Enhanced de novo lipogenesis in the leptin-unresponsive pancreatic islets of prediabetic Zucker diabetic fatty rats. Role in the pathogenesis of lipotoxic diabetes

Diabetes

Volumn 47, Issue 12, 1998, Pages 1904-1908

  Zhou, Yan Ting ^a   Shimabukuro, Michio ^a   Lee, Young ^a   Koyama, Kazunori ^a   Higa, Moritake ^a   Ferguson, Tagan ^b   Unger, Roger H ^a,b  

^a UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^b VA NORTH TEXAS HEALTH CARE SYSTEM   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A CARBOXYLASE; FATTY ACID SYNTHASE; LEPTIN; MESSENGER RNA;

ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETES MELLITUS; FATTY ACID SYNTHESIS; LIPID ANALYSIS; LIPOGENESIS; NONHUMAN; OBESITY; PANCREAS ISLET; PATHOGENESIS; PRIORITY JOURNAL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

EID: 0031738017     PISSN: 00121797     EISSN: None     Source Type: Journal    
DOI: 10.2337/diabetes.47.12.1904     Document Type: Article

References (27)

1. Penicaud L, Ferre P, Assimacopoulos-Jeannet F, Perdereau D, Leturque A, Jeanrenaud B, Picon L, Girard J: Increased gene expression of lipogenic enzymes and glucose transporter in white adipose tissue of suckling and weaned obese Zucker rats. Biochem J 279:303-308, 1991
2. Guichard C, Dugail I, Le Liepvre X, Lavau M: Genetic regulation of fatty acid synthase expression in adipose tissue: overtranscription of the gene in genet- ically obese rats. J Lipid Res 33:679-687, 1992
3. Philips FC, Cleary MP: Metabolic measurements among homozygous (fa/fa) obese, heterozygous (Fa/fa) lean, and homozygous (Fa/fa) lean Zucker rat pups at 17 days of age. J Nutr 124:1230-1237, 1904
4. York DA, Shargill NS, Godbole V: Serum insulin and lipogenesis in the suckling 'fatty' fa/fa rat. Diabetologia 21:143-148, 1981
5. McGarry JD, Foster DW: Regulation of hepatic fatty acid oxidation and ketone body production. Ann Rev Biochem 49:395-420, 1980
6. Iida M, Murakami T, Ishida K, Mizuno A, Kuwajima M, Shima K: Substitution at codon 269 (glutamine → proline) of the leptin receptor (OB-R) cDNA is the only mutation found in the Zucker fatty (fa/fa) rat. Biochem Biophys Res Commun 224:597-604, 1996
7. Phillips MS, Liu QY, Hanmiond HA, Dugan V, Hey PJ, Caskey CT, Hess JF: Leptin receptor missense mutation in the fatty Zucker rat. Nat Genet 13:18-19, 1996
8. Lee Y, Hirose H, Zhou YT, Esser V, McGarry JD, Unger RH: Increased lipogenic capacity of the islets of obese rats: a role in the pathogenesis of NIDDM. Diabetes 46:408-113, 1997
9. Bai Y, Zhang S, Kim KS, Lee JK, Kim KH: Obese gene expression alters the ability of 30A5 preadipocytes to respond to lipogenic hormones. J Biol Chem 271:13939-13942, 1996
10. Zhou YT, Shimabukuro M, Koyama K, Lee Y, Wang MY, Trieu F, Newgard CB, linger RH: Induction by leptin of uncoupling protein-2 and enzymes of fatty acid oxidation. Proc Natl Acad Sci USA 94:6386-6390, 1997
11. Lee Y, Hirose H, Ohneda M, Johnson JH, McGarry JD, Unger RH: β-Cell lipotoxicity in the pathogenesis of non-insulin-dependent diabetes mellitus of obese rats: impairment in adipocyte-β-cell relationships. Proc Natl Acad Sci USA 91:10878-10882, 1994
12. Shimabukuro M, Zhou Y-T, Levi M, Unger RH: Fatty acid-induced β-cell apoptosis: a link between obesity and diabetes. Proc Natl Acad Sci USA 95:2498-2502, 1998
13. Brun T, Roche E, Assimacopoulos-Jeannet F, Corkey BE, Kim KH, Prentki M: Evidence of an anaplerotic/malonyl-CoA pathway in pancreatic β-cell nutrient signaling. Diabetes 45:190-198, 1996
14. Brun T, Assimacopoulos-Jeannet F, Corkey BE, Prentki M: Long-chain fatty acids inhibit acetyl-CoA carboxylase gene expression in the pancreatic β-cell line INS-1. Diabetes 46:393-400, 1997
15. Chen G, Koyama K, Yuan X, Lee Y, Zhou YT, O'Doherty R, Newgard CB, Unger RH: Disappearance of body fat in normal rats induced by adenovirus-mediated leptin gene therapy. Proc Natl Acad Sci USA 93:14795-14799, 1996
16. Naber SP, McDonald JM, Jarett L, McDaniel ML, Ludvigsen CW, Lacy PE: Preliminary characterization of calcium binding in islet cell plasma membranes. Diabetologia 19:439-444, 1980
17. Johnson JH, Crider BP, McCorkle K, Alford M, Unger RH: Inhibition of glucose transport into rat islet cells by immunoglobulins from patients with newonset insulin-dependent diabetes mellitus. N Engl J Med 322:653-659, 1990
18. Chen S, Ogawa A, Ohneda M, Unger RH, Foster DW, McGarry JD: More direct evidence for malonyl-CoA-carnitine palmitoyltransferase I interaction as a key event in pancreatic β-cell signaling. Diabetes 43:878-883, 1994
19. Bligh EG, Dyer WJ: A rapid method of total lipid extraction and purification. Can J Biochem Physiol 37:911-917, 1959
20. Shimabukuro M, Koyama K, Chen G, Wang MY, Trieu F, Lee Y, Newgard CB, Unger RH: Direct antidiabetic effect of leptin through triglyceride depletion of tissues. Proc Natl Acad Sci USA 94:4637-4641, 1997
21. Prip-Buus C, Perdereau D, Foufelle F, Maury J, Ferre P, Girard J: Induction of fatty acid-synthase gene expression by glucose in primary culture of rat hepatocytes: dependency upon glucokinase activity. Eur J Biochem 230:309-316, 1995
22. Roche E, Farfari S, Witters LA, Assimacopoulos-Jeannet F, Thumelin S, Brun T, Corkey BE, Saha AK, Prentki M: Long-term exposure of β-INS cells to high glucose concentration increases anapleresis, lipogenesis, and lipogenic gene expression. Diabetes 47:1086-1094, 1998
23. Koyama K, Shimabukuro M, Chen G, Wang MY, Lee Y, Kalra PS, Dube MG, Kalra SP, Newgard CB, Unger RH: Resistance to adenovirally induced hyperleptinemia in rats: comparison of ventromedial hypothalamic lesions and mutated leptin receptors. J Clin Invest 102:728-733, 1998
24. Foufelle F, Perdereau D, Gouhot B, Ferre P, Girard J: Effect of diets rich in medium-chain and long-chain triglycerides on lipogenic-enzyme gene expression in liver and adipose tissue of the weaned rat. Eur J Biochem 208:381-387, 1992
25. Maryneissen G, Leclercq-Meyer V, Sener A, Malaisse W: Perturbation of pancreatic islet function in glucose-infused rats. Metabolism 39:87-95, 1990
26. Unger RH: How obesity causes diabetes in Zucker diabetic fatty rats. Trends Endocrinol 8:276-282, 1997
27. Wang M-Y, Koyama K, Shimabukuro M, Newgard CB, Unger RH: OB-Rb gene transfer to leptin-resistant islets reverses diabetogenic phenotype. Proc Natl Acad Sci U S A 95:714-718, 1998