In vitro evaluation of amino acid prodrugs of novel antitumour 2-(4-amino-3-methylphenyl)benzothiazoles

British Journal of Cancer

Volumn 86, Issue 8, 2002, Pages 1348-1354

  Bradshaw, T D ^a   Chua, M S ^a   Browne, H L ^a   Trapani, V ^a   Sausville, E A ^b   Stevens, M F G ^a  

^a UNIVERSITY OF NOTTINGHAM   (United Kingdom)

^b Laboratory of Cell Biology   (United Kingdom)

Author keywords

2 (4 aminophenyl)benzothiazole; CYP1A1; Prodrug

Indexed keywords

2 (4 AMINO 3 METHYLPHENYL)BENZOTHIAZOLE DERIVATIVE; ALANINE DERIVATIVE; AMINO ACID DERIVATIVE; BENZOTHIAZOLE DERIVATIVE; CYTOCHROME P450; CYTOCHROME P450 1A1; FLUORINE; HYDROGEN; LYSINE DERIVATIVE; PRODRUG; UNCLASSIFIED DRUG;

ANIMAL CELL; ANTINEOPLASTIC ACTIVITY; ARTICLE; CONTROLLED STUDY; DRUG BIOAVAILABILITY; DRUG CONJUGATION; DRUG FORMULATION; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SOLUBILITY; DRUG SYNTHESIS; DRUG TRANSFORMATION; ENZYME ACTIVITY; EVALUATION; GROWTH INHIBITION; HUMAN; HUMAN CELL; LIPOPHILICITY; METABOLIC REGULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION;

AMINES; AMINO ACIDS; ANILINE COMPOUNDS; BENZOTHIAZOLES; BLOTTING, WESTERN; CELL DIVISION; CYTOCHROME P-450 CYP1A1; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; HUMANS; NEOPLASMS; PRODRUGS; THIAZOLES; TIME FACTORS; TUMOR CELLS, CULTURED;

EID: 0037156957     PISSN: 00070920     EISSN: None     Source Type: Journal    
DOI: 10.1038/sj.bjc.6600225     Document Type: Article

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