Immunization of aged mice with a pneumococcal conjugate vaccine combined with an unmethylated CpG-containing oligodeoxynucleotide restores defective immunoglobulin G antipolysaccharide responses and specific CD4 +-T-cell priming to young adult levels

Infection and Immunity

Volumn 74, Issue 4, 2006, Pages 2177-2186

  Sen, Goutam ^a   Chen, Quanyi ^a   Snapper, Clifford M ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BACTERIAL POLYSACCHARIDE; CPG OLIGODEOXYNUCLEOTIDE; IMMUNOGLOBULIN G ANTIBODY; INTERLEUKIN 10; PNEUMOCOCCUS VACCINE;

ADOLESCENT; AGED; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD4 LYMPHOCYTE COUNT; CELL SPECIFICITY; CONTROLLED STUDY; CYTOKINE PRODUCTION; ELDERLY CARE; FEMALE; HELPER CELL; HUMORAL IMMUNITY; LIGAND BINDING; MOUSE; NONHUMAN; PERITONEUM CELL; PRIORITY JOURNAL; PROTEIN PURIFICATION; SEROTYPING; SPLEEN CELL; STREPTOCOCCUS PNEUMONIAE; VACCINE PRODUCTION;

ADJUVANTS, IMMUNOLOGIC; AGING; ANIMALS; BACTERIAL PROTEINS; CD4-POSITIVE T-LYMPHOCYTES; CPG ISLANDS; CYTOKINES; DNA METHYLATION; EPITOPES, T-LYMPHOCYTE; FEMALE; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; INTERLEUKIN-10; MACROPHAGES, PERITONEAL; MICE; MICE, INBRED BALB C; OLIGODEOXYRIBONUCLEOTIDES; PNEUMOCOCCAL VACCINES; POLYSACCHARIDES; SPLEEN; VACCINES, CONJUGATE; VACCINES, DNA;

EID: 33645530404     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.74.4.2177-2186.2006     Document Type: Article

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