CD11b facilitates the development of peripheral tolerance by suppressing Th17 differentiation

Journal of Experimental Medicine

Volumn 204, Issue 7, 2007, Pages 1519-1524

  Ehirchiou, Driss ^a   Xiong, Ying ^a   Xu, Guangwu ^b   Chen, Wanjun ^c   Shi, Yufang ^b   Zhang, Li ^a  

^a UNIVERSITY OF MARYLAND SCHOOL OF MEDICINE   (United States)

^b RUTGERS ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^c NATIONAL INSTITUTE OF DENTAL AND CRANIOFACIAL RESEARCH   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CD11B ANTIGEN; CD18 ANTIGEN; INTEGRIN RECEPTOR; INTERLEUKIN 17; INTERLEUKIN 6;

ANIMAL CELL; ANTIGEN PRESENTING CELL; ANTIGEN SPECIFICITY; ARTICLE; CELL DIFFERENTIATION; CELL LINEAGE; CELL MATURATION; CELL TRANSFER; CONTROLLED STUDY; CYTOKINE PRODUCTION; FEEDING; GENE EXPRESSION; HELPER CELL; IMMUNE RESPONSE; IMMUNIZATION; LYMPH NODE; MOUSE; NONHUMAN; PRIORITY JOURNAL; T LYMPHOCYTE; WILD TYPE;

ANIMALS; ANTIGEN-PRESENTING CELLS; ANTIGENS; ANTIGENS, CD11B; CELL DIFFERENTIATION; CELL DIVISION; CYTOKINES; HYPERSENSITIVITY, DELAYED; IMMUNE TOLERANCE; INTERLEUKIN-17; MICE; MICE, KNOCKOUT; T-LYMPHOCYTES;

EID: 34447288230     PISSN: 00221007     EISSN: 00221007     Source Type: Journal    
DOI: 10.1084/jem.20062292     Document Type: Article

References (27)

1. Steinman, R.M., D. Hawiger, and M.C. Nussenzweig. 2003. Tolerogenic dendritic cells. Annu. Rev. Immunol. 21:685-711.
2. Bluestone, J.A., and A.K. Abbas. 2003. Natural versus adaptive regulatory T cells. Nat. Rev. Immunol. 3:253-257.
3. Weiner, H.L. 2000. Oral tolerance, an active immunologic process mediated by multiple mechanisms. J. Clin. Invest. 106:935-937.
4. Akbari, O., G.J. Freeman, E.H. Meyer, E.A. Greenfield, T.T. Chang, A.H. Sharpe, G. Berry, R.H. DeKruyff, and D.T. Umetsu. 2002. Antigen-specific regulatory T cells develop via the ICOS-ICOS- ligand pathway and inhibit allergen-induced airway hyperreactivity. Nat. Med. 8:1024-1032.
5. Vigouroux, S., E. Yvon, E. Biagi, and M.K. Brenner. 2004. Antigen-induced regulatory T cells. Blood. 104:26-33.
6. Chen, Y., J. Inobe, R. Marks, P. Gonnella, V.K. Kuchroo, and H.L. Weiner. 1995. Peripheral deletion of antigen-reactive T cells in oral tolerance. Nature. 376:177-180.
7. Akbari, O., R.H. DeKruyff, and D.T. Umetsu. 2001. Pulmonary dendritic cells producing IL-10 mediate tolerance induced by respiratory exposure to antigen. Nat. Immunol. 2:725-731.
8. Chen, W., M.E. Frank, W. Jin, and S.M. Wahl. 2001. TGF-beta released by apoptotic T cells contributes to an immunosuppressive milieu. Immunity. 14:715-725.
9. Veldhoen, M., R.J. Hocking, C.J. Atkins, R.M. Locksley, and B. Stockinger. 2006. TGFbeta in the context of an inflammatory cytokine milieu supports de novo differentiation of IL-17-producing T cells. Immunity. 24:179-189.
10. Bettelli, E., Y. Carrier, W. Gao, T. Korn, T.B. Strom, M. Oukka, H.L. Weiner, and V.K. Kuchroo. 2006. Reciprocal developmental pathways for the generation of pathogenic effector TH17 and regulatory T cells. Nature. 441:235-238.
11. Zhang, M., H. Tang, Z. Guo, H. An, X. Zhu, W. Song, J. Guo, X. Huang, T. Chen, J. Wang, and X. Cao. 2004. Splenic stroma drives mature dendritic cells to differentiate into regulatory dendritic cells. Nat. Immunol. 5:1124-1133.
12. Ross, G.D., and J.D. Lambris. 1982. Identification of a C3bi-specific membrane complement receptor that is expressed on lymphocytes, monocytes, neutrophils, and erythrocytes. J. Exp. Med. 155:96-110.
13. Hammerberg, C., S.K. Katiyar, M.C. Carroll, and K.D. Cooper. 1998. Activated complement component 3 (C3) is required for ultraviolet induction of immunosuppression and antigenic tolerance. J. Exp. Med. 187:1133-1138.
14. Sohn, J.H., P.S. Bora, H.J. Suk, H. Molina, H.J. Kaplan, and N.S. Bora. 2003. Tolerance is dependent on complement C3 fragment iC3b binding to antigen-presenting cells. Nat. Med. 9:206-212.
15. Watts, G.M., F.J. Beurskens, I. Martin-Padura, C.M. Ballantyne, L.B. Klickstein, M.B. Brenner, and D.M. Lee. 2005. Manifestations of inflammatory arthritis are critically dependent on LFA-1. J. Immunol. 174:3668-3675.
16. Kevil, C.G., M.J. Hicks, X. He, J. Zhang, C.M. Ballantyne, C. Raman, T.R. Schoeb, and D.C. Bullard. 2004. Loss of LFA-1, but not Mac-1, protects MRL/MpJ-Fas(lpr) mice from autoimmune disease. Am. J. Pathol. 165:609-616.
17. Kanwar, S., C.W. Smith, F.R. Shardonofsky, and A.R. Burns. 2001. The role of Mac-1 (CD11b/CD18) in antigen-induced airway eosinophilia in mice. Am. J. Respir. Cell Mol. Biol. 25:170-177.
18. Miller, A., O. Lider, A.B. Roberts, M.B. Sporn, and H.L. Weiner. 1992. Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc. Natl. Acad. Sci. USA. 89:421-425.
19. Schmits, R., T.M. Kundig, D.M. Baker, G. Shumaker, J.J. Simard, G. Duncan, A. Wakeham, A. Shahinian, A. van der Heiden, M.F. Bachmann, et al. 1996. LFA-1-deficient mice show normal CTL responses to virus but fail to reject immunogenic tumor. J. Exp. Med. 183:1415-1426.
20. Harrington, L.E., R.D. Hatton, P.R. Mangan, H. Turner, T.L. Murphy, K.M. Murphy, and C.T. Weaver. 2005. Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages. Nat. Immunol. 6:1123-1132.
21. Weaver, C.T., L.E. Harrington, P.R. Mangan, M. Gavrieli, and K.M. Murphy. 2006. Th17: an effector CD4 T cell lineage with regulatory T cell ties. Immunity. 24:677-688.
22. Mangan, P.R., L.E. Harrington, D.B. O'Quinn, W.S. Helms, D.C. Bullard, C.O. Elson, R.D. Hatton, S.M. Wahl, T.R. Schoeb, and C.T. Weaver. 2006. Transforming growth factor-beta induces development of the T(H)17 lineage. Nature. 441:231-234.
23. Fujino, S., A. Andoh, S. Bamba, A. Ogawa, K. Hata, Y. Araki, T. Bamba, and Y. Fujiyama. 2003. Increased expression of interleukin 17 in inflammatory bowel disease. Gut. 52:65-70.
24. Langrish, C.L., Y. Chen, W.M. Blumenschein, J. Mattson, B. Basham, J.D. Sedgwick, T. McClanahan, R.A. Kastelein, and D.J. Cua. 2005. IL-23 drives a pathogenic T cell population that induces autoimmune inflammation. J. Exp. Med. 201:233-240.
25. McKenzie, B.S., R.A. Kastelein, and D.J. Cua. 2006. Understanding the IL-23-IL-17 immune pathway. Trends Immunol. 27:17-23.
26. Murphy, C.A., C.L. Langrish, Y. Chen, W. Blumenschein, T. McClanahan, R.A. Kastelein, J.D. Sedgwick, and D.J. Cua. 2003. Divergent pro- and antiinflammatory roles for IL-23 and IL-12 in joint autoimmune inflammation. J. Exp. Med. 198:1951-1957.
27. Lu, H., C.W. Smith, J. Perrard, D.C. Bullard, L. Tang, M.L. Entman, A.L. Beaudet, and C.M. Ballantyne. 1997. LFA-1 is sufficient in mediating neutrophil emigration in Mac-1 deficient mice. J. Clin. Invest. 99:1340-1350.