메뉴 건너뛰기




Volumn 51, Issue 1, 2008, Pages 131-144

Cellular Senescence, Cardiovascular Risk, and CKD: A Review of Established and Hypothetical Interconnections

Author keywords

atherosclerosis; diabetes; endothelial progenitor cell; hypertension; inflammation; oxidative stress; p53; renal failure; telomerase; Telomeres

Indexed keywords

ACETYLCYSTEINE; ACETYLSALICYLIC ACID; ATORVASTATIN; C REACTIVE PROTEIN; EBSELEN; NITRIC OXIDE; PRAVASTATIN; RALOXIFENE; TELOMERASE;

EID: 37349080616     PISSN: 02726386     EISSN: None     Source Type: Journal    
DOI: 10.1053/j.ajkd.2007.07.035     Document Type: Review
Times cited : (49)

References (151)
  • 1
    • 0037422592 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part I: Aging arteries: A "set up" for vascular disease
    • Lakatta E.G., and Levy D. Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part I: Aging arteries: A "set up" for vascular disease. Circulation 107 (2003) 139-146
    • (2003) Circulation , vol.107 , pp. 139-146
    • Lakatta, E.G.1    Levy, D.2
  • 3
    • 0028957303 scopus 로고
    • Age-related changes in vascular responses: A review
    • Marin J. Age-related changes in vascular responses: A review. Mech Ageing Dev 79 (1995) 71-114
    • (1995) Mech Ageing Dev , vol.79 , pp. 71-114
    • Marin, J.1
  • 4
    • 0026650622 scopus 로고
    • Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries
    • Schneiderman J., Sawdey M.S., Keeton M.R., et al. Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc Natl Acad Sci U S A 89 (1992) 6998-7002
    • (1992) Proc Natl Acad Sci U S A , vol.89 , pp. 6998-7002
    • Schneiderman, J.1    Sawdey, M.S.2    Keeton, M.R.3
  • 6
    • 0037469206 scopus 로고    scopus 로고
    • Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part III: Cellular and molecular clues to heart and arterial aging
    • Lakatta E.G. Arterial and cardiac aging: Major shareholders in cardiovascular disease enterprises. Part III: Cellular and molecular clues to heart and arterial aging. Circulation 107 (2003) 490-497
    • (2003) Circulation , vol.107 , pp. 490-497
    • Lakatta, E.G.1
  • 7
    • 33846121333 scopus 로고    scopus 로고
    • Vascular cell senescence: Contribution to atherosclerosis
    • Minamino T., and Komuro I. Vascular cell senescence: Contribution to atherosclerosis. Circ Res 100 (2007) 15-26
    • (2007) Circ Res , vol.100 , pp. 15-26
    • Minamino, T.1    Komuro, I.2
  • 8
    • 0035098313 scopus 로고    scopus 로고
    • Cardiovascular disease determinants in chronic renal failure: Clinical approach and treatment
    • Locatelli F., Bommer J., London G.M., et al. Cardiovascular disease determinants in chronic renal failure: Clinical approach and treatment. Nephrol Dial Transplant 16 (2001) 459-468
    • (2001) Nephrol Dial Transplant , vol.16 , pp. 459-468
    • Locatelli, F.1    Bommer, J.2    London, G.M.3
  • 9
    • 11244306482 scopus 로고    scopus 로고
    • The pattern of inflammation and a potential new clinical meaning and usefulness of C-reactive protein in end-stage renal failure patients
    • Tsirpanlis G. The pattern of inflammation and a potential new clinical meaning and usefulness of C-reactive protein in end-stage renal failure patients. Kidney Blood Press Res 28 (2005) 55-61
    • (2005) Kidney Blood Press Res , vol.28 , pp. 55-61
    • Tsirpanlis, G.1
  • 10
    • 0031738068 scopus 로고    scopus 로고
    • Controlling the epidemic of cardiovascular disease in chronic renal disease: What do we know? What do we need to learn? Where do we go from here?
    • Levey A.S., Beto J.A., Coronado B.E., et al. Controlling the epidemic of cardiovascular disease in chronic renal disease: What do we know? What do we need to learn? Where do we go from here?. Am J Kidney Dis 32 (1998) 853-906
    • (1998) Am J Kidney Dis , vol.32 , pp. 853-906
    • Levey, A.S.1    Beto, J.A.2    Coronado, B.E.3
  • 11
    • 0031733696 scopus 로고    scopus 로고
    • Epidemiology of cardiovascular disease in chronic renal failure
    • Foley R.N., Parfrey P.S., and Sarnak M. Epidemiology of cardiovascular disease in chronic renal failure. Am J Kidney Dis 32 suppl 3 (1998) S112-S119
    • (1998) Am J Kidney Dis , vol.32 , Issue.SUPPL. 3
    • Foley, R.N.1    Parfrey, P.S.2    Sarnak, M.3
  • 12
    • 0033057143 scopus 로고    scopus 로고
    • The clinical epidemiology of cardiac disease in chronic renal failure
    • Parfrey P.S., and Foley R.N. The clinical epidemiology of cardiac disease in chronic renal failure. J Am Soc Nephrol 10 (1999) 1606-1615
    • (1999) J Am Soc Nephrol , vol.10 , pp. 1606-1615
    • Parfrey, P.S.1    Foley, R.N.2
  • 13
    • 33751311529 scopus 로고    scopus 로고
    • Telomere biology and cardiovascular disease
    • Fuster J.J., and Andres V. Telomere biology and cardiovascular disease. Circ Res 99 (2006) 1167-1180
    • (2006) Circ Res , vol.99 , pp. 1167-1180
    • Fuster, J.J.1    Andres, V.2
  • 14
    • 33646437235 scopus 로고    scopus 로고
    • Premature senescence of endothelial cells: Methusaleh's dilemma
    • Chen J., and Goligorsky M.S. Premature senescence of endothelial cells: Methusaleh's dilemma. Am J Physiol Heart Circ Physiol 290 (2006) 1729-1739
    • (2006) Am J Physiol Heart Circ Physiol , vol.290 , pp. 1729-1739
    • Chen, J.1    Goligorsky, M.S.2
  • 15
    • 1542781659 scopus 로고    scopus 로고
    • When cells get stressed: An integrative view of cellular senescence
    • Ben-Porath I., and Weinberg R.A. When cells get stressed: An integrative view of cellular senescence. J Clin Invest 113 (2004) 8-13
    • (2004) J Clin Invest , vol.113 , pp. 8-13
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 16
    • 0035989631 scopus 로고    scopus 로고
    • Historical claims and current interpretations of replicative aging
    • Wright W.E., and Shay J.W. Historical claims and current interpretations of replicative aging. Nat Biotechnol 20 (2002) 682-688
    • (2002) Nat Biotechnol , vol.20 , pp. 682-688
    • Wright, W.E.1    Shay, J.W.2
  • 17
    • 0034682721 scopus 로고    scopus 로고
    • Cellular senescence: Mitotic clock or culture shock?
    • Sherr C.J., and DePinho R.A. Cellular senescence: Mitotic clock or culture shock?. Cell 102 (2000) 407-410
    • (2000) Cell , vol.102 , pp. 407-410
    • Sherr, C.J.1    DePinho, R.A.2
  • 18
    • 0034069237 scopus 로고    scopus 로고
    • Cancer, aging and cellular senescence
    • Campisi J. Cancer, aging and cellular senescence. In Vivo 14 (2000) 183-188
    • (2000) In Vivo , vol.14 , pp. 183-188
    • Campisi, J.1
  • 19
    • 0033673408 scopus 로고    scopus 로고
    • Protein oxidation and degradation during cellular senescence of human BJ fibroblasts. I. Effects of proliferative senescence
    • Sitte N., Merker K., Von Zglinicki T., Grune T., and Davies K.J. Protein oxidation and degradation during cellular senescence of human BJ fibroblasts. I. Effects of proliferative senescence. FASEB J 14 (2000) 2495-2502
    • (2000) FASEB J , vol.14 , pp. 2495-2502
    • Sitte, N.1    Merker, K.2    Von Zglinicki, T.3    Grune, T.4    Davies, K.J.5
  • 20
    • 0037667702 scopus 로고    scopus 로고
    • Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence
    • Narita M., Nunez S., Heard E., et al. Rb-mediated heterochromatin formation and silencing of E2F target genes during cellular senescence. Cell 113 (2003) 703-716
    • (2003) Cell , vol.113 , pp. 703-716
    • Narita, M.1    Nunez, S.2    Heard, E.3
  • 21
    • 0035545802 scopus 로고    scopus 로고
    • Putting the stress on senescence
    • Serrano M., and Blasco M.A. Putting the stress on senescence. Curr Opin Cell Biol 13 (2001) 748-753
    • (2001) Curr Opin Cell Biol , vol.13 , pp. 748-753
    • Serrano, M.1    Blasco, M.A.2
  • 22
    • 14644410453 scopus 로고    scopus 로고
    • The signals and pathways activating cellular senescence
    • Ben-Porath I., and Weinberg R.A. The signals and pathways activating cellular senescence. Int J Biochem Cell Biol 37 (2005) 961-976
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 961-976
    • Ben-Porath, I.1    Weinberg, R.A.2
  • 23
    • 13944270339 scopus 로고    scopus 로고
    • Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors
    • Campisi J. Senescent cells, tumor suppression, and organismal aging: Good citizens, bad neighbors. Cell 120 (2005) 513-522
    • (2005) Cell , vol.120 , pp. 513-522
    • Campisi, J.1
  • 24
    • 13944260728 scopus 로고    scopus 로고
    • Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation
    • Parrinello S., Coppe J.-P., Krtolica A., and Campisi J. Stromal-epithelial interactions in aging and cancer: Senescent fibroblasts alter epithelial cell differentiation. Cell Sci 118 (2005) 485-496
    • (2005) Cell Sci , vol.118 , pp. 485-496
    • Parrinello, S.1    Coppe, J.-P.2    Krtolica, A.3    Campisi, J.4
  • 25
    • 0037452888 scopus 로고    scopus 로고
    • Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci
    • Zhang H., Pan K.-H., and Cohen S.N. Senescence-specific gene expression fingerprints reveal cell-type-dependent physical clustering of up-regulated chromosomal loci. Proc Natl Acad Sci U S A 100 (2003) 3251-3256
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 3251-3256
    • Zhang, H.1    Pan, K.-H.2    Cohen, S.N.3
  • 26
    • 0036829090 scopus 로고    scopus 로고
    • Cancer and aging: A model for the cancer promoting effects of the aging stroma
    • Krtolica A., and Campisi J. Cancer and aging: A model for the cancer promoting effects of the aging stroma. Int J Biochem Cell Biol 34 (2002) 1401-1414
    • (2002) Int J Biochem Cell Biol , vol.34 , pp. 1401-1414
    • Krtolica, A.1    Campisi, J.2
  • 27
    • 3342929538 scopus 로고    scopus 로고
    • DNA damage checkpoint kinase Chk2 triggers replicative senescence
    • Gire Roux P., Wynford-Thomas D., Brondello J.M., and Dulic V. DNA damage checkpoint kinase Chk2 triggers replicative senescence. EMBO J 23 (2004) 2554-2563
    • (2004) EMBO J , vol.23 , pp. 2554-2563
    • Gire Roux, P.1    Wynford-Thomas, D.2    Brondello, J.M.3    Dulic, V.4
  • 28
    • 0035501411 scopus 로고    scopus 로고
    • Accumulation of oxidative DNA damage, 8-oxo-2′-deoxyguanoside, and change of repair systems during in vitro cellular aging of cultured human skin fibroblasts
    • Kaneko T., Tahara S., Taguchi T., and Kondo H. Accumulation of oxidative DNA damage, 8-oxo-2′-deoxyguanoside, and change of repair systems during in vitro cellular aging of cultured human skin fibroblasts. Mutat Res 487 (2001) 19-30
    • (2001) Mutat Res , vol.487 , pp. 19-30
    • Kaneko, T.1    Tahara, S.2    Taguchi, T.3    Kondo, H.4
  • 29
    • 0028345161 scopus 로고
    • Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells
    • Chen Q., and Ames B.N. Senescence-like growth arrest induced by hydrogen peroxide in human diploid fibroblast F65 cells. Proc Natl Acad Sci U S A 91 (1994) 4130-4134
    • (1994) Proc Natl Acad Sci U S A , vol.91 , pp. 4130-4134
    • Chen, Q.1    Ames, B.N.2
  • 30
    • 0032485213 scopus 로고    scopus 로고
    • Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts
    • Robles S.J., and Adami G.R. Agents that cause DNA double strand breaks lead to p16INK4a enrichment and the premature senescence of normal fibroblasts. Oncogene 16 (1998) 1113-1123
    • (1998) Oncogene , vol.16 , pp. 1113-1123
    • Robles, S.J.1    Adami, G.R.2
  • 31
    • 0036167004 scopus 로고    scopus 로고
    • Limits to lifespan
    • Lloyd A.C. Limits to lifespan. Nat Cell Biol 4 (2002) E25-E27
    • (2002) Nat Cell Biol , vol.4
    • Lloyd, A.C.1
  • 33
    • 0026054961 scopus 로고
    • A role for both RB and p53 in the regulation of human cellular senescence
    • Shay J.W., Pereira-Smith O.M., and Wright W.E. A role for both RB and p53 in the regulation of human cellular senescence. Exp Cell Res 196 (1991) 33-39
    • (1991) Exp Cell Res , vol.196 , pp. 33-39
    • Shay, J.W.1    Pereira-Smith, O.M.2    Wright, W.E.3
  • 34
    • 0043026840 scopus 로고    scopus 로고
    • Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells
    • Satyanarayana A., Wiemann S.U., Buer J., et al. Telomere shortening impairs organ regeneration by inhibiting cell cycle re-entry of a subpopulation of cells. EMBO J 22 (2003) 4003-4013
    • (2003) EMBO J , vol.22 , pp. 4003-4013
    • Satyanarayana, A.1    Wiemann, S.U.2    Buer, J.3
  • 35
    • 0037013154 scopus 로고    scopus 로고
    • A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy
    • Schmitt C.A., Fridman J.S., Yang M., et al. A senescence program controlled by p53 and p16INK4a contributes to the outcome of cancer therapy. Cell 109 (2002) 335-346
    • (2002) Cell , vol.109 , pp. 335-346
    • Schmitt, C.A.1    Fridman, J.S.2    Yang, M.3
  • 36
    • 0029047362 scopus 로고
    • A novel biomarker identifies senescent human cells in culture and in aging skin in vivo
    • Dimri G.P., Lee X., Basile G., et al. A novel biomarker identifies senescent human cells in culture and in aging skin in vivo. Proc Natl Acad Sci U S A 92 (1995) 9363-9367
    • (1995) Proc Natl Acad Sci U S A , vol.92 , pp. 9363-9367
    • Dimri, G.P.1    Lee, X.2    Basile, G.3
  • 37
    • 0028924516 scopus 로고
    • Increased p53 protein associated with aging in human diploid fibroblasts
    • Kuju K.S., and Lehman J.M. Increased p53 protein associated with aging in human diploid fibroblasts. Exp Cell Res 217 (1995) 336-345
    • (1995) Exp Cell Res , vol.217 , pp. 336-345
    • Kuju, K.S.1    Lehman, J.M.2
  • 38
    • 0037686707 scopus 로고    scopus 로고
    • Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53
    • Dirac A.M., and Bernards R. Reversal of senescence in mouse fibroblasts through lentiviral suppression of p53. J Biol Chem 278 (2003) 11731-11734
    • (2003) J Biol Chem , vol.278 , pp. 11731-11734
    • Dirac, A.M.1    Bernards, R.2
  • 39
    • 11244254444 scopus 로고    scopus 로고
    • Cellular senescence induced by p-53-ras cooperation is independent of p21waf1 in murine embryo fibroblasts
    • Castro M.E., del Valle Guijarro M., Moneo V., and Carnero A. Cellular senescence induced by p-53-ras cooperation is independent of p21waf1 in murine embryo fibroblasts. J Cell Biochem 92 (2004) 514-524
    • (2004) J Cell Biochem , vol.92 , pp. 514-524
    • Castro, M.E.1    del Valle Guijarro, M.2    Moneo, V.3    Carnero, A.4
  • 40
    • 4043176258 scopus 로고    scopus 로고
    • Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts
    • Favetta L.A., Robert C., King W.A., and Betts D.H. Expression profiles of p53 and p66shc during oxidative stress-induced senescence in fetal bovine fibroblasts. Exp Cell Res 299 (2004) 36-48
    • (2004) Exp Cell Res , vol.299 , pp. 36-48
    • Favetta, L.A.1    Robert, C.2    King, W.A.3    Betts, D.H.4
  • 41
  • 43
    • 0036407698 scopus 로고    scopus 로고
    • Bcl-2 can promote p-53 dependent senescence versus apoptosis without affecting the G1/S transition
    • Rincheval V., Renaud F., Lemaire C., et al. Bcl-2 can promote p-53 dependent senescence versus apoptosis without affecting the G1/S transition. Biochem Biophys Res Commun 298 (2002) 282-288
    • (2002) Biochem Biophys Res Commun , vol.298 , pp. 282-288
    • Rincheval, V.1    Renaud, F.2    Lemaire, C.3
  • 44
    • 0038292179 scopus 로고    scopus 로고
    • Caspase inhibition switches doxorubicin-induced apoptosis to senescence
    • Rebbaa A., Zheng X., Chou P.M., and Mirkin B.L. Caspase inhibition switches doxorubicin-induced apoptosis to senescence. Oncogene 22 (2003) 2805-2811
    • (2003) Oncogene , vol.22 , pp. 2805-2811
    • Rebbaa, A.1    Zheng, X.2    Chou, P.M.3    Mirkin, B.L.4
  • 45
    • 0037204535 scopus 로고    scopus 로고
    • Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cells
    • Zhang J., Patel J.M., and Block E.R. Enhanced apoptosis in prolonged cultures of senescent porcine pulmonary artery endothelial cells. Mech Ageing Dev 123 (2002) 613-625
    • (2002) Mech Ageing Dev , vol.123 , pp. 613-625
    • Zhang, J.1    Patel, J.M.2    Block, E.R.3
  • 46
    • 14544277627 scopus 로고    scopus 로고
    • Telomeres and telomerase: Their mechanism of action and the effects of altering their functions
    • Blackburn E.H. Telomeres and telomerase: Their mechanism of action and the effects of altering their functions. FEBS Lett 579 (2005) 859-862
    • (2005) FEBS Lett , vol.579 , pp. 859-862
    • Blackburn, E.H.1
  • 47
    • 0842346436 scopus 로고    scopus 로고
    • Beginning to understand the end of the chromosome
    • Cech T.R. Beginning to understand the end of the chromosome. Cell 116 (2004) 273-279
    • (2004) Cell , vol.116 , pp. 273-279
    • Cech, T.R.1
  • 48
    • 0035929353 scopus 로고    scopus 로고
    • Switching and signaling at the telomere
    • Blackburn E.H. Switching and signaling at the telomere. Cell 106 (2001) 661-673
    • (2001) Cell , vol.106 , pp. 661-673
    • Blackburn, E.H.1
  • 49
    • 22944488871 scopus 로고    scopus 로고
    • Telomeres and human disease: Ageing, cancer and beyond
    • Blasco M.A. Telomeres and human disease: Ageing, cancer and beyond. Nat Rev Genet 6 (2005) 611-622
    • (2005) Nat Rev Genet , vol.6 , pp. 611-622
    • Blasco, M.A.1
  • 50
    • 0030982721 scopus 로고    scopus 로고
    • The terminal DNA structure of mammalian chromosomes
    • McElligott R., and Wellinger R.J. The terminal DNA structure of mammalian chromosomes. EMBO J 16 (1997) 3705-3714
    • (1997) EMBO J , vol.16 , pp. 3705-3714
    • McElligott, R.1    Wellinger, R.J.2
  • 51
    • 0030978765 scopus 로고    scopus 로고
    • The DNA structures at the ends of eukaryotic chromosomes
    • Wellinger R.J., and Sen D. The DNA structures at the ends of eukaryotic chromosomes. Eur J Cancer 33 (1997) 735-749
    • (1997) Eur J Cancer , vol.33 , pp. 735-749
    • Wellinger, R.J.1    Sen, D.2
  • 52
    • 0030731928 scopus 로고    scopus 로고
    • Normal human chromosomes have long G-rich telomeric overhangs at one end
    • Wright W.E., Tesmer V.M., Huffman K.E., Levene S.D., and Shay J.W. Normal human chromosomes have long G-rich telomeric overhangs at one end. Genes Dev 11 (1997) 2801-2809
    • (1997) Genes Dev , vol.11 , pp. 2801-2809
    • Wright, W.E.1    Tesmer, V.M.2    Huffman, K.E.3    Levene, S.D.4    Shay, J.W.5
  • 53
    • 0033553536 scopus 로고    scopus 로고
    • Mammalian telomeres end in a large duplex loop
    • Griffith J.D., Comeau L., Rosenfield S., et al. Mammalian telomeres end in a large duplex loop. Cell 97 (1999) 503-514
    • (1999) Cell , vol.97 , pp. 503-514
    • Griffith, J.D.1    Comeau, L.2    Rosenfield, S.3
  • 54
    • 0025279931 scopus 로고
    • Telomeres shorten during ageing of human fibroblasts
    • Harley C.B., Futcher A.B., and Greider C.W. Telomeres shorten during ageing of human fibroblasts. Nature 345 (1990) 458-460
    • (1990) Nature , vol.345 , pp. 458-460
    • Harley, C.B.1    Futcher, A.B.2    Greider, C.W.3
  • 55
    • 0037192462 scopus 로고    scopus 로고
    • Senescence induced by altered telomere state, not telomere loss
    • Karlseder J., Smogorzewska A., and de Lange T. Senescence induced by altered telomere state, not telomere loss. Science 295 (2002) 2446-2449
    • (2002) Science , vol.295 , pp. 2446-2449
    • Karlseder, J.1    Smogorzewska, A.2    de Lange, T.3
  • 56
    • 0037457987 scopus 로고    scopus 로고
    • Evidence that exposure of the telomere 3′ overhang sequence induces senescence
    • Li C.-Z., Eller M.S., Firoozabadi R., and Gilchrest B.A. Evidence that exposure of the telomere 3′ overhang sequence induces senescence. Proc Natl Acad Sci U S A 100 (2003) 527-531
    • (2003) Proc Natl Acad Sci U S A , vol.100 , pp. 527-531
    • Li, C.-Z.1    Eller, M.S.2    Firoozabadi, R.3    Gilchrest, B.A.4
  • 57
    • 0010045614 scopus 로고    scopus 로고
    • Extension of life-span by introduction of telomerase into normal human cells
    • Bodnar A.G., Quellete M., Frolkis M., et al. Extension of life-span by introduction of telomerase into normal human cells. Science 279 (1998) 349-352
    • (1998) Science , vol.279 , pp. 349-352
    • Bodnar, A.G.1    Quellete, M.2    Frolkis, M.3
  • 58
    • 0032567967 scopus 로고    scopus 로고
    • Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span
    • Vaziri H., and Benchimol S. Reconstitution of telomerase activity in normal human cells leads to elongation of telomeres and extended replicative life span. Curr Biol 8 (1998) 279-282
    • (1998) Curr Biol , vol.8 , pp. 279-282
    • Vaziri, H.1    Benchimol, S.2
  • 59
    • 0033616762 scopus 로고    scopus 로고
    • Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening
    • Zhu J., Wang H., Bishop J.M., and Blackburn E.H. Telomerase extends the lifespan of virus-transformed human cells without net telomere lengthening. Proc Natl Acad Sci U S A 96 (1999) 3723-3728
    • (1999) Proc Natl Acad Sci U S A , vol.96 , pp. 3723-3728
    • Zhu, J.1    Wang, H.2    Bishop, J.M.3    Blackburn, E.H.4
  • 60
    • 0043199578 scopus 로고    scopus 로고
    • Telomerase maintains telomere structure in normal human cells
    • Masutomi K., Yu E.Y., Khurts S., et al. Telomerase maintains telomere structure in normal human cells. Cell 114 (2003) 241-253
    • (2003) Cell , vol.114 , pp. 241-253
    • Masutomi, K.1    Yu, E.Y.2    Khurts, S.3
  • 61
    • 33646126516 scopus 로고    scopus 로고
    • Novel roles for telomerase in aging
    • Geserick C., and Blasco M.A. Novel roles for telomerase in aging. Mech Aging Dev 127 (2006) 579-583
    • (2006) Mech Aging Dev , vol.127 , pp. 579-583
    • Geserick, C.1    Blasco, M.A.2
  • 62
    • 0037007075 scopus 로고    scopus 로고
    • Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction
    • Minamino T., Miyauchi H., Yoshida T., Ishida Y., Yoshida H., and Komuro I. Endothelial cell senescence in human atherosclerosis: Role of telomere in endothelial dysfunction. Circulation 105 (2002) 1541-1544
    • (2002) Circulation , vol.105 , pp. 1541-1544
    • Minamino, T.1    Miyauchi, H.2    Yoshida, T.3    Ishida, Y.4    Yoshida, H.5    Komuro, I.6
  • 63
    • 0035130153 scopus 로고    scopus 로고
    • Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: Evidence for senescent endothelial cells in vivo at sites of atherosclerosis
    • Vasile E., Tomita Y., Brown L.F., Kocher O., and Dvorak H.F. Differential expression of thymosin beta-10 by early passage and senescent vascular endothelium is modulated by VPF/VEGF: Evidence for senescent endothelial cells in vivo at sites of atherosclerosis. FASEB J 15 (2001) 458-466
    • (2001) FASEB J , vol.15 , pp. 458-466
    • Vasile, E.1    Tomita, Y.2    Brown, L.F.3    Kocher, O.4    Dvorak, H.F.5
  • 64
    • 0035146421 scopus 로고    scopus 로고
    • Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries
    • Fenton M., Barker S., Kurz D.J., and Erusalimsky J.D. Cellular senescence after single and repeated balloon catheter denudations of rabbit carotid arteries. Arterioscler Thromb Vasc Biol 21 (2001) 220-226
    • (2001) Arterioscler Thromb Vasc Biol , vol.21 , pp. 220-226
    • Fenton, M.1    Barker, S.2    Kurz, D.J.3    Erusalimsky, J.D.4
  • 65
    • 0034235774 scopus 로고    scopus 로고
    • Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery
    • Liao S., Curci J.A., Kelley B.J., Sicard G.A., and Thompson R.W. Accelerated replicative senescence of medial smooth muscle cells derived from abdominal aortic aneurysms compared to the adjacent inferior mesenteric artery. J Surg Res 92 (2000) 85-95
    • (2000) J Surg Res , vol.92 , pp. 85-95
    • Liao, S.1    Curci, J.A.2    Kelley, B.J.3    Sicard, G.A.4    Thompson, R.W.5
  • 67
    • 33846457372 scopus 로고    scopus 로고
    • Implications of early structural-functional changes in the endothelium for vascular disease
    • Simionescu M. Implications of early structural-functional changes in the endothelium for vascular disease. Arterioscler Thromb Vasc Biol 27 (2007) 266-274
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 266-274
    • Simionescu, M.1
  • 68
    • 33344468578 scopus 로고    scopus 로고
    • Nitric oxide and endothelial cell aging
    • Haendeler J. Nitric oxide and endothelial cell aging. Eur J Clin Pharmacol 62 (2006) 137-140
    • (2006) Eur J Clin Pharmacol , vol.62 , pp. 137-140
    • Haendeler, J.1
  • 69
    • 0032750425 scopus 로고    scopus 로고
    • Nitric oxide-An endothelial cell survival factor
    • Dimmeler S., and Zeiher A.M. Nitric oxide-An endothelial cell survival factor. Cell Death Differ 6 (1999) 964-968
    • (1999) Cell Death Differ , vol.6 , pp. 964-968
    • Dimmeler, S.1    Zeiher, A.M.2
  • 70
    • 0035851216 scopus 로고    scopus 로고
    • Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: Important role of nitric oxide
    • Hoffman J., Haendeler J., Aicher A., et al. Aging enhances the sensitivity of endothelial cells toward apoptotic stimuli: Important role of nitric oxide. Circ Res 89 (2001) 709-715
    • (2001) Circ Res , vol.89 , pp. 709-715
    • Hoffman, J.1    Haendeler, J.2    Aicher, A.3
  • 71
    • 0035955754 scopus 로고    scopus 로고
    • eNOS activity is reduced in senescent human endothelial cells. Preservation by hTERT immortalization
    • Matsushita H., Chang E., Glassford A.J., Cooke J.P., Chiu C.-P., and Tsao P.S. eNOS activity is reduced in senescent human endothelial cells. Preservation by hTERT immortalization. Circ Res 89 (2001) 793-798
    • (2001) Circ Res , vol.89 , pp. 793-798
    • Matsushita, H.1    Chang, E.2    Glassford, A.J.3    Cooke, J.P.4    Chiu, C.-P.5    Tsao, P.S.6
  • 72
    • 0034730782 scopus 로고    scopus 로고
    • Nitric oxide activates telomerase and delays endothelial cell senescence
    • Vasa M., Breitschopf K., Zeiher A.M., and Dimmeler S. Nitric oxide activates telomerase and delays endothelial cell senescence. Circ Res 87 (2000) 540-542
    • (2000) Circ Res , vol.87 , pp. 540-542
    • Vasa, M.1    Breitschopf, K.2    Zeiher, A.M.3    Dimmeler, S.4
  • 73
    • 33750944018 scopus 로고    scopus 로고
    • Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes
    • Hayashi T., Matsui-Hirai H., Miyazaki-Akita A., et al. Endothelial cellular senescence is inhibited by nitric oxide: Implications in atherosclerosis associated with menopause and diabetes. Proc Natl Acad Sci USA 103 (2006) 17018-17023
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 17018-17023
    • Hayashi, T.1    Matsui-Hirai, H.2    Miyazaki-Akita, A.3
  • 74
    • 3042591085 scopus 로고    scopus 로고
    • Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells
    • Kurz D.J., Decary S., Hong Y., Trivier E., Akhmedov A., and Erusalimsky J.D. Chronic oxidative stress compromises telomere integrity and accelerates the onset of senescence in human endothelial cells. J Cell Sci 117 (2004) 2417-2426
    • (2004) J Cell Sci , vol.117 , pp. 2417-2426
    • Kurz, D.J.1    Decary, S.2    Hong, Y.3    Trivier, E.4    Akhmedov, A.5    Erusalimsky, J.D.6
  • 75
    • 3142557059 scopus 로고    scopus 로고
    • Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence
    • Deshpande S.S., Qi B., Park Y.C., and Irani K. Constitutive activation of rac1 results in mitochondrial oxidative stress and induces premature endothelial cell senescence. Arterioscler Thromb Vasc Biol 23 (2003) e1-e6
    • (2003) Arterioscler Thromb Vasc Biol , vol.23
    • Deshpande, S.S.1    Qi, B.2    Park, Y.C.3    Irani, K.4
  • 76
    • 0034684652 scopus 로고    scopus 로고
    • Enhanced peroxynitrite formation is associated with vascular aging
    • van der Loo B., Labugger R., Skepper J.N., et al. Enhanced peroxynitrite formation is associated with vascular aging. J Exp Med 192 (2000) 1731-1744
    • (2000) J Exp Med , vol.192 , pp. 1731-1744
    • van der Loo, B.1    Labugger, R.2    Skepper, J.N.3
  • 77
    • 5344246626 scopus 로고    scopus 로고
    • Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl l-arginine accelerates endothelial cell senescence
    • Scalera F., Borlak J., Beckmann B., et al. Endogenous nitric oxide synthesis inhibitor asymmetric dimethyl l-arginine accelerates endothelial cell senescence. Arterioscler Thromb Vasc Biol 24 (2004) 1816-1822
    • (2004) Arterioscler Thromb Vasc Biol , vol.24 , pp. 1816-1822
    • Scalera, F.1    Borlak, J.2    Beckmann, B.3
  • 79
    • 34147222679 scopus 로고    scopus 로고
    • Telomerase induction in T cells: A cure for aging and disease?
    • Effros R.B. Telomerase induction in T cells: A cure for aging and disease?. Exp Gerontol 42 (2007) 416-420
    • (2007) Exp Gerontol , vol.42 , pp. 416-420
    • Effros, R.B.1
  • 81
    • 0027194495 scopus 로고
    • Senescence stimulates U937-endothelial cell interactions
    • Maier J.A., Statuto M., and Ragnotti G. Senescence stimulates U937-endothelial cell interactions. Exp Cell Res 208 (1993) 270-274
    • (1993) Exp Cell Res , vol.208 , pp. 270-274
    • Maier, J.A.1    Statuto, M.2    Ragnotti, G.3
  • 82
    • 0027241856 scopus 로고
    • The pathogenesis of atherosclerosis: A perspective for the 1990s
    • Ross R. The pathogenesis of atherosclerosis: A perspective for the 1990s. Nature 362 (1993) 801-809
    • (1993) Nature , vol.362 , pp. 801-809
    • Ross, R.1
  • 83
    • 30044438392 scopus 로고    scopus 로고
    • Dampening inflammation
    • Henson P.M. Dampening inflammation. Nat Immunol 6 (2005) 1179-1181
    • (2005) Nat Immunol , vol.6 , pp. 1179-1181
    • Henson, P.M.1
  • 84
    • 30044449982 scopus 로고    scopus 로고
    • Resolution of inflammation: The beginning programs the end
    • Serhan C.N., and Savill J. Resolution of inflammation: The beginning programs the end. Nat Immunol 6 (2005) 1191-1197
    • (2005) Nat Immunol , vol.6 , pp. 1191-1197
    • Serhan, C.N.1    Savill, J.2
  • 85
    • 11144220581 scopus 로고    scopus 로고
    • Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice
    • Liu J., Thewke D.P., Ru Su Y., Linton M.R.F., Fazio S., and Sinensky M.S. Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol 25 (2005) 174-179
    • (2005) Arterioscler Thromb Vasc Biol , vol.25 , pp. 174-179
    • Liu, J.1    Thewke, D.P.2    Ru Su, Y.3    Linton, M.R.F.4    Fazio, S.5    Sinensky, M.S.6
  • 86
    • 0032978142 scopus 로고    scopus 로고
    • The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo
    • Guevara N.V., Kim H.-S., Antonova E.I., and Chan L. The absence of p53 accelerates atherosclerosis by increasing cell proliferation in vivo. Nat Med 5 (1999) 335-339
    • (1999) Nat Med , vol.5 , pp. 335-339
    • Guevara, N.V.1    Kim, H.-S.2    Antonova, E.I.3    Chan, L.4
  • 87
    • 0035957575 scopus 로고    scopus 로고
    • Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE 3-Leiden transgenic mice
    • van Vlijmen B.J.M., Gerritsen G., Franken A.L., et al. Macrophage p53 deficiency leads to enhanced atherosclerosis in APOE 3-Leiden transgenic mice. Circ Res 88 (2001) 780-786
    • (2001) Circ Res , vol.88 , pp. 780-786
    • van Vlijmen, B.J.M.1    Gerritsen, G.2    Franken, A.L.3
  • 88
    • 0042190568 scopus 로고    scopus 로고
    • Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling
    • Merched A.J., Williams E., and Chan L. Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling. Arterioscler Thromb Vasc Biol 23 (2003) 1608-1614
    • (2003) Arterioscler Thromb Vasc Biol , vol.23 , pp. 1608-1614
    • Merched, A.J.1    Williams, E.2    Chan, L.3
  • 89
    • 33646149159 scopus 로고    scopus 로고
    • Activation of peroxisome proliferator-activated receptor γ suppresses telomerase activity in vascular smooth muscle cells
    • Ogawa D., Nomiyama T., Nakamachi T., et al. Activation of peroxisome proliferator-activated receptor γ suppresses telomerase activity in vascular smooth muscle cells. Circ Res 98 (2006) e50-e59
    • (2006) Circ Res , vol.98
    • Ogawa, D.1    Nomiyama, T.2    Nakamachi, T.3
  • 90
    • 1442314705 scopus 로고    scopus 로고
    • Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice
    • Poch E., Carbonell P., Franco S., Díez-Juan A., Blasco M.A., and Andrés V. Short telomeres protect from diet-induced atherosclerosis in apolipoprotein E-null mice. FASEB J 18 (2004) 418-420
    • (2004) FASEB J , vol.18 , pp. 418-420
    • Poch, E.1    Carbonell, P.2    Franco, S.3    Díez-Juan, A.4    Blasco, M.A.5    Andrés, V.6
  • 91
    • 33747625689 scopus 로고    scopus 로고
    • Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis. Effects of telomerase and oxidative stress
    • Matthews C., Gorenne I., Scott S., et al. Vascular smooth muscle cells undergo telomere-based senescence in human atherosclerosis. Effects of telomerase and oxidative stress. Circ Res 99 (2006) 156-164
    • (2006) Circ Res , vol.99 , pp. 156-164
    • Matthews, C.1    Gorenne, I.2    Scott, S.3
  • 93
    • 33846416903 scopus 로고    scopus 로고
    • The emerging role of vascular smooth muscle cell apoptosis in atherosclerosis and plaque stability
    • Clarke M., and Bennett M. The emerging role of vascular smooth muscle cell apoptosis in atherosclerosis and plaque stability. Am J Nephrol 26 (2006) 531-535
    • (2006) Am J Nephrol , vol.26 , pp. 531-535
    • Clarke, M.1    Bennett, M.2
  • 94
    • 33847612773 scopus 로고    scopus 로고
    • Biomarkers of atherosclerotic plaque instability and rupture
    • Koenig W., and Khuseyinova N. Biomarkers of atherosclerotic plaque instability and rupture. Arterioscler Thromb Vasc Biol 27 (2007) 15-26
    • (2007) Arterioscler Thromb Vasc Biol , vol.27 , pp. 15-26
    • Koenig, W.1    Khuseyinova, N.2
  • 96
    • 0037188926 scopus 로고    scopus 로고
    • Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells
    • Chen J., Brodsky S.V., Goligorsky D.M., et al. Glycated collagen I induces premature senescence-like phenotypic changes in endothelial cells. Circ Res 90 (2002) 1290-1298
    • (2002) Circ Res , vol.90 , pp. 1290-1298
    • Chen, J.1    Brodsky, S.V.2    Goligorsky, D.M.3
  • 97
    • 33748351173 scopus 로고    scopus 로고
    • Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway
    • Kunieda T., Minamino T., Nishi J., et al. Angiotensin II induces premature senescence of vascular smooth muscle cells and accelerates the development of atherosclerosis via a p21-dependent pathway. Circulation 114 (2006) 953-960
    • (2006) Circulation , vol.114 , pp. 953-960
    • Kunieda, T.1    Minamino, T.2    Nishi, J.3
  • 98
    • 33645287357 scopus 로고    scopus 로고
    • Cellular senescence impairs circadian expression of clock genes in vitro and in vivo
    • Kunieda T., Minamino T., Katsuno T., et al. Cellular senescence impairs circadian expression of clock genes in vitro and in vivo. Circ Res 98 (2006) 532-539
    • (2006) Circ Res , vol.98 , pp. 532-539
    • Kunieda, T.1    Minamino, T.2    Katsuno, T.3
  • 99
    • 0034107095 scopus 로고    scopus 로고
    • Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells
    • Misiti S., Nanni S., Fontemaggi G., et al. Induction of hTERT expression and telomerase activity by estrogens in human ovary epithelium cells. Mol Cell Biol 20 (2000) 3764-3771
    • (2000) Mol Cell Biol , vol.20 , pp. 3764-3771
    • Misiti, S.1    Nanni, S.2    Fontemaggi, G.3
  • 100
    • 33748078758 scopus 로고    scopus 로고
    • Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production
    • Perez-Rivero G., Ruiz-Torres M.P., Rivas-Elena J.V., et al. Mice deficient in telomerase activity develop hypertension because of an excess of endothelin production. Circulation 114 (2006) 309-317
    • (2006) Circulation , vol.114 , pp. 309-317
    • Perez-Rivero, G.1    Ruiz-Torres, M.P.2    Rivas-Elena, J.V.3
  • 101
    • 18244386227 scopus 로고    scopus 로고
    • Rise in insulin resistance is associated with escalated telomere attrition
    • Gardner J.P., Li S., Srinivasan S.R., et al. Rise in insulin resistance is associated with escalated telomere attrition. Circulation 111 (2005) 2171-2177
    • (2005) Circulation , vol.111 , pp. 2171-2177
    • Gardner, J.P.1    Li, S.2    Srinivasan, S.R.3
  • 102
    • 34249329365 scopus 로고    scopus 로고
    • Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy
    • Adaikalakoteswari A., Balasubramanyam M., Ravikumar R., Deepa R., and Mohan V. Association of telomere shortening with impaired glucose tolerance and diabetic macroangiopathy. Atherosclerosis 195 (2007) 83-89
    • (2007) Atherosclerosis , vol.195 , pp. 83-89
    • Adaikalakoteswari, A.1    Balasubramanyam, M.2    Ravikumar, R.3    Deepa, R.4    Mohan, V.5
  • 103
    • 24044458568 scopus 로고    scopus 로고
    • Telomere shortening occurs in Asian Indian type 2 diabetic patients
    • Adaikalakoteswari A., Balasubramanyam M., and Mohan V. Telomere shortening occurs in Asian Indian type 2 diabetic patients. Diabet Med 22 (2005) 1151-1156
    • (2005) Diabet Med , vol.22 , pp. 1151-1156
    • Adaikalakoteswari, A.1    Balasubramanyam, M.2    Mohan, V.3
  • 105
    • 32544457689 scopus 로고    scopus 로고
    • Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation
    • Aviv A., Valdes A., Gardner J.P., Swaminathan R., Kimura M., and Spector T.D. Menopause modifies the association of leukocyte telomere length with insulin resistance and inflammation. J Clin Endocrinol Metab 91 (2006) 635-640
    • (2006) J Clin Endocrinol Metab , vol.91 , pp. 635-640
    • Aviv, A.1    Valdes, A.2    Gardner, J.P.3    Swaminathan, R.4    Kimura, M.5    Spector, T.D.6
  • 106
  • 107
    • 23844517498 scopus 로고    scopus 로고
    • Obesity, cigarette smoking, and telomere length in women
    • Valdes A.M., Andrew T., Gardner P., et al. Obesity, cigarette smoking, and telomere length in women. Lancet 366 (2005) 662-664
    • (2005) Lancet , vol.366 , pp. 662-664
    • Valdes, A.M.1    Andrew, T.2    Gardner, P.3
  • 108
    • 33746316181 scopus 로고    scopus 로고
    • Insulin resistance, oxidative stress, hypertension, and leukocyte length in men from the Framingham Heart Study
    • Demissie S., Levy D., Benjamin E.J., et al. Insulin resistance, oxidative stress, hypertension, and leukocyte length in men from the Framingham Heart Study. Aging Cell 5 (2006) 325-330
    • (2006) Aging Cell , vol.5 , pp. 325-330
    • Demissie, S.1    Levy, D.2    Benjamin, E.J.3
  • 109
    • 10344229954 scopus 로고    scopus 로고
    • Accelerated telomere shortening in response to life stress
    • Epel E.S., Blackburn E.H., Lin J., et al. Accelerated telomere shortening in response to life stress. Proc Natl Acad Sci U S A 101 (2004) 17312-17315
    • (2004) Proc Natl Acad Sci U S A , vol.101 , pp. 17312-17315
    • Epel, E.S.1    Blackburn, E.H.2    Lin, J.3
  • 110
    • 32944477215 scopus 로고    scopus 로고
    • Cell aging in relation to stress arousal and cardiovascular disease risk factors
    • Epel E.S., Lin J., Wilhelm F.H., et al. Cell aging in relation to stress arousal and cardiovascular disease risk factors. Psychoneuroendocrinology 31 (2006) 277-287
    • (2006) Psychoneuroendocrinology , vol.31 , pp. 277-287
    • Epel, E.S.1    Lin, J.2    Wilhelm, F.H.3
  • 111
    • 4143052506 scopus 로고    scopus 로고
    • Endothelial progenitor cells: Characterization and role in vascular biology
    • Urbich C., and Dimmeler S. Endothelial progenitor cells: Characterization and role in vascular biology. Circ Res 95 (2004) 343-353
    • (2004) Circ Res , vol.95 , pp. 343-353
    • Urbich, C.1    Dimmeler, S.2
  • 112
    • 18144377085 scopus 로고    scopus 로고
    • Impaired progenitor cell activity in age-related endothelial dysfunction
    • Heiss C., Keymel S., Niesler U., Ziemann J., Kelm M., and Kalka C. Impaired progenitor cell activity in age-related endothelial dysfunction. J Am Coll Cardiol 45 (2005) 1441-1448
    • (2005) J Am Coll Cardiol , vol.45 , pp. 1441-1448
    • Heiss, C.1    Keymel, S.2    Niesler, U.3    Ziemann, J.4    Kelm, M.5    Kalka, C.6
  • 113
    • 12344256734 scopus 로고    scopus 로고
    • Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress
    • Imanishi T., Hano T., and Nishio I. Angiotensin II accelerates endothelial progenitor cell senescence through induction of oxidative stress. J Hypertens 23 (2005) 97-104
    • (2005) J Hypertens , vol.23 , pp. 97-104
    • Imanishi, T.1    Hano, T.2    Nishio, I.3
  • 114
    • 3843063565 scopus 로고    scopus 로고
    • Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction
    • Imanishi T., Hano T., Sawamura T., and Nishio I. Oxidized low-density lipoprotein induces endothelial progenitor cell senescence, leading to cellular dysfunction. Clin Exp Pharmacol Physiol 31 (2004) 407-410
    • (2004) Clin Exp Pharmacol Physiol , vol.31 , pp. 407-410
    • Imanishi, T.1    Hano, T.2    Sawamura, T.3    Nishio, I.4
  • 115
    • 2442422177 scopus 로고    scopus 로고
    • C-Reactive protein attenuates endothelial progenitor cell survival, differentiation, and function. Further evidence of a mechanistic link between C-reactive protein and cardiovascular disease
    • Verma S., Kuliszewski M.A., Li S.-H., et al. C-Reactive protein attenuates endothelial progenitor cell survival, differentiation, and function. Further evidence of a mechanistic link between C-reactive protein and cardiovascular disease. Circulation 109 (2004) 2058-2067
    • (2004) Circulation , vol.109 , pp. 2058-2067
    • Verma, S.1    Kuliszewski, M.A.2    Li, S.-H.3
  • 116
    • 33750205432 scopus 로고    scopus 로고
    • C-Reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells
    • Fujii H., Li S.H., Szmitko P.E., Fedak P., and Verma S. C-Reactive protein alters antioxidant defenses and promotes apoptosis in endothelial progenitor cells. Arterioscler Thromb Vasc Biol 26 (2006) 2476-2482
    • (2006) Arterioscler Thromb Vasc Biol , vol.26 , pp. 2476-2482
    • Fujii, H.1    Li, S.H.2    Szmitko, P.E.3    Fedak, P.4    Verma, S.5
  • 117
    • 29244453955 scopus 로고    scopus 로고
    • Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension
    • Imanishi T., Moriwaki C., Hano T., and Nishio I. Endothelial progenitor cell senescence is accelerated in both experimental hypertensive rats and patients with essential hypertension. J Hypertens 23 (2005) 1831-1837
    • (2005) J Hypertens , vol.23 , pp. 1831-1837
    • Imanishi, T.1    Moriwaki, C.2    Hano, T.3    Nishio, I.4
  • 118
    • 33846568008 scopus 로고    scopus 로고
    • Human telomere biology: Pitfalls of moving from the laboratory to epidemiology
    • Aviv A., Valdes A.M., and Spector T.D. Human telomere biology: Pitfalls of moving from the laboratory to epidemiology. Int J Epidemiol 35 (2006) 1424-1429
    • (2006) Int J Epidemiol , vol.35 , pp. 1424-1429
    • Aviv, A.1    Valdes, A.M.2    Spector, T.D.3
  • 119
    • 1242272818 scopus 로고    scopus 로고
    • Telomere length and possible link to X chromosome
    • Nawrot T.S., Staessen J.A., Gardner J.P., and Aviv A. Telomere length and possible link to X chromosome. Lancet 363 (2004) 507-510
    • (2004) Lancet , vol.363 , pp. 507-510
    • Nawrot, T.S.1    Staessen, J.A.2    Gardner, J.P.3    Aviv, A.4
  • 120
    • 33344470218 scopus 로고    scopus 로고
    • Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected, female sibling pairs
    • Andrew T., Aviv A., Falchi M., et al. Mapping genetic loci that determine leukocyte telomere length in a large sample of unselected, female sibling pairs. Am J Hum Genet 78 (2006) 480-486
    • (2006) Am J Hum Genet , vol.78 , pp. 480-486
    • Andrew, T.1    Aviv, A.2    Falchi, M.3
  • 121
    • 19944410471 scopus 로고    scopus 로고
    • Mapping of a major locus that determines telomere length in humans
    • Vasa-Nicotera M., Brouilette S., Mangino M., et al. Mapping of a major locus that determines telomere length in humans. Am J Hum Genet 76 (2005) 147-151
    • (2005) Am J Hum Genet , vol.76 , pp. 147-151
    • Vasa-Nicotera, M.1    Brouilette, S.2    Mangino, M.3
  • 122
    • 33947317206 scopus 로고    scopus 로고
    • The epigenetic regulation of mammalian telomeres
    • Blasco M.A. The epigenetic regulation of mammalian telomeres. Nat Rev Genet 8 (2007) 299-309
    • (2007) Nat Rev Genet , vol.8 , pp. 299-309
    • Blasco, M.A.1
  • 123
    • 33947287991 scopus 로고    scopus 로고
    • Epigenetic control of cellular senescence in disease: Opportunities for therapeutic intervention
    • Atkinson S.P., and Keith W.N. Epigenetic control of cellular senescence in disease: Opportunities for therapeutic intervention. Expert Rev Mol Med 9 (2007) 1-26
    • (2007) Expert Rev Mol Med , vol.9 , pp. 1-26
    • Atkinson, S.P.1    Keith, W.N.2
  • 124
    • 33748307395 scopus 로고    scopus 로고
    • The effects of social status on biological ageing as measured by white cell telomere length
    • Cherkas L.F., Aviv A., Valdes A.M., et al. The effects of social status on biological ageing as measured by white cell telomere length. Aging Cell 5 (2006) 361-367
    • (2006) Aging Cell , vol.5 , pp. 361-367
    • Cherkas, L.F.1    Aviv, A.2    Valdes, A.M.3
  • 127
    • 30044450820 scopus 로고    scopus 로고
    • Inflammation in atherosclerosis and other conditions: A response to danger
    • Tsirpanlis G. Inflammation in atherosclerosis and other conditions: A response to danger. Kidney Blood Press Res 28 (2005) 211-217
    • (2005) Kidney Blood Press Res , vol.28 , pp. 211-217
    • Tsirpanlis, G.1
  • 128
    • 4644310560 scopus 로고    scopus 로고
    • Role of oxidative modifications in atherosclerosis
    • Stocker R., and Keaney J.F. Role of oxidative modifications in atherosclerosis. Physiol Rev 84 (2004) 1381-1478
    • (2004) Physiol Rev , vol.84 , pp. 1381-1478
    • Stocker, R.1    Keaney, J.F.2
  • 130
    • 0037308404 scopus 로고    scopus 로고
    • Association between telomere length blood and mortality in people aged 60 years or older
    • Cawthon R.M., Smith K.R., O'Brien E., Sivatchenko A., and Kerber R.A. Association between telomere length blood and mortality in people aged 60 years or older. Lancet 361 (2003) 393-395
    • (2003) Lancet , vol.361 , pp. 393-395
    • Cawthon, R.M.1    Smith, K.R.2    O'Brien, E.3    Sivatchenko, A.4    Kerber, R.A.5
  • 132
    • 0344990162 scopus 로고    scopus 로고
    • Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders
    • Obana N., Takagi S., Kinouchi Y., et al. Telomere shortening of peripheral blood mononuclear cells in coronary disease patients with metabolic disorders. Intern Med 42 (2003) 150-153
    • (2003) Intern Med , vol.42 , pp. 150-153
    • Obana, N.1    Takagi, S.2    Kinouchi, Y.3
  • 133
    • 10744225878 scopus 로고    scopus 로고
    • Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects
    • Benetos A., Gardner J.P., Zureik M., et al. Short telomeres are associated with increased carotid atherosclerosis in hypertensive subjects. Hypertension 43 (2004) 182-185
    • (2004) Hypertension , vol.43 , pp. 182-185
    • Benetos, A.1    Gardner, J.P.2    Zureik, M.3
  • 134
    • 33847016883 scopus 로고    scopus 로고
    • Telomere length is associated with left ventricular function in the oldest old: The Newcastle 85+ study
    • Collerton J., Martin-Ruiz C., Kenny A., et al. Telomere length is associated with left ventricular function in the oldest old: The Newcastle 85+ study. Eur Heart J 28 (2007) 172-176
    • (2007) Eur Heart J , vol.28 , pp. 172-176
    • Collerton, J.1    Martin-Ruiz, C.2    Kenny, A.3
  • 135
    • 33646794390 scopus 로고    scopus 로고
    • No association between telomere length and survival among the elderly and oldest old
    • Bischoff C., Petersen H.C., Graakjaer J., et al. No association between telomere length and survival among the elderly and oldest old. Epidemiology 17 (2006) 190-194
    • (2006) Epidemiology , vol.17 , pp. 190-194
    • Bischoff, C.1    Petersen, H.C.2    Graakjaer, J.3
  • 136
    • 33845864725 scopus 로고    scopus 로고
    • Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study
    • Fitzpatrick A.L., Kronmal R.A., Gardner J.P., et al. Leukocyte telomere length and cardiovascular disease in the Cardiovascular Health Study. Am J Epidemiol 165 (2007) 14-21
    • (2007) Am J Epidemiol , vol.165 , pp. 14-21
    • Fitzpatrick, A.L.1    Kronmal, R.A.2    Gardner, J.P.3
  • 137
    • 33846049673 scopus 로고    scopus 로고
    • Telomere length, risk of coronary disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study
    • Brouilette S.W., Moore J.S., McMahon A.D., et al. Telomere length, risk of coronary disease, and statin treatment in the West of Scotland Primary Prevention Study: A nested case-control study. Lancet 369 (2007) 107-114
    • (2007) Lancet , vol.369 , pp. 107-114
    • Brouilette, S.W.1    Moore, J.S.2    McMahon, A.D.3
  • 138
    • 0038814315 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes
    • Assmus B., Urbich C., Aicher A., et al. HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes. Circ Res 92 (2003) 1049-1055
    • (2003) Circ Res , vol.92 , pp. 1049-1055
    • Assmus, B.1    Urbich, C.2    Aicher, A.3
  • 139
    • 33846056587 scopus 로고    scopus 로고
    • Can telomere length predict cardiovascular risk?
    • Spyridopoulos I., and Dimmeler S. Can telomere length predict cardiovascular risk?. Lancet 369 (2007) 81-82
    • (2007) Lancet , vol.369 , pp. 81-82
    • Spyridopoulos, I.1    Dimmeler, S.2
  • 140
    • 8544236989 scopus 로고    scopus 로고
    • Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells
    • Spyridopoulos I., Haendeler J., Urbich C., et al. Statins enhance migratory capacity by upregulation of the telomere repeat-binding factor TRF2 in endothelial progenitor cells. Circulation 110 (2004) 3136-3142
    • (2004) Circulation , vol.110 , pp. 3136-3142
    • Spyridopoulos, I.1    Haendeler, J.2    Urbich, C.3
  • 141
    • 1842611977 scopus 로고    scopus 로고
    • Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells
    • Haendeler J., Hoffmann J., Diehl J.F., et al. Antioxidants inhibit nuclear export of telomerase reverse transcriptase and delay replicative senescence of endothelial cells. Circ Res 94 (2004) 768-775
    • (2004) Circ Res , vol.94 , pp. 768-775
    • Haendeler, J.1    Hoffmann, J.2    Diehl, J.F.3
  • 142
    • 1242275127 scopus 로고    scopus 로고
    • Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen
    • Brodsky S.V., Gealekman O., Chen J., et al. Prevention and reversal of premature endothelial cell senescence and vasculopathy in obesity-induced diabetes by ebselen. Circ Res 94 (2004) 377-384
    • (2004) Circ Res , vol.94 , pp. 377-384
    • Brodsky, S.V.1    Gealekman, O.2    Chen, J.3
  • 145
    • 33747722742 scopus 로고    scopus 로고
    • Raloxifene increases proliferation and upregulates telomerase activity in human umbilical vein endothelial cells
    • Doshida M., Ohmichi M., Tsutsumi S., et al. Raloxifene increases proliferation and upregulates telomerase activity in human umbilical vein endothelial cells. J Biol Chem 281 (2006) 24270-24278
    • (2006) J Biol Chem , vol.281 , pp. 24270-24278
    • Doshida, M.1    Ohmichi, M.2    Tsutsumi, S.3
  • 146
    • 15944405331 scopus 로고    scopus 로고
    • Stress-induced premature senescence in mononuclear cells from patients on long-term hemodialysis
    • Ramirez R., Carracedo J., Soriano S., et al. Stress-induced premature senescence in mononuclear cells from patients on long-term hemodialysis. Am J Kidney Dis 45 (2005) 353-359
    • (2005) Am J Kidney Dis , vol.45 , pp. 353-359
    • Ramirez, R.1    Carracedo, J.2    Soriano, S.3
  • 147
    • 33748319340 scopus 로고    scopus 로고
    • Replicative senescence in patients with chronic kidney failure
    • Jimenez R., Carracedo J., Santamaria R., et al. Replicative senescence in patients with chronic kidney failure. Kidney Int Suppl 99 (2005) S11-S15
    • (2005) Kidney Int Suppl , vol.99
    • Jimenez, R.1    Carracedo, J.2    Santamaria, R.3
  • 149
    • 33645670620 scopus 로고    scopus 로고
    • Telomerase activity is decreased in peripheral blood mononuclear cells of hemodialysis patients
    • Tsirpanlis G., Chatzipanagiotou S., Boufidou F., et al. Telomerase activity is decreased in peripheral blood mononuclear cells of hemodialysis patients. Am J Nephrol 26 (2006) 91-96
    • (2006) Am J Nephrol , vol.26 , pp. 91-96
    • Tsirpanlis, G.1    Chatzipanagiotou, S.2    Boufidou, F.3
  • 150
    • 33845639997 scopus 로고    scopus 로고
    • Serum oxidized low-density lipoprotein is inversely correlated to telomerase activity in peripheral blood mononuclear cells of haemodialysis patients
    • Tsirpanlis G., Chatzipanagiotou S., Boufidou F., et al. Serum oxidized low-density lipoprotein is inversely correlated to telomerase activity in peripheral blood mononuclear cells of haemodialysis patients. Nephrology (Carlton) 11 (2006) 506-509
    • (2006) Nephrology (Carlton) , vol.11 , pp. 506-509
    • Tsirpanlis, G.1    Chatzipanagiotou, S.2    Boufidou, F.3
  • 151
    • 33845343267 scopus 로고    scopus 로고
    • Grading evidence and recommendations for clinical practice guidelines in nephrology. A position statement from Kidney Disease: Improving Global Outcomes (KDIGO)
    • Uhlig K., MacLeod A., Craig J., et al. Grading evidence and recommendations for clinical practice guidelines in nephrology. A position statement from Kidney Disease: Improving Global Outcomes (KDIGO). Kidney Int 70 (2006) 2058-2065
    • (2006) Kidney Int , vol.70 , pp. 2058-2065
    • Uhlig, K.1    MacLeod, A.2    Craig, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.