Mucoadhesive polymers in peroral peptide drug delivery. IV. Polycarbophil and chitosan are potent enhancers of peptide transport across intestinal mucosae in vitro

Journal of Controlled Release

Volumn 45, Issue 1, 1997, Pages 15-23

  Luessen H L ^a,d   Rentel, C O ^a   Kotze A F ^b   Lehr, C M ^c   De Boer, A G ^a   Verhoef, J C ^a   Junginger, H E ^a  

^a LEIDEN UNIVERSITY   (Netherlands)

^b NORTH WEST UNIVERSITY   (South Africa)

^c SAARLAND UNIVERSITY   (Germany)

^d LTS Lohmann Therapie Systeme AG   (Germany)

Author keywords

Caco 2 cell monolayers; Chitosan; Intestinal loop model; Mucoadhesion; Peroral peptide drug delivery; Poly(acrylate; Polycarbophil

Indexed keywords

ARGIPRESSIN[DEGLYCINAMIDE]; CHITOSAN; CHITOSAN DERIVATIVE; CHITOSAN GLUTAMATE; DAICHITOSAN; NOVEON; PENETRATION ENHANCING AGENT; POLYCARBOPHIL; SEACURE; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CELL STRAIN CACO 2; DRUG DELIVERY SYSTEM; HUMAN; HUMAN CELL; IN VITRO STUDY; INTESTINE ABSORPTION; INTESTINE MUCOSA; MALE; NONHUMAN; ORAL DRUG ADMINISTRATION; PRIORITY JOURNAL; RAT;

EID: 0031018133     PISSN: 01683659     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0168-3659(96)01536-2     Document Type: Article

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