2
  • 93
    • 0024317126 scopus 로고
    • Chemical delivery systems for some penicillinase-resistant semisynthetic penicillins
    • Pop, E., Wu, W.-M. and Bodor, N. (1989a) Chemical delivery systems for some penicillinase-resistant semisynthetic penicillins. J. Med. Chem. 32: 1789-1795.
    • (1989) J. Med. Chem. , vol.32 , pp. 1789-1795
    • Pop, E.1    Wu, W.-M.2    Bodor, N.3
  • 94
    • 0024311241 scopus 로고
    • Brain-specific chemical delivery systems for β-lactam antibiotics. Synthesis and properties of some dihydtopyridine and dihydroisoquinoline derivatives of benzylpenicillin
    • Pop, E. Wu, W.-M., Shek, E. and Bodor, N. (1989b) Brain-specific chemical delivery systems for β-lactam antibiotics. Synthesis and properties of some dihydtopyridine and dihydroisoquinoline derivatives of benzylpenicillin. J. Med. Chem. 32: 1774-1781.
    • (1989) J. Med. Chem. , vol.32 , pp. 1774-1781
    • Pop, E.1    Wu, W.-M.2    Shek, E.3    Bodor, N.4
  • 95
    • 85053093423 scopus 로고
    • The challenge of liposome targeting in vivo
    • Gregoriadis, G. (ed.) CRC Press, Boca Raton
    • Poste, G., Kirsh, R. and Koestler, T. (1984) The challenge of liposome targeting in vivo. In: Liposome Technology, Vol. III, pp. 1-28, Gregoriadis, G. (ed.) CRC Press, Boca Raton.
    • (1984) Liposome Technology , vol.3 , pp. 1-28
    • Poste, G.1    Kirsh, R.2    Koestler, T.3
  • 96
    • 0021741835 scopus 로고
    • Biological approaches to the controlled delivery of dings: A critical review
    • Poznansky, M. S. and Juliano, M. S. (1984) Biological approaches to the controlled delivery of dings: a critical review. Pharmacol. Rev. 36: 277-287.
    • (1984) Pharmacol. Rev. , vol.36 , pp. 277-287
    • Poznansky, M.S.1    Juliano, M.S.2
  • 97
    • 0028354438 scopus 로고
    • Chemical delivery system to transport a pyroglutamyl peptide to the central nervous system
    • Prokai, L., Ouyang, X.-D., Wu, W.-M. and Bodor, N. (1994a) Chemical delivery system to transport a pyroglutamyl peptide to the central nervous system J. Am. Chem. Soc. 116: 2643-2644.
    • (1994) J. Am. Chem. Soc. , vol.116 , pp. 2643-2644
    • Prokai, L.1    Ouyang, X.-D.2    Wu, W.-M.3    Bodor, N.4
  • 98
    • 0029069037 scopus 로고
    • Ocular delivery of the β-adrenergic antagonist alprenolol by sequential bioactivation of its methoxime analog
    • Prokai, L., Wu, W.-M., Somogyi, G. and Bodor, N. (1994b) Ocular delivery of the β-adrenergic antagonist alprenolol by sequential bioactivation of its methoxime analog. J. Med. Chem. 38: 2018-2020.
    • (1994) J. Med. Chem. , vol.38 , pp. 2018-2020
    • Prokai, L.1    Wu, W.-M.2    Somogyi, G.3    Bodor, N.4
  • 99
    • 0030471676 scopus 로고    scopus 로고
    • Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design
    • Prokai-Tatrai, K., Prokai, L. and Bodor, N. (1996) Brain-targeted delivery of a leucine-enkephalin analogue by retrometabolic design. J. Med. Chem. 39: 4775-4782.
    • (1996) J. Med. Chem. , vol.39 , pp. 4775-4782
    • Prokai-Tatrai, K.1    Prokai, L.2    Bodor, N.3
  • 100
    • 0023276725 scopus 로고
    • Improved delivery through biological membranes. XXX. Synthesis and biological aspects of a 1,4-dihydropyridine based chemical delivery system for brain-sustained delivery of hydroxy CCNU
    • Raghavan, K., Shek, E. and Bodor, N. (1987) Improved delivery through biological membranes. XXX. Synthesis and biological aspects of a 1,4-dihydropyridine based chemical delivery system for brain-sustained delivery of hydroxy CCNU. Anticancer Drug Des. 2: 25-36.
    • (1987) Anticancer Drug Des. , vol.2 , pp. 25-36
    • Raghavan, K.1    Shek, E.2    Bodor, N.3
  • 101
    • 0024470454 scopus 로고
    • Drug delivery systems. 1. Site-specific drug delivery using liposomes as carriers
    • Ranade, V. V. (1989) Drug delivery systems. 1. Site-specific drug delivery using liposomes as carriers. J. Clin. Pharmacol. 29: 685-094.
    • (1989) J. Clin. Pharmacol. , vol.29 , pp. 685-1094
    • Ranade, V.V.1
  • 102
    • 0022449966 scopus 로고
    • Potential treatment of herpes simplex virus encephalitis by brain-specific delivery of trifluorothymidine using a dihydropyridine ↔ pyridinium salt redox delivery system
    • Rand, K., Bodor, N., El-Koussi, A., Raad, I., Miyake, A., Houck, H. and Gildersleeve, N. (1986) Potential treatment of herpes simplex virus encephalitis by brain-specific delivery of trifluorothymidine using a dihydropyridine ↔ pyridinium salt redox delivery system. J. Med. Virol. 20: 1-8.
    • (1986) J. Med. Virol. , vol.20 , pp. 1-8
    • Rand, K.1    Bodor, N.2    El-Koussi, A.3    Raad, I.4    Miyake, A.5    Houck, H.6    Gildersleeve, N.7
  • 103
    • 0028337474 scopus 로고
    • In vitro evaluation of a controlled-release site-specific diisovaleryl tert-butalone chemical delivery system for the eye
    • Reddy, I. K. and Bodor, N. (1994) In vitro evaluation of a controlled-release site-specific diisovaleryl tert-butalone chemical delivery system for the eye. J. Pharm. Sci. 83: 450-453.
    • (1994) J. Pharm. Sci. , vol.83 , pp. 450-453
    • Reddy, I.K.1    Bodor, N.2
  • 104
    • 0029879875 scopus 로고    scopus 로고
    • Design, synthesis, and pharmacokinetic evaluation of a chemical delivery system for drug targeting to lung tissue
    • Saah, M., Wu, W.-M., Eberst, K., Marvanyos, E. and Bodor, N. (1996) Design, synthesis, and pharmacokinetic evaluation of a chemical delivery system for drug targeting to lung tissue. J. Pharm. Sci. 85: 496-504.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 496-504
    • Saah, M.1    Wu, W.-M.2    Eberst, K.3    Marvanyos, E.4    Bodor, N.5
  • 105
    • 0010545313 scopus 로고
    • An example of SN1 cleavage of a sulfide
    • Schubert, W. M. and Motoyama, Y. (1965) An example of SN1 cleavage of a sulfide. J. Am. Chem. Soc. 87: 5507-5508.
    • (1965) J. Am. Chem. Soc. , vol.87 , pp. 5507-5508
    • Schubert, W.M.1    Motoyama, Y.2
  • 106
    • 0029863220 scopus 로고    scopus 로고
    • Studies on inhibition of μ and δ opioid receptor binding by dithiothreitol and N-ethylmaleimide
    • Shahrestanifar, M., Wang, W. W. and Howells, R. D. (1996) Studies on inhibition of μ and δ opioid receptor binding by dithiothreitol and N-ethylmaleimide. J. Biol. Chem. 271: 5505-5512.
    • (1996) J. Biol. Chem. , vol.271 , pp. 5505-5512
    • Shahrestanifar, M.1    Wang, W.W.2    Howells, R.D.3
  • 107
    • 0000602498 scopus 로고
    • Oxidation of aryloxyβ-amino alcohols with activated dimethylsulfoxide. A novel C-N oxidation facilitated by neighboring group effect
    • Simay, A., Prokai, L. and Bodor, N. (1989) Oxidation of aryloxyβ-amino alcohols with activated dimethylsulfoxide. A novel C-N oxidation facilitated by neighboring group effect. Tetrahedron 45: 4091-4102.
    • (1989) Tetrahedron , vol.45 , pp. 4091-4102
    • Simay, A.1    Prokai, L.2    Bodor, N.3
  • 108
    • 0344717449 scopus 로고
    • Selective protection of stereospecihc enkephalin and opiate binding against inactivation by N-ethylmaleimide: Evidence for two classes of opiate receptors
    • Smith, J. R. and Simon, E. J. (1980) Selective protection of stereospecihc enkephalin and opiate binding against inactivation by N-ethylmaleimide: evidence for two classes of opiate receptors. Proc. Natl. Acad. Sci. USA 77: 281-284.
    • (1980) Proc. Natl. Acad. Sci. USA , vol.77 , pp. 281-284
    • Smith, J.R.1    Simon, E.J.2
  • 109
    • 0023488488 scopus 로고
    • Theory and practice of site-specific drug delivery
    • Tomlinson, E. (1987) Theory and practice of site-specific drug delivery. Adv. Drug Delivery Rev. 1: 87-164.
    • (1987) Adv. Drug Delivery Rev. , vol.1 , pp. 87-164
    • Tomlinson, E.1
  • 111
    • 0023915671 scopus 로고
    • AIDS dementia: Synthesis and properties of a derivative of 3′-azido-3′-deoxythimidine (AZT) that may become "locked" in the central nervous system
    • Torrence, P. T., Kinjo, J., Lesiak, K., Balzarini, J. and DeClerq, E. (1988) AIDS dementia: synthesis and properties of a derivative of 3′-azido-3′-deoxythimidine (AZT) that may become "locked" in the central nervous system. FEBS Lett. 234: 135-140.
    • (1988) FEBS Lett. , vol.234 , pp. 135-140
    • Torrence, P.T.1    Kinjo, J.2    Lesiak, K.3    Balzarini, J.4    DeClerq, E.5
  • 112
    • 0018401184 scopus 로고
    • Magnetically responsive microspheres and other carriers for the biophysical targeting of amitumor agents
    • Widder, K. J., Senyei, A. E. and Ramies, D. F. (1979) Magnetically responsive microspheres and other carriers for the biophysical targeting of amitumor agents. Adv. Pharmacol. Chemother. 16: 213-271.
    • (1979) Adv. Pharmacol. Chemother. , vol.16 , pp. 213-271
    • Widder, K.J.1    Senyei, A.E.2    Ramies, D.F.3
  • 113
    • 0028907497 scopus 로고
    • Soft drugs. XX. Design, synthesis and evaluation of ultra-short acting beta-blockers
    • Yang, H., Wu, W.-M. and Bodor, N. (1995) Soft drugs. XX. Design, synthesis and evaluation of ultra-short acting beta-blockers. Pharm. Res. 12: 329-336
    • (1995) Pharm. Res. , vol.12 , pp. 329-336
    • Yang, H.1    Wu, W.-M.2    Bodor, N.3


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