The C-terminal fragment of the Alzheimer's disease amyloid protein precursor is degraded by a proteasome-dependent mechanism distinct from γ-secretase

European Journal of Biochemistry

Volumn 268, Issue 20, 2001, Pages 5329-5336

  Nunan, Janelle ^a   Shearman, Mark S ^b   Checler, Frédéric ^c   Cappai, Roberto ^a   Evin, Geneviève ^a   Beyreuther, Konrad ^d   Masters, Colin L ^a   Small, David H ^a  

^a UNIVERSITY OF MELBOURNE   (Australia)

^b NEUROSCIENCE RESEARCH CENTRE   (United Kingdom)

^c INSTITUT DE PHARMACOLOGIE MOLÉCULAIRE ET CELLULAIRE   (France)

^d UNIVERSITY OF HEIDELBERG   (Germany)

Author keywords

secretase; A ; Alzheimer's disease; Amyloid; Proteasome

Indexed keywords

AMYLOID PRECURSOR PROTEIN; GAMMA SECRETASE; PROTEASOME; PROTEASOME INHIBITOR;

ALZHEIMER DISEASE; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CELL; BRAIN CORTEX; CARBOXY TERMINAL SEQUENCE; CONTROLLED STUDY; EMBRYO; HUMAN; IMMUNOPRECIPITATION; INCUBATION TIME; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN DOMAIN; TRANSGENE; TRANSGENIC MOUSE;

ALZHEIMER DISEASE; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; BLOTTING, WESTERN; CELLS, CULTURED; CYSTEINE ENDOPEPTIDASES; ENDOPEPTIDASES; HUMANS; MICE; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MULTIENZYME COMPLEXES; NEURONS; PEPTIDE FRAGMENTS; PROTEASE INHIBITORS; PROTEASOME ENDOPEPTIDASE COMPLEX; RECOMBINANT PROTEINS; TIME FACTORS;

EID: 0034797234     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02465.x     Document Type: Article

References (40)

1. The distribution of tangles, plaques and related immunohistochemical markers in healthy ageing and Alzheimer's disease
2. Amyloid plaque core protein in Alzheimer disease and Down syndrome
3. Amyloid β-peptide is produced by cultured cells during normal metabolism
4. Neurotoxicity of a fragment of the amyloid precursor associated with Alzheimer's disease
5. Soluble pool of Aβ amyloid as a determinant of severity of neurodegeneration in Alzheimer's disease
6. The precursor of Alzheimer's disease amyloid A4 protein resembles a cell-surface receptor
7. Regulation of APP cleavage by α, β and γ-secretases
8. Seeding 'one-dimensional crystallization' of amyloid: A pathogenic mechanism in Alzheimer's disease and scrapie?
9. Cellular mechanisms of β-amyloid production and secretion
10. β-secretase cleavage of Alzheimer's amyloid precursor protein by the transmembrane aspartic protease BACE
11. Purification and cloning of amyloid precursor protein β-secretase from human brain
12. A furin-like convertase mediates propeptide cleavage of BACE, the Alzheimer's β-secretase
13. In search of γ-secretase: Presenilin at the cutting edge
14. Photoactivated γ-secretase inhibitors directed to the active site covalently label presenilin 1
15. Calpain inhibitor 1 increases β-amyloid peptide production by inhibiting the degradation of the substrate of γ-secretase
16. Alzheimer's disease: Correlation of the suppression of β-amyloid peptide secretion from cultured cells with inhibition of the chymotrypsin-like activity of the proteasome
17. Specific increase in amyloid β-protein 42 secretion ratio by calpain inhibition
18. A distinct ER/IC γ-secretase competes with the proteasome for cleavage of APP
19. Acetylcholinesterase is increased in the brains of transgenic mice expressing the C-terminal fragment (CT100) of the β-amyloid protein precursor of Alzheimer's disease
20. Characterization of new polyclonal antibodies specific for 40 and 42 amino acid-long amyloid β-peptides: Their use to examine the cell biology of presenilins and the immunohistochemistry of sporadic Alzheimer's disease and cerebral amyloid angiopathy case
21. Processing of the Alzheimer's disease amyloid precursor protein in pichia pastoris: Immunodetection of α-, β-, and γ-secretase products
22. Analysis of heterogeneous βA4 peptides in human cerebrospinal fluid and blood by a newly developed sensitive western blot assay
23. Subcellular localization of the Alzheimer's disease amyloid precursor protein and derived polypeptides expressed in a recombinant yeast system
24. Expression of human amyloid precursor protein ectodomains in Pichia pastoris: Analysis of culture conditions, purification and characterization
25. Intracellular accumulation of detergent-soluble amyloidogenic Aβ fragment of Alzheimer's disease precursor psotein in the hippocampus of aged transgenic mice
26. Membrane inserted APP fragments containing the βA4 sequence of Alzheimer's disease do not aggregate
27. The Alzheimer's disease amyloid precursor protein modulates copper-induced toxicity and oxidative stress in primary neuronal cultures
28. Cleavage of structural proteins during the assembly of the head of the bacteriophage T4
29. Intracellular production of βA4 amyloid of Alzheimer's disease: Modulation by phosphoramidon and lack of coupling to the secretion of the amyloid precursor protein
30. Constitutive and protein kinase C-regulated secretory cleavage of Alzheimer's β-amyloid precursor protein: Different control of early and late events by the proteasome
31. Proteasome contributes to the α-secretase pathway of amyloid precursor protein in human cells
32. Aβ-generating enzymes: Recent advances in β- and γ-secretase research
33. Amyloid precursor protein metabolism in primary cell cultures of neurons, astrocytes and microglia
34. Processing of amyloid precursor protein in human primary neuron and astrocyte cultures
35. Turnover of amyloid β-protein in mouse brain and acute reduction of its level by phorbol ester
36. Intracellular accumulation of β-amyloid in cells expressing the Swedish mutant amyloid precursor protein
37. Potentially amyloidogenic, carboxyl-terminal derivatives of the amyloid protein precursor
38. The proteasome
39. Impaired proteasome function in Alzheimer's disease
40. Inhibition of the ubiquitin-proteasome system in Alzheimer's disease