Toll-like receptors: Linking innate and adaptive immunity

Microbes and Infection

Volumn 6, Issue 15, 2004, Pages 1382-1387

  Pasare, Chandrashekhar ^a   Medzhitov, Ruslan ^a  

^a YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

Auto immunity; Dendritic cells; Suppresor T cells; Tolerance; Toll like receptors (TLRs)

Indexed keywords

CD28 ANTIGEN; CHEMOKINE; HEAT SHOCK PROTEIN 60; HEAT SHOCK PROTEIN 70; INTERLEUKIN 1BETA; INTERLEUKIN 6; LIGAND; MYELOID DIFFERENTIATION FACTOR 88; TOLL LIKE RECEPTOR; TOLL LIKE RECEPTOR 1; TOLL LIKE RECEPTOR 10; TOLL LIKE RECEPTOR 2; TOLL LIKE RECEPTOR 3; TOLL LIKE RECEPTOR 4; TOLL LIKE RECEPTOR 5; TOLL LIKE RECEPTOR 6; TOLL LIKE RECEPTOR 7; TOLL LIKE RECEPTOR 8; TOLL LIKE RECEPTOR 9; TUMOR NECROSIS FACTOR; CELL SURFACE RECEPTOR; CYTOKINE; MEMBRANE PROTEIN;

AUTOIMMUNITY; CELL MATURATION; DENDRITIC CELL; DNA VIRUS; FUNGUS; GRAM NEGATIVE BACTERIUM; GRAM POSITIVE BACTERIUM; IMMUNE SYSTEM; INNATE IMMUNITY; NONHUMAN; PATTERN RECOGNITION; PRIORITY JOURNAL; PROTOZOON; RNA VIRUS; SHORT SURVEY; SUPPRESSOR CELL; ANIMAL; HUMAN; IMMUNOLOGY; INFECTION; PHYSIOLOGY; REVIEW; SIGNAL TRANSDUCTION;

FUNGI; POSIBACTERIA; PROTOZOA; RNA VIRUSES;

ANIMALS; AUTOIMMUNITY; CYTOKINES; DENDRITIC CELLS; HUMANS; IMMUNITY, NATURAL; INFECTION; MEMBRANE GLYCOPROTEINS; RECEPTORS, CELL SURFACE; SIGNAL TRANSDUCTION; TOLL-LIKE RECEPTORS;

EID: 16644366474     PISSN: 12864579     EISSN: 1769714X     Source Type: Journal    
DOI: 10.1016/j.micinf.2004.08.018     Document Type: Short Survey

References (59)

1. C.A. Janeway Jr., Approaching the asymptote? Evolution and revolution in immunology, Cold Spring Harbor Symp, Quant. Biol. 54 (Pt. 1) (1989) 1-13.
2. C.A. Janeway Jr., R. Medzhitov, Innate immune recognition, Annu. Rev. Immunol. 20 (2002) 197-216.
3. K. Takeda, T. Kaisho, S. Akira, Toll-like receptors, Annu. Rev. Immunol. 21 (2003) 335-376.
4. M. Schnare, G.M. Barton, A.C. Holt, K. Takeda, S. Akira, R. Medzhitov, Toll-like receptors control activation of adaptive immune responses, Nat. Immunol. 2 (2001) 947-950.
5. C. Pasare, R. Medzhitov, Toll pathway-dependent blockade of CD4+CD25+ T cell-mediated suppression by dendritic cells, Science 299 (2003) 1033-1036.
6. A. Poltorak, X. He, I. Smirnova, M.Y. Liu, C. Van Huffel, X. Du, et al., Defective LPS signaling in C3H/HeJ and C57BL/10ScCr mice: mutations in TLR4 gene, Science 282 (1998) 2085-2088.
7. S.T. Qureshi, L. Lariviere, G. Leveque, S. Clermont, K.J. Moore, P. Gros, et al., Endotoxin-tolerant mice have mutations in Toll-like receptor 4 (TLR4), J. Exp. Med. 189 (1999) 615-625.
8. O. Takeuchi, K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, et al., Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components, Immunity 11 (1999) 443-451.
9. L. Alexopoulou, A.C. Holt, R. Medzhitov, R.A. Flavell, Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3, Nature 413 (2001) 732-738.
10. F. Heil, H. Hemmi, H. Hochrein, F. Ampenberger, C. Kirschning, S. Akira, G. Lipford, H. Wagner, S. Bauer, Species-specific recognition of single-stranded RNA via Toll-like receptor 7 and 8, Science 303 (2004) 1526-1529.
11. S.S. Diebold, T. Kaisho, H. Hemmi, S. Akira, E.S.C. Reis, Innate antiviral responses by means of TLR7-mediated recognition of single-stranded RNA, Science 303 (2004) 1529-1531.
12. H. Hemmi, O. Takeuchi, T. Kawai, T. Kaisho, S. Sato, H. Sanjo, et al., A Toll-like receptor recognizes bacterial DNA, Nature 408 (2000) 740-745.
13. J. Lund, A. Sato, S. Akira, R. Medzhitov, A. Iwasaki, Toll-like receptor 9-mediated recognition of Herpes simplex virus-2 by plasmacytoid dendritic cells, J. Exp. Med. 198 (2003) 513-520.
14. G.M. Barton, R. Medzhitov, Toll-like receptor signaling pathways, Science 300 (2003) 1524-1525.
15. A. Asea, M. Rehli, E. Kabingu, J.A. Boch, O. Bare, P.E. Auron, M.A. Stevenson, S.K. Calderwood, Novel signal transduction pathway utilized by extracellular hsp70: role of Toll-like receptor (TLR) 2 and TLR4, J. Biol. Chem. 277 (2002) 15028-15034.
16. K. Ohashi, V. Burkart, S. Flohe, H. Kolb, Cutting edge: heat shock protein 60 is a putative endogenous ligand of the Toll-like receptor-4 complex, J. Immunol. 164 (2000) 558-561.
17. R.M. Vabulas, P. Ahmad-Nejad, S. Ghose, C.J. Kirschning, R.D. Issels, H. Wagner, Hsp70 as endogenous stimulus of the Toll/interleukin-1 receptor signal pathway, J. Biol. Chem. 277 (2002) 15107-15112.
18. H. Bausinger, D. Lipsker, U. Ziylan, S. Manie, J.P. Briand, J.P. Cazenave, S. Muller, J.F. Haeuw, C. Ravanat, H. De la Salle, et al., Endotoxin-free heat-shock protein 70 fails to induce APC activation, Eur. J. Immunol. 32 (2002) 3708-3713.
19. B. Gao, M.F. Tsan, Recombinant human heat shock protein 60 does not induce the release of tumor necrosis factor (alpha) from murine macrophages, J. Biol. Chem. 278 (2003) 22523-22529.
20. B. Gao, M.F. Tsan, Endotoxin contamination in recombinant human heat shock protein 70 (hsp70) preparation is responsible for the induction of tumor necrosis factor alpha release by murine macrophages, J. Biol. Chem. 278 (2003) 174-179.
21. T.K. Starr, S.C. Jameson, K.A. Hogquist, Positive and negative selection of T cells, Annu. Rev. Immunol. 21 (2003) 139-176.
22. C.C. Goodnow, J. Crosbie, S. Adelstein, T.B. Lavoie, S.J. Smith-Gill, R.A. Brink, et al., Altered immunoglobulin expression and functional silencing of self-reactive B lymphocytes in transgenic mice, Nature 334 (1988) 676-682.
23. S.B. Hartley, J. Crosbie, R. Brink, A.B. Kantor, A. Basten, C.C. Goodnow, Elimination from peripheral lymphoid tissues of self-reactive B lymphocytes recognizing membrane-bound antigens, Nature 353 (1991) 765-769.
24. J.G. Cyster, S.B. Hartley, C.C. Goodnow, Competition for follicular niches excludes self-reactive cells from the recirculating B-cell repertoire, Nature 371 (1994) 389-395.
25. J.G. Cyster, C.C. Goodnow, Antigen-induced exclusion from follicles and anergy are separate and complementary processes that influence peripheral B cell fate, Immunity 3 (1995) 691-701.
26. M.S. Anderson, E.S. Venanzi, L. Klein, Z. Chen, S.P. Berzins, S.J. Turley, H. Von Boehmer, R. Bronson, A. Dierich, C. Benoist, et al., Projection of an immunological self shadow within the thymus by the AIRE protein, Science 298 (2002) 1395-1401.
27. A. Liston, S. Lesage, J. Wilson, L. Peltonen, C.C. Goodnow, AIRE regulates negative selection of organ-specific T cells, Nat. Immunol. 4 (2003) 350-354.
28. P. Peterson, K. Nagamine, H. Scott, M. Heino, J. Kudoh, N. Shimizu, et al., APECED: a monogenic autoimmune disease providing new clues to self-tolerance, Immunol. Today 19 (1998) 384-386.
29. J.A. Punt, B.A. Osborne, Y. Takahama, S.O. Sharrow, A. Singer, Negative selection of CD4+CD8+ thymocytes by T cell receptor-induced apoptosis requires a costimulatory signal that can be provided by CD28, J. Exp. Med. 179 (1994) 709-713.
30. J.A. Punt, W Havran, R. Abe, A. Sarin, A. Singer, T cell receptor (TCR)-induced death of immature CD4+CD8+ thymocytes by two distinct mechanisms differing in their requirement for CD28 costimulation: implications for negative selection in the thymus, J. Exp. Med. 186 (1997) 1911-1922.
31. H. Kishimoto, Z. Cai, A. Brunmark, M.R. Jackson, P.A. Peterson, J. Sprent, Differing roles for B7 and intercellular adhesion molecule-1 in negative selection of thymocytes, J. Exp. Med. 184 (1996) 531-537.
32. J. Sprent, H. Kishimoto, The thymus and negative selection, Immunol. Rev. 185 (2002) 126-135.
33. D.J. Lenschow, T.L. Walunas, J.A. Bluestone, CD28/B7 system of T cell costimulation, Annu. Rev. Immunol. 14 (1996) 233-258.
34. Y. Liu, C.A. Janeway Jr., Cells that present both specific ligand and costimulatory activity are the most efficient inducers of clonal expansion of normal CD4 T cells, Proc. Natl. Acad. Sci. USA 89 (1992) 3845-3849.
35. J. Banchereau, R.M. Steinman, Dendritic cells and the control of immunity, Nature 392 (1998) 245-252.
36. R. Medzhitov, Toll-like receptors and innate immunity, Nat. Rev. Immunol. 1 (2001) 135-145.
37. G.T. Belz, G.M. Behrens, C.M. Smith, J.F. Miller, C. Jones, K. Lejon, C.G. Fathman, S.N. Mueller, K. Shortman, F.R. Carbone, et al., The CD8alpha(+) dendritic cell is responsible for inducing peripheral self-tolerance to tissue-associated antigens, J. Exp. Med. 196 (2002) 1099-1104.
38. D. Hawiger, K. Inaba, Y. Dorsett, M. Guo, K. Mahnke, M. Rivera, J.V. Ravetch, R.M. Steinman, M.C. Nussenzweig, Dendritic cells induce peripheral T cell unresponsiveness under steady state conditions in vivo, J. Exp. Med. 194 (2001) 769-779.
39. M. Menges, S. Rossner, C. Voigtlander, H. Schindler, N.A. Kukutsch, C. Bogdan, K. Erb, G. Schuler, M.B. Lutz, Repetitive injections of dendritic cells matured with tumor necrosis factor alpha induce antigen-specific protection of mice from autoimmunity, J. Exp. Med. 195 (2002) 15-21.
40. A. Wakkach, N. Fournier, V. Brun, J.P. Breittmayer, F. Cottrez, H. Groux, Characterization of dendritic cells that induce tolerance and T regulatory 1 cell differentiation in vivo, Immunity 18 (2003) 605-617.
41. S. Sakaguchi, N. Sakaguchi, M. Asano, M. Itoh, M. Toda, Immunologic self-tolerance maintained by activated T cells expressing IL-2 receptor alpha-chains (CD25). Breakdown of a single mechanism of self-tolerance causes various autoimmune diseases, J. Immunol. 155 (1995) 1151-1164.
42. J.D. Fontenot, M.A. Gavin, A.Y. Rudensky, Foxp3 programs the development and function of CD4+CD25+ regulatory T cells, Nat. Immunol. 4 (2003) 330-336.
43. S. Hori, T. Nomura, S. Sakaguchi, Control of regulatory T cell development by the transcription factor Foxp3, Science 299 (2003) 1057-1061.
44. M. Asano, M. Toda, N. Sakaguchi, S. Sakaguchi, Autoimmune disease as a consequence of developmental abnormality of a T cell subpopulation, J. Exp. Med. 184 (1996) 387-396.
45. H. Graux, A. O'Garra, M. Bigler, M. Rouleau, S. Antonenko, J.E. de Vries, et al., A CD4+ T-cell subset inhibits antigen-specific T-cell responses and prevents colitis, Nature 389 (1997) 737-742.
46. Y. Chen, V.K. Kuchroo, J. Inobe, D.A. Hafler, H.L. Weiner, Regulatory T cell clones induced by oral tolerance: suppression of autoimmune encephalomyelitis, Science 265 (1994) 1237-1240.
47. S. Thoma-Uszynski, S. Stenger, O. Takeuchi, M.T. Ochoa, M. Engele, P.A. Sieling, P.F. Barnes, M. Rollinghoff, P.L. Bolcskei, M. Wagner, et al., Induction of direct antimicrobial activity through mammalian Toll-like receptors, Science 291 (2001) 1544-1547.
48. T. Ayabe, D.P. Satchell, C.L. Wilson, W.C. Parks, M.E. Selsted, A.J. Ouellette, Secretion of microbicidal alpha-defensins by intestinal Paneth cells in response to bacteria, Nat. Immunol. 1 (2000) 113-118.
49. A. Krug, G.D. Luker, W. Barchet, D.A. Leib, S. Akira, M. Colonna, Herpes simplex virus type 1 activates murine natural interferon-producing cells through Toll-like receptor 9, Blood 103 (2004) 1433-1437.
50. R.M. Steinman, D. Hawiger, M.C. Nussenzweig, Tolerogenic dendritic cells, Annu. Rev. Immunol. 21 (2003) 685-711.
51. T. Kaisho, O. Takeuchi, T. Kawai, K. Hoshino, S. Akira, Endotoxin-induced maturation of MyD88-deficient dendritic cells, J. Immunol. 166 (2001) 5688-5694.
52. E.A. Leadbetter, I.R. Rifkin, A.M. Hohlbaum, B.C. Beaudette, M.J. Shlomchik, A. Marshak-Rothstein, Chromatin-IgG complexes activate B cells by dual engagement of IgM and Toll-like receptors, Nature 416 (2002) 603-607.
53. L. Rui, C.G. Vinuesa, J. Blasioli, C.C. Goodnow, Resistance to CpG DNA-induced autoimmunity through tolerogenic B cell antigen receptor ERK signaling, Nat. Immunol. 4 (2003) 594-600.
54. H. Drakesmith, B. Chain, P. Beverley, How can dendritic cells cause autoimmune disease? Immunol. Today 21 (2000) 214-217.
55. T. Alonzi, E. Fattori, D. Lazzaro, P. Costa, L. Probert, G. Kollias, et al., Interleukin 6 is required for the development of collagen-induced arthritis, J. Exp. Med. 187 (1998) 461-468.
56. H. Kobayashi, S. Ohshima, K. Nishioka, N. Yamaguchi, M. Umeshita-Sasai, T. Ishii, T. Mima, T. Kishimoto, I. Kawase, Y. Saeki, Antigen induced arthritis (AIA) can be transferred by bone marrow transplantation: evidence that interleukin 6 is essential for induction of AIA, J. Rheumatol. 29 (2002) 1176-1182.
57. S. Ohshima, Y. Saeki, T. Mima, M. Sasai, K. Nishioka, S. Nomura, et al., Interleukin 6 plays a key role in the development of antigen-induced arthritis, Proc. Natl. Acad. Sci. USA 95 (1998) 8222-8226.
58. H.B. Richards, M. Satoh, M. Shaw, C. Libert, V. Poli, W.H. Reeves, Interleukin 6 dependence of anti-DNA antibody production: evidence for two pathways of autoantibody formation in pristane-induced lupus, J. Exp. Med. 188 (1998) 985-990.
59. N.R. Rose, The role of infection in the pathogenesis of autoimmune disease, Semin. Immunol. 10 (1998) 5-13.