Dynamic association of a tumor amplified kinase, Aurora-A, with the centrosome and mitotic spindle

Cell Motility and the Cytoskeleton

Volumn 55, Issue 2, 2003, Pages 134-146

  Stenoien, David L ^a   Sen, S ^b   Mancini, M A ^a   Brinkley, B R ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF TEXAS MD ANDERSON CANCER CENTER   (United States)

Author keywords

Centrosome; FRAP; GFP Aurora A kinase; Mitotic spindle

Indexed keywords

ADENOSINE TRIPHOSPHATE; ALPHA TUBULIN; AURORA A KINASE; GAMMA TUBULIN; GREEN FLUORESCENT PROTEIN; PHOSPHOTRANSFERASE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; BLEACHING; CARBOXY TERMINAL SEQUENCE; CELL NUCLEUS; CELL ULTRASTRUCTURE; CENTROSOME; CHROMOSOME SEGREGATION; CYTOSKELETON; GENE AMPLIFICATION; GENE EXPRESSION; GENE MAPPING; HUMAN; HUMAN CELL; INTERPHASE; MICROTUBULE; MITOSIS; MITOSIS SPINDLE; MOLECULAR DYNAMICS; OSCILLATION; PRIORITY JOURNAL; PROTEIN TARGETING;

ANTIGENS, NUCLEAR; CELL CYCLE PROTEINS; CELL DIVISION; CELL MOVEMENT; CELL TRANSFORMATION, NEOPLASTIC; CENTROSOME; GREEN FLUORESCENT PROTEINS; HELA CELLS; HUMANS; LUMINESCENT PROTEINS; MITOTIC SPINDLE APPARATUS; MUTATION; NEOPLASMS; NUCLEAR MATRIX-ASSOCIATED PROTEINS; NUCLEAR PROTEINS; PROTEIN KINASES; PROTEIN STRUCTURE, TERTIARY; PROTEIN TRANSPORT; PROTEIN-SERINE-THREONINE KINASES; RECOMBINANT FUSION PROTEINS; TUBULIN; XENOPUS PROTEINS;

MAMMALIA;

EID: 0038323936     PISSN: 08861544     EISSN: None     Source Type: Journal    
DOI: 10.1002/cm.10120     Document Type: Article

References (20)

1. Bischoff JR, Anderson L, Zhu Y, Mossie K, Ng L, Souza B, Schryver B, Flanagan P, Clairvoyant F, Ginther C, Chen CS, Novotny M., Slamon DJ, Plowman GD. 1998. A homologue of Drosophila aurora kinase is oncogenic and amplified in human colorectal cancers. EMBO J 17:3052-3065.
2. Brinkley BR, Stubblefield E. 1967. Ulatrastructure and interaction of the kinetochore and centriole in mitosis and meiosis. In: Prescott DM, Golstein L, McConkey E, editors. Advances in cell biology. New York, NY: Appleton-Century-Crofts. p 119-185.
3. Chan CS, Botstein D. 1993. Isolation and characterization of chromosome-gain and increase-in-ploidy mutants in yeast. Genetics 135:677-691.
4. Chen S-S, Chang P-C, Cheng Y-W, Tang F-M, Lin Y-S. 2002. Suppression of the STK15 oncogenic activity requires a transactivation-independent p53 function. EMBO J 21:4491-4499.
5. Giet R, Prigent C. 2001. The non-catalytic domain of the Xenopus laevis aurora kinase localises the proteins to the centrosome. J Cell Sci 114:2095-2104.
6. Goepfert TM, Brinkley BR. 2000. The centrosome-associated aurora/Ip1-like kinase family, vol 49. In: Palazzo RE, Schatten G, editors. San Diego: Academic Press. p 331-342.
7. Goepfert TM, Adigun YE, Zhong L, Gay J, Medina D, Brinkley BR. 2002. Centrosome amplification and overexpression of aurora A are early events in rat mammary carcinogenesis. Cancer Res 62:4115-4122.
8. Hager GL, Lim CS, Elbi C, Baumann CT. 2000. Trafficking of nuclear receptors in living cells. J Steroid Biochem Mol Biol 74:249-254.
9. He D, Zeng C, Brinkley BR. 1995. Nuclear matrix proteins as structural and functional components of the mitotic apparatus, vol. 162B. In: Brezney R, Jeon KW, editors. San Diego: Academic Press. p 1-74.
10. Katayama H, Brinkley WR, Sen S. 2003. The Aurora kinases: role in cell transformation and tumorigenesis. In: Kumar R, editor. Cancer and metastisis reviews. The Netherlands: Kluwer Academic Publishers. Vol 22, p 451-464.
11. Khodjakov A, Rieder CL. 1999. The sudden recruitment of gamma-tubulin to the centrosome at the onset of mitosis and its dynamic exchange throughout the cell cycle, do not require microtubules. J Cell Biol 146:585-596.
12. Misteli T. 2001. Protein dynamics: implications for nuclear architecture and gene expression. Science 291:843-847.
13. Moore MS, Blobel G. 1992. The two steps of nuclear import, targeting to the nuclear envelope and translocation through the nuclear pore, require different cytosolic factors. Cell 69:939-950.
14. Mountain V, Compton DA. 2000. Dissecting the role of molecular motors in the mitotic spindle. Anat Rec 261:14-24.
15. Phair RD, Misteli T. 2000. High mobility of proteins in the mammalian cell nucleus. Nature 404:604-609.
16. Piel M, Meyer P, Khodjakov A, Rieder CL, Bornens M. 2000. The respective contributions of the mother and daughter centrioles to centrosome activity and behavior in vertebrate cells. J Cell Biol 149:317-330.
17. Sen S, Zhou H., Zhang R-D, Yoon DS, Vakar-Lopez F, Ito S, Jiang F, Johnston D, Grossman HB, Ruifrok AC, Katz RL, Brinkley W, Czerniak B. 2002. Amplification/overexpression of a motitic kinase gene in human bladder cancer. J Natl Cancer Inst 94:1320-1328.
18. Stenoien DL, Patel K, Mancini MG, Dutertre M, Smith CL, O'Malley BW, Mancini MA. 2001. FRAP reveals that mobility of oestrogen receptor-alpha is ligand- and proteasome-dependent. Nat Cell Biol 3:15-23.
19. Zheng Y, Jung MK, Oakley BR. 1991. Gamma-tubulin is present in Drosophila melanogaster and Homo sapiens and is associated with the centrosome. Cell 65:817-823.
20. Zhou H, Huang J, Zhong L, Kuo W-L, Gray JW, Sahin A, Brinkley BR, Sen S. 1998. Tumor amplified kinase STK15/BTAK induces centrosome amplification, aneuploidy and transformation. Nat Genet 20:189-193.