Bcl-2 can promote p53-dependent senescence versus apoptosis without affecting the G1/S transition

Biochemical and Biophysical Research Communications

Volumn 298, Issue 2, 2002, Pages 282-288

  Rincheval, Vincent ^a   Renaud, Flore ^b   Lemaire, Christophe ^a   Godefroy, Nelly ^a   Trotot, Pascale ^a   Boulo, Viviane ^c   Mignotte, Bernard ^a,b   Vayssière, Jean Luc ^a  

^a LABORATOIRE DES SCIENCES DU CLIMAT ET DE L ENVIRONNEMENT   (France)

^b PSL RESEARCH UNIVERSITY   (France)

^c CNRS   (France)

Author keywords

Apoptosis; Bcl 2; Cell cycle; Senescence

Indexed keywords

PROTEIN BCL 2; PROTEIN P53; VIRUS LARGE T ANTIGEN;

ANIMAL CELL; APOPTOSIS; ARTICLE; CELL AGING; CELL CYCLE G1 PHASE; CELL CYCLE G2 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL LINE; CELL PROLIFERATION; CONTROLLED STUDY; EMBRYO; FIBROBLAST; HEAT; MITOSIS INHIBITION; NONHUMAN; PHASE TRANSITION; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; SENESCENCE; SIMIAN VIRUS 40; TEMPERATURE SENSITIVE MUTANT;

EID: 0036407698     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)02454-3     Document Type: Article

References (30)

1. L. Hayflick, The limited in vitro lifetime of human diploid cell strains, Exp. Cell Res. 37 (1965) 614-636.
2. J.A. DeCaprio, J.W. Ludlow, J. Figge, J.Y. Shew, C.M. Huang, W.H. Lee, E. Marsilio, E. Paucha, D.M. Livingston, SV40 large tumor antigen forms a specific complex with the product of the retinoblastoma susceptibility gene, Cell 54 (1988) 275-283.
3. J.Y. Zhu, M. Abate, P.W. Rice, C.N. Cole, The ability of simian virus-40 large T antigen to immortalize primary mouse embryo fibroblasts cosegregates with its ability to bind to p53, J. Virol. 65 (1991) 6872-6880.
4. D.W. Goodrich, N.P. Wang, Y.W. Qian, E.Y. Lee, W.H. Lee, The retinoblastoma gene product regulates progression through the G1 phase of the cell cycle, Cell 67 (1991) 293-302.
5. P.A. Futreal, J.C. Barrett, Failure of senescent cells to phosphorylate the RB protein, Oncogene 6 (1991) 1109-1113.
6. J.W. Harper, G.R. Adami, N. Wei, K. Keyomarsi, S.J. Elledge, The p21 Cdk-interacting protein Cip1 is a potent inhibitor of G1 cyclin- dependent kinases, Cell 75 (1993) 805-816.
7. K.M. Ryan, A.C. Phillips, K.H. Vousden, Regulation and function of the p53 tumor suppressor protein, Curr. Opin. Cell Biol. 13 (2001) 332-337.
8. M. Narita, S. Shimizu, T. Ito, T. Chittenden, R.J. Lutz, H. Matsuda, Y. Tsujimoto, Bax interacts with the permeability transition pore to induce permeability transition and cytochrome c release in isolated mitochondria, Proc. Natl. Acad. Sci. USA 95 (1998) 14681-14686.
9. B. Mignotte, J.L. Vayssière, Mitochondria and apoptosis, Eur. J. Biochem. 252 (1998) 1-15.
10. Z.N. Oltvai, C.L. Milliman, S.J. Korsmeyer, bcl-2 Heterodimerizes in vivo with a conserved homolog, bax, that accelerates programmed cell death, Cell 74 (1993) 609-619.
11. E. Wang, Senescent human fibroblasts resist programmed cell death, and failure to suppress bcl2 is involved, Cancer Res. 55 (1995) 2284-2292.
12. G. Vairo, T.J. Soos, T.M. Upton, J. Zalvide, J.A. DeCaprio, M.E. Ewen, A. Koff, J.M. Adams, Bcl-2 retards cell cycle entry through p27(Kip1), pRB relative p130, and altered E2F regulation, Mol. Cell. Biol. 20 (2000) 4745-4753.
13. C.A. Petit, M.Y. Gardes, J. Feunteun, Immortalization of rodent embryo fibroblast by SV40 is maintained by the A gene, Virology 127 (1983) 74-82.
14. D.Q. Zheng, J.L. Vayssière, H. Lecoeur, P.X. Petit, A. Spatz, B. Mignotte, J. Feunteun, Apoptosis is antagonized by large T antigens in the pathway to immortalization by polyomaviruses, Oncogene 9 (1994) 3345-3351.
15. V. Rincheval, F. Renaud, C. Lemaire, B. Mignotte, J.L. Vayssi3 ere, Inhibition of Bcl-2-dependent cell survival by a caspase inhibitor: A possible new pathway for Bcl-2 to regulate cell death, FEBS Lett. 460 (1999) 203-206.
16. J.M. Chirgwin, A.E. Przybyla, R.J. Mac Donald, W.J. Rutter, Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease, Biochemistry 18 (1979) 5294-5299.
17. F. Renaud, S. Desset, L. Oliver, G. Gimenez-Gallego, E. Van Obberghen, Y. Courtois, M. Laurent, The neurotrophic activity of fibroblast growth factor 1 (FGF1) depends on endogenous FGF1 expression and is independent of the mitogen-activated protein kinase cascade pathway, J. Biol. Chem. 271 (1996) 2801-2811.
18. Z. Ikram, T. Norton, P.S. Jat, The biological clock that measures the mitotic life-span of mouse embryo fibroblasts continues to function in the presence of simian virus 40 large tumor antigen, Proc. Natl. Acad. Sci. USA 91 (1994) 6448-6452.
19. D. Bartkowiak, S. Hogner, H. Baust, W. Nothdurft, E.M. Rottinger, Comparative analysis of apoptosis in HL60 detected by annexin-V and fluorescein-diacetate, Cytometry 37 (1999) 191-196.
20. T. Miyashita, M. Harigai, M. Hanada, J.C. Reed, Identification of a p53-dependent negative response element in the bcl-2 gene, Cancer Res. 54 (1994) 3131-3135.
21. H. Hermeking, C. Lengauer, K. Polyak, T.C. He, L. Zhang, S. Thiagalingam, K.W. Kinzler, B. Vogelstein, 14-3-3 sigma is a p53-regulated inhibitor of G2/M progression, Mol. Cell 1 (1997) 3-11.
22. X.W. Wang, Q. Zhan, J.D. Coursen, M.A. Khan, H.U. Kontny, L. Yu, M.C. Hollander, P.M. O'Connor, A.J. Fornace Jr., C.C. Harris, GADD45 induction of a G2/M cell cycle checkpoint, Proc. Natl. Acad. Sci. USA 96 (1999) 3706-3711.
23. G.P. Dimri, X. Lee, G. Basile, M. Acosta, G. Scott, C. Roskelley, E.E. Medrano, M. Linskens, I. Rubelj, O. Pereira-Smith, et al., A biomarker that identifies senescent human cells in culture and in aging skin in vivo, Proc. Natl. Acad. Sci. USA 92 (1995) 9363-9367.
24. E.S. Gonos, J.S. Burns, G.R. Mazars, A. Kobrna, T.E. Riley, S.C. Barnett, G. Zafarana, R.L. Ludwig, Z. Ikram, A.J. Powell, P.S. Jat, Rat embryo fibroblasts immortalized with simian virus 40 large T antigen undergo senescence upon its inactivation, Mol. Cell. Biol. 16 (1996) 5127-5138.
25. J.L. Vayssière, P.X. Petit, Y. Risler, B. Mignotte, Commitment to apoptosis is associated with changes in mitochondrial biogenesis and activity in cell lines conditionally immortalized with Simian virus 40, Proc. Natl. Acad. Sci. USA 91 (1994) 11752-11756.
26. I. Guénal, C. Sidotide Fraisse, S. Gaumer, B. Mignotte, Bcl-2 and Hsp27 act at different levels to suppress programmed cell death, Oncogene 15 (1997) 347-360.
27. T. Miyashita, S. Krajewski, M. Krajewska, H.G. Wang, H.K. Lin, D. Liebermann, B. Hoffman, J.C. Reed, Tumor suppressor p53 is a regulator of Bcl-2 and bax gene expression in vitro and in vivo, Oncogene 9 (1994) 1799-1805.
28. M. Neuberg, L. Buckbinder, B. Seizinger, N. Kley, The p53/IGF-1 receptor axis in the regulation of programmed cell death, Endocrine 7 (1997) 107-109.
29. J.W. Harbour, D.C. Dean, The Rb/E2F pathway: expanding roles and emerging paradigms, Genes Dev. 14 (2000) 2393-2409.
30. X.Q. Qin, D.M. Livingston, W.G. Kaelin Jr., P.D. Adams, Deregulated transcription factor E2F-1 expression leads to S-phase entry and p53-mediated apoptosis, Proc. Natl. Acad. Sci. USA 91 (1994) 10918-10922.