Allele-specific inhibitors of protein tyrosine phosphatases

Journal of the American Chemical Society

Volumn 127, Issue 9, 2005, Pages 2824-2825

  Hoffman, Hillary E ^a   Blair, Elizabeth R ^a   Johndrow, James E ^a   Bishop, Anthony C ^a  

^a AMHERST COLLEGE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

PROTEIN TYROSINE PHOSPHATASE;

ARTICLE; CATALYSIS; ENZYME ACTIVE SITE; HYDROGEN BOND; HYDROPHOBICITY; PROTEIN DEPHOSPHORYLATION; PROTEIN ENGINEERING; PROTEIN FAMILY; PROTEIN SYNTHESIS;

ALLELES; AMINO ACID SEQUENCE; BINDING SITES; ENZYME INHIBITORS; MODELS, MOLECULAR; PROTEIN ENGINEERING; PROTEIN-TYROSINE-PHOSPHATASE; SUBSTRATE SPECIFICITY;

EID: 14844282319     PISSN: 00027863     EISSN: None     Source Type: Journal    
DOI: 10.1021/ja043378w     Document Type: Article

References (12)

1. (a) Ubersax, J. A.; Woodbury, E. L.; Quang, P. N.; Paraz, M.; Blethrow, J. D.; Shah, K.; Shokat, K. M.; Morgan, D. O. Nature 2003, 425, 859-864.
2. (b) Shokat, K. M. et al. Nature 2000, 407, 395-401.
3. (c) Holt, J. R.; Gillespie, S. K.; Provance, D. W.; Shah, K.; Shokat, K. M.; Corey, D. P.; Mercer, J. A.; Gillespie, P. Cell 2002, 108, 371-381.
4. (d) Lin, Q.; Jiang, F.; Schultz, P. G.; Gray, N. S. J. Am. Chem. Soc. 2001, 123, 11608-11613.
5. (e) Belshaw, P. J.; Schreiber, S. L. J. Am. Chem. Soc. 1997, 119, 1805-1806.
6. Andersen, J. N.; Mortensen, O. H.; Peters, G. H.; Drake, P. G.; Iversen, L. F.; Olsen, O. H.; Jansen, P. G.; Andersen, H. S.; Tonks, N. K.; Moller, N. P. Mol. Cell. Biol. 2001, 21, 7117-7136.
7. Andersen, H. S.; Iversen, L. F.; Jeppesen, C. B.; Branner, S.; Norris, K.; Rasmussen, H. B.; Moller, K. B.; Moller, N. P. J. Biol. Chem. 2000, 275, 7101-7108.
8. Sarmiento, M.; Puius, Y. A.; Vetter, S. W.; Keng, Y. F.; Wu, L.; Zhao, Y.; Lawrence, D. S.; Almo, S. C.; Zhang, Z. Y. Biochemistry 2000, 39, 8171-8179.
9. V49A PTPlB has been prepared and characterized previously; a catalytic efficiency reduction of less than 2-fold was observed when assayed at pH 7 and 30°C with pNPP. Guo, X. L.; Shen, K.; Wang, F.; Lawrence, D. S.; Zhang, Z. Y. J. Biol. Chem. 2002, 277, 41014-41022.
10. Showalter, H. D. H.; Sun, L.; Sercel, A. D.; Winters, R. T.; Denny, W. A.; Palmer, B. D. J. Org. Chem. 1996, 61, 1155-1158.
11. I value for this enzyme was not obtainable due to low activity of the commercial enzyme.
12. Taylor, S. D. Curr. Top. Med. Chem. 2003, 3, 759-782.