Sepsis under siege: A new understanding of sepsis might lead to the development of therapies to treat septic shock

EMBO Reports

Volumn 7, Issue 7, 2006, Pages 667-669

  Hunter, Philip ^a  

^a NONE

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; DROTRECOGIN; HEPARAN SULFATE; HEPARIN; HIGH MOBILITY GROUP PROTEIN; PROTEIN ANTIBODY; TOLL LIKE RECEPTOR; TUMOR NECROSIS FACTOR;

ARTICLE; CLINICAL FEATURE; CLINICAL TRIAL; COMPLEMENT ACTIVATION; COST OF ILLNESS; DISEASE SEVERITY; DRUG MECHANISM; GRAM NEGATIVE INFECTION; HIGH MOBILITY GROUP BOX DOMAIN; HUMAN; IMMUNOPATHOLOGY; IMMUNOSTIMULATION; MEDICAL RESEARCH; MOLECULAR RECOGNITION; MULTIPLE ORGAN FAILURE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN INDUCTION; RISK FACTOR; SEPSIS; SEPTIC SHOCK;

HMGB1 PROTEIN; HUMANS; MODELS, IMMUNOLOGICAL; PROTEIN C; RECOMBINANT PROTEINS; SEPSIS; SHOCK, SEPTIC; TOLL-LIKE RECEPTOR 4; TOLL-LIKE RECEPTORS;

EID: 33745620179     PISSN: 1469221X     EISSN: 14693178     Source Type: Journal    
DOI: 10.1038/sj.embor.7400742     Document Type: Article

References (6)

1. Bernard GR et al (2001) Efficacy and safety of recombinant human activated protein C for severe sepsis. N Engl J Med 344: 699-709
2. Brunn GJ, Platt JL (2006) The etiology of sepsis: Turned inside out. Trends Mol Med 12: 10-16
3. Pfeiffer R (1894) Weitere Untersuchungen über das Wesen der Choleraimmunität und über specifisch baktericide Processe. Ztschr Hyg Infektionskrankh xviii: 1-16
4. Poltorak A et al (1998) Genetic and physical mapping of the Lps locus: identification of the Toll-4 receptor as a candidate gene in the critical region. Blood Cells Mol Dis 24: 340-355
5. Poltorak A, Ricciardi-Castagnoli P, Citterio S, Beutler B (2000) Physical contact between lipopolysaccharide and Toll-like receptor 4 revealed by genetic complementation. Proc Natl Acad Sci USA 97: 2163-2167
6. Tracey KJ et al (1986) Shock and tissue injury induced by recombinant human cachectin. Science 234: 470-474