In vitro hydrolysis of polyunsaturated fatty acid N-acyloxymethyl derivatives of theophylline

International Journal of Pharmaceutics

Volumn 165, Issue 1, 1998, Pages 87-96

  Redden, Peter ^a   Douglas, Jo Anne E ^a   Burke, Michael J ^a   Horrobin, David F ^a  

^a Scotia Research Institute   (Canada)

Author keywords

Enzymatic hydrolysis; Fatty acids; Human plasma; N acyloxymethyl theophylline derivatives; Prodrugs; Theophylline

Indexed keywords

ACETIC ACID DERIVATIVE; DRUG VEHICLE; ELAIDIC ACID; ESTERASE; FATTY ACID DERIVATIVE; GAMMA LINOLENIC ACID; ICOSAPENTAENOIC ACID; LINOELAIDIC ACID; LINOLEIC ACID; LINOLENIC ACID; LIVER ENZYME; NONANOIC ACID; OLEIC ACID; POLYUNSATURATED FATTY ACID; PRODRUG; STEARIC ACID DERIVATIVE; THEOPHYLLINE; THEOPHYLLINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG FORMULATION; DRUG HYDROLYSIS; HUMAN; KINETICS; LIPOPHILICITY; NONHUMAN; PLASMA; PRIORITY JOURNAL;

EID: 0032550320     PISSN: 03785173     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0378-5173(98)00007-6     Document Type: Article

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