Cholesterol-lowering statins possess anti-inflammatory activity that might be useful for treatment of MS

Neurology

Volumn 59, Issue 7, 2002, Pages 970-971

  Zamvil, Scott S ^a   Steinman, Lawrence ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIINFLAMMATORY AGENT; ATORVASTATIN; BETA1 INTERFERON; COMPACTIN; HYPOCHOLESTEROLEMIC AGENT; MEVINOLIN; SIMVASTATIN;

ALLERGIC ENCEPHALOMYELITIS; ANTIINFLAMMATORY ACTIVITY; CELL ACTIVATION; DISEASE SEVERITY; DRUG EFFECT; DRUG POTENCY; DRUG SAFETY; DRUG TOLERABILITY; EDITORIAL; HUMAN; IN VITRO STUDY; MONONUCLEAR CELL; MULTIPLE SCLEROSIS; PRIORITY JOURNAL; T LYMPHOCYTE ACTIVATION;

EID: 0037044249     PISSN: 00283878     EISSN: None     Source Type: Journal    
DOI: 10.1212/WNL.59.7.970     Document Type: Editorial

References (10)

1. Kobashigawa JA, Katznelson S, Laks H, et al. Effect of pravastatin on outcomes after cardiac transplantation. N Engl J Med 1995;333:621-627.
2. Pahan K, Sheikh FG, Namboodiri AM, Singh I. Lovastatin and phenylacetate inhibit the induction of nitric oxide synthase and cytokines in rat primary astrocytes, microglia, and macrophages. J Clin Invest 1997;100:2671-2679.
3. Stuve O, von Budingen H-C, Youssef S, et al. The potential role of HMG-CoA reductase inhibitors in multiple sclerosis therapy. Recent Res Dev Immunol 2002;4:507-521.
4. Steinman L. Multiple sclerosis: a two-stage disease. Nat Immunol 2001;2:762-764.
5. Stanislaus R, Pahan K, Singh AK, Singh I. Amelioration of experimental allergic encephalomyelitis in Lewis rats by lovastatin. Neurosci Lett 1999;269:71-74.
6. Kwak B, Mulhaupt F, Myit S, Mach F. Statins as a newly recognized type of immunomodulator. Nat Med 2000;6:1399-1402.
7. Neuhaus O, Strasser-Fuchs S, Fazekas F, et al. Statins as immunomodulators: comparison with interferonβ-1b in MS. Neurology 2002;59:990-997.
8. Youssef S, Stuve O, Ruiz PJ, Steinman L, Zamvil SS. The HMG-CoA reductase inhibitor, atorvastatin, promotes a Th2 bias, suppresses CNS CIITA expression and reverses paralysis in CNS autoimmune disease. Neurology 2002;58:A384. Abstract.
9. Goldstein JL, Brown MS. Regulation of the mevalonate pathway. Nature 1990;343:425-430.
10. Weitz-Schmidt G, Welzenbach K, Brinkmann V, et al. Statins selectively inhibit leukocyte function antigen-1 by binding to a novel regulatory integrin site. Nat Med 2001;7:687-692.