1-Ethylazacycloalkan-2-one indomethacin esters as new oral prodrugs: Chemical stability, enzymatic hydrolysis, anti-inflammatory activity and gastrointestinal toxicity

International Journal of Pharmaceutics

Volumn 156, Issue 2, 1997, Pages 245-250

  Bonina, Francesco ^a   Trombetta, Domenico ^b   Borzi', Antonella ^a   De Pasquale, Anna ^b   Saija, Antonella ^b  

^a UNIVERSITY OF CATANIA   (Italy)

^b UNIVERSITY OF MESSINA   (Italy)

Author keywords

Anti inflammatory activity; Hydrolysis; Indomethacin; Prodrugs; Rodents; Ulcerogenicity

Indexed keywords

INDOMETACIN; INDOMETACIN DERIVATIVE; PRODRUG;

ANALGESIC ACTIVITY; ANIMAL EXPERIMENT; ANTIINFLAMMATORY ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG HYDROLYSIS; DRUG STABILITY; EDEMA; GASTROINTESTINAL TOXICITY; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT; ULCEROGENESIS;

EID: 0030822089     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(97)00197-X     Document Type: Article

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