Effects of nicotinamide on prevention and treatment of streptozotocin-induced diabetes mellitus in rats

Chinese Medical Journal

Volumn 109, Issue 11, 1996, Pages 819-822

  Hu, Yuanfeng ^a   Wang, Yufei ^a   Wang, Lijuan ^a   Zhang, Hong ^a   Zhang, Hongde ^a   Zhao, Baohua ^a   Zhang, Aifang ^a   Li, Yu ^a  

^a SHANGHAI FIRST PEOPLE S HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

NICOTINAMIDE;

ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CONTROLLED STUDY; DRUG EFFICACY; FEMALE; GLUCOSE METABOLISM; INTRAMUSCULAR DRUG ADMINISTRATION; INTRAPERITONEAL DRUG ADMINISTRATION; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; RAT; STREPTOZOCIN DIABETES;

ANIMALS; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; FEMALE; FREE RADICAL SCAVENGERS; ISLETS OF LANGERHANS; MALE; NIACINAMIDE; RANDOM ALLOCATION; RATS; RATS, SPRAGUE-DAWLEY;

EID: 0029768312     PISSN: 03666999     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (9)

1. Yamada K, Nonaka K, Hanafusa T, et al. Preventive and therapeutic effects of large dose nicotinamide injection on diabetes associated with insulitis. Diabetes 1982; 31:749.
2. Elliott RB. Dietary prevention and enhancement of diabetes in NOD mouse. In: Proceedings of 19th International Workshop on Immunology of Diabetes. Jerusalem 1990:34.
3. Uchigata Y, Yamamoto H, Nagai H, et al. Effect of poly (ADP-ribose) synthetase inhibitor administration to rat before and after injection of alloxan and streptozotocin on islet proinsulin synthesis. Diabetes 1983; 32:316.
4. Ledoux SP, Hall CR, Forbes PM, et al. Mechanisms of nicotinamide and thymidine protection from alloxan and streptozotocin toxicity. Diabetes 1988; 37:1015.
5. Shafrir E. Diabetes in animals. In: Rifkin H, Porte D, eds. Diabetes mellitus. 4th ed. New York: Elsevier, 1990:299.
6. Horio F, Fukuda M, Katoh H, et al. Reactive oxygen intermediates in autoimmune islet cell destruction of the NOD mouse induced by peritoneal exudate cells (rich in macrophages) but not T cells. Diabetologia 1994; 77:22.
7. Maclaren N, Lafferty K. The 12th international immunology and diabetes workshop. Diabetes 1993; 42:1099.
8. Elliott RB, Chase HP. Prevention or delay of type 1 (insulin-dependent) diabetes mellitus in children using nicotinamide. Diabetologia 1991; 34:362.
9. Vague P, Picq R, Bernai M, et al. Effect of nicotinamide treatment on the residual insulin secretion in type 1 (insulin-dependent) diabetic patients. Diabetologia 1989; 32:316.