A gatekeeper residue for inhibitor sensitization of protein tyrosine phosphatases

Bioorganic and Medicinal Chemistry Letters

Volumn 16, Issue 15, 2006, Pages 4002-4006

  Bishop, Anthony C ^a   Blair, Elizabeth R ^a  

^a AMHERST COLLEGE   (United States)

Author keywords

Inhibitor sensitization; Protein engineering; Protein tyrosine phosphatases; PTP1B

Indexed keywords

ALANINE; ISOLEUCINE; LEUCINE; PROTEIN TYROSINE PHOSPHATASE; PROTEIN TYROSINE PHOSPHATASE INHIBITOR; THIOPHENE;

ARTICLE; CHEMICAL ANALYSIS; CHEMICAL GENETICS; ENZYME INHIBITION; GENETIC ANALYSIS; MUTATION; PROTEIN DOMAIN; PROTEIN FUNCTION; SENSITIZATION; WILD TYPE;

ENZYME INHIBITORS; MODELS, MOLECULAR; PROTEIN-TYROSINE-PHOSPHATASE;

PYRONIA TITHONUS;

EID: 33745136159     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2006.05.011     Document Type: Article

References (22)

1. Bishop A., Buzko O., Heyeck-Dumas S., Jung I., Kraybill B., Liu Y., Shah K., Ulrich S., Witucki L., Yang F., Zhang C., and Shokat K.M. Annu. Rev. Biophys. Biomol. Struct. 29 (2000) 577
2. Koh J.T., and Biggins J.B. Curr. Top. Med. Chem. 5 (2005) 413
3. Bishop A.C., Shah K., Liu Y., Witucki L., Kung C., and Shokat K.M. Curr. Biol. 8 (1998) 257
4. Lin Q., Jiang F., Schultz P.G., and Gray N.S. J. Am. Chem. Soc. 123 (2001) 11608
5. Alaimo P., Knight Z.A., and Shokat K.M. Bioorg. Med. Chem. 13 (2005) 2825
6. Bishop A.C., Ubersax J.A., Petsch D.T., Matheos D.P., Gray N.S., Blethrow J., Shimizu E., Tsien J.Z., Schultz P.G., Rose M.D., Wood J.L., Morgan D.O., and Shokat K.M. Nature 407 (2000) 395
7. Benjamin K.R., Zhang C., Shokat K.M., and Herskowitz I. Genes Dev. 17 (2003) 1524
8. Carroll A.S., Bishop A.C., DeRisi J.L., Shokat K.M., and O'Shea E.K. Proc. Natl. Acad. Sci. U.S.A. 98 (2001) 12578
9. Abeliovich H., Zhang C., Dunn W.A., Shokat K.M., and Klionsky D.J. Mol. Biol. Cell 14 (2003) 477
10. Wang H., Shimizu E., Tang Y.P., Cho M., Kyin M., Zuo W., Robinson D.A., Alaimo P.J., Zhang C., Morimoto H., Zhuo M., Feng R., Shokat K.M., and Tsien J.Z. Proc. Natl. Acad. Sci. U.S.A. (2003) 4287
11. Fan Q.W., Zhang C., Shokat K.M., and Weiss W.A. Curr. Biol. 12 (2002) 1386
12. Kenski D.M., Zhang C., von Zastrow M., and Shokat K.M. J. Biol. Chem. 280 (2005) 35051
13. Hoffman H.E., Blair E.R., Johndrow J.E., and Bishop A.C. J. Am. Chem. Soc. 127 (2005) 2824
14. Blair E.R., Hoffman H.E., and Bishop A.C. Bioorg. Med. Chem. 14 (2006) 464
15. Andersen J.N., Mortensen O.H., Peters G.H., Drake P.G., Iversen L.F., Olsen O.H., Jansen P.G., Andersen H.S., Tonks N.K., and Moller N.P. Mol. Cell. Biol. 21 (2001) 7117
16. Iversen L.F., Andersen H.S., Branner S., Mortensen S.B., Peters G.H., Norris K., Olsen O.H., Jeppesen C.B., Lundt B.F., Ripka W., Moller K.B., and Moller N.P. J. Biol. Chem. 275 (2000) 10300
17. Iversen L.F., Andersen H.S., Moller K.B., Olsen O.H., Peters G.H., Branner S., Mortensen S.B., Hansen T.K., Lau J., Ge Y., Holsworth D.D., Newman M.J., and Hundahl Moller N.P. Biochemistry 40 (2001) 14812
18. Andersen H.S., Olsen O.H., Iversen L.F., Sorensen A.L., Mortensen S.B., Christensen M.S., Branner S., Hansen T.K., Lau J.F., Jeppesen L., Moran E.J., Su J., Bakir F., Judge L., Shahbaz M., Collins T., Vo T., Newman M., Ripka W.C., and Moller N.P. J. Med. Chem. 45 (2002) 4443
19. Pedersen A.K., Guo X.L., Moller K.B., Peters G.H., Andersen H.S., Kastrup J.S., Mortensen S.B., Iversen L.F., Zhang Z.Y., and Moller N.P. Biochem. J. 378 (2004) 421
20. Drake P.G., Peters G.H., Andersen H.S., Hendriks W., and Moller N.P. Biochem. J. 373 (2003) 393
21. Bialy L., and Waldmann H. Angew. Chem., Int. Ed. 44 (2005) 3814
22. Montalibet J., Skorey K., McKay D., Scapin G., Asante-Appiah E., and Kennedy B.P. J. Biol. Chem. 281 (2006) 5258