Mechanism of enzymatic fluorination in Streptomyces cattleya

Journal of the American Chemical Society

Volumn 129, Issue 47, 2007, Pages 14597-14604

  Zhu, Xiaofeng ^a   Robinson, David A ^a   McEwan, Andrew R ^a   O'Hagan, David ^a   Naismith, James H ^a  

^a UNIVERSITY OF ST ANDREWS   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

ISOTHERMAL CALORIMETRY (ITC); NUCLEOPHILIC ATTACK; PROTEIN LIGATION; STREPTOMYCES CATTLEYA;

FLUORINATION; METABOLITES; MOLECULAR MECHANICS; X RAY CRYSTALLOGRAPHY;

ENZYME ACTIVITY;

4 FLUOROTHREONINE; 5' FLUORO 5' DEOXYADENOSINE SYNTHETASE; ADENOSINE; FLUORIDE ION; FLUOROACETIC ACID; METHIONINE; S ADENOSYLMETHIONINE; SYNTHETASE; THREONINE; UNCLASSIFIED DRUG;

ARTICLE; CALORIMETRY; CHEMICAL BINDING; COMPLEX FORMATION; ENZYME ISOLATION; ENZYME KINETICS; ENZYME MECHANISM; FLUORINATION; NONHUMAN; SITE DIRECTED MUTAGENESIS; STREPTOMYCES; STREPTOMYCES CATTLEYA; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ANIONS; BINDING SITES; CALORIMETRY; FLUORINE; HALOGENS; KINETICS; LIGASES; MODELS, MOLECULAR; MOLECULAR STRUCTURE; MUTAGENESIS, SITE-DIRECTED; S-ADENOSYLMETHIONINE; STREPTOMYCES;

EID: 36749093357     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja0731569     Document Type: Article

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