Robust in vitro activity of RebF and RebH, a two-component reductase/halogenase, generating 7-chlorotryptophan during rebeccamycin biosynthesis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 102, Issue 11, 2005, Pages 3960-3965

  Yeh, Ellen ^a   Garneau, Sylvie ^a   Walsh, Christopher T ^a  

^a HARVARD MEDICAL SCHOOL   (United States)

Author keywords

Enzymology; Flavoenzyme; Natural product biosynthesis

Indexed keywords

7 CHLOROTRYPTOPHAN; BROMIDE; CHLORIDE ION; FLAVINE ADENINE NUCLEOTIDE; FLAVOPROTEIN; HALOGEN; OXIDOREDUCTASE; OXYGEN; PROTEIN REBF; PROTEIN REBH; QUERCETIN; REBECCAMYCIN; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE; TRYPTOPHAN; TRYPTOPHAN DERIVATIVE; UNCLASSIFIED DRUG;

ANTIBIOTIC BIOSYNTHESIS; ARTICLE; BROMINATION; CATALYSIS; CHEMICAL MODIFICATION; CHEMICAL STRUCTURE; CHLORINATION; ENZYME ACTIVITY; ENZYME PURIFICATION; GENE ACTIVITY; GENE CLUSTER; GENE EXPRESSION; GENE PROBE; HALOGENATION; IN VITRO STUDY; MATHEMATICAL ANALYSIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; REBF GENE; REBH GENE;

CARBAZOLES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FLAVIN-ADENINE DINUCLEOTIDE; INDOLES; KINETICS; OXIDOREDUCTASES; TRYPTOPHAN;

EID: 15244349569     PISSN: 00278424     EISSN: None     Source Type: Journal    
DOI: 10.1073/pnas.0500755102     Document Type: Article

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