Cyclic amide derivatives as potential prodrugs II: N- hydroxymethylsuccinimide- / isatin esters of some NSAIDs as prodrugs with an improved therapeutic index

European Journal of Medicinal Chemistry

Volumn 34, Issue 7-8, 1999, Pages 551-562

  Mahfouz, Nadia M ^a   Omar, Farghaly A ^a   Aboul Fadl, Tarek ^a  

^a University of Assiut   (Egypt)

Author keywords

In vitro stability; Lipophilicity; N hydroxy methylisatin (HMIS); N hydroxymethylsuccinimide (HMSI); NSAI prodrugs; Ulcerogenicity

Indexed keywords

AMIDE; N HYDROXYMETHYLSUCCINIMIDE; NONSTEROID ANTIINFLAMMATORY AGENT; PRODRUG; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; BIOAVAILABILITY; CELL PROTECTION; DERIVATIZATION; DRUG STABILITY; DRUG SYNTHESIS; ENZYME DEGRADATION; GASTROINTESTINAL TOXICITY; SCANNING ELECTRON MICROSCOPY; STOMACH MUCOSA; TARGET CELL;

EID: 0032710426     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0223-5234(00)80025-2     Document Type: Article

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