메뉴 건너뛰기




Volumn 14, Issue 2, 2003, Pages 477-490

Chemical genetic analysis of Apg1 reveals a non-kinase role in the induction of autophagy

Author keywords

[No Author keywords available]

Indexed keywords

AMINOPEPTIDASE I; MEMBRANE PROTEIN; NITROGEN; PROTEIN APG1; PROTEIN KINASE; UNCLASSIFIED DRUG;

EID: 0037329201     PISSN: 10591524     EISSN: None     Source Type: Journal    
DOI: 10.1091/mbc.E02-07-0413     Document Type: Article
Times cited : (139)

References (41)
  • 1
    • 0033231275 scopus 로고    scopus 로고
    • A t-SNARE/Sec1p complex composed of Tlg2p and Vps45p is required for cytoplasm to vacuole targeting of aminopeptidase I
    • Abeliovich, H., Darsow, T., and Emr, S.D. (1999). A t-SNARE/Sec1p complex composed of Tlg2p and Vps45p is required for cytoplasm to vacuole targeting of aminopeptidase I. EMBO J. 18, 6005-6016.
    • (1999) EMBO J. , vol.18 , pp. 6005-6016
    • Abeliovich, H.1    Darsow, T.2    Emr, S.D.3
  • 2
    • 0034722378 scopus 로고    scopus 로고
    • Dissection of autophagosome biogenesis into distinct nucleation and expansion steps
    • Abeliovich, H., Dunn, W.A., Jr., Kim, J., and Klionsky, D.J. (2000). Dissection of autophagosome biogenesis into distinct nucleation and expansion steps. J. Cell Biol. 151, 1025-1033.
    • (2000) J. Cell Biol. , vol.151 , pp. 1025-1033
    • Abeliovich, H.1    Dunn W.A., Jr.2    Kim, J.3    Klionsky, D.J.4
  • 3
    • 0032496164 scopus 로고    scopus 로고
    • Tlg2p, a yeast syntaxin homolog that resides on the Golgi and Endocytic structures
    • Abeliovich, H., Grote, E., Novick, P., and Ferro-Novick, S. (1998). Tlg2p, a yeast syntaxin homolog that resides on the Golgi and Endocytic structures. J. Biol. Chem. 273, 11719-11727.
    • (1998) J. Biol. Chem. , vol.273 , pp. 11719-11727
    • Abeliovich, H.1    Grote, E.2    Novick, P.3    Ferro-Novick, S.4
  • 4
    • 0034820160 scopus 로고    scopus 로고
    • Autophagy in yeast: Mechanistic insights and physiological function
    • Abeliovich, H., and Klionsky, D.J. (2001). Autophagy in yeast: mechanistic insights and physiological function. Microbiol. Mol. Biol. Rev. 65, 463-479.
    • (2001) Microbiol. Mol. Biol. Rev. , vol.65 , pp. 463-479
    • Abeliovich, H.1    Klionsky, D.J.2
  • 5
    • 0031417385 scopus 로고    scopus 로고
    • Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome
    • Baba, M., Osumi, M., Scott, S.V., Klionsky, D.J., and Ohsumi, Y. (1997). Two distinct pathways for targeting proteins from the cytoplasm to the vacuole/lysosome. J. Cell Biol. 139, 1687-1695.
    • (1997) J. Cell Biol. , vol.139 , pp. 1687-1695
    • Baba, M.1    Osumi, M.2    Scott, S.V.3    Klionsky, D.J.4    Ohsumi, Y.5
  • 7
    • 0034699382 scopus 로고    scopus 로고
    • A chemical switch for inhibitor-sensitive alleles of any protein kinase
    • Bishop, A.C. et al. (2000). A chemical switch for inhibitor-sensitive alleles of any protein kinase. Nature 407, 395-401.
    • (2000) Nature , vol.407 , pp. 395-401
    • Bishop, A.C.1
  • 8
    • 0033518610 scopus 로고    scopus 로고
    • Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach
    • Bishop, A.C., Kung, C.-y. Shah, K., Witucki, L., Shokat, K.M., and Liu, Y. (1999). Generation of monospecific nanomolar tyrosine kinase inhibitors via a chemical genetic approach. J. Am. Chem. Soc. 121, 627-631.
    • (1999) J. Am. Chem. Soc. , vol.121 , pp. 627-631
    • Bishop, A.C.1    Kung, C.-Y.2    Shah, K.3    Witucki, L.4    Shokat, K.M.5    Liu, Y.6
  • 9
    • 0025363276 scopus 로고
    • Studies on the mechanisms of autophagy: Formation of the autophagic vacuole
    • Dunn, W.A., Jr. (1990a). Studies on the mechanisms of autophagy: formation of the autophagic vacuole. J. Cell Biol. 110, 1923-1933.
    • (1990) J. Cell Biol. , vol.110 , pp. 1923-1933
    • Dunn W.A., Jr.1
  • 10
    • 0025340880 scopus 로고
    • Studies on the mechanism of autophagy: Maturation of the autophagic vacuole
    • Dunn, W.A., Jr. (1990b). Studies on the mechanism of autophagy: maturation of the autophagic vacuole. J. Cell Biol. 110, 1935-1945.
    • (1990) J. Cell Biol. , vol.110 , pp. 1935-1945
    • Dunn W.A., Jr.1
  • 11
    • 0030919092 scopus 로고    scopus 로고
    • Analyses of APG13 gene involved in autophagy in yeast Saccharomyces cerevisiae
    • Funakoshi, T., Matsuura, A., Noda, T., and Ohsumi, Y. (1997). Analyses of APG13 gene involved in autophagy in yeast Saccharomyces cerevisiae. Gene 192, 207-213.
    • (1997) Gene , vol.192 , pp. 207-213
    • Funakoshi, T.1    Matsuura, A.2    Noda, T.3    Ohsumi, Y.4
  • 12
    • 0032546925 scopus 로고    scopus 로고
    • The vesicle transport protein Vps33p is an ATP-binding protein that localizes to the cytosol in an energy-dependent manner
    • Gerhardt, B., Kordas, T.J., Thompson, C.M., Patel, P., and Vida, T. (1998). The vesicle transport protein Vps33p is an ATP-binding protein that localizes to the cytosol in an energy-dependent manner. J. Biol. Chem. 273, 15818-15829.
    • (1998) J. Biol. Chem. , vol.273 , pp. 15818-15829
    • Gerhardt, B.1    Kordas, T.J.2    Thompson, C.M.3    Patel, P.4    Vida, T.5
  • 13
    • 0029953575 scopus 로고    scopus 로고
    • Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway
    • Harding, T.M., Hefner-Gravink, A., Thumm, M., and Klionsky, D.J. (1996). Genetic and phenotypic overlap between autophagy and the cytoplasm to vacuole protein targeting pathway. J. Biol. Chem. 271, 17621-17624.
    • (1996) J. Biol. Chem. , vol.271 , pp. 17621-17624
    • Harding, T.M.1    Hefner-Gravink, A.2    Thumm, M.3    Klionsky, D.J.4
  • 14
    • 0028800171 scopus 로고
    • Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway
    • Harding, T.M., Morano, K.A., Scott, S.V., and Klionsky, D.J. (1995). Isolation and characterization of yeast mutants in the cytoplasm to vacuole protein targeting pathway. J. Cell Biol. 131, 591-602.
    • (1995) J. Cell Biol. , vol.131 , pp. 591-602
    • Harding, T.M.1    Morano, K.A.2    Scott, S.V.3    Klionsky, D.J.4
  • 15
    • 0037050004 scopus 로고    scopus 로고
    • Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry
    • Ho, Y. et al. (2002). Systematic identification of protein complexes in Saccharomyces cerevisiae by mass spectrometry. Nature 415, 180-183.
    • (2002) Nature , vol.415 , pp. 180-183
    • Ho, Y.1
  • 16
    • 0034050457 scopus 로고    scopus 로고
    • The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways
    • Huang, W.-P., Scott, S.V., Kim, J., and Klionsky, D.J. (2000). The itinerary of a vesicle component, Aut7p/Cvt5p, terminates in the yeast vacuole via the autophagy/Cvt pathways. J. Biol. Chem. 275, 5845-5851.
    • (2000) J. Biol. Chem. , vol.275 , pp. 5845-5851
    • Huang, W.-P.1    Scott, S.V.2    Kim, J.3    Klionsky, D.J.4
  • 18
    • 0030455820 scopus 로고    scopus 로고
    • Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast
    • James, P., Halladay, J., and Craig, E.A. (1996). Genomic libraries and a host strain designed for highly efficient two-hybrid selection in yeast. Genetics 144, 1425-1436.
    • (1996) Genetics , vol.144 , pp. 1425-1436
    • James, P.1    Halladay, J.2    Craig, E.A.3
  • 19
  • 20
    • 0033791650 scopus 로고    scopus 로고
    • Autophagy, cytoplasm-to vacuole targeting pathway, and pexophagy in yeast and mammalian cells
    • Kim, J., and Klionsky, D.J. (2000). Autophagy, cytoplasm-to vacuole targeting pathway, and pexophagy in yeast and mammalian cells. Annu. Rev. Biochem. 69, 303-342.
    • (2000) Annu. Rev. Biochem. , vol.69 , pp. 303-342
    • Kim, J.1    Klionsky, D.J.2
  • 21
    • 0035897414 scopus 로고    scopus 로고
    • Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole
    • Kim, J. et al. (2001). Cvt9/Gsa9 functions in sequestering selective cytosolic cargo destined for the vacuole. J. Cell Biol. 153, 381-396.
    • (2001) J. Cell Biol. , vol.153 , pp. 381-396
    • Kim, J.1
  • 23
    • 0026640551 scopus 로고
    • Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway
    • Klionsky, D.J., Cueva, R., and Yaver, D.S. (1992). Aminopeptidase I of Saccharomyces cerevisiae is localized to the vacuole independent of the secretory pathway. J. Cell Biol. 119, 287-299.
    • (1992) J. Cell Biol. , vol.119 , pp. 287-299
    • Klionsky, D.J.1    Cueva, R.2    Yaver, D.S.3
  • 24
    • 0034537290 scopus 로고    scopus 로고
    • Autophagy as a regulated pathway of cellular degradation
    • Klionsky, D.J., and Emr, S.D. (2000). Autophagy as a regulated pathway of cellular degradation. Science. 290, 1717-1721.
    • (2000) Science , vol.290 , pp. 1717-1721
    • Klionsky, D.J.1    Emr, S.D.2
  • 25
    • 0032008085 scopus 로고    scopus 로고
    • Engineering Src family protein kinases with unnatural nucleotide specificity
    • Liu, Y., Shah, K., Yang, F., Witucki, L., and Shokat, K.M. (1998). Engineering Src family protein kinases with unnatural nucleotide specificity. Chem. Biol. 5, 91-101.
    • (1998) Chem. Biol. , vol.5 , pp. 91-101
    • Liu, Y.1    Shah, K.2    Yang, F.3    Witucki, L.4    Shokat, K.M.5
  • 26
    • 0031820288 scopus 로고    scopus 로고
    • Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae
    • Longtine, M.S., McKenzie, A., Demarini, D.J., Shah, N.G., Wach, A., Brachat, A., Phillipsen, P., and Pringle, J.R. (1998). Additional modules for versatile and economical PCR-based gene deletion and modification in Saccharomyces cerevisiae. Yeast 14, 953-961.
    • (1998) Yeast , vol.14 , pp. 953-961
    • Longtine, M.S.1    McKenzie, A.2    Demarini, D.J.3    Shah, N.G.4    Wach, A.5    Brachat, A.6    Phillipsen, P.7    Pringle, J.R.8
  • 27
    • 0026356891 scopus 로고
    • Predicting coiled coils from protein sequences
    • Lupas, A., Van Dyke, M., and Stock, J. (1991). Predicting coiled coils from protein sequences. Science 252, 1162-1164.
    • (1991) Science , vol.252 , pp. 1162-1164
    • Lupas, A.1    Van Dyke, M.2    Stock, J.3
  • 28
    • 0030983504 scopus 로고    scopus 로고
    • Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae
    • Matsuura, A., Tsukada, M., Wada, Y., and Ohsumi, Y. (1997). Apg1p, a novel protein kinase required for the autophagic process in Saccharomyces cerevisiae. Gene 192, 245-250.
    • (1997) Gene , vol.192 , pp. 245-250
    • Matsuura, A.1    Tsukada, M.2    Wada, Y.3    Ohsumi, Y.4
  • 29
    • 0014105804 scopus 로고
    • Tables for estimating sedimentation through linear concentration gradients of sucrose solution
    • McEwen, C.R. (1967). Tables for estimating sedimentation through linear concentration gradients of sucrose solution. Anal. Biochem. 20, 114-149.
    • (1967) Anal. Biochem. , vol.20 , pp. 114-149
    • McEwen, C.R.1
  • 30
    • 0029036915 scopus 로고
    • Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae
    • Noda, T., Matsuura, A., Wada, Y., and Ohsumi, Y. (1995). Novel system for monitoring autophagy in the yeast Saccharomyces cerevisiae. Biochem. Biophys. Res. Commun. 210, 126-132.
    • (1995) Biochem. Biophys. Res. Commun. , vol.210 , pp. 126-132
    • Noda, T.1    Matsuura, A.2    Wada, Y.3    Ohsumi, Y.4
  • 31
    • 0032512636 scopus 로고    scopus 로고
    • Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast
    • Noda, T., and Ohsumi, Y. (1998). Tor, a phosphatidylinositol kinase homologue, controls autophagy in yeast. J. Biol. Chem. 273, 3963-3966.
    • (1998) J. Biol. Chem. , vol.273 , pp. 3963-3966
    • Noda, T.1    Ohsumi, Y.2
  • 32
    • 0029682161 scopus 로고    scopus 로고
    • In vitro recombination and mutagenesis by overlap extension PCR
    • Pogulis, R.J., Vallejo, A., and Pease, L.R. (1996). In vitro recombination and mutagenesis by overlap extension PCR. Methods Mol. Biol. 57, 167-176.
    • (1996) Methods Mol. Biol. , vol.57 , pp. 167-176
    • Pogulis, R.J.1    Vallejo, A.2    Pease, L.R.3
  • 33
    • 0030852279 scopus 로고    scopus 로고
    • Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism
    • Scott, S.V., Baba, M., Ohsumi, Y., and Klionsky, D.J. (1997). Aminopeptidase I is targeted to the vacuole by a nonclassical vesicular mechanism. J. Cell Biol. 138, 37-44.
    • (1997) J. Cell Biol. , vol.138 , pp. 37-44
    • Scott, S.V.1    Baba, M.2    Ohsumi, Y.3    Klionsky, D.J.4
  • 34
    • 0034964443 scopus 로고    scopus 로고
    • Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway
    • Scott, S.V., Guan, J., Hutchins, M.U., Kim, J., and Klionsky, D.J. (2001). Cvt19 is a receptor for the cytoplasm-to-vacuole targeting pathway. Mol. Cell 7, 1131-1141.
    • (2001) Mol. Cell , vol.7 , pp. 1131-1141
    • Scott, S.V.1    Guan, J.2    Hutchins, M.U.3    Kim, J.4    Klionsky, D.J.5
  • 35
    • 0029913505 scopus 로고    scopus 로고
    • Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole
    • Scott, S.V., Hefner-Gravink, A., Morano, K.A., Noda, T., Ohsumi, Y., and Klionsky, D.J. (1996). Cytoplasm-to-vacuole targeting and autophagy employ the same machinery to deliver proteins to the yeast vacuole. Proc. Natl. Acad. Sci. USA 93, 12304-12308.
    • (1996) Proc. Natl. Acad. Sci. USA , vol.93 , pp. 12304-12308
    • Scott, S.V.1    Hefner-Gravink, A.2    Morano, K.A.3    Noda, T.4    Ohsumi, Y.5    Klionsky, D.J.6
  • 36
    • 0034682772 scopus 로고    scopus 로고
    • Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting
    • Scott, S.V. et al. (2000). Apg13p and Vac8p are part of a complex of phosphoproteins that are required for cytoplasm to vacuole targeting. J. Biol. Chem. 275, 25840-25849.
    • (2000) J. Biol. Chem. , vol.275 , pp. 25840-25849
    • Scott, S.V.1
  • 37
    • 0024669291 scopus 로고
    • A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae
    • Sikorsky, R.S., and Hieter, P. (1989). A system of shuttle vectors and yeast host strains designed for efficient manipulation of DNA in Saccharomyces cerevisiae. Genetics 122, 19-27.
    • (1989) Genetics , vol.122 , pp. 19-27
    • Sikorsky, R.S.1    Hieter, P.2
  • 38
    • 0026668042 scopus 로고
    • Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction
    • Takeshige, K., Baba, M., Tsuboi, S., Noda, T., and Ohsumi, Y. (1992). Autophagy in yeast demonstrated with proteinase-deficient mutants and conditions for its induction. J. Cell Biol. 119, 301-311.
    • (1992) J. Cell Biol. , vol.119 , pp. 301-311
    • Takeshige, K.1    Baba, M.2    Tsuboi, S.3    Noda, T.4    Ohsumi, Y.5
  • 40
    • 0027424777 scopus 로고
    • Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae
    • Tsukada, M., and Ohsumi, Y. (1993). Isolation and characterization of autophagy-defective mutants of Saccharomyces cerevisiae. FEBS Lett. 333, 169-174.
    • (1993) FEBS Lett. , vol.333 , pp. 169-174
    • Tsukada, M.1    Ohsumi, Y.2
  • 41
    • 0034306202 scopus 로고    scopus 로고
    • Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p
    • Weiss, E.L., Bishop, A.C., Shokat, K.M., and Drubin, D.G. (2000). Chemical genetic analysis of the budding-yeast p21-activated kinase Cla4p. Nat. Cell Biol. 2, 677-685.
    • (2000) Nat. Cell Biol. , vol.2 , pp. 677-685
    • Weiss, E.L.1    Bishop, A.C.2    Shokat, K.M.3    Drubin, D.G.4


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.