HMG-CoA reductase inhibitors reduce senescence and increase proliferation of endothelial progenitor cells via regulation of cell cycle regulatory genes

Circulation Research

Volumn 92, Issue 9, 2003, Pages 1049-1055

  Assmus, Birgit ^a   Urbich, Carmen ^a   Aicher, Alexandra ^a   Hofmann, Wolf K ^a   Haendeler, Judith ^a   Rössig, Lothar ^a   Spyridopoulos, Ioakim ^a   Zeiher, Andreas M ^a   Dimmeler, Stefanie ^a  

^a GOETHE UNIVERSITY   (Germany)

Author keywords

Aging; Angiogenesis; Progenitor cells; Statins; Telomerase

Indexed keywords

2 MORPHOLINO 8 PHENYLCHROMONE; 4 (1 AMINOETHYL) N (4 PYRIDYL)CYCLOHEXANECARBOXAMIDE; ACETYLCYSTEINE; ANTIOXIDANT; ATORVASTATIN; BETA GALACTOSIDASE; BROXURIDINE; CELL CYCLE PROTEIN; COMPACTIN; CYCLINE; FARNESYL DIPHOSPHATE; FASUDIL; GERANYLGERANYL PYROPHOSPHATE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVALONIC ACID; N ACETYL S NITROSOPENICILLAMINE; N(G) METHYLARGININE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE INHIBITOR; PHOSPHOTRANSFERASE INHIBITOR; PROTEIN P27; PYROPHOSPHORIC ACID DERIVATIVE; REACTIVE OXYGEN METABOLITE; RHO KINASE; TELOMERASE; UNCLASSIFIED DRUG; WORTMANNIN;

ARTICLE; CELL CYCLE; CELL ISOLATION; CELL LABELING; CELL PROLIFERATION; COLONY FORMING UNIT; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA MICROARRAY; DOWN REGULATION; DRUG EFFECT; ENDOTHELIUM CELL; ENZYME ACTIVITY; ENZYME ASSAY; GENE CONTROL; GENE EXPRESSION; GENE EXPRESSION REGULATION; HUMAN; HUMAN CELL; HUMAN CELL CULTURE; NORMAL HUMAN; PRIORITY JOURNAL; QUANTITATIVE ANALYSIS; REGULATOR GENE; SENESCENCE; STEM CELL; UPREGULATION;

CELL AGING; CELL CYCLE PROTEINS; CELL DIVISION; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P27; CYCLINS; ENDOTHELIUM, VASCULAR; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; GENES, CDC; HEPTANOIC ACIDS; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; LEUKOCYTES, MONONUCLEAR; LOVASTATIN; OLIGONUCLEOTIDE ARRAY SEQUENCE ANALYSIS; PYRROLES; SIGNAL TRANSDUCTION; STEM CELLS; TELOMERASE; TUMOR SUPPRESSOR PROTEINS;

EID: 0038814315     PISSN: 00097330     EISSN: None     Source Type: Journal    
DOI: 10.1161/01.RES.0000070067.64040.7C     Document Type: Article

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