메뉴 건너뛰기




Volumn 19, Issue 6, 2007, Pages 409-417

Transcriptional regulation of Th17 cell differentiation

Author keywords

IL 17; Mucosal immunity; Regulatory T cells; ROR t; Th17

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 17; INTERLEUKIN 2; INTERLEUKIN 21; INTERLEUKIN 23; INTERLEUKIN 27; INTERLEUKIN 4; INTERLEUKIN 6; NEUROPEPTIDE RECEPTOR; RETINOIC ACID RELATED ORPHAN RECEPTOR; TRANSCRIPTION FACTOR FOXP3; TRANSFORMING GROWTH FACTOR BETA; UNCLASSIFIED DRUG;

EID: 39449101603     PISSN: 10445323     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.smim.2007.10.011     Document Type: Review
Times cited : (402)

References (68)
  • 1
    • 0024353079 scopus 로고
    • TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties
    • Mosmann T.R., and Coffman R.L. TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties. Annu Rev Immunol 7 (1989) 145-173
    • (1989) Annu Rev Immunol , vol.7 , pp. 145-173
    • Mosmann, T.R.1    Coffman, R.L.2
  • 2
    • 0037434789 scopus 로고    scopus 로고
    • Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain
    • Cua D.J., Sherlock J., Chen Y., Murphy C.A., Joyce B., Seymour B., et al. Interleukin-23 rather than interleukin-12 is the critical cytokine for autoimmune inflammation of the brain. Nature 421 (2003) 744-748
    • (2003) Nature , vol.421 , pp. 744-748
    • Cua, D.J.1    Sherlock, J.2    Chen, Y.3    Murphy, C.A.4    Joyce, B.5    Seymour, B.6
  • 4
    • 0346962972 scopus 로고    scopus 로고
    • Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation
    • Murphy C.A., Langrish C.L., Chen Y., Blumenschein W., McClanahan T., Kastelein R.A., et al. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J Exp Med 198 (2003) 1951-1957
    • (2003) J Exp Med , vol.198 , pp. 1951-1957
    • Murphy, C.A.1    Langrish, C.L.2    Chen, Y.3    Blumenschein, W.4    McClanahan, T.5    Kastelein, R.A.6
  • 5
    • 33750505009 scopus 로고    scopus 로고
    • Interleukin-23 drives innate and T cell-mediated intestinal inflammation
    • Hue S., Ahern P., Buonocore S., Kullberg M.C., Cua D.J., McKenzie B.S., et al. Interleukin-23 drives innate and T cell-mediated intestinal inflammation. J Exp Med 203 (2006) 2473-2483
    • (2006) J Exp Med , vol.203 , pp. 2473-2483
    • Hue, S.1    Ahern, P.2    Buonocore, S.3    Kullberg, M.C.4    Cua, D.J.5    McKenzie, B.S.6
  • 6
    • 33750530394 scopus 로고    scopus 로고
    • IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis
    • Kullberg M.C., Jankovic D., Feng C.G., Hue S., Gorelick P.L., McKenzie B.S., et al. IL-23 plays a key role in Helicobacter hepaticus-induced T cell-dependent colitis. J Exp Med 203 (2006) 2485-2494
    • (2006) J Exp Med , vol.203 , pp. 2485-2494
    • Kullberg, M.C.1    Jankovic, D.2    Feng, C.G.3    Hue, S.4    Gorelick, P.L.5    McKenzie, B.S.6
  • 8
    • 5644277476 scopus 로고    scopus 로고
    • Interleukin-17 family members and inflammation
    • Kolls J.K., and Linden A. Interleukin-17 family members and inflammation. Immunity 21 (2004) 467-476
    • (2004) Immunity , vol.21 , pp. 467-476
    • Kolls, J.K.1    Linden, A.2
  • 9
    • 32244442562 scopus 로고    scopus 로고
    • TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells
    • Veldhoen M., Hocking R.J., Atkins C.J., Locksley R.M., and Stockinger B. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity 24 (2006) 179-189
    • (2006) Immunity , vol.24 , pp. 179-189
    • Veldhoen, M.1    Hocking, R.J.2    Atkins, C.J.3    Locksley, R.M.4    Stockinger, B.5
  • 10
    • 33646577466 scopus 로고    scopus 로고
    • Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells
    • Bettelli E., Carrier Y., Gao W., Korn T., Strom T.B., Oukka M., et al. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature 441 (2006) 235-238
    • (2006) Nature , vol.441 , pp. 235-238
    • Bettelli, E.1    Carrier, Y.2    Gao, W.3    Korn, T.4    Strom, T.B.5    Oukka, M.6
  • 12
    • 33748588423 scopus 로고    scopus 로고
    • The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells
    • Ivanov I.I., McKenzie B.S., Zhou L., Tadokoro C.E., Lepelley A., Lafaille J.J., et al. The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells. Cell 126 (2006) 1121-1133
    • (2006) Cell , vol.126 , pp. 1121-1133
    • Ivanov, I.I.1    McKenzie, B.S.2    Zhou, L.3    Tadokoro, C.E.4    Lepelley, A.5    Lafaille, J.J.6
  • 13
    • 33750142276 scopus 로고    scopus 로고
    • Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease
    • Veldhoen M., Hocking R.J., Flavell R.A., and Stockinger B. Signals mediated by transforming growth factor-beta initiate autoimmune encephalomyelitis, but chronic inflammation is needed to sustain disease. Nat Immunol 7 (2006) 1151-1156
    • (2006) Nat Immunol , vol.7 , pp. 1151-1156
    • Veldhoen, M.1    Hocking, R.J.2    Flavell, R.A.3    Stockinger, B.4
  • 14
    • 0029562554 scopus 로고
    • The RXR heterodimers and orphan receptors
    • Mangelsdorf D.J., and Evans R.M. The RXR heterodimers and orphan receptors. Cell 83 (1995) 841-850
    • (1995) Cell , vol.83 , pp. 841-850
    • Mangelsdorf, D.J.1    Evans, R.M.2
  • 15
    • 0032217092 scopus 로고    scopus 로고
    • RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells
    • He Y.W., Deftos M.L., Ojala E.W., and Bevan M.J. RORgamma t, a novel isoform of an orphan receptor, negatively regulates Fas ligand expression and IL-2 production in T cells. Immunity 9 (1998) 797-806
    • (1998) Immunity , vol.9 , pp. 797-806
    • He, Y.W.1    Deftos, M.L.2    Ojala, E.W.3    Bevan, M.J.4
  • 16
    • 0031573445 scopus 로고    scopus 로고
    • Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene
    • Medvedev A., Chistokhina A., Hirose T., and Jetten A.M. Genomic structure and chromosomal mapping of the nuclear orphan receptor ROR gamma (RORC) gene. Genomics 46 (1997) 93-102
    • (1997) Genomics , vol.46 , pp. 93-102
    • Medvedev, A.1    Chistokhina, A.2    Hirose, T.3    Jetten, A.M.4
  • 17
    • 0030605240 scopus 로고    scopus 로고
    • Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element
    • Medvedev A., Yan Z.H., Hirose T., Giguere V., and Jetten A.M. Cloning of a cDNA encoding the murine orphan receptor RZR/ROR gamma and characterization of its response element. Gene 181 (1996) 199-206
    • (1996) Gene , vol.181 , pp. 199-206
    • Medvedev, A.1    Yan, Z.H.2    Hirose, T.3    Giguere, V.4    Jetten, A.M.5
  • 18
    • 0028670212 scopus 로고
    • ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle
    • Hirose T., Smith R.J., and Jetten A.M. ROR gamma: the third member of ROR/RZR orphan receptor subfamily that is highly expressed in skeletal muscle. Biochem Biophys Res Commun 205 (1994) 1976-1983
    • (1994) Biochem Biophys Res Commun , vol.205 , pp. 1976-1983
    • Hirose, T.1    Smith, R.J.2    Jetten, A.M.3
  • 19
    • 0141567438 scopus 로고    scopus 로고
    • The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches
    • Eberl G., and Littman D.R. The role of the nuclear hormone receptor RORgammat in the development of lymph nodes and Peyer's patches. Immunol Rev 195 (2003) 81-90
    • (2003) Immunol Rev , vol.195 , pp. 81-90
    • Eberl, G.1    Littman, D.R.2
  • 20
    • 0034733039 scopus 로고    scopus 로고
    • Requirement for RORgamma in thymocyte survival and lymphoid organ development
    • Sun Z., Unutmaz D., Zou Y.R., Sunshine M.J., Pierani A., Brenner-Morton S., et al. Requirement for RORgamma in thymocyte survival and lymphoid organ development. Science 288 (2000) 2369-2373
    • (2000) Science , vol.288 , pp. 2369-2373
    • Sun, Z.1    Unutmaz, D.2    Zou, Y.R.3    Sunshine, M.J.4    Pierani, A.5    Brenner-Morton, S.6
  • 21
    • 3042720708 scopus 로고    scopus 로고
    • Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells
    • Eberl G., and Littman D.R. Thymic origin of intestinal alphabeta T cells revealed by fate mapping of RORgammat+ cells. Science 305 (2004) 248-251
    • (2004) Science , vol.305 , pp. 248-251
    • Eberl, G.1    Littman, D.R.2
  • 22
    • 0346496018 scopus 로고    scopus 로고
    • An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells
    • Eberl G., Marmon S., Sunshine M.J., Rennert P.D., Choi Y., and Littman D.R. An essential function for the nuclear receptor RORgamma(t) in the generation of fetal lymphoid tissue inducer cells. Nat Immunol 5 (2004) 64-73
    • (2004) Nat Immunol , vol.5 , pp. 64-73
    • Eberl, G.1    Marmon, S.2    Sunshine, M.J.3    Rennert, P.D.4    Choi, Y.5    Littman, D.R.6
  • 23
    • 0035238364 scopus 로고    scopus 로고
    • The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes
    • Jetten A.M., Kurebayashi S., and Ueda E. The ROR nuclear orphan receptor subfamily: critical regulators of multiple biological processes. Prog Nucleic Acid Res Mol Biol 69 (2001) 205-247
    • (2001) Prog Nucleic Acid Res Mol Biol , vol.69 , pp. 205-247
    • Jetten, A.M.1    Kurebayashi, S.2    Ueda, E.3
  • 24
    • 9644278059 scopus 로고    scopus 로고
    • Biology of IL-21 and the IL-21 receptor
    • Mehta D.S., Wurster A.L., and Grusby M.J. Biology of IL-21 and the IL-21 receptor. Immunol Rev 202 (2004) 84-95
    • (2004) Immunol Rev , vol.202 , pp. 84-95
    • Mehta, D.S.1    Wurster, A.L.2    Grusby, M.J.3
  • 25
    • 25444434157 scopus 로고    scopus 로고
    • Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation
    • Leonard W.J., and Spolski R. Interleukin-21: a modulator of lymphoid proliferation, apoptosis and differentiation. Nat Rev Immunol 5 (2005) 688-698
    • (2005) Nat Rev Immunol , vol.5 , pp. 688-698
    • Leonard, W.J.1    Spolski, R.2
  • 26
    • 34547188748 scopus 로고    scopus 로고
    • IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways
    • Zhou L., Ivanov I.I., Spolski R., Min R., Shenderov K., Egawa T., et al. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways. Nat Immunol 8 (2007) 967-974
    • (2007) Nat Immunol , vol.8 , pp. 967-974
    • Zhou, L.1    Ivanov, I.I.2    Spolski, R.3    Min, R.4    Shenderov, K.5    Egawa, T.6
  • 27
    • 34547204946 scopus 로고    scopus 로고
    • Essential autocrine regulation by IL-21 in the generation of inflammatory T cells
    • Nurieva R., Yang X.O., Martinez G., Zhang Y., Panopoulos A.D., Ma L., et al. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells. Nature 448 (2007) 480-483
    • (2007) Nature , vol.448 , pp. 480-483
    • Nurieva, R.1    Yang, X.O.2    Martinez, G.3    Zhang, Y.4    Panopoulos, A.D.5    Ma, L.6
  • 28
    • 34547232503 scopus 로고    scopus 로고
    • IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells
    • Korn T., Bettelli E., Gao W., Awasthi A., Jager A., Strom T.B., et al. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells. Nature 448 (2007) 484-487
    • (2007) Nature , vol.448 , pp. 484-487
    • Korn, T.1    Bettelli, E.2    Gao, W.3    Awasthi, A.4    Jager, A.5    Strom, T.B.6
  • 30
    • 34249026701 scopus 로고    scopus 로고
    • Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17
    • LeibundGut-Landmann S., Gross O., Robinson M.J., Osorio F., Slack E.C., Tsoni S.V., et al. Syk- and CARD9-dependent coupling of innate immunity to the induction of T helper cells that produce interleukin 17. Nat Immunol 8 (2007) 630-638
    • (2007) Nat Immunol , vol.8 , pp. 630-638
    • LeibundGut-Landmann, S.1    Gross, O.2    Robinson, M.J.3    Osorio, F.4    Slack, E.C.5    Tsoni, S.V.6
  • 32
    • 36849036211 scopus 로고    scopus 로고
    • IL-21 is produced by TH17 cells and drives IL-17 production in a STAT3-dependent manner
    • Wei L., Laurence A., Elias K.M., and O'Shea J.J. IL-21 is produced by TH17 cells and drives IL-17 production in a STAT3-dependent manner. J Biol Chem 282 (2007) 34605-34610
    • (2007) J Biol Chem , vol.282 , pp. 34605-34610
    • Wei, L.1    Laurence, A.2    Elias, K.M.3    O'Shea, J.J.4
  • 33
    • 34250762587 scopus 로고    scopus 로고
    • Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells
    • Chang S., and Aune T.M. Dynamic changes in histone-methylation 'marks' across the locus encoding interferon-gamma during the differentiation of T helper type 2 cells. Nat Immunol 8 (2007) 723-731
    • (2007) Nat Immunol , vol.8 , pp. 723-731
    • Chang, S.1    Aune, T.M.2
  • 34
    • 34250773899 scopus 로고    scopus 로고
    • Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma
    • Schoenborn J.R., Dorschner M.O., Sekimata M., Santer D.M., Shnyreva M., Fitzpatrick D.R., et al. Comprehensive epigenetic profiling identifies multiple distal regulatory elements directing transcription of the gene encoding interferon-gamma. Nat Immunol 8 (2007) 732-742
    • (2007) Nat Immunol , vol.8 , pp. 732-742
    • Schoenborn, J.R.1    Dorschner, M.O.2    Sekimata, M.3    Santer, D.M.4    Shnyreva, M.5    Fitzpatrick, D.R.6
  • 35
    • 33646012294 scopus 로고    scopus 로고
    • T helper cell differentiation: regulation by cis elements and epigenetics
    • Lee G.R., Kim S.T., Spilianakis C.G., Fields P.E., and Flavell R.A. T helper cell differentiation: regulation by cis elements and epigenetics. Immunity 24 (2006) 369-379
    • (2006) Immunity , vol.24 , pp. 369-379
    • Lee, G.R.1    Kim, S.T.2    Spilianakis, C.G.3    Fields, P.E.4    Flavell, R.A.5
  • 36
    • 34147138648 scopus 로고    scopus 로고
    • Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation
    • Akimzhanov A.M., Yang X.O., and Dong C. Chromatin remodeling of interleukin-17 (IL-17)-IL-17F cytokine gene locus during inflammatory helper T cell differentiation. J Biol Chem 282 (2007) 5969-5972
    • (2007) J Biol Chem , vol.282 , pp. 5969-5972
    • Akimzhanov, A.M.1    Yang, X.O.2    Dong, C.3
  • 37
    • 27544490377 scopus 로고    scopus 로고
    • Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages
    • Harrington L.E., Hatton R.D., Mangan P.R., Turner H., Murphy T.L., Murphy K.M., et al. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat Immunol 6 (2005) 1123-1132
    • (2005) Nat Immunol , vol.6 , pp. 1123-1132
    • Harrington, L.E.1    Hatton, R.D.2    Mangan, P.R.3    Turner, H.4    Murphy, T.L.5    Murphy, K.M.6
  • 38
    • 27544465354 scopus 로고    scopus 로고
    • A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17
    • Park H., Li Z., Yang X.O., Chang S.H., Nurieva R., Wang Y.H., et al. A distinct lineage of CD4 T cells regulates tissue inflammation by producing interleukin 17. Nat Immunol 6 (2005) 1133-1141
    • (2005) Nat Immunol , vol.6 , pp. 1133-1141
    • Park, H.1    Li, Z.2    Yang, X.O.3    Chang, S.H.4    Nurieva, R.5    Wang, Y.H.6
  • 39
    • 33646164439 scopus 로고    scopus 로고
    • Expanding the effector CD4 T-cell repertoire: the Th17 lineage
    • Harrington L.E., Mangan P.R., and Weaver C.T. Expanding the effector CD4 T-cell repertoire: the Th17 lineage. Curr Opin Immunol 18 (2006) 349-356
    • (2006) Curr Opin Immunol , vol.18 , pp. 349-356
    • Harrington, L.E.1    Mangan, P.R.2    Weaver, C.T.3
  • 40
    • 33746863277 scopus 로고    scopus 로고
    • T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17
    • Rangachari M., Mauermann N., Marty R.R., Dirnhofer S., Kurrer M.O., Komnenovic V., et al. T-bet negatively regulates autoimmune myocarditis by suppressing local production of interleukin 17. J Exp Med 203 (2006) 2009-2019
    • (2006) J Exp Med , vol.203 , pp. 2009-2019
    • Rangachari, M.1    Mauermann, N.2    Marty, R.R.3    Dirnhofer, S.4    Kurrer, M.O.5    Komnenovic, V.6
  • 41
    • 33748174156 scopus 로고    scopus 로고
    • T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype
    • Mathur A.N., Chang H.C., Zisoulis D.G., Kapur R., Belladonna M.L., Kansas G.S., et al. T-bet is a critical determinant in the instability of the IL-17-secreting T-helper phenotype. Blood 108 (2006) 1595-1601
    • (2006) Blood , vol.108 , pp. 1595-1601
    • Mathur, A.N.1    Chang, H.C.2    Zisoulis, D.G.3    Kapur, R.4    Belladonna, M.L.5    Kansas, G.S.6
  • 42
    • 0034677646 scopus 로고    scopus 로고
    • A novel transcription factor, T-bet, directs Th1 lineage commitment
    • Szabo S.J., Kim S.T., Costa G.L., Zhang X., Fathman C.G., and Glimcher L.H. A novel transcription factor, T-bet, directs Th1 lineage commitment. Cell 100 (2000) 655-669
    • (2000) Cell , vol.100 , pp. 655-669
    • Szabo, S.J.1    Kim, S.T.2    Costa, G.L.3    Zhang, X.4    Fathman, C.G.5    Glimcher, L.H.6
  • 43
    • 0037059462 scopus 로고    scopus 로고
    • Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells
    • Szabo S.J., Sullivan B.M., Stemmann C., Satoskar A.R., Sleckman B.P., and Glimcher L.H. Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells. Science 295 (2002) 338-342
    • (2002) Science , vol.295 , pp. 338-342
    • Szabo, S.J.1    Sullivan, B.M.2    Stemmann, C.3    Satoskar, A.R.4    Sleckman, B.P.5    Glimcher, L.H.6
  • 45
    • 34547820890 scopus 로고    scopus 로고
    • IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells
    • Wang Y.H., Angkasekwinai P., Lu N., Voo K.S., Arima K., Hanabuchi S., et al. IL-25 augments type 2 immune responses by enhancing the expansion and functions of TSLP-DC-activated Th2 memory cells. J Exp Med 204 (2007) 1837-1847
    • (2007) J Exp Med , vol.204 , pp. 1837-1847
    • Wang, Y.H.1    Angkasekwinai, P.2    Lu, N.3    Voo, K.S.4    Arima, K.5    Hanabuchi, S.6
  • 46
    • 33747588291 scopus 로고    scopus 로고
    • Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells
    • Batten M., Li J., Yi S., Kljavin N.M., Danilenko D.M., Lucas S., et al. Interleukin 27 limits autoimmune encephalomyelitis by suppressing the development of interleukin 17-producing T cells. Nat Immunol 7 (2006) 929-936
    • (2006) Nat Immunol , vol.7 , pp. 929-936
    • Batten, M.1    Li, J.2    Yi, S.3    Kljavin, N.M.4    Danilenko, D.M.5    Lucas, S.6
  • 47
    • 33747593830 scopus 로고    scopus 로고
    • Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system
    • Stumhofer J.S., Laurence A., Wilson E.H., Huang E., Tato C.M., Johnson L.M., et al. Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system. Nat Immunol 7 (2006) 937-945
    • (2006) Nat Immunol , vol.7 , pp. 937-945
    • Stumhofer, J.S.1    Laurence, A.2    Wilson, E.H.3    Huang, E.4    Tato, C.M.5    Johnson, L.M.6
  • 48
    • 0038326688 scopus 로고    scopus 로고
    • Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment
    • Takeda A., Hamano S., Yamanaka A., Hanada T., Ishibashi T., Mak T.W., et al. Cutting edge: role of IL-27/WSX-1 signaling for induction of T-bet through activation of STAT1 during initial Th1 commitment. J Immunol 170 (2003) 4886-4890
    • (2003) J Immunol , vol.170 , pp. 4886-4890
    • Takeda, A.1    Hamano, S.2    Yamanaka, A.3    Hanada, T.4    Ishibashi, T.5    Mak, T.W.6
  • 49
    • 4644225089 scopus 로고    scopus 로고
    • An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells
    • Kamiya S., Owaki T., Morishima N., Fukai F., Mizuguchi J., and Yoshimoto T. An indispensable role for STAT1 in IL-27-induced T-bet expression but not proliferation of naive CD4+ T cells. J Immunol 173 (2004) 3871-3877
    • (2004) J Immunol , vol.173 , pp. 3871-3877
    • Kamiya, S.1    Owaki, T.2    Morishima, N.3    Fukai, F.4    Mizuguchi, J.5    Yoshimoto, T.6
  • 50
    • 33947162110 scopus 로고    scopus 로고
    • Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation
    • Laurence A., Tato C.M., Davidson T.S., Kanno Y., Chen Z., Yao Z., et al. Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation. Immunity 26 (2007) 371-381
    • (2007) Immunity , vol.26 , pp. 371-381
    • Laurence, A.1    Tato, C.M.2    Davidson, T.S.3    Kanno, Y.4    Chen, Z.5    Yao, Z.6
  • 52
    • 34548128307 scopus 로고    scopus 로고
    • The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4
    • Brustle A., Heink S., Huber M., Rosenplanter C., Stadelmann C., Yu P., et al. The development of inflammatory T(H)-17 cells requires interferon-regulatory factor 4. Nat Immunol 8 (2007) 958-966
    • (2007) Nat Immunol , vol.8 , pp. 958-966
    • Brustle, A.1    Heink, S.2    Huber, M.3    Rosenplanter, C.4    Stadelmann, C.5    Yu, P.6
  • 53
    • 4444304040 scopus 로고    scopus 로고
    • Roles of alphav integrins in vascular biology and pulmonary pathology
    • Sheppard D. Roles of alphav integrins in vascular biology and pulmonary pathology. Curr Opin Cell Biol 16 (2004) 552-557
    • (2004) Curr Opin Cell Biol , vol.16 , pp. 552-557
    • Sheppard, D.1
  • 54
    • 34548208943 scopus 로고    scopus 로고
    • Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice
    • Travis M.A., Reizis B., Melton A.C., Masteller E., Tang Q., Proctor J.M., et al. Loss of integrin alpha(v)beta8 on dendritic cells causes autoimmunity and colitis in mice. Nature 449 (2007) 361-365
    • (2007) Nature , vol.449 , pp. 361-365
    • Travis, M.A.1    Reizis, B.2    Melton, A.C.3    Masteller, E.4    Tang, Q.5    Proctor, J.M.6
  • 55
    • 34547757390 scopus 로고    scopus 로고
    • Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid
    • Sun C.M., Hall J.A., Blank R.B., Bouladoux N., Oukka M., Mora J.R., et al. Small intestine lamina propria dendritic cells promote de novo generation of Foxp3 T reg cells via retinoic acid. J Exp Med 204 (2007) 1775-1785
    • (2007) J Exp Med , vol.204 , pp. 1775-1785
    • Sun, C.M.1    Hall, J.A.2    Blank, R.B.3    Bouladoux, N.4    Oukka, M.5    Mora, J.R.6
  • 56
    • 34547788180 scopus 로고    scopus 로고
    • A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism
    • Coombes J.L., Siddiqui K.R., Arancibia-Carcamo C.V., Hall J., Sun C.M., Belkaid Y., et al. A functionally specialized population of mucosal CD103+ DCs induces Foxp3+ regulatory T cells via a TGF-beta and retinoic acid-dependent mechanism. J Exp Med 204 (2007) 1757-1764
    • (2007) J Exp Med , vol.204 , pp. 1757-1764
    • Coombes, J.L.1    Siddiqui, K.R.2    Arancibia-Carcamo, C.V.3    Hall, J.4    Sun, C.M.5    Belkaid, Y.6
  • 57
    • 34447503805 scopus 로고    scopus 로고
    • Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid
    • Mucida D., Park Y., Kim G., Turovskaya O., Scott I., Kronenberg M., et al. Reciprocal TH17 and regulatory T cell differentiation mediated by retinoic acid. Science 317 (2007) 256-260
    • (2007) Science , vol.317 , pp. 256-260
    • Mucida, D.1    Park, Y.2    Kim, G.3    Turovskaya, O.4    Scott, I.5    Kronenberg, M.6
  • 58
    • 34548764423 scopus 로고    scopus 로고
    • Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses
    • Denning T.L., Wang Y.C., Patel S.R., Williams I.R., and Pulendran B. Lamina propria macrophages and dendritic cells differentially induce regulatory and interleukin 17-producing T cell responses. Nat Immunol 8 (2007) 1086-1094
    • (2007) Nat Immunol , vol.8 , pp. 1086-1094
    • Denning, T.L.1    Wang, Y.C.2    Patel, S.R.3    Williams, I.R.4    Pulendran, B.5
  • 59
    • 34447288230 scopus 로고    scopus 로고
    • CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation
    • Ehirchiou D., Xiong Y., Xu G., Chen W., Shi Y., and Zhang L. CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation. J Exp Med 204 (2007) 1519-1524
    • (2007) J Exp Med , vol.204 , pp. 1519-1524
    • Ehirchiou, D.1    Xiong, Y.2    Xu, G.3    Chen, W.4    Shi, Y.5    Zhang, L.6
  • 60
    • 34548446004 scopus 로고    scopus 로고
    • Oral tolerance: Passing CD11b on the way to tolerance
    • Veldhoen M. Oral tolerance: Passing CD11b on the way to tolerance. Immunol Cell Biol 85 (2007) 397-398
    • (2007) Immunol Cell Biol , vol.85 , pp. 397-398
    • Veldhoen, M.1
  • 61
    • 25144515561 scopus 로고    scopus 로고
    • Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 2005:jem.20050193.
    • Happel KI, Dubin PJ, Zheng M, Ghilardi N, Lockhart C, Quinton LJ, et al. Divergent roles of IL-23 and IL-12 in host defense against Klebsiella pneumoniae. J Exp Med 2005:jem.20050193.
  • 62
    • 35348915412 scopus 로고    scopus 로고
    • IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance
    • Zelante T., De Luca A., Bonifazi P., Montagnoli C., Bozza S., Moretti S., et al. IL-23 and the Th17 pathway promote inflammation and impair antifungal immune resistance. Eur J Immunol 37 (2007) 2695-2706
    • (2007) Eur J Immunol , vol.37 , pp. 2695-2706
    • Zelante, T.1    De Luca, A.2    Bonifazi, P.3    Montagnoli, C.4    Bozza, S.5    Moretti, S.6
  • 63
    • 34548125305 scopus 로고    scopus 로고
    • Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells
    • Acosta-Rodriguez E.V., Napolitani G., Lanzavecchia A., and Sallusto F. Interleukins 1beta and 6 but not transforming growth factor-beta are essential for the differentiation of interleukin 17-producing human T helper cells. Nat Immunol 8 (2007) 942-949
    • (2007) Nat Immunol , vol.8 , pp. 942-949
    • Acosta-Rodriguez, E.V.1    Napolitani, G.2    Lanzavecchia, A.3    Sallusto, F.4
  • 64
    • 33745873727 scopus 로고    scopus 로고
    • A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis
    • Sutton C., Brereton C., Keogh B., Mills K.H., and Lavelle E.C. A crucial role for interleukin (IL)-1 in the induction of IL-17-producing T cells that mediate autoimmune encephalomyelitis. J Exp Med 203 (2006) 1685-1691
    • (2006) J Exp Med , vol.203 , pp. 1685-1691
    • Sutton, C.1    Brereton, C.2    Keogh, B.3    Mills, K.H.4    Lavelle, E.C.5
  • 66
    • 34548125310 scopus 로고    scopus 로고
    • T(H)-17 differentiation: of mice and men
    • Laurence A., and O'Shea J.J. T(H)-17 differentiation: of mice and men. Nat Immunol 8 (2007) 903-905
    • (2007) Nat Immunol , vol.8 , pp. 903-905
    • Laurence, A.1    O'Shea, J.J.2
  • 68
    • 33845340501 scopus 로고    scopus 로고
    • A genome-wide association study identifies IL23R as an inflammatory bowel disease gene
    • Duerr R.H., Taylor K.D., Brant S.R., Rioux J.D., Silverberg M.S., Daly M.J., et al. A genome-wide association study identifies IL23R as an inflammatory bowel disease gene. Science 314 (2006) 1461-1463
    • (2006) Science , vol.314 , pp. 1461-1463
    • Duerr, R.H.1    Taylor, K.D.2    Brant, S.R.3    Rioux, J.D.4    Silverberg, M.S.5    Daly, M.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.