Synthesis, aggregation, and neurotoxicity of the Alzheimer's Aβ1-42 amyloid peptide and its isoaspartyl isomers

Bioorganic and Medicinal Chemistry Letters

Volumn 9, Issue 7, 1999, Pages 953-956

  Fukuda, Hiroyuki ^a   Shimizu, Takahiko ^b   Nakajima, Mitsunari ^b   Mori, Hiroshi ^c   Shirasawa, Takuji ^b  

^a PE Biosystems Japan Ltd   (Japan)

^b TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

^c OSAKA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

Author keywords

amyloid peptide; Aggregation; Alzheimer's disease; Solid phase synthesis

Indexed keywords

AMYLOID BETA PROTEIN; AMYLOID PROTEIN;

ALZHEIMER DISEASE; AMINO ACID COMPOSITION; ARTICLE; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; ISOMERISM; MASS SPECTROMETRY; NERVE CELL NECROSIS; NEUROTOXICITY; NUCLEAR MAGNETIC RESONANCE; PEPTIDE SYNTHESIS; PROTEIN AGGREGATION; PROTEIN PURIFICATION; SOLID PHASE EXTRACTION;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN; ANIMALS; ASPARTIC ACID; CELL SURVIVAL; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; ISOMERISM; MICROSCOPY, ELECTRON; NEURONS; PEPTIDE FRAGMENTS; RATS; RATS, WISTAR; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 0033526118     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0960-894X(99)00121-3     Document Type: Article

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