메뉴 건너뛰기




Volumn 12, Issue 1, 2008, Pages 115-127

Applying small RNA molecules to the directed treatment of human diseases: Realizing the potential

Author keywords

Delivery; MicroRNA; RNA drugs; Small interfering RNA; Therapeutics

Indexed keywords

AGN 211745; AKLI 5; ALN RSV 01; AMPHOTERICIN B LIPID COMPLEX; ANTIBODY; APOLIPOPROTEIN B; ATELOCOLLAGEN; BEVASIRANIB; CASPASE 8; CYCLODEXTRIN; DAUNORUBICIN; DNA; DOXORUBICIN; HYBRID PROTEIN; IMMUNOLIPOSOME; MICRORNA; PCS 01; RNA DERIVATIVE; RTP 108I; SIRNA 027; SIRNA 034; SMALL INTERFERING RNA; TT 033; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

EID: 39049156763     PISSN: 14728222     EISSN: None     Source Type: Journal    
DOI: 10.1517/14728222.12.1.115     Document Type: Review
Times cited : (30)

References (115)
  • 2
    • 0023921083 scopus 로고
    • Oligodeoxynucleotides as inhibitors of gene expression: A review
    • Stein CA, Cohen JS. Oligodeoxynucleotides as inhibitors of gene expression: a review. Cancer Res 1988;48(10):2659-68
    • (1988) Cancer Res , vol.48 , Issue.10 , pp. 2659-2668
    • Stein, C.A.1    Cohen, J.S.2
  • 4
    • 0001457668 scopus 로고    scopus 로고
    • Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA
    • Cheng JQ Ruggeri B, Klein WM, et al. Amplification of AKT2 in human pancreatic cancer cells and inhibition of AKT2 expression and tumorigenicity by antisense RNA. Proc Natl Acad Sci USA 1996;93(8):3636-41
    • (1996) Proc Natl Acad Sci USA , vol.93 , Issue.8 , pp. 3636-3641
    • Cheng, J.Q.1    Ruggeri, B.2    Klein, W.M.3
  • 5
    • 0035044572 scopus 로고    scopus 로고
    • Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia
    • Singh M, Savitz SI, Hoque R, et al. Cell-specific caspase expression by different neuronal phenotypes in transient retinal ischemia. J Neurochem 2001;77(2):466-75
    • (2001) J Neurochem , vol.77 , Issue.2 , pp. 466-475
    • Singh, M.1    Savitz, S.I.2    Hoque, R.3
  • 6
    • 0035861684 scopus 로고    scopus 로고
    • 3 expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes
    • 3 expression and integrin-mediated signaling in glioma cells by adenovirus-mediated transfer of antisense urokinase-type plasminogen activator receptor (uPAR) and sense p16 genes. J Biol Chem 2001;276(50):47171-7
    • (2001) J Biol Chem , vol.276 , Issue.50 , pp. 47171-47177
    • Adachi, Y.1    Lakka, S.S.2    Chandrasekar, N.3
  • 7
    • 0037444555 scopus 로고    scopus 로고
    • Ischemic insults derepress the gene silencer REST in neurons destined to die
    • Calderone A, Jover T, Noh K-M, et al. Ischemic insults derepress the gene silencer REST in neurons destined to die. J Neurosci 2003;23(6):2112-21
    • (2003) J Neurosci , vol.23 , Issue.6 , pp. 2112-2121
    • Calderone, A.1    Jover, T.2    Noh, K.-M.3
  • 8
    • 9444239300 scopus 로고    scopus 로고
    • Disruption of WT1 gene expression and exon 5 splicing following cytotoxic drug treatment: Antisense down-regulation of exon 5 alters target gene expression and inhibits cell survival
    • Renshaw J, Orr RM, Walton MI, et al. Disruption of WT1 gene expression and exon 5 splicing following cytotoxic drug treatment: antisense down-regulation of exon 5 alters target gene expression and inhibits cell survival. Mol Cancer Ther 2004;3(11):1467-84
    • (2004) Mol Cancer Ther , vol.3 , Issue.11 , pp. 1467-1484
    • Renshaw, J.1    Orr, R.M.2    Walton, M.I.3
  • 9
    • 0242658826 scopus 로고    scopus 로고
    • A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity
    • London CA, Sekhon HS, Arora V, et al. A novel antisense inhibitor of MMP-9 attenuates angiogenesis, human prostate cancer cell invasion and tumorigenicity. Cancer Gene Ther 2003;10(11):823-32
    • (2003) Cancer Gene Ther , vol.10 , Issue.11 , pp. 823-832
    • London, C.A.1    Sekhon, H.S.2    Arora, V.3
  • 10
    • 39049160914 scopus 로고    scopus 로고
    • http://www.genta.com/Products-genasense.html
  • 11
    • 33846914204 scopus 로고    scopus 로고
    • Gene therapy progress and prospects: RNA aptamers
    • Que-Gewirth NS, Sullenger BA. Gene therapy progress and prospects: RNA aptamers. Gene Ther 2007;14(4):283-91
    • (2007) Gene Ther , vol.14 , Issue.4 , pp. 283-291
    • Que-Gewirth, N.S.1    Sullenger, B.A.2
  • 12
    • 33748283311 scopus 로고    scopus 로고
    • DNA and RNA aptamers: From tools for basic research towards therapeutic applications
    • Ulrich H, Trujillo CA, Nery AA, et al. DNA and RNA aptamers: from tools for basic research towards therapeutic applications. Comb Chem High Throughput Screen 2006;9(8):619-32
    • (2006) Comb Chem High Throughput Screen , vol.9 , Issue.8 , pp. 619-632
    • Ulrich, H.1    Trujillo, C.A.2    Nery, A.A.3
  • 13
    • 0005620475 scopus 로고    scopus 로고
    • Aptamers as therapeutic and diagnostic agents
    • Brody EN, Gold L. Aptamers as therapeutic and diagnostic agents. J Biotechnol 2000;74(1):5-13
    • (2000) J Biotechnol , vol.74 , Issue.1 , pp. 5-13
    • Brody, E.N.1    Gold, L.2
  • 14
    • 21744446220 scopus 로고    scopus 로고
    • Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration
    • Ng EW, Adamis AP. Targeting angiogenesis, the underlying disorder in neovascular age-related macular degeneration. Can J Ophthalmol 2005;40(3):352-68
    • (2005) Can J Ophthalmol , vol.40 , Issue.3 , pp. 352-368
    • Ng, E.W.1    Adamis, A.P.2
  • 15
    • 0345827805 scopus 로고    scopus 로고
    • Technology evaluation: Pegaptanib, Eyetech/Pfizer
    • Vinores SA. Technology evaluation: pegaptanib, Eyetech/Pfizer. Curr Opin Mol Ther 2003;5(6):673-9
    • (2003) Curr Opin Mol Ther , vol.5 , Issue.6 , pp. 673-679
    • Vinores, S.A.1
  • 17
    • 24744446474 scopus 로고    scopus 로고
    • In vivo inhibition of lung cancer by GRN163L: A novel human telomerase inhibitor
    • Dikmen ZG, Gellert GC, Jackson S, et al. In vivo inhibition of lung cancer by GRN163L: a novel human telomerase inhibitor. Cancer Res 2005;65(17):7866-73
    • (2005) Cancer Res , vol.65 , Issue.17 , pp. 7866-7873
    • Dikmen, Z.G.1    Gellert, G.C.2    Jackson, S.3
  • 18
    • 30944442508 scopus 로고    scopus 로고
    • Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma
    • Djojosubroto MW, Chin AC, Go N, et al. Telomerase antagonists GRN163 and GRN163L inhibit tumor growth and increase chemosensitivity of human hepatoma. Hepatology 2005;42(5):1127-36
    • (2005) Hepatology , vol.42 , Issue.5 , pp. 1127-1136
    • Djojosubroto, M.W.1    Chin, A.C.2    Go, N.3
  • 19
    • 0037686295 scopus 로고    scopus 로고
    • Killing the messenger: Short RNAs that silence gene expression
    • Dykxhoorn DM, Novina CD, Sharp PA. Killing the messenger: short RNAs that silence gene expression. Nat Rev Mol Cell Biol 2003;4(6):457-67
    • (2003) Nat Rev Mol Cell Biol , vol.4 , Issue.6 , pp. 457-467
    • Dykxhoorn, D.M.1    Novina, C.D.2    Sharp, P.A.3
  • 20
    • 33845242919 scopus 로고    scopus 로고
    • MicroRNAs: Regulators of gene expression and cell differentiation
    • Shivdasani RA. MicroRNAs: regulators of gene expression and cell differentiation. Blood 2006;108(12):3646-53
    • (2006) Blood , vol.108 , Issue.12 , pp. 3646-3653
    • Shivdasani, R.A.1
  • 21
    • 33645294070 scopus 로고    scopus 로고
    • Oncomirs - microRNAs with a role in cancer
    • Esquela-Kerscher A, Slack FJ. Oncomirs - microRNAs with a role in cancer. Nat Rev Cancer 2006;6(4):259-69
    • (2006) Nat Rev Cancer , vol.6 , Issue.4 , pp. 259-269
    • Esquela-Kerscher, A.1    Slack, F.J.2
  • 22
    • 0037685280 scopus 로고    scopus 로고
    • Expression profiling reveals off-target gene regulation by RNAi
    • Jackson AL, Bartz SR, Schelter J, et al. Expression profiling reveals off-target gene regulation by RNAi. Nat Biotechnol 2003;21(6):635-7
    • (2003) Nat Biotechnol , vol.21 , Issue.6 , pp. 635-637
    • Jackson, A.L.1    Bartz, S.R.2    Schelter, J.3
  • 23
    • 33749438388 scopus 로고    scopus 로고
    • Designing siRNA that distinguish between genes that differ by a single nucleotide
    • Schwarz DS, Ding H, Kennington L, et al. Designing siRNA that distinguish between genes that differ by a single nucleotide. PLoS Genet 2006;2(9):E140
    • (2006) PLoS Genet , vol.2 , Issue.9
    • Schwarz, D.S.1    Ding, H.2    Kennington, L.3
  • 24
    • 33745614074 scopus 로고    scopus 로고
    • Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing
    • Jackson AL, Burchard J, Leake D, et al. Position-specific chemical modification of siRNAs reduces "off-target" transcript silencing. RNA 2006;12(7):1197-205
    • (2006) RNA , vol.12 , Issue.7 , pp. 1197-1205
    • Jackson, A.L.1    Burchard, J.2    Leake, D.3
  • 25
    • 33646188259 scopus 로고    scopus 로고
    • 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets
    • Birmingham A, Anderson EM, Reynolds A, et al. 3′ UTR seed matches, but not overall identity, are associated with RNAi off-targets. Nat Methods 2006;3(3):199-204
    • (2006) Nat Methods , vol.3 , Issue.3 , pp. 199-204
    • Birmingham, A.1    Anderson, E.M.2    Reynolds, A.3
  • 26
    • 0038132996 scopus 로고    scopus 로고
    • Allele-specific silencing of dominant disease genes
    • Miller VM, Xia H, Marrs GL, et al. Allele-specific silencing of dominant disease genes. Proc Natl Acad Sci USA 2003;100(12):7195-200
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.12 , pp. 7195-7200
    • Miller, V.M.1    Xia, H.2    Marrs, G.L.3
  • 27
    • 1342306385 scopus 로고    scopus 로고
    • Targeting Alzheimer's disease genes with RNA interference: An efficient strategy for silencing mutant alleles
    • Miller VM, Gouvion CM, Davidson BL, Paulson HL. Targeting Alzheimer's disease genes with RNA interference: an efficient strategy for silencing mutant alleles. Nucleic Acids Res 2004;32(2):661-8
    • (2004) Nucleic Acids Res , vol.32 , Issue.2 , pp. 661-668
    • Miller, V.M.1    Gouvion, C.M.2    Davidson, B.L.3    Paulson, H.L.4
  • 28
    • 33747201641 scopus 로고    scopus 로고
    • Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo
    • Xia X, Zhou H, Huang Y, Xu Z. Allele-specific RNAi selectively silences mutant SOD1 and achieves significant therapeutic benefit in vivo. Neurobiol Dis 2006;23(3):578-86
    • (2006) Neurobiol Dis , vol.23 , Issue.3 , pp. 578-586
    • Xia, X.1    Zhou, H.2    Huang, Y.3    Xu, Z.4
  • 29
    • 39049141925 scopus 로고    scopus 로고
    • www.ambion.com/techlib/misc/siRNA_finder.html
  • 30
    • 1542336952 scopus 로고    scopus 로고
    • Rational siRNA design for RNA interference
    • Reynolds A, Leake D, Boese Q, et al. Rational siRNA design for RNA interference. Nat Biotechnol 2004;22(3):326-30
    • (2004) Nat Biotechnol , vol.22 , Issue.3 , pp. 326-330
    • Reynolds, A.1    Leake, D.2    Boese, Q.3
  • 31
    • 0037144546 scopus 로고    scopus 로고
    • A microRNA in a multiple-turnover RNAi enzyme complex
    • Hutvagner G, Zamore PD. A microRNA in a multiple-turnover RNAi enzyme complex. Science 2002;297(5589):2056-60
    • (2002) Science , vol.297 , Issue.5589 , pp. 2056-2060
    • Hutvagner, G.1    Zamore, P.D.2
  • 32
    • 33847245910 scopus 로고    scopus 로고
    • Comparison of siRNA-induced off-target RNA and protein effects
    • Aleman LM, Doench J, Sharp PA. Comparison of siRNA-induced off-target RNA and protein effects. RNA 2007;13(3):385-95
    • (2007) RNA , vol.13 , Issue.3 , pp. 385-395
    • Aleman, L.M.1    Doench, J.2    Sharp, P.A.3
  • 33
    • 1942533474 scopus 로고    scopus 로고
    • Layzer JM, McCaffrey AP, Tanner AK, et al. In vivo activity of nuclease-resistant siRNAs. RNA 2004;10(5):766-71
    • Layzer JM, McCaffrey AP, Tanner AK, et al. In vivo activity of nuclease-resistant siRNAs. RNA 2004;10(5):766-71
  • 34
    • 0038606999 scopus 로고    scopus 로고
    • Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells
    • Csauderna F, Fechtner M, Dames S, et al. Structural variations and stabilising modifications of synthetic siRNAs in mammalian cells. Nucleic Acids Res 2003;31(11):2705-16
    • (2003) Nucleic Acids Res , vol.31 , Issue.11 , pp. 2705-2716
    • Csauderna, F.1    Fechtner, M.2    Dames, S.3
  • 35
    • 0027730383 scopus 로고
    • Posttranscriptional regulation of the heterochronic gene lin- 14 by lin-4 mediates temporal pattern formation in C. elegans
    • Wightman B, Ha I, Ruvkun G. Posttranscriptional regulation of the heterochronic gene lin- 14 by lin-4 mediates temporal pattern formation in C. elegans. Cell 1993;75(5):855-62
    • (1993) Cell , vol.75 , Issue.5 , pp. 855-862
    • Wightman, B.1    Ha, I.2    Ruvkun, G.3
  • 36
    • 17844364875 scopus 로고    scopus 로고
    • Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing
    • Grishok A, Pasquinelli AE, Conte D, et al. Genes and mechanisms related to RNA interference regulate expression of the small temporal RNAs that control C. elegans developmental timing. Cell 2001;106(1):23-34
    • (2001) Cell , vol.106 , Issue.1 , pp. 23-34
    • Grishok, A.1    Pasquinelli, A.E.2    Conte, D.3
  • 37
    • 0037009520 scopus 로고    scopus 로고
    • Two classes of short interfering RNA in RNA silencing
    • Hamilton A, Voinner O, Chappell L, Baulcombe D. Two classes of short interfering RNA in RNA silencing. EMBO J 2002;21(17):4671-9
    • (2002) EMBO J , vol.21 , Issue.17 , pp. 4671-4679
    • Hamilton, A.1    Voinner, O.2    Chappell, L.3    Baulcombe, D.4
  • 38
    • 2142654329 scopus 로고    scopus 로고
    • MicroRNA-directed cleavage of HOXB8 mRNA
    • Yekta S, Shih IH, Bartel DP. MicroRNA-directed cleavage of HOXB8 mRNA. Science 2004;304(5670):594-6
    • (2004) Science , vol.304 , Issue.5670 , pp. 594-596
    • Yekta, S.1    Shih, I.H.2    Bartel, D.P.3
  • 39
    • 0027751663 scopus 로고
    • The C. elegant heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14
    • Lee RC, Feinbaum RL, Ambros V. The C. elegant heterochronic gene lin-4 encodes small RNAs with antisense complementarity to lin-14. Cell 1993;75(5):843-54
    • (1993) Cell , vol.75 , Issue.5 , pp. 843-854
    • Lee, R.C.1    Feinbaum, R.L.2    Ambros, V.3
  • 40
    • 0033572284 scopus 로고    scopus 로고
    • The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation
    • Olsen PH, Ambros V. The lin-4 regulatory RNA controls developmental timing in Caenorhabditis elegans by blocking LIN-14 protein synthesis after the initiation of translation. Dev Biol 1999;216(2):671-80
    • (1999) Dev Biol , vol.216 , Issue.2 , pp. 671-680
    • Olsen, P.H.1    Ambros, V.2
  • 41
    • 4644310115 scopus 로고    scopus 로고
    • Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis
    • Pillai RS, Artus CG, Filipowicz W. Tethering of human Ago proteins to mRNA mimics the miRNA-mediated repression of protein synthesis. RNA 2004;10(10):1518-25
    • (2004) RNA , vol.10 , Issue.10 , pp. 1518-1525
    • Pillai, R.S.1    Artus, C.G.2    Filipowicz, W.3
  • 43
    • 22144478256 scopus 로고    scopus 로고
    • MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies
    • Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R. MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. Nat Cell Biol 2005;7(7):719-23
    • (2005) Nat Cell Biol , vol.7 , Issue.7 , pp. 719-723
    • Liu, J.1    Valencia-Sanchez, M.A.2    Hannon, G.J.3    Parker, R.4
  • 44
    • 33645119514 scopus 로고    scopus 로고
    • MicroRNAs direct rapid deadenylation of mRNA
    • Wu L, Fan J, Belasco JG. MicroRNAs direct rapid deadenylation of mRNA. Proc Natl Acad Sci USA 2006;103(11):4034-9
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.11 , pp. 4034-4039
    • Wu, L.1    Fan, J.2    Belasco, J.G.3
  • 45
    • 34547944309 scopus 로고    scopus 로고
    • MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F
    • Mathonnet G, Fabian MR, Svitkin YV, et al. MicroRNA inhibition of translation initiation in vitro by targeting the cap-binding complex eIF4F. Science 2007;317(5845):1764-7
    • (2007) Science , vol.317 , Issue.5845 , pp. 1764-1767
    • Mathonnet, G.1    Fabian, M.R.2    Svitkin, Y.V.3
  • 46
    • 2442604466 scopus 로고    scopus 로고
    • Viral virulence protein suppresses RNA silencing-mediated defense but upregulates the role of microrna in host gene expression
    • Chen J, Li WX, Xie D, Ping JR, Ding SW. Viral virulence protein suppresses RNA silencing-mediated defense but upregulates the role of microrna in host gene expression. Plant Cell 2004;16(5):1302-13
    • (2004) Plant Cell , vol.16 , Issue.5 , pp. 1302-1313
    • Chen, J.1    Li, W.X.2    Xie, D.3    Ping, J.R.4    Ding, S.W.5
  • 47
    • 0037418839 scopus 로고    scopus 로고
    • bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila
    • Brennecke J, Hipfner DR, Stark A, Russell RB, Cohen SM. bantam encodes a developmentally regulated microRNA that controls cell proliferation and regulates the proapoptotic gene hid in Drosophila. Cell 2003;113(1):25-36
    • (2003) Cell , vol.113 , Issue.1 , pp. 25-36
    • Brennecke, J.1    Hipfner, D.R.2    Stark, A.3    Russell, R.B.4    Cohen, S.M.5
  • 48
    • 14844364472 scopus 로고    scopus 로고
    • Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis
    • Cheng AM, Byrom MW, Shelton J, Ford LP. Antisense inhibition of human miRNAs and indications for an involvement of miRNA in cell growth and apoptosis. Nucleic Acids Res 2005;33(4):1290-7
    • (2005) Nucleic Acids Res , vol.33 , Issue.4 , pp. 1290-1297
    • Cheng, A.M.1    Byrom, M.W.2    Shelton, J.3    Ford, L.P.4
  • 49
    • 34548012848 scopus 로고    scopus 로고
    • The let-7 MicroRNA represses cell proliferation pathways in human cells
    • Johnson CD, Esquela-Kerscher A, Stefani G, et al. The let-7 MicroRNA represses cell proliferation pathways in human cells. Cancer Res 2007;67(16):7713-22
    • (2007) Cancer Res , vol.67 , Issue.16 , pp. 7713-7722
    • Johnson, C.D.1    Esquela-Kerscher, A.2    Stefani, G.3
  • 50
    • 33744521896 scopus 로고    scopus 로고
    • Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines
    • Meng F, Henson R, Lang M, et al. Involvement of human micro-RNA in growth and response to chemotherapy in human cholangiocarcinoma cell lines. Gastroenterology 2006;130(7):2113-29
    • (2006) Gastroenterology , vol.130 , Issue.7 , pp. 2113-2129
    • Meng, F.1    Henson, R.2    Lang, M.3
  • 51
    • 26944498633 scopus 로고    scopus 로고
    • Prediction and validation of microRNAs and their targets
    • Bentwich I. Prediction and validation of microRNAs and their targets. FEBS Lett 2005;579(26):5904-10
    • (2005) FEBS Lett , vol.579 , Issue.26 , pp. 5904-5910
    • Bentwich, I.1
  • 52
    • 11844278458 scopus 로고    scopus 로고
    • Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets
    • Lewis BP, Burge CB, Bartel DP. Conserved seed pairing, often flanked by adenosines, indicates that thousands of human genes are microRNA targets. Cell 2005;120(1):15
    • (2005) Cell , vol.120 , Issue.1 , pp. 15
    • Lewis, B.P.1    Burge, C.B.2    Bartel, D.P.3
  • 53
    • 33644819964 scopus 로고    scopus 로고
    • Unique microRNA molecular profiles in lung cancer diagnosis and prognosis
    • Yanaihara N, Caplen N, Bowman E, et al. Unique microRNA molecular profiles in lung cancer diagnosis and prognosis. Cancer Cell 2006;9(3):189-98
    • (2006) Cancer Cell , vol.9 , Issue.3 , pp. 189-198
    • Yanaihara, N.1    Caplen, N.2    Bowman, E.3
  • 54
    • 33144490646 scopus 로고    scopus 로고
    • A microRNA expression signature of human solid tumors defines cancer gene targets
    • Volinia S, Calin GA, Liu CG, et al. A microRNA expression signature of human solid tumors defines cancer gene targets. Proc Natl Acad Sci USA 2006;103(7):2257-61
    • (2006) Proc Natl Acad Sci USA , vol.103 , Issue.7 , pp. 2257-2261
    • Volinia, S.1    Calin, G.A.2    Liu, C.G.3
  • 55
    • 33750370444 scopus 로고    scopus 로고
    • MicroRNA signatures in human cancers
    • Calin GA, Croce CM. MicroRNA signatures in human cancers. Nat Rev Cancer 2006;6(11):857-66
    • (2006) Nat Rev Cancer , vol.6 , Issue.11 , pp. 857-866
    • Calin, G.A.1    Croce, C.M.2
  • 56
    • 27244434788 scopus 로고    scopus 로고
    • A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia
    • Calin GA, Ferracin M, Cimmino A, et al. A MicroRNA signature associated with prognosis and progression in chronic lymphocytic leukemia. N Engl J Med 2005;353(17):1793-801
    • (2005) N Engl J Med , vol.353 , Issue.17 , pp. 1793-1801
    • Calin, G.A.1    Ferracin, M.2    Cimmino, A.3
  • 57
    • 4143142117 scopus 로고    scopus 로고
    • MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias
    • Calm GA, Liu CG, Sevignani C, et al. MicroRNA profiling reveals distinct signatures in B cell chronic lymphocytic leukemias. Proc Natl Acad Sci USA 2004;101(32):11755-60
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.32 , pp. 11755-11760
    • Calm, G.A.1    Liu, C.G.2    Sevignani, C.3
  • 59
    • 24644490196 scopus 로고    scopus 로고
    • Elucidation of the small RNA component of the transcriptome
    • Lu C, Tej SS, Luo S, et al. Elucidation of the small RNA component of the transcriptome. Science 2005;309(5740): 1567-9
    • (2005) Science , vol.309 , Issue.5740 , pp. 1567-1569
    • Lu, C.1    Tej, S.S.2    Luo, S.3
  • 60
    • 0346727383 scopus 로고    scopus 로고
    • High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma
    • Metzler M, Wilda M, Busch K, Viehmann S, Borkhardt A. High expression of precursor microRNA-155/BIC RNA in children with Burkitt lymphoma. Genes Chromosomes Cancer 2004;39(2):167-9
    • (2004) Genes Chromosomes Cancer , vol.39 , Issue.2 , pp. 167-169
    • Metzler, M.1    Wilda, M.2    Busch, K.3    Viehmann, S.4    Borkhardt, A.5
  • 62
    • 34247495591 scopus 로고    scopus 로고
    • miR-21-mediated tumor growth
    • Si ML, Zhu S, Wu H, et al. miR-21-mediated tumor growth. Oncogene 2006;26(19):2799-803
    • (2006) Oncogene , vol.26 , Issue.19 , pp. 2799-2803
    • Si, M.L.1    Zhu, S.2    Wu, H.3
  • 63
    • 20444467290 scopus 로고    scopus 로고
    • A microRNA polycistron as a potential human oncogene
    • He L, Thomson JM, Hemann MT, et al. A microRNA polycistron as a potential human oncogene. Nature 2005;435(7043):828-33
    • (2005) Nature , vol.435 , Issue.7043 , pp. 828-833
    • He, L.1    Thomson, J.M.2    Hemann, M.T.3
  • 64
    • 27544495514 scopus 로고    scopus 로고
    • A polycistronic microRNA cluster, miR-17-92, is overexpresaed in human lung cancers and enhances cell proliferation
    • Hayashita Y, Osada H, Tatematsu Y, et al. A polycistronic microRNA cluster, miR-17-92, is overexpresaed in human lung cancers and enhances cell proliferation. Cancer Res 2005;65(21):9628-32
    • (2005) Cancer Res , vol.65 , Issue.21 , pp. 9628-9632
    • Hayashita, Y.1    Osada, H.2    Tatematsu, Y.3
  • 65
    • 33748302836 scopus 로고    scopus 로고
    • Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster
    • Dews M, Homayouni A, Yu D, et al. Augmentation of tumor angiogenesis by a Myc-activated microRNA cluster. Nat Genet 2006;38(9):1060-5
    • (2006) Nat Genet , vol.38 , Issue.9 , pp. 1060-1065
    • Dews, M.1    Homayouni, A.2    Yu, D.3
  • 66
    • 33646471662 scopus 로고    scopus 로고
    • Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E{micro}-miR155 transgenic mice
    • Costinean S, Zanesi N, Pekarsky Y, et al. Pre-B cell proliferation and lymphoblastic leukemia/high-grade lymphoma in E{micro}-miR155 transgenic mice. Proc Natl Acad Sci USA 2006;103:7024-9
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 7024-7029
    • Costinean, S.1    Zanesi, N.2    Pekarsky, Y.3
  • 67
    • 22244467087 scopus 로고    scopus 로고
    • MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells
    • Chan JA, Krichevsky AM, Kosik KS. MicroRNA-21 is an antiapoptotic factor in human glioblastoma cells. Cancer Res 2005;65(14):6029-33
    • (2005) Cancer Res , vol.65 , Issue.14 , pp. 6029-6033
    • Chan, J.A.1    Krichevsky, A.M.2    Kosik, K.S.3
  • 68
    • 20044395613 scopus 로고    scopus 로고
    • RAS Is Regulated by the let-7 MicroRNA Family
    • Johnson SM, Grosshans H, Shingara J, et al. RAS Is Regulated by the let-7 MicroRNA Family. Cell 2005;120(5):635
    • (2005) Cell , vol.120 , Issue.5 , pp. 635
    • Johnson, S.M.1    Grosshans, H.2    Shingara, J.3
  • 69
    • 25444520537 scopus 로고    scopus 로고
    • miR-15 and miR-16 induce apoptosis by targeting BCL2
    • Cimmino A, Calin GA, Fabbri M, et al. miR-15 and miR-16 induce apoptosis by targeting BCL2. Proc Natl Acad Sci USA 2005;102(39):13944-9
    • (2005) Proc Natl Acad Sci USA , vol.102 , Issue.39 , pp. 13944-13949
    • Cimmino, A.1    Calin, G.A.2    Fabbri, M.3
  • 70
    • 0036828639 scopus 로고    scopus 로고
    • The Argonaute family: Tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis
    • Carmell MA, Xuan Z, Zhang MQ, Hannon GJ. The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. Genes Dev 2002;16(21):2733-42
    • (2002) Genes Dev , vol.16 , Issue.21 , pp. 2733-2742
    • Carmell, M.A.1    Xuan, Z.2    Zhang, M.Q.3    Hannon, G.J.4
  • 71
    • 20144373433 scopus 로고    scopus 로고
    • Reduced capression of dicer associated with poor prognosis in lung cancer patients
    • Karube Y, Tanaka H, Osada H, et al. Reduced capression of dicer associated with poor prognosis in lung cancer patients. Cancer Sci 2005;96(2):111-5
    • (2005) Cancer Sci , vol.96 , Issue.2 , pp. 111-115
    • Karube, Y.1    Tanaka, H.2    Osada, H.3
  • 72
    • 33947236349 scopus 로고    scopus 로고
    • Up-regulation of dicer, a component of the MicroRNA machinery in prostate adenocarcinoma
    • Chiosea S, Jelezcova E, Chandran U, et al. Up-regulation of dicer, a component of the MicroRNA machinery in prostate adenocarcinoma. Am J Pathol 2006;169(5):1812-20
    • (2006) Am J Pathol , vol.169 , Issue.5 , pp. 1812-1820
    • Chiosea, S.1    Jelezcova, E.2    Chandran, U.3
  • 73
    • 33646056975 scopus 로고    scopus 로고
    • A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors
    • Voorhoeve PM, Le Sage C, Schrier M, et al. A genetic screen implicates miRNA-372 and miRNA-373 as oncogenes in testicular germ cell tumors. Cell 2006;124(6):1169-81
    • (2006) Cell , vol.124 , Issue.6 , pp. 1169-1181
    • Voorhoeve, P.M.1    Le Sage, C.2    Schrier, M.3
  • 74
    • 0037019339 scopus 로고    scopus 로고
    • RNA interference in adult mice
    • Mccaffrey AP, Meuse L, Pham TT, et al. RNA interference in adult mice. Nature 2002;418(6893):38-9
    • (2002) Nature , vol.418 , Issue.6893 , pp. 38-39
    • Mccaffrey, A.P.1    Meuse, L.2    Pham, T.T.3
  • 75
    • 0036727416 scopus 로고    scopus 로고
    • Efficient delivery of siRNA for inhibition of gene expression in postnatal mice
    • Lewis DL, Hagstrom JE, Loomis AG, Wolff JA, Herweijer H. Efficient delivery of siRNA for inhibition of gene expression in postnatal mice. Nat Genet 2002;32(1):107-8
    • (2002) Nat Genet , vol.32 , Issue.1 , pp. 107-108
    • Lewis, D.L.1    Hagstrom, J.E.2    Loomis, A.G.3    Wolff, J.A.4    Herweijer, H.5
  • 76
    • 6944238701 scopus 로고    scopus 로고
    • Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury
    • Hamar P, Song E, Kokeny G, et al. Small interfering RNA targeting Fas protects mice against renal ischemia-reperfusion injury. Proc Natl Acad Sci USA 2004;101(41):14883-8
    • (2004) Proc Natl Acad Sci USA , vol.101 , Issue.41 , pp. 14883-14888
    • Hamar, P.1    Song, E.2    Kokeny, G.3
  • 77
    • 0037348329 scopus 로고    scopus 로고
    • RNA interference targeting Fas protects mice from fulminant hepatitis
    • Song E, Lee SK, Wang J, et al. RNA interference targeting Fas protects mice from fulminant hepatitis. Nat Med 2003;9(3):347-51
    • (2003) Nat Med , vol.9 , Issue.3 , pp. 347-351
    • Song, E.1    Lee, S.K.2    Wang, J.3
  • 78
    • 0038610713 scopus 로고    scopus 로고
    • Caspase 8 small interfering RNA prevents acute liver failure in mice
    • Zender L, Hutker S, Liedtke C, et al. Caspase 8 small interfering RNA prevents acute liver failure in mice. Proc Natl Acad Sci USA 2003;100(13):7797-802
    • (2003) Proc Natl Acad Sci USA , vol.100 , Issue.13 , pp. 7797-7802
    • Zender, L.1    Hutker, S.2    Liedtke, C.3
  • 79
    • 0141552295 scopus 로고    scopus 로고
    • Gene silencing by systemic delivery of synthetic siRNAs in adult mice
    • Sorensen DR, Leirdal M, Sioud M. Gene silencing by systemic delivery of synthetic siRNAs in adult mice. J Mol Biol 2003;327(4):761-6
    • (2003) J Mol Biol , vol.327 , Issue.4 , pp. 761-766
    • Sorensen, D.R.1    Leirdal, M.2    Sioud, M.3
  • 80
    • 9144247189 scopus 로고    scopus 로고
    • Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs
    • Soutschek J, Akinc A, Bramlage B, et al. Therapeutic silencing of an endogenous gene by systemic administration of modified siRNAs. Nature 2004;432(7014):73
    • (2004) Nature , vol.432 , Issue.7014 , pp. 73
    • Soutschek, J.1    Akinc, A.2    Bramlage, B.3
  • 81
    • 24744466699 scopus 로고    scopus 로고
    • Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque
    • Li BJ, Tang Q, Cheng D, et al. Using siRNA in prophylactic and therapeutic regimens against SARS coronavirus in Rhesus macaque. Nat Med 2005;11(9):944-51
    • (2005) Nat Med , vol.11 , Issue.9 , pp. 944-951
    • Li, B.J.1    Tang, Q.2    Cheng, D.3
  • 83
    • 20044385081 scopus 로고    scopus 로고
    • In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury
    • Lomas-Neira JL, Chung CS, Wesche DE, Pen M, Ayala A. In vivo gene silencing (with siRNA) of pulmonary expression of MIP-2 versus KC results in divergent effects on hemorrhage-induced, neutrophil-mediated septic acute lung injury. J Leukoc Biol 2005;77(6):846-53
    • (2005) J Leukoc Biol , vol.77 , Issue.6 , pp. 846-853
    • Lomas-Neira, J.L.1    Chung, C.S.2    Wesche, D.E.3    Pen, M.4    Ayala, A.5
  • 84
    • 0001563133 scopus 로고
    • A correlation between surface charge and coagulant action of phospholipids
    • Bangham AD. A correlation between surface charge and coagulant action of phospholipids. Nature 1961;192:1197-8
    • (1961) Nature , vol.192 , pp. 1197-1198
    • Bangham, A.D.1
  • 85
    • 0022273741 scopus 로고
    • Selective toxicity and enhanced therapeutic index of liposomal polyene antibiotics in systemic fungal infections
    • Juliano RL, Lopez-Berestein G, Hopfer R, et al. Selective toxicity and enhanced therapeutic index of liposomal polyene antibiotics in systemic fungal infections. Ann NY Acad Sci 1985;446:390-402
    • (1985) Ann NY Acad Sci , vol.446 , pp. 390-402
    • Juliano, R.L.1    Lopez-Berestein, G.2    Hopfer, R.3
  • 86
    • 0021745628 scopus 로고
    • Potential of liposomes to ameliorate anthracycline-induced cardiotoxicity
    • Rahman A, Fumagalli A, Goodman A, Schein PS. Potential of liposomes to ameliorate anthracycline-induced cardiotoxicity. Semin Oncol 1984;11(4 Suppl 3):45-55
    • (1984) Semin Oncol , vol.11 , Issue.4 SUPPL. 3 , pp. 45-55
    • Rahman, A.1    Fumagalli, A.2    Goodman, A.3    Schein, P.S.4
  • 87
    • 0021211853 scopus 로고
    • Cardiotoxicity of free and liposomally encapsulated rubomycin (daunorubicin) in mice
    • Fichtner I, Arndt D, Elbe B, Reszka R. Cardiotoxicity of free and liposomally encapsulated rubomycin (daunorubicin) in mice. Oncology 1984;41(5):363-9
    • (1984) Oncology , vol.41 , Issue.5 , pp. 363-369
    • Fichtner, I.1    Arndt, D.2    Elbe, B.3    Reszka, R.4
  • 88
    • 0342720605 scopus 로고
    • Use of anionic liposomes for the reduction of chronic doxorubicin-induced cardiotoxicity
    • Forssen EA, Tokes ZA. Use of anionic liposomes for the reduction of chronic doxorubicin-induced cardiotoxicity. Proc Natl Acad Sci USA 1981;78(3):1873-7
    • (1981) Proc Natl Acad Sci USA , vol.78 , Issue.3 , pp. 1873-1877
    • Forssen, E.A.1    Tokes, Z.A.2
  • 89
    • 21344457432 scopus 로고    scopus 로고
    • RNA interference: From gene silencing to gene-specific therapeutics
    • Leung RK, Whittaker PA. RNA interference: from gene silencing to gene-specific therapeutics. Pharmacol Ther 2005;107(2):222-39
    • (2005) Pharmacol Ther , vol.107 , Issue.2 , pp. 222-239
    • Leung, R.K.1    Whittaker, P.A.2
  • 90
  • 91
    • 0036638142 scopus 로고    scopus 로고
    • Dass CR Liposame-mediated delivery of oligodeoxynucleotides in vivo. Drug Deliv 2002;9(3):169-80
    • Dass CR Liposame-mediated delivery of oligodeoxynucleotides in vivo. Drug Deliv 2002;9(3):169-80
  • 92
    • 33746883220 scopus 로고    scopus 로고
    • A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium
    • Santel A, Aleku M, Keil O, et al. A novel siRNA-lipoplex technology for RNA interference in the mouse vascular endothelium. Gene Ther 2006;13(16):1222-34
    • (2006) Gene Ther , vol.13 , Issue.16 , pp. 1222-1234
    • Santel, A.1    Aleku, M.2    Keil, O.3
  • 93
    • 3242733298 scopus 로고    scopus 로고
    • Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo
    • Minakuchi Y, Takeshita F, Kosaka N, et al. Atelocollagen-mediated synthetic small interfering RNA delivery for effective gene silencing in vitro and in vivo. Nucleic Acids Res 2004;32(13):E109
    • (2004) Nucleic Acids Res , vol.32 , Issue.13
    • Minakuchi, Y.1    Takeshita, F.2    Kosaka, N.3
  • 94
    • 0030475293 scopus 로고    scopus 로고
    • The efficacy of Marlex mesh in the repair of severe, recurrent vaginal prolapse of the anterior midvaginal wall
    • Julian TM. The efficacy of Marlex mesh in the repair of severe, recurrent vaginal prolapse of the anterior midvaginal wall. Am J Obstet Gynecol 1996;175(6):1472-5
    • (1996) Am J Obstet Gynecol , vol.175 , Issue.6 , pp. 1472-1475
    • Julian, T.M.1
  • 95
    • 39049146859 scopus 로고    scopus 로고
    • http://clinicaltrials.gov/
  • 96
    • 33746581992 scopus 로고    scopus 로고
    • Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo
    • Aigner A. Delivery systems for the direct application of siRNAs to induce RNA interference (RNAi) in vivo. J Biomed Biotechnol 2006;2006(4):71659
    • (2006) J Biomed Biotechnol , vol.2006 , Issue.4 , pp. 71659
    • Aigner, A.1
  • 97
    • 19444375104 scopus 로고    scopus 로고
    • Patil SD, Rhodes DG, Burgess DJ. DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J 2005;7(1):E61-E77
    • Patil SD, Rhodes DG, Burgess DJ. DNA-based therapeutics and DNA delivery systems: a comprehensive review. AAPS J 2005;7(1):E61-E77
  • 98
    • 33748636431 scopus 로고    scopus 로고
    • Linear cyclodextrin-containing polymers and their use as delivery agents
    • Heidel JD. Linear cyclodextrin-containing polymers and their use as delivery agents. Expert Opin Drug Deliv 2006;3(5):641-6
    • (2006) Expert Opin Drug Deliv , vol.3 , Issue.5 , pp. 641-646
    • Heidel, J.D.1
  • 99
    • 34447306000 scopus 로고    scopus 로고
    • Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing
    • Bartlett DW, Davis ME. Effect of siRNA nuclease stability on the in vitro and in vivo kinetics of siRNA-mediated gene silencing. Biotechnol Bioeng 2007;97(4):909-21
    • (2007) Biotechnol Bioeng , vol.97 , Issue.4 , pp. 909-921
    • Bartlett, D.W.1    Davis, M.E.2
  • 100
    • 33947696667 scopus 로고    scopus 로고
    • Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles
    • Bartlett DW, Davis ME. Physicochemical and biological characterization of targeted, nucleic acid-containing nanoparticles. Bioconjug Chem 2007;18(2):456-68
    • (2007) Bioconjug Chem , vol.18 , Issue.2 , pp. 456-468
    • Bartlett, D.W.1    Davis, M.E.2
  • 101
    • 0038812123 scopus 로고    scopus 로고
    • Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes
    • Xu L, Huang CC, Huang W, et al. Systemic tumor-targeted gene delivery by anti-transferrin receptor scFv-immunoliposomes. Mol Cancer Ther 2002;1(5):337-46
    • (2002) Mol Cancer Ther , vol.1 , Issue.5 , pp. 337-346
    • Xu, L.1    Huang, C.C.2    Huang, W.3
  • 102
    • 23844474160 scopus 로고    scopus 로고
    • Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors
    • Song E, Zhu P, Lee SK, et al. Antibody mediated in vivo delivery of small interfering RNAs via cell-surface receptors. Nat Biotechnol 2005;23(6):709-17
    • (2005) Nat Biotechnol , vol.23 , Issue.6 , pp. 709-717
    • Song, E.1    Zhu, P.2    Lee, S.K.3
  • 103
    • 34247255870 scopus 로고    scopus 로고
    • Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1
    • Peer D, Zhu P, Carman CV, Lieberman J, Shimaoka M. Selective gene silencing in activated leukocytes by targeting siRNAs to the integrin lymphocyte function-associated antigen-1. Proc Natl Acad Sci USA 2007;104(10):4095-100
    • (2007) Proc Natl Acad Sci USA , vol.104 , Issue.10 , pp. 4095-4100
    • Peer, D.1    Zhu, P.2    Carman, C.V.3    Lieberman, J.4    Shimaoka, M.5
  • 104
    • 0001359591 scopus 로고
    • Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans
    • Napoli C, Lemieux C, Jorgensen R. Introduction of a chimeric chalcone synthase gene into petunia results in reversible co-suppression of homologous genes in trans. Plant Cell 1990;2:279-89
    • (1990) Plant Cell , vol.2 , pp. 279-289
    • Napoli, C.1    Lemieux, C.2    Jorgensen, R.3
  • 105
    • 0032545933 scopus 로고    scopus 로고
    • Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans
    • Fire A, Xu S, Montgomery MK, Kostas SA, Driver SE, Mello CC. Potent and specific genetic interference by double-stranded RNA in Caenorhabditis elegans. Nature 1998;391:806-11
    • (1998) Nature , vol.391 , pp. 806-811
    • Fire, A.1    Xu, S.2    Montgomery, M.K.3    Kostas, S.A.4    Driver, S.E.5    Mello, C.C.6
  • 106
    • 0034708122 scopus 로고    scopus 로고
    • The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans
    • Reinhart BJ, Slack FJ, Basson M, et al. The 21-nucleotide let-7 RNA regulates developmental timing in Caenorhabditis elegans Nature 2000;403(6772):901-6
    • (2000) Nature , vol.403 , Issue.6772 , pp. 901-906
    • Reinhart, B.J.1    Slack, F.J.2    Basson, M.3
  • 107
    • 0034737298 scopus 로고    scopus 로고
    • RNAi: Double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals
    • Zamore PD, Tuschl T, Sharp PA, Bartel DP. RNAi: double-stranded RNA directs the ATP-dependent cleavage of mRNA at 21 to 23 nucleotide intervals. Cell 2000;101(1):25-33
    • (2000) Cell , vol.101 , Issue.1 , pp. 25-33
    • Zamore, P.D.1    Tuschl, T.2    Sharp, P.A.3    Bartel, D.P.4
  • 108
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001;411:494-8
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 109
    • 0035955374 scopus 로고    scopus 로고
    • Identification of novel genes coding for small expressed RNAs
    • Lagos-Quintana M, Rauhut R, Lendeckel W, Tuschl T. Identification of novel genes coding for small expressed RNAs. Science 2001;294:853-8
    • (2001) Science , vol.294 , pp. 853-858
    • Lagos-Quintana, M.1    Rauhut, R.2    Lendeckel, W.3    Tuschl, T.4
  • 110
    • 18744396337 scopus 로고    scopus 로고
    • Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia
    • Calin GA, Dumitru CD, Shimizu M, et al. Frequent deletions and down-regulation of micro-RNA genes miR15 and miR16 at 13q14 in chronic lymphocytic leukemia. Proc Natl Acad Sci USA 2002;99:15524-9
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 15524-15529
    • Calin, G.A.1    Dumitru, C.D.2    Shimizu, M.3
  • 111
    • 0037026601 scopus 로고    scopus 로고
    • Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference
    • Jiang M, Milner J. Selective silencing of viral gene expression in HPV-positive human cervical carcinoma cells treated with siRNA, a primer of RNA interference. Oncogene 2002;21:6041-8
    • (2002) Oncogene , vol.21 , pp. 6041-6048
    • Jiang, M.1    Milner, J.2
  • 113
    • 39049117728 scopus 로고    scopus 로고
    • http://www.wiley.co.uk./genmed/clinical/
  • 114
    • 39049168399 scopus 로고    scopus 로고
    • www.alynylam.com
  • 115
    • 39049100260 scopus 로고    scopus 로고
    • www.cytrx.com


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.