[3H]-L-685,458 as a radiotracer that maps γ-secretase complex in the rat brain: Relevance to Aβ genesis and presence of active presenilin-1 components

Brain Research

Volumn 1157, Issue 1, 2007, Pages 81-91

  Xiong, Kun ^a,b   Clough, Richard W ^a   Luo, Xue Gang ^b   Struble, Robert G ^a   Li, Yue Ming ^c   Yan, Xiao Xin ^a  

^a SOUTHERN ILLINOIS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b CENTRAL SOUTH UNIVERSITY   (China)

^c MEMORIAL SLOAN KETTERING CANCER CENTER   (United States)

Author keywords

Alzheimer; Amyloid; Autoradiography; Neuroplasticity; Presenilin

Indexed keywords

AMYLOID BETA PROTEIN; GAMMA SECRETASE; L 685458 H 3; PRESENILIN 1; TRACER; UNCLASSIFIED DRUG; CARBAMIC ACID DERIVATIVE; DIPEPTIDE; ENZYME INHIBITOR; L 685458; PEPTIDE FRAGMENT; SECRETASE; TRITIUM;

AMYGDALOID NUCLEUS; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUTORADIOGRAPHY; BINDING SITE; BRAIN MAPPING; BRAIN REGION; CEREBELLUM CORTEX; CONTROLLED STUDY; DISSOCIATION; ENZYME ACTIVITY; IN VITRO STUDY; LIGAND BINDING; MALE; NERVE CELL CULTURE; NERVE CELL PLASTICITY; NERVE ENDING; NEWBORN; NONHUMAN; OLFACTORY BULB; OLFACTORY CORTEX; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; RECEPTOR BINDING; RECEPTOR DENSITY; ANIMAL; BINDING COMPETITION; BIOSYNTHESIS; BRAIN; CELL CULTURE; DRUG EFFECT; ENZYMOLOGY; FEMALE; HIPPOCAMPUS; HISTOLOGY; METABOLISM; METHODOLOGY; ORGAN CULTURE TECHNIQUE; PHYSIOLOGY; RADIOASSAY; SPRAGUE DAWLEY RAT;

RATTUS;

AMYLOID BETA-PROTEIN; AMYLOID PRECURSOR PROTEIN SECRETASES; ANIMALS; ANIMALS, NEWBORN; BINDING SITES; BINDING, COMPETITIVE; BRAIN; BRAIN MAPPING; CARBAMATES; CELLS, CULTURED; DIPEPTIDES; ENZYME INHIBITORS; FEMALE; MALE; MOSSY FIBERS, HIPPOCAMPAL; OLFACTORY BULB; ORGAN CULTURE TECHNIQUES; PEPTIDE FRAGMENTS; PRESENILIN-1; RADIOLIGAND ASSAY; RATS; RATS, SPRAGUE-DAWLEY; TRITIUM;

EID: 34250642769     PISSN: 00068993     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.brainres.2007.04.068     Document Type: Article

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