Statins cause intracellular accumulation of amyloid precursor protein, β-secretase-cleaved fragments, and amyloid β-peptide via an isoprenoid-dependent mechanism

Journal of Biological Chemistry

Volumn 280, Issue 19, 2005, Pages 18755-18770

  Cole, Sarah L ^a   Grudzien, Aneta ^a   Manhart, Ingrid O ^a   Kelly, Brent L ^a   Oakley, Holly ^a   Vassar, Robert ^a  

^a NORTHWESTERN UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ALCOHOLS; CHOLESTEROL; DISEASES; GENETIC ENGINEERING; POLYPEPTIDES;

AMYLOID PRECURSOR PROTEIN (APP); ISOPRENOIDS; NONSTEROL ISOPRONOIDS;

PROTEINS;

AMYLOID BETA PROTEIN; AMYLOID PRECURSOR PROTEIN; BETA SECRETASE; CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; ISOPRENOID; MEVINOLIN; SIMVASTATIN; ASPARTIC PROTEINASE; BACE1 PROTEIN, HUMAN; BACE1 PROTEIN, MOUSE; ENZYME INHIBITOR; PROTEINASE; SECRETASE; TERPENE;

ADENOVIRUS; ALZHEIMER DISEASE; ANIMAL CELL; ARTICLE; ASTROCYTE; CONTROLLED STUDY; DRUG EFFECT; EMBRYO; HUMAN; HUMAN CELL; IMMUNOCYTOCHEMISTRY; MOUSE; NERVE CELL CULTURE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN PROCESSING; PROTEIN SECRETION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VIRUS INFECTION; ANIMAL; BIOLOGICAL MODEL; CELL CULTURE; CELL LINE; CHEMISTRY; DOSE RESPONSE; ENDOCYTOSIS; ENZYME LINKED IMMUNOSORBENT ASSAY; FLUORESCENCE MICROSCOPY; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; IN VITRO STUDY; METABOLISM; NERVE CELL; TIME; TRANSPORT AT THE CELLULAR LEVEL;

ADENOVIRIDAE; AMYLOID BETA-PROTEIN; AMYLOID BETA-PROTEIN PRECURSOR; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ASPARTIC ENDOPEPTIDASES; ASTROCYTES; BIOLOGICAL TRANSPORT; CELL LINE; CELLS, CULTURED; CHOLESTEROL; DOSE-RESPONSE RELATIONSHIP, DRUG; ENDOCYTOSIS; ENDOPEPTIDASES; ENZYME INHIBITORS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; IMMUNOBLOTTING; IMMUNOHISTOCHEMISTRY; MICE; MICROSCOPY, FLUORESCENCE; MODELS, BIOLOGICAL; NEURONS; PROTEIN ISOPRENYLATION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TERPENES; TIME FACTORS;

EID: 21444445440     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M413895200     Document Type: Article

References (71)

1. Glenner, G. G., and Wong, C. W. (1984) Biochem. Biophys. Res. Commun. 120, 885-890
2. Masters, C. L., Multhaup, G., Simms, G., Pottigiesser, J., Martins, R. N., and Beyreuther, K. (1985) EMBO J. 4, 2757-2763
3. Younkin, S. G. (1998) J. Physiol. Paris 92, 289-292
4. Selkoe, D. J. (2001) Physiol. Rev. 81, 741-766
5. Gouras, G. K., Tsai, J., Naslund, J., Vincent, B., Edgar, M., Checler, F., Greenfield, J. P., Haroutunian, V., Buxbaum, J. D., Xu, H., Greengard, P., and Relkin, N. R. (2000) Am. J. Pathol. 156, 15-20
6. Blasko, I., Veerhuis, R., Stampfer-Kountchev, M., Saurwein-Teissl, M., Eikelenboom, P., and Grubeck-Loebenstein, B. (2000) Neurobiol. Dis. 7, 682-689
7. Nilsberth, C., Westlind-Danielsson, A., Eckman, C. B., Condron, M. M., Axelman, K., Forsell, C., Stenh, C., Luthman, J., Teplow, D. B., Younkin, S. G., Naslund, J., and Lannfelt, L. (2001) Nat. Neurosci. 4, 887-893
8. Takahashi, R. H., Milner, T. A., Li, F., Nam, E. E., Edgar, M. A., Yamaguchi, H., Beal, M. F., Xu, H., Greengard, P., and Gouras, G. K. (2002) Am. J. Pathol. 161, 1869-1879
9. Takahashi, R. H., Almeida, C. G., Kearney, P. F., Yu, F., Lin, M. T., Milner, T. A., and Gouras, G. K. (2004) J. Neurosci. 24, 3592-3599
10. Gyure, K. A., Durham, R., Stewart, W. F., Smialek, J. E., and Troncoso, J. C. (2001) Arch. Pathol. Lab. Med. 125, 489-492
11. Mori, C., Spooner, E. T., Wisniewsk, K. E., Wisniewski, T. M., Yamaguch, H., Saido, T. C., Tolan, D. R., Selkoe, D. J., and Lemere, C. A. (2002) Amyloid 9, 88-102
12. Busciglio, J., Pelsman, A., Wong, C., Pigino, G., Yuan, M., Mori, H., and Yankner, B. A. (2002) Neuron 33, 677-688
13. Oddo, S., Caccamo, A., Shepherd, J. D., Murphy, M. P., Golde, T. E., Kayed, R., Metherate, R., Mattson, M. P., Akbari, Y., and LaFerla, F. M. (2003) Neuron 39, 409-421
14. Schmitz, C., Rutten, B. P., Pielen, A., Schafer, S., Wirths, O., Tremp, G., Czech, C., Blanchard, V., Multhaup, G., Rezaie, P., Korr, H., Steinbusch, H. W., Pradier, L., and Bayer, T. A. (2004) Am. J. Pathol. 164, 1495-1502
15. Cataldo, A. M., Petanceska, S., Terio, N. B., Peterhoff, C. M., Durham, R., Mercken, M., Mehta, P. D., Buxbaum, J., Haroutunian, V., and Nixon, R. A. (2004) Neurobiol. Aging 25, 1263-1272
16. Vassar, R. (2004) J. Mol. Neurosci. 23, 105-114
17. Sisodia, S. S., Kim, S. H., and Thinakaran, G. (1999) Am. J. Hum. Genet. 65, 7-12
18. Vassar, R., Bennett, B. D., Babu-Khan, S., Kahn, S., Mendiaz, E. A., Denis, P., Teplow, D. B., Ross, S., Amarante, P., Loeloff, R., Luo, Y., Fisher, S., Fuller, J., Edenson, S., Lue, J., Jarosinski, M. A., Biere, A. L., Curran, E., Burgess, T., Louis, J.-C., Collins, F., Treanor, J., Rogers, G., and Citron, M. (1999) Science 286, 735-741
19. Skovronsky, D. M., Moore, D. B., Milla, M. E., Doms, R. W., and Lee, V. M. (2000) J. Biol. Chem. 275, 2568-2575
20. Jarvik, G. P., Wijsman, E. M., Kukull, W. A., Schellenberg, G. D., Yu, C., and Larson, E. B. (1995) Neurology 45, 1092-1096
21. Kivipelto, M., Helkala, E. L., Laakso, M. P., Hanninen, T., Hallikainen, M., Alhainen, K., Iivonen, S., Mannermaa, A., Tuomilehto, J., Nissinen, A., and Soininen, H. (2002) Ann. Intern. Med. 137, 149-155
22. Kuo, Y. M., Emmerling, M. R., Bisgaier, C. L., Essenburg, A. D., Lampert, H. C., Drumm, D., and Roher, A. E. (1998) Biochem. Biophys. Res. Commun. 252, 711-715
23. Hofman, A., Ott, A., Breteler, M. M., Bots, M. L., Slooter, A. J., van Harskamp, F., van Duijn, C. N., Van Broeckhoven, C., and Grobbee, D. E. (1997) Lancet 349, 151-154
24. Honig, L. S., Tang, M. X., Albert, S., Costa, R., Luchsinger, J., Manly, J., Stern, Y., and Mayeux, R. (2003) Arch. Neurol. 60, 1707-1712
25. Luchsinger, J. A., Tang, M. X., Stern, Y., Shea, S., and Mayeux, R. (2001) AM. J. Epidemiol. 154, 635-641
26. McIlroy, S. P., Dynan, K. B., Lawson, J. T., Patterson, C. C., and Passmore, A. P. (2002) Stroke 33, 2351-2356
27. Knebl, J., DeFazio, P., Clearfield, M. B., Little, L., McConathy, W. J., McPherson, R., and Lacko, A. G. (1994) Mech. Ageing Dev. 73, 69-77
28. Wolozin, B., Kellman, W., Ruosseau, P., Celesia, G. G., and Siegel, G. (2000) Arch. Neurol. 57, 1439-1443
29. Jick, H., Zornberg, G. L., Jick, S. S., Seshadri, S., and Drachman, D. A. (2000) Lancet 356, 1627-1631
30. Werner, N., Nickenig, G., and Laufs, U. (2002) Basic Res. Cardiol. 97, 105-116
31. Mason, J. C. (2003) Clin. Sci. (Lond.) 105, 251-266
32. Bi, X., Baudry, M., Liu, J., Yao, Y., Fu, L., Brucher, F., and Lynch, G. (2004) J. Biol. Chem. 279, 48238-48245
33. Kato, T., Hashikabe, H., Iwata, C., Akimoto, K., and Hattori, Y. (2004) Biochim. Biophys. Acta 1689, 267-272
34. Simons, M., Keller, P., De Strooper, B., Beyreuther, K., Dotti, C. G., and Simons, K. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6460-6464
35. Frears, E. R., Stephens, D. J., Walters, C. E., Davies, H., and Austen, B. M. (1999) Neuroreport 10, 1699-1705
36. Buxbaum, J. D., Geoghagen, N. S., and Friedhoff, L. T. (2001) J. Alzheimers Dis. 3, 221-229
37. Fassbender, K., Simons, M., Bergmann, C., Stroick, M., Lutjohann, D., Keller, P., Runz, H., Kuhl, S., Bertsch, T., von Bergmann, K., Hennerici, M., Beyreuther, K., and Hartmann, T. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5856-5861
38. Kojro, E., Gimpl, G., Lammich, S., Marz, W., and Fahrenholz, F. (2001) Proc. Natl. Acad. Sci. U. S. A. 98, 5815-5820
39. Ehehalt, R., Keller, P., Haass, C., Thiele, C., and Simons, K. (2003) J. Cell Biol. 160, 113-123
40. Bodovitz, S., and Klein, W. L. (1996) J. Biol. Chem. 271, 4436-4440
41. Racchi, M., Baetta, R., Salvietti, N., Ianna, P., Franceschini, G., Paoletti, R., Fumagalli, R., Govoni, S., Trabucchi, M., and Soma, M. (1997) Biochem. J. 322, 893-898
42. Galbete, J. L., Martin, T. R., Peressini, E., Modena, P., Bianchi, R., and Forloni, G. (2000) Biochem. J. 348, 307-313
43. Puglielli, L., Konopka, G., Pack-Chung, E., Ingano, L. A., Berezovska, O., Hyman, B. T., Chang, T. Y., Tanzi, R. E., and Kovacs, D. M. (2001) Nat. Cell Biol. 3, 905-912
44. Runz, H., Rietdorf, J., Tomic, I., de Bernard, M., Beyreuther, K., Pepperkok, R., and Hartmann, T. (2002) J. Neurosci. 22, 1679-1689
45. Burns, M., Gaynor, K., Olm, V., Mercken, M., LaFrancois, J., Wang, L., Mathews, P. M., Noble, W., Matsuoka, Y., and Duff, K. (2003) J. Neurosci. 23, 5645-5649
46. Jin, L. W., Maezawa, I., Vincent, I., and Bird, T. (2004) Am. J. Pathol. 164, 975-985
47. Yamazaki, T., Chang, T. Y., Haass, C., and Ihara, Y. (2001) J. Biol. Chem. 276, 4454-4460
48. Ross, S. L., Martin, F., Simonet, L., Jacobsen, F., Deshpande, R., Vassar, R., Bennett, B., Luo, Y., Wooden, S., Hu, S., Citron, M., and Burgess, T. L. (1998) J. Biol. Chem. 273, 15309-15312
49. He, T.-C., Zhou, S., da Costa, L. T., Yu, J., Kinzler, K. W., and Vogelstein, B. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 2509-2514
50. Goslin, K., and Banker, G. A. (1991) Rat Hippocampal Neurons in Low Density Culture, MIT Press, Cambridge, MA
51. Hsiao, K. K., Borchelt, D. R., Olson, K., Johannsdottir, R., Kitt, C., Yunis, W., Xu, S., Eckman, C., Younkin, S., Price, D., Iadecole, C., Clark, H. B., and Carlson, G. (1995) Neuron 15, 1203-1218
52. Meske, V., Albert, F., Richter, D., Schwarze, J., and Ohm, T. G. (2003) Eur. J. Neurosci. 17, 93-102
53. Heider, J. G., and Boyett, R. L. (1978) J. Lipid Res. 19, 514-518
54. Brown, M. S., and Goldstein, J. L. (1980) J. Lipid Res. 21, 505-517
55. Goldstein, J. L., and Brown, M. S. (1990) Nature 343, 425-430
56. Keller, P., and Simons, K. (1998) J. Cell Biol. 140, 1357-1367
57. Rodal, S. K., Skretting, G., Garred, O., Vilhardt, F., van Deurs, B., and Sandvig, K. (1999) Mol. Biol. Cell 10, 961-974
58. Slunt, H. H., Thinakaran, G., Von Koch, C., Lo, A. C., Tanzi, R. E., and Sisodia, S. S. (1994) J. Biol. Chem. 269, 2637-2644
59. Oltersdorf, T., Ward, P. J., Henriksson, T., Beattie, E. C., Neve, R., Lieberburg, I., and Fritz, L. C. (1990) J. Biol. Chem. 265, 4492-4497
60. Nordstedt, C., Gandy, S. E., Alafuzoff, I., Caporaso, G. L., Iverfeldt, K., Grebb, J. A., Winblad, B., and Greengard, P. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 8910-8914
61. Hsiao, K., Chapman, P., Nilsen, S., Eckman, C., Harigaya, Y., Younkin, S., Yang, F., and Cole, G. (1996) Science 274, 99-103
62. Kim, S. H., Yin, Y. I., Li, Y. M., and Sisodia, S. S. (2004) J. Biol. Chem. 279, 48615-48619
63. Skovronsky, D. M., Doms, R. W., and Lee, V. M. (1998) J. Cell Biol. 141, 1031-1039
64. Vicent, D., Maratos-Flier, E., and Kahn, C. R. (2000) Mol. Cell. Biol. 20, 2158-2166
65. Ridley, A. J. (2001) Traffic 2, 303-310
66. Farnsworth, C. C., Gelb, M. H., and Glomset, J. A. (1990) Science 247, 320-322
67. Epstein, W. W., Lever, D., Leining, L. M., Bruenger, E., and Rilling, H. C. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 9668-9670
68. Rilling, H. C., Breunger, E., Epstein, W. W., and Crain, P. F. (1990) Science 247, 318-320
69. Dugan, J. M., deWit, C., McConlogue, L., and Maltese, W. A. (1995) J. Biol. Chem. 270, 10982-10989
70. McConlogue, L., Castellano, F., deWit, C., Schenk, D., and Maltese, W. A. (1996) J. Biol. Chem. 271, 1343-1348
71. Cordy, J., M., Hussain, I., Dingwall, C., Hooper, N. M., and Turner, A. J. (2003) Proc. Natl. Acad. Sci. U. S. A. 100, 11735-11740