The toxic conformation of the 42-residue amyloid β peptide and its relevance to oxidative stress in Alzheimer's disease

Mini-Reviews in Medicinal Chemistry

Volumn 7, Issue 10, 2007, Pages 1001-1008

  Irie, K ^a   Murakami, K ^a   Masuda, Y ^a   Morimoto, A ^a   Ohigashi, H ^a   Hara, H ^b   Ohashi, R ^a   Takegoshi, K ^a   Fukuda, H ^c   Nagao, M ^a   Shimizu, T ^d   Shirasawa, T ^d  

^a KYOTO UNIVERSITY   (Japan)

^b Bruker Corporation   (United States)

^c THE UNIVERSITY OF TOKYO   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Alzheimer's disease; Amyloid ; Cerebral amyloid angiopathy; ESR; Neurotoxicity; Oxidative stress; Proline; Solid state NMR

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; AMYLOID BETA PROTEIN[1-42]; APTAMER; COPPER; CYSTEINE; FREE RADICAL; GLUTATHIONE REDUCTASE; IRON; METHIONINE; MONOCLONAL ANTIBODY; PROLINE; PROTEIN INHIBITOR; SUPEROXIDE DISMUTASE; TYROSINE; ZINC;

ALZHEIMER DISEASE; AMINO ACID SUBSTITUTION; AMINO TERMINAL SEQUENCE; ANTIOXIDANT ACTIVITY; ATOMIC FORCE MICROSCOPY; BETA SHEET; CARBOXY TERMINAL SEQUENCE; CELL STRAIN; CIRCULAR DICHROISM; DRUG RESEARCH; ELECTRON MICROSCOPY; GENE MUTATION; HUMAN; INFRARED SPECTROSCOPY; NEUROFIBRILLARY TANGLE; NEUROTOXICITY; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; OXIDATION REDUCTION STATE; OXIDATIVE STRESS; PATHOGENESIS; PROTEIN AGGREGATION; PROTEIN CONFORMATION; PROTEIN INTERACTION; PROTEIN STRUCTURE; PROTEIN SYNTHESIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; REVIEW; SENILE PLAQUE; STRUCTURE ANALYSIS; X RAY CRYSTALLOGRAPHY;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; CEREBRAL AMYLOID ANGIOPATHY; FREE RADICALS; HUMANS; NEUROTOXICITY SYNDROMES; OXIDATIVE STRESS; PEPTIDE FRAGMENTS; PROTEIN STRUCTURE, TERTIARY;

EID: 35048818925     PISSN: 13895575     EISSN: None     Source Type: Journal    
DOI: 10.2174/138955707782110187     Document Type: Review

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