메뉴 건너뛰기




Volumn , Issue , 2006, Pages 73-92

CpG oligodeoxynucleotides as vaccine adjuvants

Author keywords

[No Author keywords available]

Indexed keywords


EID: 35748944306     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1016/B978-012088403-2/50006-X     Document Type: Chapter
Times cited : (6)

References (150)
  • 1
    • 0036318851 scopus 로고    scopus 로고
    • Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments
    • Ahmad-Nejad P., hacker H., Rutz M., Bauer S., Vabulas R.M., Wagner H. Bacterial CpG-DNA and lipopolysaccharides activate Toll-like receptors at distinct cellular compartments. Eur. J. Immunol. 2002, 32:1958-1968.
    • (2002) Eur. J. Immunol. , vol.32 , pp. 1958-1968
    • Ahmad-Nejad, P.1    Hacker, H.2    Rutz, M.3    Bauer, S.4    Vabulas, R.M.5    Wagner, H.6
  • 2
    • 0034886143 scopus 로고    scopus 로고
    • Toll-like receptors: critical proteins linking innate and acquired immunity
    • Akira S., Takeda K., Kaisho T. Toll-like receptors: critical proteins linking innate and acquired immunity. Nature Immunol. 2001, 2:675-680.
    • (2001) Nature Immunol. , vol.2 , pp. 675-680
    • Akira, S.1    Takeda, K.2    Kaisho, T.3
  • 3
    • 0035909372 scopus 로고    scopus 로고
    • Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3
    • Alexopoulou L., Holt A.C., Medzhitov R., Flavell R.A. Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3. Nature 2001, 413:732-738.
    • (2001) Nature , vol.413 , pp. 732-738
    • Alexopoulou, L.1    Holt, A.C.2    Medzhitov, R.3    Flavell, R.A.4
  • 4
    • 20044379241 scopus 로고    scopus 로고
    • Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice
    • Alignani D., Maletto B., Liscovsky M., Ropolo A., Moron G., Pistoresi-Palencia M.C. Orally administered OVA/CpG-ODN induces specific mucosal and systemic immune response in young and aged mice. J. Leukoc. Biol. 2005, 77:898-905.
    • (2005) J. Leukoc. Biol. , vol.77 , pp. 898-905
    • Alignani, D.1    Maletto, B.2    Liscovsky, M.3    Ropolo, A.4    Moron, G.5    Pistoresi-Palencia, M.C.6
  • 6
    • 0033765934 scopus 로고    scopus 로고
    • Cancer immunotherapy using dendritic cell-derived exosomes
    • Amigorena S. Cancer immunotherapy using dendritic cell-derived exosomes. Medicina (Buenos Aires) 2000, 60(Suppl. 2):51-54.
    • (2000) Medicina (Buenos Aires) , vol.60 , Issue.SUPPL. 2 , pp. 51-54
    • Amigorena, S.1
  • 7
    • 0036235478 scopus 로고    scopus 로고
    • Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells
    • An H., Yu Y., Zhang M., Xu H., Qi R., Yan X., Liu S., Wang W., Guo Z., Guo J., Qin Z., Cao X. Involvement of ERK, p38 and NF-kappaB signal transduction in regulation of TLR2, TLR4 and TLR9 gene expression induced by lipopolysaccharide in mouse dendritic cells. Immunology 2002, 106:38-45.
    • (2002) Immunology , vol.106 , pp. 38-45
    • An, H.1    Yu, Y.2    Zhang, M.3    Xu, H.4    Qi, R.5    Yan, X.6    Liu, S.7    Wang, W.8    Guo, Z.9    Guo, J.10    Qin, Z.11    Cao, X.12
  • 8
    • 0034177875 scopus 로고    scopus 로고
    • Neonatal administration of IL-12 enhances the protective efficacy of antiviral vaccines
    • Arulanandam B.P., Mittler J.N., Lee W.T., O'Toole M., Metzger D.W. Neonatal administration of IL-12 enhances the protective efficacy of antiviral vaccines. J. Immunol. 2000, 164:3698-3704.
    • (2000) J. Immunol. , vol.164 , pp. 3698-3704
    • Arulanandam, B.P.1    Mittler, J.N.2    Lee, W.T.3    O'Toole, M.4    Metzger, D.W.5
  • 11
    • 4644258165 scopus 로고    scopus 로고
    • Modulation of airway inflammation by immunostimulatory CpG oligodeoxy-nucleotides in a murine model of allergic aspergillosis
    • Banerjee B., Kelly K.J., Fink J.N., Henderson J.D., Bansal N.K., Kurup V.P. Modulation of airway inflammation by immunostimulatory CpG oligodeoxy-nucleotides in a murine model of allergic aspergillosis. Infect. Immunity 2004, 72:6087-6094.
    • (2004) Infect. Immunity , vol.72 , pp. 6087-6094
    • Banerjee, B.1    Kelly, K.J.2    Fink, J.N.3    Henderson, J.D.4    Bansal, N.K.5    Kurup, V.P.6
  • 13
    • 0029905740 scopus 로고    scopus 로고
    • Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects
    • Barrios C., Brandt C., Berney M., Lambert P.H., Siegrist C.A. Partial correction of the TH2/TH1 imbalance in neonatal murine responses to vaccine antigens through selective adjuvant effects. Eur. J. Immunol. 1996, 26:2666-2670.
    • (1996) Eur. J. Immunol. , vol.26 , pp. 2666-2670
    • Barrios, C.1    Brandt, C.2    Berney, M.3    Lambert, P.H.4    Siegrist, C.A.5
  • 15
    • 0043204311 scopus 로고    scopus 로고
    • Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escapes
    • Beckebaum S., Cicinnati V.R., Zhang X., Ferencik S., Frilling A., Grosse-Wilde H., Broelsch C.E., Gerken G. Hepatitis B virus-induced defect of monocyte-derived dendritic cells leads to impaired T helper type 1 response in vitro: mechanisms for viral immune escapes. Immunology 2003, 109:487-495.
    • (2003) Immunology , vol.109 , pp. 487-495
    • Beckebaum, S.1    Cicinnati, V.R.2    Zhang, X.3    Ferencik, S.4    Frilling, A.5    Grosse-Wilde, H.6    Broelsch, C.E.7    Gerken, G.8
  • 16
    • 0842326199 scopus 로고    scopus 로고
    • Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection
    • Berry L.J., Hickey D.K., Skelding K.A., Bao S., Rendina A.M., Hansbro P.M., Gockel C.M., Beagley K.W. Transcutaneous immunization with combined cholera toxin and CpG adjuvant protects against Chlamydia muridarum genital tract infection. Infect. Immunity 2004, 72:1019-1028.
    • (2004) Infect. Immunity , vol.72 , pp. 1019-1028
    • Berry, L.J.1    Hickey, D.K.2    Skelding, K.A.3    Bao, S.4    Rendina, A.M.5    Hansbro, P.M.6    Gockel, C.M.7    Beagley, K.W.8
  • 17
    • 0345120862 scopus 로고    scopus 로고
    • Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-gamma production in cells from allergic individuals and inhibit IgE synthesis in vitro
    • Bohle B., Jahn-Schmid B., Maurer D., Kraft D., Ebner C. Oligodeoxynucleotides containing CpG motifs induce IL-12, IL-18 and IFN-gamma production in cells from allergic individuals and inhibit IgE synthesis in vitro. Eur. J. Immunol. 1999, 29:2344-2353.
    • (1999) Eur. J. Immunol. , vol.29 , pp. 2344-2353
    • Bohle, B.1    Jahn-Schmid, B.2    Maurer, D.3    Kraft, D.4    Ebner, C.5
  • 19
    • 0004582004 scopus 로고    scopus 로고
    • CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice
    • Brazolot Millan C.L., Weeratna R., Krieg A.M., Siegrist C.A., Davis H.L. CpG DNA can induce strong Th1 humoral and cell-mediated immune responses against hepatitis B surface antigen in young mice. Proc. Natl. Acad. Sci. USA 1998, 95:15553-15558.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 15553-15558
    • Brazolot Millan, C.L.1    Weeratna, R.2    Krieg, A.M.3    Siegrist, C.A.4    Davis, H.L.5
  • 22
  • 23
    • 0033574415 scopus 로고    scopus 로고
    • Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction
    • Chow J.C., Young D.W., Golenbock D.T., Christ W.J., Gusovsky F. Toll-like receptor-4 mediates lipopolysaccharide-induced signal transduction. J. Biol. Chem. 1999, 274:10689-10692.
    • (1999) J. Biol. Chem. , vol.274 , pp. 10689-10692
    • Chow, J.C.1    Young, D.W.2    Golenbock, D.T.3    Christ, W.J.4    Gusovsky, F.5
  • 24
    • 0033969664 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance antipolysaccharide immunoglobulin G2a (IgG2a) and IgG3 antibodies
    • Chu R.S., McCool T., Greenspan N.S., Schreiber J.R., Harding C.V. CpG oligodeoxynucleotides act as adjuvants for pneumococcal polysaccharide-protein conjugate vaccines and enhance antipolysaccharide immunoglobulin G2a (IgG2a) and IgG3 antibodies. Infect. Immunity 2000, 68:1450-1456.
    • (2000) Infect. Immunity , vol.68 , pp. 1450-1456
    • Chu, R.S.1    McCool, T.2    Greenspan, N.S.3    Schreiber, J.R.4    Harding, C.V.5
  • 25
    • 0035911644 scopus 로고    scopus 로고
    • Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells
    • Chuang T., Ulevitch R.J. Identification of hTLR10: a novel human Toll-like receptor preferentially expressed in immune cells. Biochim. Biophys. Acta 2001, 1518:157-161.
    • (2001) Biochim. Biophys. Acta , vol.1518 , pp. 157-161
    • Chuang, T.1    Ulevitch, R.J.2
  • 26
    • 0034457684 scopus 로고    scopus 로고
    • Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9
    • Chuang T.H., Ulevitch R.J. Cloning and characterization of a sub-family of human toll-like receptors: hTLR7, hTLR8 and hTLR9. Eur. Cytokine Netw. 2000, 11:372-378.
    • (2000) Eur. Cytokine Netw. , vol.11 , pp. 372-378
    • Chuang, T.H.1    Ulevitch, R.J.2
  • 27
    • 0031015314 scopus 로고    scopus 로고
    • Asthma: an epidemic in the absence of infection?
    • Cookson W.O., Moffatt M.F. Asthma: an epidemic in the absence of infection?. Science 1997, 275:41-42.
    • (1997) Science , vol.275 , pp. 41-42
    • Cookson, W.O.1    Moffatt, M.F.2
  • 29
    • 11344257404 scopus 로고    scopus 로고
    • CPG 7909, an immunostimulatory TLR9 agonist iligodeoxynucleotide, as adjuvant to Engerix-B((R)) HBV vaccine in healthy adults: a double-blind phase I/II study
    • Cooper C.L., Davis H.L., Morris M.L., Efler S.M., Adhami M.A., Krieg A.M., Cameron D.W., Heathcote J. CPG 7909, an immunostimulatory TLR9 agonist iligodeoxynucleotide, as adjuvant to Engerix-B((R)) HBV vaccine in healthy adults: a double-blind phase I/II study. J. Clin. Immunol 2004, 24:693-701.
    • (2004) J. Clin. Immunol , vol.24 , pp. 693-701
    • Cooper, C.L.1    Davis, H.L.2    Morris, M.L.3    Efler, S.M.4    Adhami, M.A.5    Krieg, A.M.6    Cameron, D.W.7    Heathcote, J.8
  • 31
    • 0034235701 scopus 로고    scopus 로고
    • Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity
    • Davila E., Celis E. Repeated administration of cytosine-phosphorothiolated guanine-containing oligonucleotides together with peptide/protein immunization results in enhanced CTL responses with anti-tumor activity. J. Immunol. 2000, 165:539-547.
    • (2000) J. Immunol. , vol.165 , pp. 539-547
    • Davila, E.1    Celis, E.2
  • 32
    • 0038745486 scopus 로고    scopus 로고
    • Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade
    • Davila E., Kennedy R., Celis E. Generation of antitumor immunity by cytotoxic T lymphocyte epitope peptide vaccination, CpG-oligodeoxynucleotide adjuvant, and CTLA-4 blockade. Cancer Res. 2003, 63:3281-3288.
    • (2003) Cancer Res. , vol.63 , pp. 3281-3288
    • Davila, E.1    Kennedy, R.2    Celis, E.3
  • 33
    • 0031964257 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen [published erratum appears in J. Immunol. 1999, 162, 3103]
    • Davis H.L., Weeratna R., Waldschmidt T.J., Tygrett L.aiSchorr J., Krieg A.M., Weeratna R. CpG DNA is a potent enhancer of specific immunity in mice immunized with recombinant hepatitis B surface antigen [published erratum appears in J. Immunol. 1999, 162, 3103]. J. Immunol. 1998, 160:870-876.
    • (1998) J. Immunol. , vol.160 , pp. 870-876
    • Davis, H.L.1    Weeratna, R.2    Waldschmidt, T.J.3    Tygrett, L.A.4    Krieg, A.M.5    Weeratna, R.6
  • 35
    • 0037108812 scopus 로고    scopus 로고
    • Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge
    • Dumais N., Patrick A., Moss R.B., Davis H.L., Rosenthal K.L. Mucosal immunization with inactivated human immunodeficiency virus plus CpG oligodeoxynucleotides induces genital immune responses and protection against intravaginal challenge. J. Infect. Dis. 2002, 186:1098-1105.
    • (2002) J. Infect. Dis. , vol.186 , pp. 1098-1105
    • Dumais, N.1    Patrick, A.2    Moss, R.B.3    Davis, H.L.4    Rosenthal, K.L.5
  • 37
    • 0035825599 scopus 로고    scopus 로고
    • Oligonucleotide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid
    • Eastcott J.W., Holmberg C.J., Dewhirst F.E., Esch T.R., Smith D.J., Taubman M.A. Oligonucleotide containing CpG motifs enhances immune response to mucosally or systemically administered tetanus toxoid. Vaccine 2001, 19:1636-1642.
    • (2001) Vaccine , vol.19 , pp. 1636-1642
    • Eastcott, J.W.1    Holmberg, C.J.2    Dewhirst, F.E.3    Esch, T.R.4    Smith, D.J.5    Taubman, M.A.6
  • 39
    • 4444370525 scopus 로고    scopus 로고
    • Human immunodeficiency virus type 1 gp120 induces abnormal maturation and functional alterations of dendritic cells: a novel mechanism for AIDS pathogenesis
    • Fantuzzi L., Purificato C., Donato K., Belardelli F., Gessani S. Human immunodeficiency virus type 1 gp120 induces abnormal maturation and functional alterations of dendritic cells: a novel mechanism for AIDS pathogenesis. J. Virol. 2004, 78:9763-9772.
    • (2004) J. Virol. , vol.78 , pp. 9763-9772
    • Fantuzzi, L.1    Purificato, C.2    Donato, K.3    Belardelli, F.4    Gessani, S.5
  • 40
    • 0033624828 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis
    • Freidag B.L., Melton G.B., Collins F., Klinman D.M., Cheever A., Stobie L., Suen W., Seder R.A. CpG oligodeoxynucleotides and interleukin-12 improve the efficacy of Mycobacterium bovis BCG vaccination in mice challenged with M. tuberculosis. Infect. Immunity 2000, 68:2948-2953.
    • (2000) Infect. Immunity , vol.68 , pp. 2948-2953
    • Freidag, B.L.1    Melton, G.B.2    Collins, F.3    Klinman, D.M.4    Cheever, A.5    Stobie, L.6    Suen, W.7    Seder, R.A.8
  • 42
    • 1842486876 scopus 로고    scopus 로고
    • Induction of potent antitumor immunity by in situ targeting of intratumoral DCs
    • Furumoto K., Soares L., Engleman E.G., Merad M. Induction of potent antitumor immunity by in situ targeting of intratumoral DCs. J. Clin. Invest. 2004, 113:774-783.
    • (2004) J. Clin. Invest. , vol.113 , pp. 774-783
    • Furumoto, K.1    Soares, L.2    Engleman, E.G.3    Merad, M.4
  • 43
    • 0028596461 scopus 로고
    • Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey
    • Galbraith W.M., Hobson W.C., Giclas P.C., Schechter P.J., Agrawal S. Complement activation and hemodynamic changes following intravenous administration of phosphorothioate oligonucleotides in the monkey. Antisense Res. Dev. 1994, 4:201-206.
    • (1994) Antisense Res. Dev. , vol.4 , pp. 201-206
    • Galbraith, W.M.1    Hobson, W.C.2    Giclas, P.C.3    Schechter, P.J.4    Agrawal, S.5
  • 44
    • 0035284751 scopus 로고    scopus 로고
    • Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract
    • Gallichan W.S., Woolstencroft R.N., Guarasci T., McCluskie M.J., Davis H.L., Rosenthal K.L. Intranasal immunization with CpG oligodeoxynucleotides as an adjuvant dramatically increases IgA and protection against herpes simplex virus-2 in the genital tract. J. Immunol. 2001, 166:3451-3457.
    • (2001) J. Immunol. , vol.166 , pp. 3451-3457
    • Gallichan, W.S.1    Woolstencroft, R.N.2    Guarasci, T.3    McCluskie, M.J.4    Davis, H.L.5    Rosenthal, K.L.6
  • 45
    • 0035881675 scopus 로고    scopus 로고
    • Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression
    • Gewirtz A.T., Navas T.A., Lyons S., Godowski P.J., Madara J.L. Cutting edge: bacterial flagellin activates basolaterally expressed TLR5 to induce epithelial proinflammatory gene expression. J. Immunol. 2001, 167:1882-1885.
    • (2001) J. Immunol. , vol.167 , pp. 1882-1885
    • Gewirtz, A.T.1    Navas, T.A.2    Lyons, S.3    Godowski, P.J.4    Madara, J.L.5
  • 47
    • 0036401363 scopus 로고    scopus 로고
    • Enhancement of rat tear IgA antibody responses following intranasal immunization with antigen and CpG ODN
    • Gill R.F., Montgomery P.C. Enhancement of rat tear IgA antibody responses following intranasal immunization with antigen and CpG ODN. Curr. Eye Res. 2002, 24:228-233.
    • (2002) Curr. Eye Res. , vol.24 , pp. 228-233
    • Gill, R.F.1    Montgomery, P.C.2
  • 48
    • 0030885444 scopus 로고    scopus 로고
    • Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells
    • Grosjean I., Caux C., Bella C., Berger I., Wild F., Banchereau J., Kaiserlian D. Measles virus infects human dendritic cells and blocks their allostimulatory properties for CD4+ T cells. J. Exp. Med. 1997, 186:801-812.
    • (1997) J. Exp. Med. , vol.186 , pp. 801-812
    • Grosjean, I.1    Caux, C.2    Bella, C.3    Berger, I.4    Wild, F.5    Banchereau, J.6    Kaiserlian, D.7
  • 49
    • 0037726807 scopus 로고    scopus 로고
    • A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant
    • Halperin S.A., Van Nest G., Smith B., Abtahi S., Whiley H., Eiden J.J. A phase I study of the safety and immunogenicity of recombinant hepatitis B surface antigen co-administered with an immunostimulatory phosphorothioate oligonucleotide adjuvant. Vaccine 2003, 21:2461-2467.
    • (2003) Vaccine , vol.21 , pp. 2461-2467
    • Halperin, S.A.1    Van Nest, G.2    Smith, B.3    Abtahi, S.4    Whiley, H.5    Eiden, J.J.6
  • 50
    • 0038236749 scopus 로고    scopus 로고
    • Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells
    • Hartmann G., Battiany J., Poeck H., Wagner M., Kerkmann M., Lubenow N., Rothenfusser S., Endres S. Rational design of new CpG oligonucleotides that combine B cell activation with high IFN-alpha induction in plasmacytoid dendritic cells. Eur. J. Immunol. 2003, 33:1633-1641.
    • (2003) Eur. J. Immunol. , vol.33 , pp. 1633-1641
    • Hartmann, G.1    Battiany, J.2    Poeck, H.3    Wagner, M.4    Kerkmann, M.5    Lubenow, N.6    Rothenfusser, S.7    Endres, S.8
  • 54
    • 0024540908 scopus 로고
    • Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets
    • Heinzel F.P., Sadick M.D., Holaday B.J., Coffman R.L., Locksley R.M. Reciprocal expression of interferon gamma or interleukin 4 during the resolution or progression of murine leishmaniasis. Evidence for expansion of distinct helper T cell subsets. J. Exp. Med. 1989, 169:59-72.
    • (1989) J. Exp. Med. , vol.169 , pp. 59-72
    • Heinzel, F.P.1    Sadick, M.D.2    Holaday, B.J.3    Coffman, R.L.4    Locksley, R.M.5
  • 57
    • 4644254242 scopus 로고    scopus 로고
    • Enhanced tumor-specific long-term immunity of hemagglutinating virus of Japan-mediated dendritic cell-tumor fused cell vaccination by coadministration with CpG oligodeoxynucleotides
    • Hiraoka K., Yamamoto S., Otsuru S., Nakai S., Tamai K., Morishita R., Ogihara T., Kaneda Y. Enhanced tumor-specific long-term immunity of hemagglutinating virus of Japan-mediated dendritic cell-tumor fused cell vaccination by coadministration with CpG oligodeoxynucleotides. J. Immunol. 2004, 173:4297-4307.
    • (2004) J. Immunol. , vol.173 , pp. 4297-4307
    • Hiraoka, K.1    Yamamoto, S.2    Otsuru, S.3    Nakai, S.4    Tamai, K.5    Morishita, R.6    Ogihara, T.7    Kaneda, Y.8
  • 58
    • 0038330428 scopus 로고    scopus 로고
    • Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA
    • Holmgren J., Harandi A.M., Czerkinsky C. Mucosal adjuvants and anti-infection and anti-immunopathology vaccines based on cholera toxin, cholera toxin B subunit and CpG DNA. Expert Rev. Vaccines 2003, 2:205-217.
    • (2003) Expert Rev. Vaccines , vol.2 , pp. 205-217
    • Holmgren, J.1    Harandi, A.M.2    Czerkinsky, C.3
  • 59
    • 0034116281 scopus 로고    scopus 로고
    • Immunostimulatory sequence oligodeoxynucleotide: a novel mucosal adjuvant
    • Horner A.A., Raz E. Immunostimulatory sequence oligodeoxynucleotide: a novel mucosal adjuvant. Clin. Immunol. 2000, 95(Pt 2):S19-S29.
    • (2000) Clin. Immunol. , vol.95 , Issue.PT 2
    • Horner, A.A.1    Raz, E.2
  • 61
    • 0036570169 scopus 로고    scopus 로고
    • Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides
    • Hornung V., Rothenfusser S., Britsch S., Krug A., Jahrsdorfer B., Giese T., Endres S., Hartmann G. Quantitative expression of toll-like receptor 1-10 mRNA in cellular subsets of human peripheral blood mononuclear cells and sensitivity to CpG oligodeoxynucleotides. J. Immunol. 2002, 168:4531-4537.
    • (2002) J. Immunol. , vol.168 , pp. 4531-4537
    • Hornung, V.1    Rothenfusser, S.2    Britsch, S.3    Krug, A.4    Jahrsdorfer, B.5    Giese, T.6    Endres, S.7    Hartmann, G.8
  • 62
    • 0032739070 scopus 로고    scopus 로고
    • Oligodeoxynucleotides containing CpG motifs modulate the allergic TH2 response of BALB/c mice to Bet v 1, the major birch pollen allergen
    • Jahn-Schmid B., Wiedermann U., Bohle B., Repa A., Kraft D., Ebner C. Oligodeoxynucleotides containing CpG motifs modulate the allergic TH2 response of BALB/c mice to Bet v 1, the major birch pollen allergen. J. Allergy Clin. Immunol. 1999, 104:1015-1023.
    • (1999) J. Allergy Clin. Immunol. , vol.104 , pp. 1015-1023
    • Jahn-Schmid, B.1    Wiedermann, U.2    Bohle, B.3    Repa, A.4    Kraft, D.5    Ebner, C.6
  • 63
    • 10644238967 scopus 로고    scopus 로고
    • CD8+ T-cell-mediated cross-clade protection in the genital tract following intranasal immunization with inactivated human immunodeficiency virus antigen plus CpG oligodeoxynucleotides
    • Jiang J.Q., Patrick A., Moss R.B., Rosenthal K.L. CD8+ T-cell-mediated cross-clade protection in the genital tract following intranasal immunization with inactivated human immunodeficiency virus antigen plus CpG oligodeoxynucleotides. J. Virol. 2005, 79:393-400.
    • (2005) J. Virol. , vol.79 , pp. 393-400
    • Jiang, J.Q.1    Patrick, A.2    Moss, R.B.3    Rosenthal, K.L.4
  • 66
    • 0035903288 scopus 로고    scopus 로고
    • Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens
    • Kadowaki N., Ho S., Antonenko S., Malefyt R.W., Kastelein R.A., Bazan F., Liu Y.J. Subsets of human dendritic cell precursors express different toll-like receptors and respond to different microbial antigens. J. Exp. Med. 2001, 194:863-869.
    • (2001) J. Exp. Med. , vol.194 , pp. 863-869
    • Kadowaki, N.1    Ho, S.2    Antonenko, S.3    Malefyt, R.W.4    Kastelein, R.A.5    Bazan, F.6    Liu, Y.J.7
  • 67
    • 0010993390 scopus 로고    scopus 로고
    • Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines
    • Kim S.K., Ragupathi G., Musselli C., Choi S.J., Park Y.S., Livingston P.O. Comparison of the effect of different immunological adjuvants on the antibody and T-cell response to immunization with MUC1-KLH and GD3-KLH conjugate cancer vaccines. Vaccine 2000, 18:597-603.
    • (2000) Vaccine , vol.18 , pp. 597-603
    • Kim, S.K.1    Ragupathi, G.2    Musselli, C.3    Choi, S.J.4    Park, Y.S.5    Livingston, P.O.6
  • 68
    • 2342548726 scopus 로고    scopus 로고
    • CpG-ODN-stimulated dendritic cells act as a potent adjuvant for E7 protein delivery to induce antigen-specific antitumour immunity in a HPV 16 E7-associated animal tumour model
    • Kim T.G., Kim C.H., Won E.H., Bae S.M., Ahn W.S., Park J.B., Sin J.I. CpG-ODN-stimulated dendritic cells act as a potent adjuvant for E7 protein delivery to induce antigen-specific antitumour immunity in a HPV 16 E7-associated animal tumour model. Immunology 2004, 112:117-125.
    • (2004) Immunology , vol.112 , pp. 117-125
    • Kim, T.G.1    Kim, C.H.2    Won, E.H.3    Bae, S.M.4    Ahn, W.S.5    Park, J.B.6    Sin, J.I.7
  • 69
    • 0037115506 scopus 로고    scopus 로고
    • Both E7 and CpG-oligodeoxynucleotide are required for protective immunity against challenge with human papillomavirus 16 (E6/E7) immortalized tumor cells: involvement of CD4+ and CD8+ T cells in protection
    • Kim T.Y., Myoung H.J., Kim J.H., Moon I.S., Kim T.G., Ahn W.S., Sin J.I. Both E7 and CpG-oligodeoxynucleotide are required for protective immunity against challenge with human papillomavirus 16 (E6/E7) immortalized tumor cells: involvement of CD4+ and CD8+ T cells in protection. Cancer Res. 2002, 62:7234-7240.
    • (2002) Cancer Res. , vol.62 , pp. 7234-7240
    • Kim, T.Y.1    Myoung, H.J.2    Kim, J.H.3    Moon, I.S.4    Kim, T.G.5    Ahn, W.S.6    Sin, J.I.7
  • 71
    • 0033429176 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma
    • Kline J.N., Krieg A.M., Waldschmidt T.J., Ballas Z.K., Jain V., Businga T.R. CpG oligodeoxynucleotides do not require TH1 cytokines to prevent eosinophilic airway inflammation in a murine model of asthma. J. Allergy Clin. Immunol. 1999, 104:1258-1264.
    • (1999) J. Allergy Clin. Immunol. , vol.104 , pp. 1258-1264
    • Kline, J.N.1    Krieg, A.M.2    Waldschmidt, T.J.3    Ballas, Z.K.4    Jain, V.5    Businga, T.R.6
  • 74
    • 12444329763 scopus 로고    scopus 로고
    • Protection of mice against Philadelphia chromosome-positive acute lymphoblastic leukemia by cell-based vaccination using nonviral, minimalistic expression vectors and immunomodulatory oligonucleotides
    • Kochling J., Konig-Merediz S.A., Stripecke R., Buchwald D., Korte A., Von Einsiedel H.G., Sack F., Henze G., Seeger K., Wittig B., Schmidt M. Protection of mice against Philadelphia chromosome-positive acute lymphoblastic leukemia by cell-based vaccination using nonviral, minimalistic expression vectors and immunomodulatory oligonucleotides. Clin. Cancer Res. 2003, 9:3142-3149.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 3142-3149
    • Kochling, J.1    Konig-Merediz, S.A.2    Stripecke, R.3    Buchwald, D.4    Korte, A.5    Von Einsiedel, H.G.6    Sack, F.7    Henze, G.8    Seeger, K.9    Wittig, B.10    Schmidt, M.11
  • 76
    • 0033082499 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming
    • Kovarik J., Bozzotti P., Love-Homan L., Pihlgren M., Davis H.L., Lambert P.H., Krieg A.M., Siegrist C.A. CpG oligodeoxynucleotides can circumvent the Th2 polarization of neonatal responses to vaccines but may fail to fully redirect Th2 responses established by neonatal priming. J. Immunol. 1999, 162:1611-1617.
    • (1999) J. Immunol. , vol.162 , pp. 1611-1617
    • Kovarik, J.1    Bozzotti, P.2    Love-Homan, L.3    Pihlgren, M.4    Davis, H.L.5    Lambert, P.H.6    Krieg, A.M.7    Siegrist, C.A.8
  • 77
    • 0036219195 scopus 로고    scopus 로고
    • CpG motifs in bacterial DNA and their immune effects
    • Krieg A.M. CpG motifs in bacterial DNA and their immune effects. Annu. Rev. Immunol. 2002, 20:709-760.
    • (2002) Annu. Rev. Immunol. , vol.20 , pp. 709-760
    • Krieg, A.M.1
  • 78
    • 0038717560 scopus 로고    scopus 로고
    • CpG motifs: the active ingredient in bacterial extracts?
    • Krieg A.M. CpG motifs: the active ingredient in bacterial extracts?. Nature Med. 2003, 9:831-835.
    • (2003) Nature Med. , vol.9 , pp. 831-835
    • Krieg, A.M.1
  • 79
    • 2342558523 scopus 로고    scopus 로고
    • Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides
    • Krieg A.M. Antitumor applications of stimulating toll-like receptor 9 with CpG oligodeoxynucleotides. Curr. Oncol. Rep. 2004, 6:88-95.
    • (2004) Curr. Oncol. Rep. , vol.6 , pp. 88-95
    • Krieg, A.M.1
  • 81
    • 7444242674 scopus 로고    scopus 로고
    • Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist
    • Krieg A.M., Efler S.M., Wittpoth M., Al Adhami M.J., Davis H.L. Induction of systemic TH1-like innate immunity in normal volunteers following subcutaneous but not intravenous administration of CPG 7909, a synthetic B-class CpG oligodeoxynucleotide TLR9 agonist. J. Immunother. 2004, 27:460-471.
    • (2004) J. Immunother. , vol.27 , pp. 460-471
    • Krieg, A.M.1    Efler, S.M.2    Wittpoth, M.3    Al Adhami, M.J.4    Davis, H.L.5
  • 82
    • 0034777579 scopus 로고    scopus 로고
    • Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12
    • Krug A., Towarowski A., Britsch S., Rothenfusser S., Hornung V., Bals R., Giese T., Engelmann H., Endres S., Krieg A.M., Hartmann G. Toll-like receptor expression reveals CpG DNA as a unique microbial stimulus for plasmacytoid dendritic cells which synergizes with CD40 ligand to induce high amounts of IL-12. Eur. J. Immunol. 2001, 31:3026-3037.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 3026-3037
    • Krug, A.1    Towarowski, A.2    Britsch, S.3    Rothenfusser, S.4    Hornung, V.5    Bals, R.6    Giese, T.7    Engelmann, H.8    Endres, S.9    Krieg, A.M.10    Hartmann, G.11
  • 83
    • 0033942450 scopus 로고    scopus 로고
    • Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity
    • Kruse M., Rosorius O., Kratzer F., Stelz G., Kuhnt C., Schuler G., Hauber J., Steinkasserer A. Mature dendritic cells infected with herpes simplex virus type 1 exhibit inhibited T-cell stimulatory capacity. J. Virol. 2000, 74:7127-7136.
    • (2000) J. Virol. , vol.74 , pp. 7127-7136
    • Kruse, M.1    Rosorius, O.2    Kratzer, F.3    Stelz, G.4    Kuhnt, C.5    Schuler, G.6    Hauber, J.7    Steinkasserer, A.8
  • 84
    • 0034812464 scopus 로고    scopus 로고
    • Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors
    • Kuwana M., Kaburaki J., Wright T.M., Kawakami Y., Ikeda Y. Induction of antigen-specific human CD4(+) T cell anergy by peripheral blood DC2 precursors. Eur. J. Immunol. 2001, 31:2547-2557.
    • (2001) Eur. J. Immunol. , vol.31 , pp. 2547-2557
    • Kuwana, M.1    Kaburaki, J.2    Wright, T.M.3    Kawakami, Y.4    Ikeda, Y.5
  • 85
    • 3843066750 scopus 로고    scopus 로고
    • Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2
    • Kwant A., Rosenthal K.L. Intravaginal immunization with viral subunit protein plus CpG oligodeoxynucleotides induces protective immunity against HSV-2. Vaccine 2004, 22:3098-3104.
    • (2004) Vaccine , vol.22 , pp. 3098-3104
    • Kwant, A.1    Rosenthal, K.L.2
  • 86
    • 20044378761 scopus 로고    scopus 로고
    • TLR9 Cpg Immunomodulator in combination with chemotherapy as treatment for advanced non-small cell lung cancer (NSCLC), a randomized, controlled phase II study
    • 14S, 41st Annual meeting of the American Society of Clinical Oncology
    • Leichman G., Gravenor D., Albert G., Schmalbach T.A. TLR9 Cpg Immunomodulator in combination with chemotherapy as treatment for advanced non-small cell lung cancer (NSCLC), a randomized, controlled phase II study. J. Clin. Oncol. 2004, 22:1726. 14S.
    • (2004) J. Clin. Oncol. , vol.22 , pp. 1726
    • Leichman, G.1    Gravenor, D.2    Albert, G.3    Schmalbach, T.A.4
  • 88
    • 0034254201 scopus 로고    scopus 로고
    • CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses
    • Lipford G.B., Sparwasser T., Zimmermann S., Heeg K., Wagner H. CpG-DNA-mediated transient lymphadenopathy is associated with a state of Th1 predisposition to antigen-driven responses. J. Immunol. 2000, 165:1228-1235.
    • (2000) J. Immunol. , vol.165 , pp. 1228-1235
    • Lipford, G.B.1    Sparwasser, T.2    Zimmermann, S.3    Heeg, K.4    Wagner, H.5
  • 89
    • 0032533269 scopus 로고    scopus 로고
    • Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocytemacrophage colony-stimulating factor
    • Liu H.M., Newbrough S.E., Bhatia S.K., Dahle C.E., Krieg A.M., Weiner G.J. Immunostimulatory CpG oligodeoxynucleotides enhance the immune response to vaccine strategies involving granulocytemacrophage colony-stimulating factor. Blood 1998, 92:3730-3736.
    • (1998) Blood , vol.92 , pp. 3730-3736
    • Liu, H.M.1    Newbrough, S.E.2    Bhatia, S.K.3    Dahle, C.E.4    Krieg, A.M.5    Weiner, G.J.6
  • 90
    • 0033938275 scopus 로고    scopus 로고
    • Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis
    • Magone M.T., Chan C.C., Beck L., Whitcup S.M., Raz E. Systemic or mucosal administration of immunostimulatory DNA inhibits early and late phases of murine allergic conjunctivitis. Eur. J. Immunol. 2000, 30:1841-1850.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 1841-1850
    • Magone, M.T.1    Chan, C.C.2    Beck, L.3    Whitcup, S.M.4    Raz, E.5
  • 91
    • 0036746072 scopus 로고    scopus 로고
    • CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice
    • Maletto B., Ropolo A., Moron V., Pistoresi-Palencia M.C. CpG-DNA stimulates cellular and humoral immunity and promotes Th1 differentiation in aged BALB/c mice. J. Leukoc. Biol. 2002, 72:447-454.
    • (2002) J. Leukoc. Biol. , vol.72 , pp. 447-454
    • Maletto, B.1    Ropolo, A.2    Moron, V.3    Pistoresi-Palencia, M.C.4
  • 92
    • 0035218374 scopus 로고    scopus 로고
    • CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice
    • Manning B.M., Enioutina E.Y., Visic D.M., Knudson A.D., Daynes R.A. CpG DNA functions as an effective adjuvant for the induction of immune responses in aged mice. Exp. Gerontol. 2001, 37:107-126.
    • (2001) Exp. Gerontol. , vol.37 , pp. 107-126
    • Manning, B.M.1    Enioutina, E.Y.2    Visic, D.M.3    Knudson, A.D.4    Daynes, R.A.5
  • 93
  • 94
    • 0037100317 scopus 로고    scopus 로고
    • Characterization of a new subpopulation of mouse CD8alpha+B220+dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential
    • Martin P., Del Hoyo G.M., Anjuere F., Arias C.F., Vargas H.H., Fernandez L., Parrillas V., Ardavin C. Characterization of a new subpopulation of mouse CD8alpha+B220+dendritic cells endowed with type 1 interferon production capacity and tolerogenic potential. Blood 2002, 100:383-390.
    • (2002) Blood , vol.100 , pp. 383-390
    • Martin, P.1    Del Hoyo, G.M.2    Anjuere, F.3    Arias, C.F.4    Vargas, H.H.5    Fernandez, L.6    Parrillas, V.7    Ardavin, C.8
  • 95
    • 0032209286 scopus 로고    scopus 로고
    • CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice
    • McCluskie M.J., Davis H.L. CpG DNA is a potent enhancer of systemic and mucosal immune responses against hepatitis B surface antigen with intranasal administration to mice. J. Immunol. 1998, 161:4463-4466.
    • (1998) J. Immunol. , vol.161 , pp. 4463-4466
    • McCluskie, M.J.1    Davis, H.L.2
  • 96
    • 0032876565 scopus 로고    scopus 로고
    • CpG DNA as mucosal adjuvant
    • McCluskie M.J., Davis H.L. CpG DNA as mucosal adjuvant. Vaccine 1999, 18:231-237.
    • (1999) Vaccine , vol.18 , pp. 231-237
    • McCluskie, M.J.1    Davis, H.L.2
  • 97
    • 0034668209 scopus 로고    scopus 로고
    • Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants
    • McCluskie M.J., Davis H.L. Oral, intrarectal and intranasal immunizations using CpG and non-CpG oligodeoxynucleotides as adjuvants. Vaccine 2000, 19:413-422.
    • (2000) Vaccine , vol.19 , pp. 413-422
    • McCluskie, M.J.1    Davis, H.L.2
  • 98
    • 0032410080 scopus 로고    scopus 로고
    • Immunization against hepatitis B virus by mucosal administration of antigen-antibody complexes
    • McCluskie M.J., Wen Y.M., Di Q., Davis H.L. Immunization against hepatitis B virus by mucosal administration of antigen-antibody complexes. Viral Immunol. 1998, 11:245-252.
    • (1998) Viral Immunol. , vol.11 , pp. 245-252
    • McCluskie, M.J.1    Wen, Y.M.2    Di, Q.3    Davis, H.L.4
  • 99
    • 0034703827 scopus 로고    scopus 로고
    • CpG DNA is an effective oral adjuvant to protein antigens in mice
    • McCluskie M.J., Weeratna R.D., Krieg A.M., Davis H.L. CpG DNA is an effective oral adjuvant to protein antigens in mice. Vaccine 2000, 19:950-957.
    • (2000) Vaccine , vol.19 , pp. 950-957
    • McCluskie, M.J.1    Weeratna, R.D.2    Krieg, A.M.3    Davis, H.L.4
  • 100
    • 0035859288 scopus 로고    scopus 로고
    • Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants
    • McCluskie M.J., Weeratna R.D., Clements J.D., Davis H.L. Mucosal immunization of mice using CpG DNA and/or mutants of the heat-labile enterotoxin of Escherichia coli as adjuvants. Vaccine 2001, 19:3759-3768.
    • (2001) Vaccine , vol.19 , pp. 3759-3768
    • McCluskie, M.J.1    Weeratna, R.D.2    Clements, J.D.3    Davis, H.L.4
  • 102
    • 0034064562 scopus 로고    scopus 로고
    • Modulation of immune responses following antigen administration by mucosal route
    • Medina E., Guzman C.A. Modulation of immune responses following antigen administration by mucosal route. FEMS Immunol. Med. Microbiol. 2000, 27:305-311.
    • (2000) FEMS Immunol. Med. Microbiol. , vol.27 , pp. 305-311
    • Medina, E.1    Guzman, C.A.2
  • 103
    • 0036493558 scopus 로고    scopus 로고
    • In vivo manipulation of dendritic cells to induce therapeutic immunity
    • Merad M., Sugie T., Engleman E.G., Fong L. In vivo manipulation of dendritic cells to induce therapeutic immunity. Blood 2002, 99:1676-1682.
    • (2002) Blood , vol.99 , pp. 1676-1682
    • Merad, M.1    Sugie, T.2    Engleman, E.G.3    Fong, L.4
  • 106
    • 0031800888 scopus 로고    scopus 로고
    • CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus
    • Moldoveanu Z., Love-Homan L., Huang W.Q., Krieg A.M. CpG DNA, a novel immune enhancer for systemic and mucosal immunization with influenza virus. Vaccine 1998, 16:1216-1224.
    • (1998) Vaccine , vol.16 , pp. 1216-1224
    • Moldoveanu, Z.1    Love-Homan, L.2    Huang, W.Q.3    Krieg, A.M.4
  • 107
    • 0034893986 scopus 로고    scopus 로고
    • Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles
    • Mui B., Raney S.G., Semple S.C., Hope M.J. Immune stimulation by a CpG-containing oligodeoxynucleotide is enhanced when encapsulated and delivered in lipid particles. J. Pharmacol. Exp. Ther. 2001, 298:1185-1192.
    • (2001) J. Pharmacol. Exp. Ther. , vol.298 , pp. 1185-1192
    • Mui, B.1    Raney, S.G.2    Semple, S.C.3    Hope, M.J.4
  • 108
    • 10444280011 scopus 로고    scopus 로고
    • Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant
    • Nesburn A.B., Ramos T.V., Zhu X., Asgarzadeh H., Nguyen V., Benmohamed L. Local and systemic B cell and Th1 responses induced following ocular mucosal delivery of multiple epitopes of herpes simplex virus type 1 glycoprotein D together with cytosine-phosphate-guanine adjuvant. Vaccine 2005, 23:873-883.
    • (2005) Vaccine , vol.23 , pp. 873-883
    • Nesburn, A.B.1    Ramos, T.V.2    Zhu, X.3    Asgarzadeh, H.4    Nguyen, V.5    Benmohamed, L.6
  • 109
    • 0031950147 scopus 로고    scopus 로고
    • Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): comparison with other delivery routes
    • Nicklin P.L., Bayley D., Giddings J., Craig S.J., Cummins L.L., Hastewell J.G., Phillips J.A. Pulmonary bioavailability of a phosphorothioate oligonucleotide (CGP 64128A): comparison with other delivery routes. Pharm. Res. 1998, 15:583-591.
    • (1998) Pharm. Res. , vol.15 , pp. 583-591
    • Nicklin, P.L.1    Bayley, D.2    Giddings, J.3    Craig, S.J.4    Cummins, L.L.5    Hastewell, J.G.6    Phillips, J.A.7
  • 110
    • 0034826521 scopus 로고    scopus 로고
    • Recent developments in adjuvants for vaccines against infectious diseases
    • O'Hagan D.T., MacKichan M.L., Singh M. Recent developments in adjuvants for vaccines against infectious diseases. Biomol. Eng 2001, 18:69-85.
    • (2001) Biomol. Eng , vol.18 , pp. 69-85
    • O'Hagan, D.T.1    MacKichan, M.L.2    Singh, M.3
  • 112
    • 0033857494 scopus 로고    scopus 로고
    • Antipeptide antibody responses following intranasal immunization: effectiveness of mucosal adjuvants
    • Olszewska W., Partidos C.D., Steward M.W. Antipeptide antibody responses following intranasal immunization: effectiveness of mucosal adjuvants. Infect. Immunity 2000, 68:4923-4929.
    • (2000) Infect. Immunity , vol.68 , pp. 4923-4929
    • Olszewska, W.1    Partidos, C.D.2    Steward, M.W.3
  • 113
    • 0344304626 scopus 로고    scopus 로고
    • Immunoprotective activity and safety of a respiratory syncytial virus vaccine: mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant
    • Prince G.A., Mond J.J., Porter D.D., Yim K.C., Lan S.J., Klinman D.M. Immunoprotective activity and safety of a respiratory syncytial virus vaccine: mucosal delivery of fusion glycoprotein with a CpG oligodeoxynucleotide adjuvant. J. Virol. 2003, 77:13156-13160.
    • (2003) J. Virol. , vol.77 , pp. 13156-13160
    • Prince, G.A.1    Mond, J.J.2    Porter, D.D.3    Yim, K.C.4    Lan, S.J.5    Klinman, D.M.6
  • 114
    • 9144234259 scopus 로고    scopus 로고
    • Oral immunization of mice with Japanese encephalitis virus envelope protein synthesized in Escherichia coli induces anti-viral antibodies
    • Rauthan M., Kaur R., Appaiahgari M.B., Vrati S. Oral immunization of mice with Japanese encephalitis virus envelope protein synthesized in Escherichia coli induces anti-viral antibodies. Microbes. Infect. 2004, 6:1305-1311.
    • (2004) Microbes. Infect. , vol.6 , pp. 1305-1311
    • Rauthan, M.1    Kaur, R.2    Appaiahgari, M.B.3    Vrati, S.4
  • 115
    • 0034602150 scopus 로고    scopus 로고
    • Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase
    • Rhee S.H., Hwang D. Murine TOLL-like receptor 4 confers lipopolysaccharide responsiveness as determined by activation of NF kappa B and expression of the inducible cyclooxygenase. J. Biol. Chem. 2000, 275:34035-34040.
    • (2000) J. Biol. Chem. , vol.275 , pp. 34035-34040
    • Rhee, S.H.1    Hwang, D.2
  • 116
    • 0042674185 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides enhance the capacity of adenovirus-mediated CD154 gene transfer to generate effective B-cell lymphoma vaccines
    • Rieger R., Kipps T.J. CpG oligodeoxynucleotides enhance the capacity of adenovirus-mediated CD154 gene transfer to generate effective B-cell lymphoma vaccines. Cancer Res. 2003, 63:4128-4135.
    • (2003) Cancer Res. , vol.63 , pp. 4128-4135
    • Rieger, R.1    Kipps, T.J.2
  • 119
    • 0037439696 scopus 로고    scopus 로고
    • CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma
    • Sandler A.D., Chihara H., Kobayashi G., Zhu X., Miller M.A., Scott D.L., Krieg A.M. CpG oligonucleotides enhance the tumor antigen-specific immune response of a granulocyte macrophage colony-stimulating factor-based vaccine strategy in neuroblastoma. Cancer Res. 2003, 63:394-399.
    • (2003) Cancer Res. , vol.63 , pp. 394-399
    • Sandler, A.D.1    Chihara, H.2    Kobayashi, G.3    Zhu, X.4    Miller, M.A.5    Scott, D.L.6    Krieg, A.M.7
  • 120
    • 4344689650 scopus 로고    scopus 로고
    • Toll-like receptors involved in the response to microbial pathogens: development of agonists for Toll-like receptor 9
    • Schetter C., Vollmer J. Toll-like receptors involved in the response to microbial pathogens: development of agonists for Toll-like receptor 9. Curr. Opin. Drug Discov. Devel. 2004, 7:204-210.
    • (2004) Curr. Opin. Drug Discov. Devel. , vol.7 , pp. 204-210
    • Schetter, C.1    Vollmer, J.2
  • 121
    • 2142713912 scopus 로고    scopus 로고
    • Delivering on the promise: HPV vaccines and cervical cancer
    • Schiller J.T., Davies P. Delivering on the promise: HPV vaccines and cervical cancer. Nat. Rev. Microbiol. 2004, 2:343-347.
    • (2004) Nat. Rev. Microbiol. , vol.2 , pp. 343-347
    • Schiller, J.T.1    Davies, P.2
  • 122
    • 0033580949 scopus 로고    scopus 로고
    • Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2
    • Schwandner R., Dziarski R., Wesche H., Rothe M., Kirschning C.J. Peptidoglycan- and lipoteichoic acid-induced cell activation is mediated by toll-like receptor 2. J. Biol. Chem. 1999, 274:17406-17409.
    • (1999) J. Biol. Chem. , vol.274 , pp. 17406-17409
    • Schwandner, R.1    Dziarski, R.2    Wesche, H.3    Rothe, M.4    Kirschning, C.J.5
  • 123
    • 0034670048 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides can reverse Th2-associated allergic airway responses and alter the B7.1/B7.2 expression in a murine model of asthma
    • Serebrisky D., Teper A.A., Huang C.K., Lee S.Y., Zhang T.F., Schofield B.H., Kattan M., Sampson H.A., Li X.M. CpG oligodeoxynucleotides can reverse Th2-associated allergic airway responses and alter the B7.1/B7.2 expression in a murine model of asthma. J. Immunol. 2000, 165:5906-5912.
    • (2000) J. Immunol. , vol.165 , pp. 5906-5912
    • Serebrisky, D.1    Teper, A.A.2    Huang, C.K.3    Lee, S.Y.4    Zhang, T.F.5    Schofield, B.H.6    Kattan, M.7    Sampson, H.A.8    Li, X.M.9
  • 124
    • 0027121651 scopus 로고
    • Schistosomiasis. Parasitizing the cytokine system
    • Sher A. Schistosomiasis. Parasitizing the cytokine system. Nature 1992, 356:565-566.
    • (1992) Nature , vol.356 , pp. 565-566
    • Sher, A.1
  • 125
    • 0034090116 scopus 로고    scopus 로고
    • Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator
    • Shirota H., Sano K., Kikuchi T., Tamura G., Shirato K. Regulation of murine airway eosinophilia and Th2 cells by antigen-conjugated CpG oligodeoxynucleotides as a novel antigen-specific immunomodulator. J. Immunol. 2000, 164:5575-5582.
    • (2000) J. Immunol. , vol.164 , pp. 5575-5582
    • Shirota, H.1    Sano, K.2    Kikuchi, T.3    Tamura, G.4    Shirato, K.5
  • 127
    • 0034532681 scopus 로고    scopus 로고
    • Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins
    • Sparwasser T., Vabulas R.M., Villmow B., Lipford G.B., Wagner H. Bacterial CpG-DNA activates dendritic cells in vivo: T helper cell-independent cytotoxic T cell responses to soluble proteins. Eur. J. Immunol. 2000, 30:3591-3597.
    • (2000) Eur. J. Immunol. , vol.30 , pp. 3591-3597
    • Sparwasser, T.1    Vabulas, R.M.2    Villmow, B.3    Lipford, G.B.4    Wagner, H.5
  • 129
  • 130
    • 0037097633 scopus 로고    scopus 로고
    • Vaccination with tumor peptide in CpG adjuvant protects via IFN-gamma-dependent CD4 cell immunity
    • Stern B.V., Boehm B.O., Tary-Lehmann M. Vaccination with tumor peptide in CpG adjuvant protects via IFN-gamma-dependent CD4 cell immunity. J. Immunol. 2002, 168:6099-6105.
    • (2002) J. Immunol. , vol.168 , pp. 6099-6105
    • Stern, B.V.1    Boehm, B.O.2    Tary-Lehmann, M.3
  • 131
    • 0033563211 scopus 로고    scopus 로고
    • Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides
    • Sur S., Wild J.S., Choudhury B.K., Sur N., Alam R., Klinman D.M. Long term prevention of allergic lung inflammation in a mouse model of asthma by CpG oligodeoxynucleotides. J. Immunol. 1999, 162:6284-6293.
    • (1999) J. Immunol. , vol.162 , pp. 6284-6293
    • Sur, S.1    Wild, J.S.2    Choudhury, B.K.3    Sur, N.4    Alam, R.5    Klinman, D.M.6
  • 135
    • 1842479742 scopus 로고    scopus 로고
    • Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery
    • Thomsen L.L., Topley P., Daly M.G., Brett S.J., Tite J.P. Imiquimod and resiquimod in a mouse model: adjuvants for DNA vaccination by particle-mediated immunotherapeutic delivery. Vaccine 2004, 22:1799-1809.
    • (2004) Vaccine , vol.22 , pp. 1799-1809
    • Thomsen, L.L.1    Topley, P.2    Daly, M.G.3    Brett, S.J.4    Tite, J.P.5
  • 137
    • 1342269881 scopus 로고    scopus 로고
    • Infection and dysfuncation of circulating blook dendritic cells and their subsets in chronic hepatitis C virus infection
    • Tsubouchi E., Akbar Sk.Md.Fazle, Horiike N., Morikazu O. Infection and dysfuncation of circulating blook dendritic cells and their subsets in chronic hepatitis C virus infection. J. Gastroenterol. 2004, 39:754-762.
    • (2004) J. Gastroenterol. , vol.39 , pp. 754-762
    • Tsubouchi, E.1    Akbar, S.F.2    Horiike, N.3    Morikazu, O.4
  • 140
    • 0033536013 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leshmaniasis via IL-12- and IFN-gamma-dependent mechanisms
    • Walker P.S., Scharton-Kersten T., Krieg A.M., Love-Homan L., Rowton E.D., Udey M.C., Vogel J.C. Immunostimulatory oligodeoxynucleotides promote protective immunity and provide systemic therapy for leshmaniasis via IL-12- and IFN-gamma-dependent mechanisms. Proc. Natl. Acad. Sci. USA 1999, 96:6970-6975.
    • (1999) Proc. Natl. Acad. Sci. USA , vol.96 , pp. 6970-6975
    • Walker, P.S.1    Scharton-Kersten, T.2    Krieg, A.M.3    Love-Homan, L.4    Rowton, E.D.5    Udey, M.C.6    Vogel, J.C.7
  • 141
    • 14844361299 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides inhibit tumor growth and reverse the immunosuppression caused by the therapy with 5-fluorouracil in murine hepatoma
    • Wang X.S., Sheng Z., Ruan Y.B., Guang Y., Yang M.L. CpG oligodeoxynucleotides inhibit tumor growth and reverse the immunosuppression caused by the therapy with 5-fluorouracil in murine hepatoma. World J. Gastroenterol. 2005, 11:1220-1224.
    • (2005) World J. Gastroenterol. , vol.11 , pp. 1220-1224
    • Wang, X.S.1    Sheng, Z.2    Ruan, Y.B.3    Guang, Y.4    Yang, M.L.5
  • 142
    • 0037150480 scopus 로고    scopus 로고
    • Activation of antigen-presenting cells by immunostimulatory plant DNA: a natural resource for potential adjuvant
    • Wang Y., Wang W., Li N., Yu Y., Cao X. Activation of antigen-presenting cells by immunostimulatory plant DNA: a natural resource for potential adjuvant. Vaccine 2002, 20:2764-2771.
    • (2002) Vaccine , vol.20 , pp. 2764-2771
    • Wang, Y.1    Wang, W.2    Li, N.3    Yu, Y.4    Cao, X.5
  • 143
    • 0033997899 scopus 로고    scopus 로고
    • CpG DNA induces stronger immune responses with less toxicity than other adjuvants
    • Weeratna R.D., McCluskie M.J., Xu Y., Davis H.L. CpG DNA induces stronger immune responses with less toxicity than other adjuvants. Vaccine 2000, 18:1755-1762.
    • (2000) Vaccine , vol.18 , pp. 1755-1762
    • Weeratna, R.D.1    McCluskie, M.J.2    Xu, Y.3    Davis, H.L.4
  • 145
    • 0042024964 scopus 로고    scopus 로고
    • CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma
    • Weigel B.J., Rodeberg D.A., Krieg A.M., Blazar B.R. CpG oligodeoxynucleotides potentiate the antitumor effects of chemotherapy or tumor resection in an orthotopic murine model of rhabdomyosarcoma. Clin. Cancer Res. 2003, 9:3105-3114.
    • (2003) Clin. Cancer Res. , vol.9 , pp. 3105-3114
    • Weigel, B.J.1    Rodeberg, D.A.2    Krieg, A.M.3    Blazar, B.R.4
  • 146
    • 0030955249 scopus 로고    scopus 로고
    • Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization
    • Weiner G.J., Liu H.M., Wooldridge J.E., Dahle C.E., Krieg A.M. Immunostimulatory oligodeoxynucleotides containing the CpG motif are effective as immune adjuvants in tumor antigen immunization. Proc. Natl. Acad. Sci. USA 1997, 94:10833-10837.
    • (1997) Proc. Natl. Acad. Sci. USA , vol.94 , pp. 10833-10837
    • Weiner, G.J.1    Liu, H.M.2    Wooldridge, J.E.3    Dahle, C.E.4    Krieg, A.M.5
  • 148
    • 0030444050 scopus 로고    scopus 로고
    • CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL
    • Yi A.K., Hornbeck P., Lafrenz D.E., Krieg A.M. CpG DNA rescue of murine B lymphoma cells from anti-IgM-induced growth arrest and programmed cell death is associated with increased expression of c-myc and bcl-xL. J. Immunol. 1996, 157:4918-4925.
    • (1996) J. Immunol. , vol.157 , pp. 4918-4925
    • Yi, A.K.1    Hornbeck, P.2    Lafrenz, D.E.3    Krieg, A.M.4
  • 149
    • 0032526607 scopus 로고    scopus 로고
    • CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry
    • Yi A.K., Chang M., Peckham D.W., Krieg A.M., Ashman R.F. CpG oligodeoxyribonucleotides rescue mature spleen B cells from spontaneous apoptosis and promote cell cycle entry. J. Immunol. 1998, 160:5898-5906.
    • (1998) J. Immunol. , vol.160 , pp. 5898-5906
    • Yi, A.K.1    Chang, M.2    Peckham, D.W.3    Krieg, A.M.4    Ashman, R.F.5
  • 150
    • 0033168728 scopus 로고    scopus 로고
    • Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2
    • Yoshimura A., Lien E., Ingalls R.R., Tuomanen E., Dziarski R., Golenbock D. Cutting edge: recognition of Gram-positive bacterial cell wall components by the innate immune system occurs via Toll-like receptor 2. J. Immunol. 1999, 163:1-5.
    • (1999) J. Immunol. , vol.163 , pp. 1-5
    • Yoshimura, A.1    Lien, E.2    Ingalls, R.R.3    Tuomanen, E.4    Dziarski, R.5    Golenbock, D.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.