Establishment of a binding assay for protein kinase C isozymes using synthetic C1 peptides and development of new medicinal leads with protein kinase C isozyme and C1 domain selectivity

Pharmacology and Therapeutics

Volumn 93, Issue 2-3, 2002, Pages 271-281

  Irie, Kazuhiro ^a   Nakahara, Akifumi ^a   Nakagawa, Yu ^a   Ohigashi, Hajime ^a   Shindo, Mayumi ^b   Fukuda, Hiroyuki ^b   Konishi, Hiroaki ^c   Kikkawa, Ushio ^c   Kashiwagi, Kaori ^c   Saito, Naoaki ^c  

^a KYOTO UNIVERSITY   (Japan)

^b Applied Biosystems Japan Ltd   (Japan)

^c KOBE UNIVERSITY   (Japan)

Author keywords

Benzolactam; Cysteine rich domain; Indolactam; Phorbol ester; Protein kinase C (PKC); Zinc finger

Indexed keywords

BENZOIC ACID DERIVATIVE; BRYOSTATIN 1; GLYCEROL 2 ACETATE 1 OLEATE; INDOLACTAM V; INGENOL 3 BENZOATE; ISOENZYME; LACTAM DERIVATIVE; LACTONE DERIVATIVE; PHORBOL DIBUTYRATE; PROTEIN KINASE C; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG; LACTAM; PEPTIDE LIBRARY; PROTEIN SERINE THREONINE KINASE; PROTOZOAL PROTEIN; ZFK PROTEIN, TRYPANOSOMA BRUCEI;

BINDING AFFINITY; BINDING ASSAY; CARCINOGENESIS; CONFERENCE PAPER; KNOCKOUT MOUSE; PEPTIDE SYNTHESIS; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN DOMAIN; PROTEIN FOLDING; PROTEIN PROTEIN INTERACTION; BINDING SITE; METABOLISM; PHYSIOLOGY; REVIEW; SYNTHESIS;

BINDING SITES; ISOENZYMES; LACTAMS; PEPTIDE LIBRARY; PHORBOL 12,13-DIBUTYRATE; PROTEIN KINASE C; PROTEIN-SERINE-THREONINE KINASES; SUPPORT, NON-U.S. GOV'T; PROTOZOAN PROTEINS;

EID: 0035990921     PISSN: 01637258     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0163-7258(02)00196-1     Document Type: Conference Paper

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