메뉴 건너뛰기




Volumn 34, Issue 2-3, 1998, Pages 171-189

Polymeric nano- and microparticles for the oral delivery of peptides and peptidomimetics

Author keywords

In vivo studies; Microparticles; Nanoparticles; Oral administration; Peptides; Peptidomimetics

Indexed keywords

ABSORPTION; BIODEGRADATION; BIOPOLYMERS; ENCAPSULATION; NANOSTRUCTURED MATERIALS; PARTICLES (PARTICULATE MATTER); PROTEINS;

EID: 0141830659     PISSN: 0169409X     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0169-409X(98)00039-8     Document Type: Review
Times cited : (240)

References (67)
  • 1
    • 0030271533 scopus 로고    scopus 로고
    • Co-polymerised peptide particles. II: Oral uptake of a novel co-polymeric nanoparticulate delivery system for peptides
    • Hillery A.M., Toth I., Florence A.T. Co-polymerised peptide particles. II: oral uptake of a novel co-polymeric nanoparticulate delivery system for peptides. J. Control. Release. 42:1996;65-73.
    • (1996) J. Control. Release , vol.42 , pp. 65-73
    • Hillery, A.M.1    Toth, I.2    Florence, A.T.3
  • 3
    • 0030948511 scopus 로고    scopus 로고
    • Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon
    • Szentkuti L. Light microscopical observations on luminally administered dyes, dextrans, nanospheres and microspheres in the pre-epithelial mucus gel layer of the rat distal colon. J. Control. Release. 46:1997;233-242.
    • (1997) J. Control. Release , vol.46 , pp. 233-242
    • Szentkuti, L.1
  • 4
    • 0029360440 scopus 로고
    • Selective transport of microparticles across Peyer's patch follicle-associated M cells from mice and rats
    • Smith M.W., Thomas N.W., Jenkins P.G., Miller N.G.A., Cremaschi D., Porta C. Selective transport of microparticles across Peyer's patch follicle-associated M cells from mice and rats. Exp. Physiol. 80:1995;735-743.
    • (1995) Exp. Physiol. , vol.80 , pp. 735-743
    • Smith, M.W.1    Thomas, N.W.2    Jenkins, P.G.3    Miller, N.G.A.4    Cremaschi, D.5    Porta, C.6
  • 5
    • 0025674686 scopus 로고
    • Nanoparticle uptake by the rat gastrointestinal mucosa: Quantitation and particle size dependency
    • Jani P., Halbert W., Langridge J., Florence A.T. Nanoparticle uptake by the rat gastrointestinal mucosa: quantitation and particle size dependency. J. Pharm. Pharmacol. 42:1990;821-826.
    • (1990) J. Pharm. Pharmacol. , vol.42 , pp. 821-826
    • Jani, P.1    Halbert, W.2    Langridge, J.3    Florence, A.T.4
  • 6
    • 0030467140 scopus 로고    scopus 로고
    • Bioadhesion of lectin-latex conjugates to rat intestinal mucosa
    • Irache J.M., Durrer C., Duchêne D., Ponchel G. Bioadhesion of lectin-latex conjugates to rat intestinal mucosa. Pharm. Res. 13:1996;1716-1719.
    • (1996) Pharm. Res. , vol.13 , pp. 1716-1719
    • Irache, J.M.1    Durrer, C.2    Duchêne, D.3    Ponchel, G.4
  • 7
    • 0029053808 scopus 로고
    • Factors affecting the oral uptake and translocation of polystyrene nanoparticles: Histological and analytical evidence
    • Florence A.T., Hillery A.M., Hussain N.A., Jani P.U. Factors affecting the oral uptake and translocation of polystyrene nanoparticles: histological and analytical evidence. J. Drug Targeting. 3:1995;65-70.
    • (1995) J. Drug Targeting , vol.3 , pp. 65-70
    • Florence, A.T.1    Hillery, A.M.2    Hussain, N.A.3    Jani, P.U.4
  • 8
    • 0029092672 scopus 로고
    • Nanoparticles as carriers for oral peptide absorption: Studies on particle uptake and fate
    • Florence A.T., Hillery A.M., Hussain N., Jani P.U. Nanoparticles as carriers for oral peptide absorption: studies on particle uptake and fate. J. Control. Release. 36:1995;39-46.
    • (1995) J. Control. Release , vol.36 , pp. 39-46
    • Florence, A.T.1    Hillery, A.M.2    Hussain, N.3    Jani, P.U.4
  • 9
    • 0030471901 scopus 로고    scopus 로고
    • Gastrointestinal uptake of biodegradable microparticles: Effect of particle size
    • Desai M.P., Labhasetwar V.D., Amidon G.L., Levy R.J. Gastrointestinal uptake of biodegradable microparticles: effect of particle size. Pharm. Res. 13:1996;1838-1845.
    • (1996) Pharm. Res. , vol.13 , pp. 1838-1845
    • Desai, M.P.1    Labhasetwar, V.D.2    Amidon, G.L.3    Levy, R.J.4
  • 10
    • 0030465871 scopus 로고    scopus 로고
    • The intestinal uptake of particles and the implications for drug and antigen delivery
    • O'Hagan D.T. The intestinal uptake of particles and the implications for drug and antigen delivery. J. Anat. 189:1996;477-482.
    • (1996) J. Anat. , vol.189 , pp. 477-482
    • O'Hagan, D.T.1
  • 11
    • 0030993565 scopus 로고    scopus 로고
    • The oral absorption of micro- And nanoparticulates: Neither exceptional nor unusual
    • Florence A.T. The oral absorption of micro- and nanoparticulates: neither exceptional nor unusual. Pharm. Res. 14:1997;259-266.
    • (1997) Pharm. Res. , vol.14 , pp. 259-266
    • Florence, A.T.1
  • 12
    • 0027432534 scopus 로고
    • Drug loaded nanoparticles - Preparation methods and drug targeting issues
    • Allémann E., Gurny R., Doelker E. Drug loaded nanoparticles - preparation methods and drug targeting issues. Eur. J. Pharm. Biopharm. 39:1993;173-191.
    • (1993) Eur. J. Pharm. Biopharm. , vol.39 , pp. 173-191
    • Allémann, E.1    Gurny, R.2    Doelker, E.3
  • 13
    • 0028283741 scopus 로고
    • Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: Protection against proteases and effect on intestinal absorption in rats
    • Lowe P.J., Temple C.S. Calcitonin and insulin in isobutylcyanoacrylate nanocapsules: protection against proteases and effect on intestinal absorption in rats. J. Pharm. Pharmacol. 46:1994;547-552.
    • (1994) J. Pharm. Pharmacol. , vol.46 , pp. 547-552
    • Lowe, P.J.1    Temple, C.S.2
  • 14
    • 0029833171 scopus 로고    scopus 로고
    • A new nanocapsule formulation with hydrophilic core: Application to the oral administration of salmon calcitonin
    • Vranckx H., Demoustier M., Deleers M. A new nanocapsule formulation with hydrophilic core: application to the oral administration of salmon calcitonin. Eur. J. Pharm. Biopharm. 42:1996;345-347.
    • (1996) Eur. J. Pharm. Biopharm. , vol.42 , pp. 345-347
    • Vranckx, H.1    Demoustier, M.2    Deleers, M.3
  • 18
    • 0017030409 scopus 로고
    • Polymerized micelles and their use as adjuvants in immunology
    • Birrenbach G., Speiser P.P. Polymerized micelles and their use as adjuvants in immunology. J. Pharm. Sci. 65:1976;1763-1766.
    • (1976) J. Pharm. Sci. , vol.65 , pp. 1763-1766
    • Birrenbach, G.1    Speiser, P.P.2
  • 22
    • 0029851440 scopus 로고    scopus 로고
    • Tissue concentration of nanoencapsulated radiolabelled cyclosporin following peroral delivery in mice or ophthalmic applications in rabbits
    • Bonduelle S., Carrier M., Pimienta C., Benoît J.P., Lenaerts V. Tissue concentration of nanoencapsulated radiolabelled cyclosporin following peroral delivery in mice or ophthalmic applications in rabbits. Eur. J. Pharm. Biopharm. 42:1996;313-319.
    • (1996) Eur. J. Pharm. Biopharm. , vol.42 , pp. 313-319
    • Bonduelle, S.1    Carrier, M.2    Pimienta, C.3    Benoît, J.P.4    Lenaerts, V.5
  • 23
    • 0026557844 scopus 로고
    • Association of cyclosporin to isohexylcyanoacrylate nanospheres and subsequent release in human plasma in vitro
    • Bonduelle S., Foucher C., Leroux J.C., Chouinard F., Cadieux C., Lenaerts V. Association of cyclosporin to isohexylcyanoacrylate nanospheres and subsequent release in human plasma in vitro. J. Microencapsulation. 9:1992;173-182.
    • (1992) J. Microencapsulation , vol.9 , pp. 173-182
    • Bonduelle, S.1    Foucher, C.2    Leroux, J.C.3    Chouinard, F.4    Cadieux, C.5    Lenaerts, V.6
  • 24
    • 0030021931 scopus 로고    scopus 로고
    • Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement
    • Molpeceres J., Guzman M., Aberturas M.R., Chacon M., Berges L. Application of central composite designs to the preparation of polycaprolactone nanoparticles by solvent displacement. J. Pharm. Sci. 85:1996;206-213.
    • (1996) J. Pharm. Sci. , vol.85 , pp. 206-213
    • Molpeceres, J.1    Guzman, M.2    Aberturas, M.R.3    Chacon, M.4    Berges, L.5
  • 27
    • 0028931757 scopus 로고
    • Body distribution in mice of intravenously injected radiolabelled cyclosporin associated with polyisohexylcyanoacrylate nanocapsules or nanospheres
    • Bonduelle S., Pimienta C., Benoît J.P., Lenaerts V. Body distribution in mice of intravenously injected radiolabelled cyclosporin associated with polyisohexylcyanoacrylate nanocapsules or nanospheres. Eur. J. Pharm. Biopharm. 41:1995;27-30.
    • (1995) Eur. J. Pharm. Biopharm. , vol.41 , pp. 27-30
    • Bonduelle, S.1    Pimienta, C.2    Benoît, J.P.3    Lenaerts, V.4
  • 29
    • 0020386375 scopus 로고
    • The production and evaluation of orally administered insulin nanoparticles
    • Oppenheim R.C., Stewart N.F., Gordon L., Patel H.M. The production and evaluation of orally administered insulin nanoparticles. Drug Dev. Ind. Pharm. 8:1982;531-546.
    • (1982) Drug Dev. Ind. Pharm. , vol.8 , pp. 531-546
    • Oppenheim, R.C.1    Stewart, N.F.2    Gordon, L.3    Patel, H.M.4
  • 30
    • 0023856501 scopus 로고
    • New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carriers
    • Damgé C., Michel C., Aprahamian M., Couvreur P. New approach for oral administration of insulin with polyalkylcyanoacrylate nanocapsules as drug carriers. Diabetes. 37:1988;246-251.
    • (1988) Diabetes , vol.37 , pp. 246-251
    • Damgé, C.1    Michel, C.2    Aprahamian, M.3    Couvreur, P.4
  • 31
    • 0027467644 scopus 로고
    • Enteral insulin delivery by microspheres in 3 different formulations using Eudragit L100 and S100
    • Morishita I., Morishita M., Takayama K., Machida Y., Nagai T. Enteral insulin delivery by microspheres in 3 different formulations using Eudragit L100 and S100. Int. J. Pharm. 91:1993;29-37.
    • (1993) Int. J. Pharm. , vol.91 , pp. 29-37
    • Morishita, I.1    Morishita, M.2    Takayama, K.3    MacHida, Y.4    Nagai, T.5
  • 32
    • 0026789983 scopus 로고
    • Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats
    • Morishita I., Morishita M., Takayama K., Machida Y., Nagai T. Hypoglycemic effect of novel oral microspheres of insulin with protease inhibitor in normal and diabetic rats. Int. J. Pharm. 78:1992;9-16.
    • (1992) Int. J. Pharm. , vol.78 , pp. 9-16
    • Morishita, I.1    Morishita, M.2    Takayama, K.3    MacHida, Y.4    Nagai, T.5
  • 33
    • 0026796246 scopus 로고
    • Novel oral microspheres of insulin with protease inhibitor protecting from enzymatic degradation
    • Morishita M., Morishita I., Takayama K., Machida Y., Nagai T. Novel oral microspheres of insulin with protease inhibitor protecting from enzymatic degradation. Int. J. Pharm. 78:1992;1-7.
    • (1992) Int. J. Pharm. , vol.78 , pp. 1-7
    • Morishita, M.1    Morishita, I.2    Takayama, K.3    MacHida, Y.4    Nagai, T.5
  • 35
    • 0025893083 scopus 로고
    • Controlled release microspheres based on Eudragit L100 for the oral administration of erythromycin
    • Morishita I., Morishita M., Machida Y., Nagai T. Controlled release microspheres based on Eudragit L100 for the oral administration of erythromycin. Drug Design Delivery. 7:1991;309-319.
    • (1991) Drug Design Delivery , vol.7 , pp. 309-319
    • Morishita, I.1    Morishita, M.2    MacHida, Y.3    Nagai, T.4
  • 37
    • 0030249065 scopus 로고    scopus 로고
    • Co-polymerised particles (CPP). I: Synthesis, characterization and in vitro studies on a novel oral nanoparticulate delivery system
    • Hillery A.M., Toth I., Shaw A.J., Florence A.T. Co-polymerised particles (CPP). I: synthesis, characterization and in vitro studies on a novel oral nanoparticulate delivery system. J. Control. Release. 41:1996;271-281.
    • (1996) J. Control. Release , vol.41 , pp. 271-281
    • Hillery, A.M.1    Toth, I.2    Shaw, A.J.3    Florence, A.T.4
  • 39
    • 0025978571 scopus 로고
    • Anti-metastatic activity in vivo of MDP-L-alanyl-cholesterol (MTP-chol) entrapped in nanocapsules
    • Yu W.P., Barratt G.M., Devissaguet J.P., Puisieux F. Anti-metastatic activity in vivo of MDP-L-alanyl-cholesterol (MTP-chol) entrapped in nanocapsules. Int. J. Immunopharmacol. 13:1991;167-173.
    • (1991) Int. J. Immunopharmacol. , vol.13 , pp. 167-173
    • Yu, W.P.1    Barratt, G.M.2    Devissaguet, J.P.3    Puisieux, F.4
  • 40
    • 0022978050 scopus 로고
    • Etude et mise au point d'un procédé original de préparation de nanocapsules de polyalkylcyanoacrylates par polymérisation interfaciale
    • Al-Khouri N., Fessi H., Roblot-Treupel L., Devissaguet J.P., Puisieux F. Etude et mise au point d'un procédé original de préparation de nanocapsules de polyalkylcyanoacrylates par polymérisation interfaciale. Pharm. Acta Helv. 61:1986;274-281.
    • (1986) Pharm. Acta Helv. , vol.61 , pp. 274-281
    • Al-Khouri, N.1    Fessi, H.2    Roblot-Treupel, L.3    Devissaguet, J.P.4    Puisieux, F.5
  • 42
    • 0025301733 scopus 로고
    • Intestinal transit of bioadhesive microspheres in an in situ loop in the rat - A comparative study with copolymers and blends based on poly(acrylic acid)
    • Lehr C.M., Bouwstra J.A., Tukker J.J., Junginger H.E. Intestinal transit of bioadhesive microspheres in an in situ loop in the rat - a comparative study with copolymers and blends based on poly(acrylic acid). J. Control. Release. 13:1990;51-62.
    • (1990) J. Control. Release , vol.13 , pp. 51-62
    • Lehr, C.M.1    Bouwstra, J.A.2    Tukker, J.J.3    Junginger, H.E.4
  • 43
    • 0026579208 scopus 로고
    • The HIV-1 protease as a therapeutic target for AIDS
    • Debouck C. The HIV-1 protease as a therapeutic target for AIDS. AIDS Res. Hum. Retroviruses. 8:1992;153-164.
    • (1992) AIDS Res. Hum. Retroviruses , vol.8 , pp. 153-164
    • Debouck, C.1
  • 44
    • 0028850112 scopus 로고
    • Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice
    • Leroux J.C., Cozens R., Roesel J.L., Galli B., Kubel F., Doelker E., Gurny R. Pharmacokinetics of a novel HIV-1 protease inhibitor incorporated into biodegradable or enteric nanoparticles following intravenous and oral administration to mice. J. Pharm. Sci. 84:1995;1387-1391.
    • (1995) J. Pharm. Sci. , vol.84 , pp. 1387-1391
    • Leroux, J.C.1    Cozens, R.2    Roesel, J.L.3    Galli, B.4    Kubel, F.5    Doelker, E.6    Gurny, R.7
  • 45
    • 0029962749 scopus 로고    scopus 로고
    • PH-sensitive nanoparticles: An effective means to improve the oral delivery of HIV-1 protease inhibitors in dogs
    • Leroux J.C., Cozens R., Roesel J.L., Galli B., Doelker E., Gurny R. pH-sensitive nanoparticles: an effective means to improve the oral delivery of HIV-1 protease inhibitors in dogs. Pharm. Res. 13:1996;485-487.
    • (1996) Pharm. Res. , vol.13 , pp. 485-487
    • Leroux, J.C.1    Cozens, R.2    Roesel, J.L.3    Galli, B.4    Doelker, E.5    Gurny, R.6
  • 46
    • 0027133051 scopus 로고
    • In vitro sustained release properties of drug loaded poly(D,L-lactic acid) nanoparticles produced by a salting-out procedure
    • Allémann E., Leroux J.C., Gurny R., Doelker E. In vitro sustained release properties of drug loaded poly(D,L-lactic acid) nanoparticles produced by a salting-out procedure. Pharm. Res. 10:1993;1732-1737.
    • (1993) Pharm. Res. , vol.10 , pp. 1732-1737
    • Allémann, E.1    Leroux, J.C.2    Gurny, R.3    Doelker, E.4
  • 48
    • 0030895312 scopus 로고    scopus 로고
    • Protease inhibitors in patients with HIV diseases. Clinically important pharmacokinetic considerations
    • Barry M., Gibbons S., Back D., Mulcahy F. Protease inhibitors in patients with HIV diseases. Clinically important pharmacokinetic considerations. Clin. Pharmacokinet. 32:1997;194-209.
    • (1997) Clin. Pharmacokinet. , vol.32 , pp. 194-209
    • Barry, M.1    Gibbons, S.2    Back, D.3    Mulcahy, F.4
  • 49
    • 0027730286 scopus 로고
    • HIV-1 protease inhibitors: Development, status, and potential role in the treatment of AIDS
    • Lang M., Roesel J.L. HIV-1 protease inhibitors: development, status, and potential role in the treatment of AIDS. Arch. Pharm. 326:1993;921-924.
    • (1993) Arch. Pharm. , vol.326 , pp. 921-924
    • Lang, M.1    Roesel, J.L.2
  • 51
    • 0027413508 scopus 로고
    • HIV protease inhibitors: Their anti-HIV activity and potential role in treatment
    • Robins T., Plattner J. HIV protease inhibitors: their anti-HIV activity and potential role in treatment. J. Acquired Immune Defic. Syndr. 6:1993;162-170.
    • (1993) J. Acquired Immune Defic. Syndr. , vol.6 , pp. 162-170
    • Robins, T.1    Plattner, J.2
  • 53
    • 0029073966 scopus 로고
    • PH-dependent oral absorption of L-735,524 a potent HIV protease inhibitor, in rats and dogs
    • Lin J.H., Chen I.W., Vastag K.J., Ostovic D. pH-dependent oral absorption of L-735,524 a potent HIV protease inhibitor, in rats and dogs. Drug Metab. Dispos. 23:1995;730-735.
    • (1995) Drug Metab. Dispos. , vol.23 , pp. 730-735
    • Lin, J.H.1    Chen, I.W.2    Vastag, K.J.3    Ostovic, D.4
  • 54
    • 0029063841 scopus 로고
    • Absorption of new HIV-1 protease inhibitor, KNI-272, after intraduodenal and intragastric administrations to rats: Effect of solvent
    • Sugahara M., Kiriyama A., Hamada Y., Kiso Y., Takada K. Absorption of new HIV-1 protease inhibitor, KNI-272, after intraduodenal and intragastric administrations to rats: effect of solvent. Biopharm. Drug Dispos. 16:1995;269-277.
    • (1995) Biopharm. Drug Dispos. , vol.16 , pp. 269-277
    • Sugahara, M.1    Kiriyama, A.2    Hamada, Y.3    Kiso, Y.4    Takada, K.5
  • 55
    • 0022966767 scopus 로고
    • Disposition kinetics and oral bioavailability of vicamine-loaded polyalkyl cyanoacrylate nanoparticles
    • Maincent P., Le Verge R., Sado P., Couvreur P., Devissaguet J.P. Disposition kinetics and oral bioavailability of vicamine-loaded polyalkyl cyanoacrylate nanoparticles. J. Pharm. Sci. 75:1986;955-958.
    • (1986) J. Pharm. Sci. , vol.75 , pp. 955-958
    • Maincent, P.1    Le Verge, R.2    Sado, P.3    Couvreur, P.4    Devissaguet, J.P.5
  • 57
    • 0028277952 scopus 로고
    • Improved peroral delivery of avarol with polybutylcyanoacrylate nanoparticles
    • Beck P.H., Kreuter J., Müller W.E.G., Schatton W. Improved peroral delivery of avarol with polybutylcyanoacrylate nanoparticles. Eur. J. Pharm. Biopharm. 40:1994;134-137.
    • (1994) Eur. J. Pharm. Biopharm. , vol.40 , pp. 134-137
    • Beck, P.H.1    Kreuter, J.2    Müller, W.E.G.3    Schatton, W.4
  • 58
    • 0029950793 scopus 로고    scopus 로고
    • Influence of coating agents on the degradation of poly(D,L-lactic acid) nanoparticles in model digestive fluids (USP XXII)
    • Landry F.B., Bazile D.V., Spenlehauer G., Veillard M., Kreuter J. Influence of coating agents on the degradation of poly(D,L-lactic acid) nanoparticles in model digestive fluids (USP XXII). Stp Pharma Sci. 6:1996;195-202.
    • (1996) Stp Pharma Sci. , vol.6 , pp. 195-202
    • Landry, F.B.1    Bazile, D.V.2    Spenlehauer, G.3    Veillard, M.4    Kreuter, J.5
  • 59
    • 0028203956 scopus 로고
    • 14C]poly(DL-lactide-co-glycolide) nanoparticles after intravenous and oral administration to mice
    • 14C]poly(DL-lactide-co-glycolide) nanoparticles after intravenous and oral administration to mice. Int. J. Pharm. 106:1994;201-211.
    • (1994) Int. J. Pharm. , vol.106 , pp. 201-211
    • Le Ray, A.M.1    Vert, M.2    Gauthier, J.C.3    Benoît, J.P.4
  • 60
    • 0028203990 scopus 로고
    • Controlled-release coevaporates of dipyridamole with acrylic polymers
    • Beten D.B., Moës A.J. Controlled-release coevaporates of dipyridamole with acrylic polymers. Int. J. Pharm. 103:1994;243-251.
    • (1994) Int. J. Pharm. , vol.103 , pp. 243-251
    • Beten, D.B.1    Moës, A.J.2
  • 62
    • 0029928882 scopus 로고    scopus 로고
    • Oral absorption improvement of poorly soluble drug using solid dispersion technique
    • Kai T., Akiyama Y., Nomura S., Sato M. Oral absorption improvement of poorly soluble drug using solid dispersion technique. Chem. Pharm. Bull. 44:1996;568-571.
    • (1996) Chem. Pharm. Bull. , vol.44 , pp. 568-571
    • Kai, T.1    Akiyama, Y.2    Nomura, S.3    Sato, M.4
  • 65
    • 0026685650 scopus 로고
    • Encapsulation of insulin for oral administration preserves interaction of the hormone with its receptor in vitro
    • Roques M., Damgé C., Michel C., Staedel C., Crémel G., Hubert P. Encapsulation of insulin for oral administration preserves interaction of the hormone with its receptor in vitro. Diabetes. 41:1992;451-456.
    • (1992) Diabetes , vol.41 , pp. 451-456
    • Roques, M.1    Damgé, C.2    Michel, C.3    Staedel, C.4    Crémel, G.5    Hubert, P.6
  • 66
    • 0028891177 scopus 로고
    • Biological effects of encapsulated insulin on transfected Chinese hamster ovary cells
    • Roques M., Crémel G., Hubert P. Biological effects of encapsulated insulin on transfected Chinese hamster ovary cells. Diabetologia. 38:1995;180-186.
    • (1995) Diabetologia , vol.38 , pp. 180-186
    • Roques, M.1    Crémel, G.2    Hubert, P.3
  • 67
    • 0026074310 scopus 로고
    • The effect of site of administration in the gastrointestinal tract on the absorption of insulin from nanocapsules in diabetic rats
    • Michel C., Aprahamian M., Defontaine L., Couvreur P., Damgé C. The effect of site of administration in the gastrointestinal tract on the absorption of insulin from nanocapsules in diabetic rats. J. Pharm. Pharmacol. 43:1991;1-5.
    • (1991) J. Pharm. Pharmacol. , vol.43 , pp. 1-5
    • Michel, C.1    Aprahamian, M.2    Defontaine, L.3    Couvreur, P.4    Damgé, C.5


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.