Reductive monoalkylation of aromatic amines via amidine intermediates

Synlett

Volumn , Issue 5, 2001, Pages 643-645

  Zhang, Jianxing ^a   Chang, Hui Min ^a   Kane, Robert R ^a  

^a BAYLOR UNIVERSITY   (United States)

Author keywords

Adenosine; Amidine; Amine; Cytidine; Monoalkylation; Nucleoside

Indexed keywords

AMIDINE; AROMATIC AMINE; NUCLEOSIDE;

ALKYLATION; ARTICLE; CATALYSIS; DEACYLATION; INTERMETHOD COMPARISON; METHYLATION; REDUCTION; SYNTHESIS;

EID: 0035036562     PISSN: 09365214     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2001-13378     Document Type: Article

References (17)

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6. 3 (9:1:0.05). 6-N-Methyladenosine (156 mg, 0.56 mmol, 85%, 56% overall) was obtained as an amorphous white solid. For non-nucleosidic substrates dichloromethane was used to wash the precipitate in the final step.
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16. 3 (9:1:0.05) as eluent. 6-N-methyladenosine (177 mg, 0.63 mmol, 63%) was obtained. For non-nucleosidic substrates dichloromethane was used in the final extraction.
17. Overall yields are excellent (>90%) if corrected for recovered starting materials, which accounts for the majority of the missing mass balance.