Synthesis, aggregation, neurotoxicity, and secondary structure of various Aβ1-42 mutants of familial Alzheimer's disease at positions 21-23

Biochemical and Biophysical Research Communications

Volumn 294, Issue 1, 2002, Pages 5-10

  Murakami, Kazuma ^a   Irie, Kazuhiro ^a   Morimoto, Akira ^a   Ohigashi, Hajime ^a   Shindo, Mayumi ^b   Nagao, Masaya ^c   Shimizu, Takahiko ^d   Shirasawa, Takuji ^d  

^a KYOTO UNIVERSITY   (Japan)

^b Applied Biosystems Japan Ltd   (Japan)

^c KYOTO UNIVERSITY   (Japan)

^d TOKYO METROPOLITAN INSTITUTE OF GERONTOLOGY   (Japan)

Author keywords

Alzheimer's disease; Amyloid ; Cerebral amyloid angiopathy; Familial Alzheimer's disease; MTT; PC12; Thioflavin T

Indexed keywords

AMYLOID BETA PROTEIN; ISOPROTEIN; MUTANT PROTEIN;

ALZHEIMER DISEASE; ANALYTIC METHOD; ANIMAL CELL; ANIMAL MODEL; ARTICLE; CELL CULTURE; CELL STRAIN; CONTROLLED STUDY; FAMILIAL DISEASE; MISSENSE MUTATION; NEUROTOXICITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN AGGREGATION; PROTEIN ANALYSIS; PROTEIN FUNCTION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; PROTEIN VARIANT; RAT; VASCULAR AMYLOIDOSIS;

ALZHEIMER DISEASE; AMINO ACID SEQUENCE; AMYLOID BETA-PROTEIN; ANIMALS; CEREBRAL AMYLOID ANGIOPATHY; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; FORMAZANS; HUMANS; MOLECULAR SEQUENCE DATA; PC12 CELLS; PEPTIDE FRAGMENTS; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; RATS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; STRUCTURE-ACTIVITY RELATIONSHIP; THIAZOLES;

EID: 0036288788     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0006-291X(02)00430-8     Document Type: Article

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