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Volumn 24, Issue 4, 2006, Pages 369-379

T Helper Cell Differentiation: Regulation by cis Elements and Epigenetics

Author keywords

[No Author keywords available]

Indexed keywords

CYTOKINE; TRANSCRIPTION FACTOR;

EID: 33646012294     PISSN: 10747613     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.immuni.2006.03.007     Document Type: Review
Times cited : (281)

References (87)
  • 1
    • 0032412441 scopus 로고    scopus 로고
    • Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation
    • Agarwal S., and Rao A. Modulation of chromatin structure regulates cytokine gene expression during T cell differentiation. Immunity 9 (1998) 765-775
    • (1998) Immunity , vol.9 , pp. 765-775
    • Agarwal, S.1    Rao, A.2
  • 2
    • 0033667895 scopus 로고    scopus 로고
    • Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo
    • Agarwal S., Avni O., and Rao A. Cell-type-restricted binding of the transcription factor NFAT to a distal IL-4 enhancer in vivo. Immunity 12 (2000) 643-652
    • (2000) Immunity , vol.12 , pp. 643-652
    • Agarwal, S.1    Avni, O.2    Rao, A.3
  • 4
    • 0036305450 scopus 로고    scopus 로고
    • T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes
    • Avni O., Lee D., Macian F., Szabo S.J., Glimcher L.H., and Rao A. T(H) cell differentiation is accompanied by dynamic changes in histone acetylation of cytokine genes. Nat. Immunol. 3 (2002) 643-651
    • (2002) Nat. Immunol. , vol.3 , pp. 643-651
    • Avni, O.1    Lee, D.2    Macian, F.3    Szabo, S.J.4    Glimcher, L.H.5    Rao, A.6
  • 6
    • 3843060051 scopus 로고    scopus 로고
    • Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development
    • Baguet A., and Bix M. Chromatin landscape dynamics of the Il4-Il13 locus during T helper 1 and 2 development. Proc. Natl. Acad. Sci. 101 (2004) 11410-11415
    • (2004) Proc. Natl. Acad. Sci. , vol.101 , pp. 11410-11415
    • Baguet, A.1    Bix, M.2
  • 8
    • 0142123203 scopus 로고    scopus 로고
    • Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock
    • Boehm A.K., Saunders A., Werner J., and Lis J.T. Transcription factor and polymerase recruitment, modification, and movement on dhsp70 in vivo in the minutes following heat shock. Mol. Cell. Biol. 23 (2003) 7628-7637
    • (2003) Mol. Cell. Biol. , vol.23 , pp. 7628-7637
    • Boehm, A.K.1    Saunders, A.2    Werner, J.3    Lis, J.T.4
  • 9
    • 0020624202 scopus 로고
    • DNA methylation and the regulation of globin gene expression
    • Busslinger M., Hurst J., and Flavell R.A. DNA methylation and the regulation of globin gene expression. Cell 34 (1983) 197-206
    • (1983) Cell , vol.34 , pp. 197-206
    • Busslinger, M.1    Hurst, J.2    Flavell, R.A.3
  • 10
    • 0024281345 scopus 로고
    • DNA methylation and gene activity
    • Cedar H. DNA methylation and gene activity. Cell 53 (1988) 3-4
    • (1988) Cell , vol.53 , pp. 3-4
    • Cedar, H.1
  • 11
    • 0034644473 scopus 로고    scopus 로고
    • Signaling to chromatin through histone modifications
    • Cheung P., Allis C.D., and Sassone-Corsi P. Signaling to chromatin through histone modifications. Cell 103 (2000) 263-271
    • (2000) Cell , vol.103 , pp. 263-271
    • Cheung, P.1    Allis, C.D.2    Sassone-Corsi, P.3
  • 12
    • 0024280908 scopus 로고
    • Developmental regulation of β-globin gene switching
    • Choi O., and Engel J.D. Developmental regulation of β-globin gene switching. Cell 55 (1988) 17-26
    • (1988) Cell , vol.55 , pp. 17-26
    • Choi, O.1    Engel, J.D.2
  • 13
    • 0038434064 scopus 로고    scopus 로고
    • A closer look at long-range chromosomal interactions
    • Dekker J. A closer look at long-range chromosomal interactions. Trends Biochem. Sci. 28 (2003) 277-280
    • (2003) Trends Biochem. Sci. , vol.28 , pp. 277-280
    • Dekker, J.1
  • 14
    • 0028446580 scopus 로고
    • A locus control region in the T cell receptor alpha/delta locus
    • Diaz P., Cado D., and Winoto A. A locus control region in the T cell receptor alpha/delta locus. Immunity 1 (1994) 207-217
    • (1994) Immunity , vol.1 , pp. 207-217
    • Diaz, P.1    Cado, D.2    Winoto, A.3
  • 15
    • 0033678508 scopus 로고    scopus 로고
    • DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease
    • El-Osta A., and Wolffe A.P. DNA methylation and histone deacetylation in the control of gene expression: basic biochemistry to human development and disease. Gene Expr. 9 (2000) 63-75
    • (2000) Gene Expr. , vol.9 , pp. 63-75
    • El-Osta, A.1    Wolffe, A.P.2
  • 16
    • 0022389048 scopus 로고
    • 5-Azacytidine treatment of a murine cytotoxic T cell line alters IFN-gamma gene induction by interleukin 2
    • Farrar W.L., Ruscetti F.W., and Young H.A. 5-Azacytidine treatment of a murine cytotoxic T cell line alters IFN-gamma gene induction by interleukin 2. J. Immunol. 135 (1985) 1551-1554
    • (1985) J. Immunol. , vol.135 , pp. 1551-1554
    • Farrar, W.L.1    Ruscetti, F.W.2    Young, H.A.3
  • 17
    • 0033624825 scopus 로고    scopus 로고
    • Locus control regions and epigenetic chromatin modifiers
    • Festenstein R., and Kioussis D. Locus control regions and epigenetic chromatin modifiers. Curr. Opin. Genet. Dev. 10 (2000) 199-203
    • (2000) Curr. Opin. Genet. Dev. , vol.10 , pp. 199-203
    • Festenstein, R.1    Kioussis, D.2
  • 19
    • 0037100265 scopus 로고    scopus 로고
    • Cutting edge: changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation
    • Fields P.E., Kim S.T., and Flavell R.A. Cutting edge: changes in histone acetylation at the IL-4 and IFN-γ loci accompany Th1/Th2 differentiation. J. Immunol. 169 (2002) 647-650
    • (2002) J. Immunol. , vol.169 , pp. 647-650
    • Fields, P.E.1    Kim, S.T.2    Flavell, R.A.3
  • 20
    • 10344234192 scopus 로고    scopus 로고
    • Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region
    • Fields P.E., Lee G.R., Kim S.T., Bartsevich V.V., and Flavell R.A. Th2-specific chromatin remodeling and enhancer activity in the Th2 cytokine locus control region. Immunity 21 (2004) 865-876
    • (2004) Immunity , vol.21 , pp. 865-876
    • Fields, P.E.1    Lee, G.R.2    Kim, S.T.3    Bartsevich, V.V.4    Flavell, R.A.5
  • 21
    • 0031861637 scopus 로고    scopus 로고
    • Locus control regions, chromatin activation and transcription
    • Fraser P., and Grosveld F. Locus control regions, chromatin activation and transcription. Curr. Opin. Cell Biol. 1999 (1998) 361-365
    • (1998) Curr. Opin. Cell Biol. , vol.1999 , pp. 361-365
    • Fraser, P.1    Grosveld, F.2
  • 22
    • 0022817308 scopus 로고
    • RNA polymerase II interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells
    • Gilmour D.S., and Lis J.T. RNA polymerase II interacts with the promoter region of the noninduced hsp70 gene in Drosophila melanogaster cells. Mol. Cell. Biol. 6 (1986) 3984-3989
    • (1986) Mol. Cell. Biol. , vol.6 , pp. 3984-3989
    • Gilmour, D.S.1    Lis, J.T.2
  • 23
    • 0033214606 scopus 로고    scopus 로고
    • Presetting of chromatin structure and transcription factor binding poise the human GADD45 gene for rapid transcriptional up-regulation
    • Graunke D.M., Fornace Jr. A.J., and Pieper R.O. Presetting of chromatin structure and transcription factor binding poise the human GADD45 gene for rapid transcriptional up-regulation. Nucleic Acids Res. 27 (1999) 3881-3890
    • (1999) Nucleic Acids Res. , vol.27 , pp. 3881-3890
    • Graunke, D.M.1    Fornace Jr., A.J.2    Pieper, R.O.3
  • 24
    • 0035070195 scopus 로고    scopus 로고
    • Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets
    • Grogan J.L., Mohrs M., Harmon B., Lacy D.A., Sedat J.W., and Locksley R.M. Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets. Immunity 14 (2001) 205-215
    • (2001) Immunity , vol.14 , pp. 205-215
    • Grogan, J.L.1    Mohrs, M.2    Harmon, B.3    Lacy, D.A.4    Sedat, J.W.5    Locksley, R.M.6
  • 25
    • 0032928813 scopus 로고    scopus 로고
    • Activation by locus control regions?
    • Grosveld F. Activation by locus control regions?. Curr. Opin. Genet. Dev. 9 (1999) 152-157
    • (1999) Curr. Opin. Genet. Dev. , vol.9 , pp. 152-157
    • Grosveld, F.1
  • 26
    • 0023663887 scopus 로고
    • Position-independent, high-level expression of the human beta-globin gene in transgenic mice
    • Grosveld F., van Assendelft G.B., Greaves D.R., and Kollias G. Position-independent, high-level expression of the human beta-globin gene in transgenic mice. Cell 51 (1987) 975-985
    • (1987) Cell , vol.51 , pp. 975-985
    • Grosveld, F.1    van Assendelft, G.B.2    Greaves, D.R.3    Kollias, G.4
  • 27
    • 0036667345 scopus 로고    scopus 로고
    • In TH2 cells the IL-4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production
    • Guo L., Hu-Li J., Zhu J., Watson C.J., Difilipantonio M.J., Pannetier C., and Paul W.E. In TH2 cells the IL-4 gene has a series of accessibility states associated with distinctive probabilities of IL-4 production. Proc. Natl. Acad. Sci. USA 99 (2002) 10623-10628
    • (2002) Proc. Natl. Acad. Sci. USA , vol.99 , pp. 10623-10628
    • Guo, L.1    Hu-Li, J.2    Zhu, J.3    Watson, C.J.4    Difilipantonio, M.J.5    Pannetier, C.6    Paul, W.E.7
  • 28
    • 1342265727 scopus 로고    scopus 로고
    • Probabilistic regulation of IL-4 production in Th2 cells: accessibility at the Il4 locus
    • Guo L., Hu-Li J., and Paul W.E. Probabilistic regulation of IL-4 production in Th2 cells: accessibility at the Il4 locus. Immunity 20 (2004) 193-203
    • (2004) Immunity , vol.20 , pp. 193-203
    • Guo, L.1    Hu-Li, J.2    Paul, W.E.3
  • 29
    • 0026467244 scopus 로고
    • A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer
    • Henkel G., Weiss D.L., McCoy R., Deloughery T., Tara D., and Brown M.A. A DNase I-hypersensitive site in the second intron of the murine IL-4 gene defines a mast cell-specific enhancer. J. Immunol. 149 (1992) 3239-3246
    • (1992) J. Immunol. , vol.149 , pp. 3239-3246
    • Henkel, G.1    Weiss, D.L.2    McCoy, R.3    Deloughery, T.4    Tara, D.5    Brown, M.A.6
  • 31
    • 12344269852 scopus 로고    scopus 로고
    • T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3
    • Hwang E.S., Szabo S.J., Schwartzberg P.L., and Glimcher L.H. T helper cell fate specified by kinase-mediated interaction of T-bet with GATA-3. Science 307 (2005) 430-433
    • (2005) Science , vol.307 , pp. 430-433
    • Hwang, E.S.1    Szabo, S.J.2    Schwartzberg, P.L.3    Glimcher, L.H.4
  • 33
    • 0035887640 scopus 로고    scopus 로고
    • The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3
    • Kishikawa H., Sun J., Choi A., Miaw S.C., and Ho I.C. The cell type-specific expression of the murine IL-13 gene is regulated by GATA-3. J. Immunol. 167 (2001) 4414-4420
    • (2001) J. Immunol. , vol.167 , pp. 4414-4420
    • Kishikawa, H.1    Sun, J.2    Choi, A.3    Miaw, S.C.4    Ho, I.C.5
  • 34
    • 24744462507 scopus 로고    scopus 로고
    • EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in T(H)1 cells
    • Koyanagi M., Baguet A., Martens J., Margueron R., Jenuwein T., and Bix M. EZH2 and histone 3 trimethyl lysine 27 associated with Il4 and Il13 gene silencing in T(H)1 cells. J. Biol. Chem. 280 (2005) 31470-31477
    • (2005) J. Biol. Chem. , vol.280 , pp. 31470-31477
    • Koyanagi, M.1    Baguet, A.2    Martens, J.3    Margueron, R.4    Jenuwein, T.5    Bix, M.6
  • 35
    • 0025992068 scopus 로고
    • Deletion analysis of the human CD2 gene locus control region in transgenic mice
    • Lang G., Mamalaki C., Greenberg D., Yannoutsos N., and Kioussis D. Deletion analysis of the human CD2 gene locus control region in transgenic mice. Nucleic Acids Res. 19 (1991) 5851-5856
    • (1991) Nucleic Acids Res. , vol.19 , pp. 5851-5856
    • Lang, G.1    Mamalaki, C.2    Greenberg, D.3    Yannoutsos, N.4    Kioussis, D.5
  • 36
    • 8644220507 scopus 로고    scopus 로고
    • Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA-3
    • Lee D.U., and Rao A. Molecular analysis of a locus control region in the T helper 2 cytokine gene cluster: a target for STAT6 but not GATA-3. Proc. Natl. Acad. Sci. USA 101 (2004) 16010-16015
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 16010-16015
    • Lee, D.U.1    Rao, A.2
  • 37
    • 0036279221 scopus 로고    scopus 로고
    • Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene
    • Lee D.U., Agarwal S., and Rao A. Th2 lineage commitment and efficient IL-4 production involves extended demethylation of the IL-4 gene. Immunity 16 (2002) 649-660
    • (2002) Immunity , vol.16 , pp. 649-660
    • Lee, D.U.1    Agarwal, S.2    Rao, A.3
  • 38
    • 1042278131 scopus 로고    scopus 로고
    • A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison
    • Lee D.U., Avni O., Chen L., and Rao A. A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J. Biol. Chem. 279 (2004) 4802-4810
    • (2004) J. Biol. Chem. , vol.279 , pp. 4802-4810
    • Lee, D.U.1    Avni, O.2    Chen, L.3    Rao, A.4
  • 39
    • 0035041537 scopus 로고    scopus 로고
    • Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level
    • Lee G.R., Fields P.E., and Flavell R.A. Regulation of IL-4 gene expression by distal regulatory elements and GATA-3 at the chromatin level. Immunity 14 (2001) 447-459
    • (2001) Immunity , vol.14 , pp. 447-459
    • Lee, G.R.1    Fields, P.E.2    Flavell, R.A.3
  • 40
    • 0037963472 scopus 로고    scopus 로고
    • Regulation of the Th2 ytokine locus by a locus control region
    • Lee G.R., Fields P.E., Griffin T.J., and Flavell R.A. Regulation of the Th2 ytokine locus by a locus control region. Immunity 19 (2003) 145-153
    • (2003) Immunity , vol.19 , pp. 145-153
    • Lee, G.R.1    Fields, P.E.2    Griffin, T.J.3    Flavell, R.A.4
  • 41
    • 12344250807 scopus 로고    scopus 로고
    • Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions
    • Lee G.R., Spilianakis C.G., and Flavell R.A. Hypersensitive site 7 of the TH2 locus control region is essential for expressing TH2 cytokine genes and for long-range intrachromosomal interactions. Nat. Immunol. 6 (2005) 42-48
    • (2005) Nat. Immunol. , vol.6 , pp. 42-48
    • Lee, G.R.1    Spilianakis, C.G.2    Flavell, R.A.3
  • 42
    • 0000344022 scopus 로고    scopus 로고
    • GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells
    • Lee H.J., Takemoto N., Kurata H., Kamogawa Y., Miyatake S., O'Garra A., and Arai N. GATA-3 induces T helper cell type 2 (Th2) cytokine expression and chromatin remodeling in committed Th1 cells. J. Exp. Med. 192 (2000) 105-115
    • (2000) J. Exp. Med. , vol.192 , pp. 105-115
    • Lee, H.J.1    Takemoto, N.2    Kurata, H.3    Kamogawa, Y.4    Miyatake, S.5    O'Garra, A.6    Arai, N.7
  • 43
    • 0033569326 scopus 로고    scopus 로고
    • Structural analysis and mapping of DNAse I hypersensitivity of HS5 of the beta-globin locus control region
    • Li Q., Duan Z., and Stamatoyannopoulos G. Structural analysis and mapping of DNAse I hypersensitivity of HS5 of the beta-globin locus control region. Genomics 61 (1999) 183-193
    • (1999) Genomics , vol.61 , pp. 183-193
    • Li, Q.1    Duan, Z.2    Stamatoyannopoulos, G.3
  • 44
    • 0033215140 scopus 로고    scopus 로고
    • Locus control regions: coming of age at a decade plus
    • Li Q., Harju S., and Peterson K.R. Locus control regions: coming of age at a decade plus. Trends Genet. 15 (1999) 403-408
    • (1999) Trends Genet. , vol.15 , pp. 403-408
    • Li, Q.1    Harju, S.2    Peterson, K.R.3
  • 46
    • 0029052136 scopus 로고
    • Presence of negative torsional tension in the promoter region of the transcriptionally poised dihydrofolate reductase gene in vivo
    • Ljungman M., and Hanawalt P.C. Presence of negative torsional tension in the promoter region of the transcriptionally poised dihydrofolate reductase gene in vivo. Nucleic Acids Res. 23 (1995) 1782-1789
    • (1995) Nucleic Acids Res. , vol.23 , pp. 1782-1789
    • Ljungman, M.1    Hanawalt, P.C.2
  • 47
    • 0034616398 scopus 로고    scopus 로고
    • Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons
    • Loots G.G., Locksley R.M., Blankespoor C.M., Wang Z.E., Miller W., Rubin E.M., and Frazer K.A. Identification of a coordinate regulator of interleukins 4, 13, and 5 by cross-species sequence comparisons. Science 288 (2000) 136-140
    • (2000) Science , vol.288 , pp. 136-140
    • Loots, G.G.1    Locksley, R.M.2    Blankespoor, C.M.3    Wang, Z.E.4    Miller, W.5    Rubin, E.M.6    Frazer, K.A.7
  • 48
    • 0027969316 scopus 로고
    • Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells
    • Madisen L., and Groudine M. Identification of a locus control region in the immunoglobulin heavy-chain locus that deregulates c-myc expression in plasmacytoma and Burkitt's lymphoma cells. Genes Dev. 8 (1994) 2212-2226
    • (1994) Genes Dev. , vol.8 , pp. 2212-2226
    • Madisen, L.1    Groudine, M.2
  • 50
    • 0037236203 scopus 로고    scopus 로고
    • Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes
    • Messi M., Giacchetto I., Nagata K., Lanzavecchia A., Natoli G., and Sallusto F. Memory and flexibility of cytokine gene expression as separable properties of human T(H)1 and T(H)2 lymphocytes. Nat. Immunol. 4 (2003) 78-86
    • (2003) Nat. Immunol. , vol.4 , pp. 78-86
    • Messi, M.1    Giacchetto, I.2    Nagata, K.3    Lanzavecchia, A.4    Natoli, G.5    Sallusto, F.6
  • 52
    • 4644320690 scopus 로고    scopus 로고
    • Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression
    • Morinobu A., Kanno Y., and O'Shea J.J. Discrete roles for histone acetylation in human T helper 1 cell-specific gene expression. J. Biol. Chem. 279 (2004) 40640-40646
    • (2004) J. Biol. Chem. , vol.279 , pp. 40640-40646
    • Morinobu, A.1    Kanno, Y.2    O'Shea, J.J.3
  • 54
    • 0032574977 scopus 로고    scopus 로고
    • Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex
    • Nan X., Ng H.H., Johnson C.A., Laherty C.D., Turner B.M., Eisenman R.N., and Bird A. Transcriptional repression by the methyl-CpG-binding protein MeCP2 involves a histone deacetylase complex. Nature 393 (1998) 386-389
    • (1998) Nature , vol.393 , pp. 386-389
    • Nan, X.1    Ng, H.H.2    Johnson, C.A.3    Laherty, C.D.4    Turner, B.M.5    Eisenman, R.N.6    Bird, A.7
  • 55
    • 0035313704 scopus 로고    scopus 로고
    • Transcriptional regulation in lymphocytes
    • Okamura H., and Rao A. Transcriptional regulation in lymphocytes. Curr. Opin. Cell Biol. 13 (2001) 239-243
    • (2001) Curr. Opin. Cell Biol. , vol.13 , pp. 239-243
    • Okamura, H.1    Rao, A.2
  • 56
    • 0033973582 scopus 로고    scopus 로고
    • Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment
    • Ouyang W., Lohning M., Gao Z., Assenmacher M., Ranganath S., Radbruch A., and Murphy K.M. Stat6-independent GATA-3 autoactivation directs IL-4-independent Th2 development and commitment. Immunity 12 (2000) 27-37
    • (2000) Immunity , vol.12 , pp. 27-37
    • Ouyang, W.1    Lohning, M.2    Gao, Z.3    Assenmacher, M.4    Ranganath, S.5    Radbruch, A.6    Murphy, K.M.7
  • 57
    • 1242274405 scopus 로고    scopus 로고
    • GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells
    • Pai S.Y., Truitt M.L., and Ho I.C. GATA-3 deficiency abrogates the development and maintenance of T helper type 2 cells. Proc. Natl. Acad. Sci. USA 101 (2004) 1993-1998
    • (2004) Proc. Natl. Acad. Sci. USA , vol.101 , pp. 1993-1998
    • Pai, S.Y.1    Truitt, M.L.2    Ho, I.C.3
  • 59
    • 0030973579 scopus 로고    scopus 로고
    • Transcription factors of the NFAT family: regulation and function
    • Rao A., Luo C., and Hogan P.G. Transcription factors of the NFAT family: regulation and function. Annu. Rev. Immunol. 15 (1997) 707-747
    • (1997) Annu. Rev. Immunol. , vol.15 , pp. 707-747
    • Rao, A.1    Luo, C.2    Hogan, P.G.3
  • 60
    • 0037103140 scopus 로고    scopus 로고
    • DNA methylation changes at human Th2 cytokine genes concide with DNase I hypersensitive site formation during CD4+ T cell differentiation
    • Santangelo S., Cousins D.J., Winkelmann N.E.E., and Staynov D.Z. DNA methylation changes at human Th2 cytokine genes concide with DNase I hypersensitive site formation during CD4+ T cell differentiation. J. Immunol. 169 (2002) 1893-1903
    • (2002) J. Immunol. , vol.169 , pp. 1893-1903
    • Santangelo, S.1    Cousins, D.J.2    Winkelmann, N.E.E.3    Staynov, D.Z.4
  • 61
    • 0034695539 scopus 로고    scopus 로고
    • Control of organ-specific demethylation by an element of the T-cell receptor-alpha locus control region
    • Santoso B., Ortiz B.D., and Winoto A. Control of organ-specific demethylation by an element of the T-cell receptor-alpha locus control region. J. Biol. Chem. 275 (2000) 1952-1958
    • (2000) J. Biol. Chem. , vol.275 , pp. 1952-1958
    • Santoso, B.1    Ortiz, B.D.2    Winoto, A.3
  • 63
    • 0036216109 scopus 로고    scopus 로고
    • Chromatin structure and gene regulation in the immune system
    • Smale S.T., and Fisher A.G. Chromatin structure and gene regulation in the immune system. Annu. Rev. Immunol. 20 (2002) 427-462
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 427-462
    • Smale, S.T.1    Fisher, A.G.2
  • 64
    • 0035984591 scopus 로고    scopus 로고
    • A 3′ enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells
    • Solymar D.C., Agarwal S., Bassing C.H., Alt F.W., and Rao A. A 3′ enhancer in the IL-4 gene regulates cytokine production by Th2 cells and mast cells. Immunity 17 (2002) 41-50
    • (2002) Immunity , vol.17 , pp. 41-50
    • Solymar, D.C.1    Agarwal, S.2    Bassing, C.H.3    Alt, F.W.4    Rao, A.5
  • 65
    • 0037114123 scopus 로고    scopus 로고
    • Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells
    • Soutto M., Zhou W., and Aune T.M. Cutting edge: distal regulatory elements are required to achieve selective expression of IFN-gamma in Th1/Tc1 effector cells. J. Immunol. 169 (2002) 6664-6667
    • (2002) J. Immunol. , vol.169 , pp. 6664-6667
    • Soutto, M.1    Zhou, W.2    Aune, T.M.3
  • 67
    • 20444494936 scopus 로고    scopus 로고
    • Interchromosomal associations between alternatively expressed loci
    • Spilianakis C., Lalioti M., Town T., Lee G.R., and Flavell R.A. Interchromosomal associations between alternatively expressed loci. Nature 435 (2005) 637-645
    • (2005) Nature , vol.435 , pp. 637-645
    • Spilianakis, C.1    Lalioti, M.2    Town, T.3    Lee, G.R.4    Flavell, R.A.5
  • 68
    • 5444237577 scopus 로고    scopus 로고
    • Long-range intrachromosomal interactions in the T helper type 2 cytokine locus
    • Spilianakis C.G., and Flavell R.A. Long-range intrachromosomal interactions in the T helper type 2 cytokine locus. Nat. Immunol. 5 (2004) 1017-1027
    • (2004) Nat. Immunol. , vol.5 , pp. 1017-1027
    • Spilianakis, C.G.1    Flavell, R.A.2
  • 69
    • 0034610814 scopus 로고    scopus 로고
    • The language of covalent histone modifications
    • Strahl B.D., and Allis C.D. The language of covalent histone modifications. Nature 403 (2000) 41-45
    • (2000) Nature , vol.403 , pp. 41-45
    • Strahl, B.D.1    Allis, C.D.2
  • 70
    • 0031593671 scopus 로고    scopus 로고
    • Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region
    • Takemoto N., Koyano-Nakagawa N., Yokota T., Arai N., Miyatake S., and Arai K. Th2-specific DNase I-hypersensitive sites in the murine IL-13 and IL-4 intergenic region. Int. Immunol. 12 (1998) 1981-1985
    • (1998) Int. Immunol. , vol.12 , pp. 1981-1985
    • Takemoto, N.1    Koyano-Nakagawa, N.2    Yokota, T.3    Arai, N.4    Miyatake, S.5    Arai, K.6
  • 71
    • 0034671565 scopus 로고    scopus 로고
    • Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster
    • Takemoto N., Kamogawa Y., Lee H.J., Kurata H., Arai K.I., O'Garra A., Arai N., and Miyatake S. Cutting edge: chromatin remodeling at the IL-4/IL-13 intergenic regulatory region for Th2-specific cytokine gene cluster. J. Immunol. 165 (2000) 6687-6691
    • (2000) J. Immunol. , vol.165 , pp. 6687-6691
    • Takemoto, N.1    Kamogawa, Y.2    Lee, H.J.3    Kurata, H.4    Arai, K.I.5    O'Garra, A.6    Arai, N.7    Miyatake, S.8
  • 72
    • 0037108359 scopus 로고    scopus 로고
    • Cutting edge: the differential involvement of the N-finger of GATA-3 in chromatin remodeling and transactivation during Th2 development
    • Takemoto N., Arai K., and Miyatake S. Cutting edge: the differential involvement of the N-finger of GATA-3 in chromatin remodeling and transactivation during Th2 development. J. Immunol. 169 (2002) 4103-4107
    • (2002) J. Immunol. , vol.169 , pp. 4103-4107
    • Takemoto, N.1    Arai, K.2    Miyatake, S.3
  • 73
    • 0036923833 scopus 로고    scopus 로고
    • Looping and interaction between Hypersensitive sites in the active β-globin locus
    • Tolhuis B., Palstra R.-J., Splinter E., Grosveld F., and de Laat W. Looping and interaction between Hypersensitive sites in the active β-globin locus. Mol. Cell 10 (2002) 1453-1465
    • (2002) Mol. Cell , vol.10 , pp. 1453-1465
    • Tolhuis, B.1    Palstra, R.-J.2    Splinter, E.3    Grosveld, F.4    de Laat, W.5
  • 74
    • 0033848849 scopus 로고    scopus 로고
    • Histone acetylation and an epigenetic code
    • Turner B.M. Histone acetylation and an epigenetic code. Bioessays 22 (2000) 836-845
    • (2000) Bioessays , vol.22 , pp. 836-845
    • Turner, B.M.1
  • 77
    • 0018905582 scopus 로고
    • DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues
    • van der Ploeg L.H., and Flavell R.A. DNA methylation in the human gamma delta beta-globin locus in erythroid and nonerythroid tissues. Cell 19 (1980) 947-958
    • (1980) Cell , vol.19 , pp. 947-958
    • van der Ploeg, L.H.1    Flavell, R.A.2
  • 78
    • 0030803595 scopus 로고    scopus 로고
    • Nucleoprotein complex formation by the enhancer binding protein NifA
    • Wang X.Y., Kolb A., Cannon W., and Buck M. Nucleoprotein complex formation by the enhancer binding protein NifA. Nucleic Acids Res. 25 (1997) 3478-3485
    • (1997) Nucleic Acids Res. , vol.25 , pp. 3478-3485
    • Wang, X.Y.1    Kolb, A.2    Cannon, W.3    Buck, M.4
  • 79
    • 0033515426 scopus 로고    scopus 로고
    • Phosphorylation of histone H3 is required for proper chromosome condensation and segregation
    • Wei Y., Yu L., Bowen J., Gorovsky M.A., and Allis C.D. Phosphorylation of histone H3 is required for proper chromosome condensation and segregation. Cell 97 (1999) 99-109
    • (1999) Cell , vol.97 , pp. 99-109
    • Wei, Y.1    Yu, L.2    Bowen, J.3    Gorovsky, M.A.4    Allis, C.D.5
  • 80
    • 14244260068 scopus 로고    scopus 로고
    • DNA methylation and the expanding epigenetics of T cell lineage commitment
    • Wilson C.B., Makar K.W., Shnyreva M., and Fitzpatrick D.R. DNA methylation and the expanding epigenetics of T cell lineage commitment. Semin. Immunol. 17 (2005) 105-119
    • (2005) Semin. Immunol. , vol.17 , pp. 105-119
    • Wilson, C.B.1    Makar, K.W.2    Shnyreva, M.3    Fitzpatrick, D.R.4
  • 81
    • 10344237554 scopus 로고    scopus 로고
    • A distinct region of the murine IFN-gamma promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells
    • Winders B.R., Schwartz R.H., and Bruniquel D. A distinct region of the murine IFN-gamma promoter is hypomethylated from early T cell development through mature naive and Th1 cell differentiation, but is hypermethylated in Th2 cells. J. Immunol. 173 (2004) 7377-7384
    • (2004) J. Immunol. , vol.173 , pp. 7377-7384
    • Winders, B.R.1    Schwartz, R.H.2    Bruniquel, D.3
  • 82
    • 0036830465 scopus 로고    scopus 로고
    • Identification of a conserved GATA-3 response element upstream proximal from the interleukin-13 gene locus
    • Yamashita M., Ukai-Tadenuma M., Kimura M., Omori M., Inami M., Taniguchi M., and Nakayama T. Identification of a conserved GATA-3 response element upstream proximal from the interleukin-13 gene locus. J. Biol. Chem. 277 (2002) 42399-42408
    • (2002) J. Biol. Chem. , vol.277 , pp. 42399-42408
    • Yamashita, M.1    Ukai-Tadenuma, M.2    Kimura, M.3    Omori, M.4    Inami, M.5    Taniguchi, M.6    Nakayama, T.7
  • 84
    • 0041929384 scopus 로고    scopus 로고
    • Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population
    • Yano S., Ghosh P., Kusaba H., Buchholz M., and Longo D.L. Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J. Immunol. 171 (2003) 2510-2516
    • (2003) J. Immunol. , vol.171 , pp. 2510-2516
    • Yano, S.1    Ghosh, P.2    Kusaba, H.3    Buchholz, M.4    Longo, D.L.5
  • 86
    • 0030810155 scopus 로고    scopus 로고
    • The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells
    • Zheng W., and Flavell R.A. The transcription factor GATA-3 is necessary and sufficient for Th2 cytokine gene expression in CD4 T cells. Cell 89 (1997) 587-596
    • (1997) Cell , vol.89 , pp. 587-596
    • Zheng, W.1    Flavell, R.A.2


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