Chitosan nanoparticles for oral drug and gene delivery

International Journal of Nanomedicine

Volumn 1, Issue 2, 2006, Pages 117-128

  Bowman, Katherine ^a   Leong, Kam W ^a  

^a Johns Hopkins University   (United States)

Author keywords

Chitosan; Nanoparticles; Oral delivery

Indexed keywords

CHITOSAN; DRUG; NANOPARTICLE;

CHEMISTRY; DRUG DELIVERY SYSTEM; GENE TARGETING; METHODOLOGY; NANOMEDICINE; ORAL DRUG ADMINISTRATION; REVIEW; ULTRASTRUCTURE;

ADMINISTRATION, ORAL; CHITOSAN; DRUG DELIVERY SYSTEMS; GENE TARGETING; NANOMEDICINE; NANOPARTICLES; PHARMACEUTICAL PREPARATIONS;

EID: 34548630860     PISSN: 11769114     EISSN: 11782013     Source Type: Journal    
DOI: 10.2147/nano.2006.1.2.117     Document Type: Review

References (72)

1. Allemann E, Leroux J-C, Gurny R. 1998. Polymeric nano-and microparticles for the oral delivery of peptides and peptidomimetics. Adv Drug Deliv Rev, 34:171-89.
2. Artursson P, Lindmark T, Davis SS, et al. 1994. Effect of chitosan on the permeability of monolayers of intestinal epithelial cells (Caco-2). Pharm Res, 11:1358-61.
3. Bacon A, Makin J, Sizer PJ, et al. 2000. Carbohydrate biopolymers enhance antibody responses to mucosally delivered vaccine antigens. Infect Immun, 68:5764-70.
4. Behrens I, Pena AI, Alonso MJ, et al. 2002. Comparative uptake studies of bioadhesive and non-bioadhesive nanoparticles in human intestinal cell lines and rats: the effect of mucus on particle adsorption and transport. Pharm Res, 19:1185-93.
5. Bernkop-Schnürch A, Krajicek ME. 1998. Mucoadhesive polymers as platforms for peroral peptide delivery and absorption: synthesis and evaluation of different chitosan-EDTA conjugates. J Control Release, 50:215-23.
6. Bernkop-Schnürch A, Scerbe-Saiko A. 1998. Synthesis and in vitro evaluation of chitosan-EDTA-protease-inhibitor conjugates which might be useful in oral delivery of peptides and proteins. Pharm Res, 15:263-9.
7. Bernkop-Schnürch A. 2000. Chitosan and its derivatives: potential excipients for peroral peptide delivery systems. Int J Pharm, 194:1-13.
8. Bernkop-Schnürch A, Kast CE, Guggi D. 2003. Permeation enhancing polymers in oral delivery of hydrophilic macromolecules: thiomer/GSH systems. J Control Release, 93:95-103.
9. Bernkop-Schnürch A, Guggi D, Pinter Y. 2004. Thiolated chitosans: development and in vitro evaluation of a mucoadhesive, permeation enhancing oral drug delivery system. J Control Release, 94:177-86.
10. Bivas-Benita M, Laloup M, Versteyhe S, et al. 2003. Generation of Toxoplasma gondii GRA1 protein and DNA vaccine loaded chitosan particles: preparation, characterization, and preliminary in vivo studies. Int J Pharm, 266:17-27.
11. Bowman K, Sarkar R, Raut S, et al. 2005. Oral delivery of non-viral DNA nanoparticles for hemophilia A. American Society of Gene Therapy, 8th Annual Meeting [abstract]. Mol Ther, 11(Suppl 1). Abs 779.
12. Chellat F, Grandjean-Laquerriere A, Le Naour R, et al. 2005. Metalloproteinase and cytokine production by THP-1 macrophages following exposure to chitosan-DNA nanoparticles. Biomaterials, 26:961-70.
13. Chen J, Yang WL, Li G, et al. 2004. Transfection of mEpo gene to intestinal epithelium in vivo mediated by oral delivery of chitosan-DNA nanoparticles. World J Gastroenterol, 10:112-16.
14. Cheung CY, Murthy N, Stayton PS, et al. 2001. A pH-sensitive polymer that enhances cationic lipid-mediated gene transfer. Bioconjug Chem, 12:906-10.
15. Chew JL, Wolfowicz CB, Mao HQ, et al. 2003. Chitosan nanoparticles containing plasmid DNA encoding house dust mite allergen, Der p 1 for oral vaccination in mice. Vaccine, 21:2720-9.
16. Clark MA, Jepson MA, Hirst BH. 2001. Exploiting M cells for drug and vaccine delivery. Adv Drug Deliv Rev, 50:81-106.
17. Deacon MP, McGurk S, Roberts CJ, et al. 2000. Atomic force microscopy of gastric mucin and chitosan mucoadhesive systems. Biochem J, 348:557-63.
18. Desai MP, Labhasetwar V, Amidon GL, et al. 1996. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm Res, 13:1838-45.
19. Desai MP, Labhasetwar V, Walter E, et al. 1997. The mechanism of uptake of biodegradable microparticles in Caco-2 cells is size dependent. Pharm Res, 14:1568-73.
20. Dhawan S, Singla AK, Sinha VR. 2004. Evaluation of mucoadhesive properties of chitosan microspheres prepared by different methods. AAPS PharmSciTech, 5 article 67:1-7.
21. Dodane V, Khan MA, Merwin JR. 1999. Effect of chitosan on epithelial permeability and structure. Int J Pharm, 182:21-32.
22. Eldridge JH, Hammond CJ, Meulbroek JA, et al. 1990. Controlled vaccine release in the gut-associated lymphoid tissues. I. Orally administered biodegradable microspheres target the Peyer's patches. J Control Release, 11:205-14.
23. El-Shabouri MH. 2002. Positively charged nanoparticles for improving the oral bioavailability of cyclosporin-A. Int J Pharm, 249:101-8.
24. Fang N, Chan V, Mao H-Q, et al. 2001. Interactions of phospholipid bilayer with chitosan: effect of molecular weight and pH. Biomacromolecules, 2:1161-8.
25. Fernandez-Urrusuno R, Calvo P, Remunan-Lopez C, et al. 1999. Enhancement of nasal absorption of insulin using chitosan nanoparticles. Pharm Res, 16:1576-81.
26. Gao S, Chen J, Xu X, et al. 2003. Galactosylated low molecular weight chitosan as DNA carrier for hepatocyte-targeting. Int J Pharm, 255:57-68.
27. Goldberg M, Gomez-Orellana I. 2003. Challenges for the oral delivery of macromolecules. Nat Rev Drug Discov, 2:289-95.
28. Hejazi R, Amiji M. 2003. Chitosan-based gastrointestinal delivery systems. J Control Release, 89:151-65.
29. Hirano S. 1996. Chitin biotechnology applications. Biotechnol Annu Rev, 2:237-58.
30. Huang M, Fong CW, Khor E, et al. 2005. Transfection efficiency of chitosan vectors: Effect of polymer molecular weight and degree of deacetylation. J Control Release, 106:391-406.
31. Jepson MA, Clark MA, Foster N, et al. 1996. Targeting to intestinal M cells. J Anat, 189:507-16.
32. Kafedjiiski K, Hoffer M, Werle M, et al. 2006. Improved synthesis and in vitro characterization of chitosan-thioethylamidine conjugate. Biomaterials, 27:127-35.
33. Kiang T, Wen J, Lim HW, et al. 2004. The effect of the degree of chitosan deacetylation on the efficiency of gene transfection. Biomaterials, 25:5293-301.
34. Kiang T, Bright C, Cheung CY, et al. 2004. Formulation of chitosan-DNA nanoparticles with poly(propyl acrylic acid) enhances gene expression. Biomater Sci Polym Ed, 15:1405-21.
35. Kim TH, Park IK, Nah JW, et al. 2004. Galactosylated chitosan/DNA nanoparticles prepared using water-soluble chitosan as a gene carrier. Biomaterials, 25:3783-92.
36. Kim TH, Kim SI, Akaike T, et al. 2005. Synergistic effect of poly(ethylenimine) on the transfection efficiency of galactosylated chitosan/DNA complexes. J Control Release, 105:354-66.
37. Kockisch S, Rees GD, Young SA, et al. 2003. Polymeric microspheres for drug delivery to the oral cavity: an in vitro evaluation of mucoadhesive potential. J Pharm Sci, 92:1614-23.
38. Köping-Höggård M, Vårum KM, Issa M, et al. 2004. Improved chitosan-mediated gene delivery based on easily dissociated chitosan polyplexes of highly defined chitosan oligomers. Gene Ther, 11:1441-52.
39. Kotzé AF, Thanou MM, LueBen HL, et al. 1999. Enhancement of paracellular drug transport with highly quaternized N-trimethyl chitosan chloride in neutral environments: in vitro evaluation in intestinal epithelial cells (Caco-2). J Pharm Sci, 88:253-7.
40. Krieg AM. 2001. Immune effects and mechanisms of action of CpG motifs. Vaccine, 19:618-22.
41. Leitner WW, Ying H, Restifo NP. 2000. DNA and RNA-based vaccines: principles, progress and prospects. Vaccine, 18:765-77.
42. Leong KW, Mao HQ, Truong-Le VL, et al. 1998. DNA-polycation nanospheres as non-viral gene delivery vehicles. J Control Release, 53:183-93.
43. Liu W, Sun S, Cao Z, et al. 2005. An investigation on the physicochemical properties of chitosan/DNA polyelectrolyte complexes. Biomaterials, 26:2705-11.
44. LueBen HL, de Leeuw BJ, Langemeyer MW, et al. 1996. Mucoadhesive polymers in peroral peptide drug delivery. VI. Carbomer and chitosan improve the intestinal absorption of the peptide drug buserelin in vivo. Pharm Res, 13:1668-72.
45. LueBen HL, de Leeuw BJ, Langemeyer MW, et al. 1997. Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro. J Control Release, 45:15-23.
46. Ma Z, Lim L-Y. 2003. Uptake of chitosan and associated insulin in Caco-2 cell monolayers: a comparison between chitosan molecules and chitosan nanoparticles. Pharm Res, 20:1812-19.
47. Ma Z, Lim TM, Lim L-Y. 2005. Pharmacological activity of peroral chitosan-insulin nanoparticles in diabetic rats. Int J Pharm, 293:271-80.
48. MacLaughlin FC, Mumper RJ, Wang J, et al. 1998. Chitosan and depolymerized chitosan oligomers as condensing carriers for in vivo plasmid delivery. J Control Release, 56:259-72.
49. Mao H-Q, Roy K, Troung-Le VL, et al. 2001. Chitosan-DNA nanoparticles as gene carriers: synthesis, characterization and transfection efficiency. J Control Release, 70:399-421.
50. Mao S, Shuai X, Unger F, et al. 2004. The depolymerization of chitosan: effects on physicochemical and biological properties. Int J Pharm, 281:45-54.
51. Neutra MR, Phillips TL, Mayer EL, et al. 1987. Transport of membrane-bound macromolecules by M cells in follicle-associated epithelium of rabbit Peyer's patch. Cell Tissue Res, 247:537-46.
52. Okoli G, Hortelano G, Leong KW. 2000. Oral delivery of plasmid DNA encoding the factor IX gene [abstract]. Proceed Intl Symp Control Rel Bioact Mater, 27. Abs 234.
53. Otterlei M, Vårum KM, Ryan L, et al. 1994. Characterization of binding and TNF-A-inducing ability of chitosans on monocytes: the involvement of CD14. Vaccine, 12:825-32.
54. Pan Y, Li YJ, Zhao HY, et al. 2002. Bioadhesive polysaccharide in protein delivery system: chitosan nanoparticles improve the intestinal absorption of insulin in vivo. Int J Pharm, 249:139-47.
55. Prego C, Garcia M, Torres D, et al. 2005. Transmucosal macromolecular drug delivery. J Control Release, 101:151-62.
56. Ren D, Yi H, Wang W, et al. 2005. The enzymatic degradation and swelling properties of chitosan matrices with different degrees of N-acetylation. Carbohydr Res, 340:2403-10.
57. Roy K, Mao HQ, Huang SK, et al. 1999. Oral gene delivery with chitosan--DNA nanoparticles generates immunologic protection in a murine model of peanut allergy. Nat Med, 5:387-91.
58. Schipper NG, Vårum KM, Artursson P. 1996. Chitosans as absorption enhancers for poorly absorbable drugs. 1: Influence of molecular weight and degree of acetylation on drug transport across human intestinal epithelial (Caco-2) cells. Pharm Res, 13:1686-92.
59. Schipper NG, Olsson S, Hoogstraate JA, et al. 1997. Chitosans as absorption enhancers for poorly absorbable drugs 2: mechanism of absorption enhancement. Pharm Res, 14:923-9.
60. Schipper NG, Vårum KM, Stenberg P, et al. 1999. Chitosans as absorption enhancers of poorly absorbable drugs. 3: Influence of mucus on absorption enhancement. Eur J Pharm Sci, 8:335-43.
61. Sheu E, Rothman S, German M, et al. 2003. The "Gene Pill" and its therapeutic applications. Curr Opin Mol Ther, 5:420-7.
62. Shibata Y, Foster LA, Metzger WJ, et al. 1997. Alveolar macrophage priming by intravenous administration of chitin particles, polymers of N-acetyl-D-glucosamine, in mice. Infect Immun, 65:1734-41.
63. Singla AK, Chawla M. 2001. Chitosan: some pharmaceutical and biological aspects-an update. J Pharm Pharmacol, 53:1047-67.
64. Snyman D, Hamman JH, Kotzé AF. 2003. Evaluation of the mucoadhesive properties of N-trimethyl chitosan chloride. Drug Dev Ind Pharm, 29:61-9.
65. Takeuchi H, Matsui Y, Sugihara H, et al. 2005. Effectiveness of submicron-sized, chitosan-coated liposomes in oral administration of peptide drugs. Int J Pharm, 303:160-70.
66. Thanou M, Verhoef JC, Marbach P, et al. 2000. Intestinal absorption of octreotide: N-trimethyl chitosan chloride (TMC) ameliorates the permeability and absorption properties of the somatostatin analogue in vitro and in vivo. J Pharm Sci, 89:951-7.
67. Thanou M, Verhoef JC, Junginger HE. 2001. Chitosan and its derivatives as intestinal absorption enhancers. Adv Drug Deliv Rev, 50:S91-101.
68. Thanou M, Verhoef JC, Verheijden JHM, et al. 2001. Intestinal absorption of octreotide using trimethyl chitosan chloride: studies in pigs. Pharm Res, 18:823-8.
69. van der Merwe SM, Verhoef JC, Verheijden JHM, et al. 2004. Trimethylated chitosan as polymeric absorption enhancer for improved peroral delivery of peptide drugs. Eur J Pharm Biopharm, 58:225-35.
70. Wang J, Tauchi Y, Deguchi Y, et al. 2000. Positively charged gelatin microspheres as gastric mucoadhesive drug delivery system for eradication of H. pylori. Drug Deliv, 7:237-43.
71. Zhang H, Neau SH. 2001. In vitro degradation of chitosan by a commercial enzyme preparation: effect of molecular weight and degree of deacetylation. Biomaterials, 22:1653-8.
72. Zhang H, Neau SH. 2002. In vitro degradation of chitosan by bacterial enzymes from rat cecal and colonic contents. Biomaterials, 23:2761-6.