Design, synthesis, and characterization of an ATP-peptide conjugate inhibitor of protein kinase A

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 11, 2004, Pages 2951-2954

  Hines, Aliya C ^a   Cole, Philip A ^a  

^a JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATE; CYCLIC AMP DEPENDENT PROTEIN KINASE INHIBITOR; PEPTIDE; PROTEIN KINASE C; PROTEIN SERINE THREONINE KINASE; PROTEIN TYROSINE KINASE; TYROSINE KINASE CSK; UNCLASSIFIED DRUG;

ARTICLE; COMPETITIVE INHIBITION; DISSOCIATION; DRUG CONJUGATION; DRUG DESIGN; DRUG POTENCY; DRUG SCREENING; DRUG SELECTIVITY; DRUG SYNTHESIS; ENZYME INHIBITION; ENZYME SUBSTRATE; INHIBITION KINETICS; TECHNIQUE;

ADENOSINE TRIPHOSPHATE; BINDING, COMPETITIVE; CYCLIC AMP-DEPENDENT PROTEIN KINASES; DRUG DESIGN; ENZYME INHIBITORS; KINETICS; OLIGOPEPTIDES; PROTEIN-SERINE-THREONINE KINASES; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 2342592115     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.03.039     Document Type: Article

References (31)

1. Hunter T. Cell. 100:2000;113
2. Mauro M.J., O'Dwyer M.E., Druker B.J. Cancer Chemother. Pharm. 48:2001;S77
3. Druker B.J. New Engl. J. Med. 345:2001;232
4. Toledo L.M., Lydon N.B., Elbaum D. Curr. Med. Chem. 6:1999;775
5. Cohen P. Nat. Rev. Drug Discov. 1:2002;309
6. Hardie G., Hanks S. The Protein Kinase Factsbook: Protein-Serine Kinases. 1995;Academic, San Diego
7. Parang K., Cole P.A. Pharm. Ther. 93:2002;145
8. Parang K., Till J.H., Ablooglu A.J., Kohanski R.A., Hubbard S.R., Cole P.A. Nat. Struct. Biol. 8:2001;37
9. Mildvan A.S. Proteins. 29:1997;401
10. Shen K., Cole P.A. J. Am. Chem. Soc. 125:2003;16172
11. Medzihradszky D., Chen S., Kenyon G.L., Gibson B.W. J. Am. Chem. Soc. 116:1994;9413
12. Hjelmquist G., Andersson J., Edlund B., Engstroom L. Biochem. Biophys. Res. Commun. 61:1974;559
13. de la Houssaye B.A., Masaracchia R.A. Anal. Biochem. 128:1983;54
14. Kates S.A., Solé N.A., Johnson C.R., Hudson D., Barany G., Albericio F. Tetrahedron Lett. 34:1993;1549
15. Yonemoto W.M., McGlone M.L., Slice L.W., Taylor S.S. Methods Enzymol. 200:1991;581
16. Lau O.D., Courtney A.D., Vassilev A., Marzilli L.A., Cotter R.J., Nakatani Y., Cole P.A. J. Biol. Chem. 275:2000;21953
17. Khalil E.M., Cole P.A. J. Am. Chem. Soc. 120:1998;6195
18. Whitehouse S., Feramisco J.R., Casnellie J.E., Krebs E.G., Walsh D.A. J. Biol. Chem. 258:1983;3693
19. Cook P.F., Neville M.E. Jr., Vrana K.E., Hartl F.T., Roskoski R. Jr. Biochemistry. 21:1982;5794
20. Admiraal S.J., Herschlag D. Chem. Biol. 2:1995;729
21. Kim K., Cole P.A. J. Am. Chem. Soc. 119:1997;11096
22. Kim K., Cole P.A. J. Am. Chem. Soc. 120:1998;6851
23. Cole P.A., Courtney A.D., Shen K., Zhang Z., Qiao Y., Lu W., Williams D.M. Acc. Chem. Res. 36:2003;444
24. Zhou J., Adams J.A. Biochemistry. 36:1997;2977
25. Aqvist J., Kolmodin K., Florian J., Warshel A. Chem. Biol. 6:1999;R71
26. Madhusudan Trafny E.A., Xuong N.H., Adams J.A., Ten Eyck L.F., Taylor S.S., Sowadski J.M. Protein Sci. 3:1994;176
27. Valiev M., Kawai R., Adams J.A., Weare J.H. J. Am. Chem. Soc. 125:2003;9926
28. Madhusudan Akamine P., Xuong N.H., Taylor S.S. Nat. Struct. Biol. 9:2002;273
29. Cook A., Lowe E.D., Chrysina E.D., Skamnaki V.T., Oikonomakos N.G., Johnson L.N. Biochemistry. 41:2002;7301
30. McPherson J.D., et al. Nature. 409:2001;934
31. Grace M.R., Walsh C.T., Cole P.A. Biochemistry. 36:1997;1874