Inflammatory signaling in cartilage: MAPK and NF-ΚB pathways in chondrocytes and the use of inhibitors for research into pathogenesis and therapy of osteoarthritis

Current Drug Targets

Volumn 8, Issue 2, 2007, Pages 305-313

  Saklatvala, Jeremy ^a  

^a IMPERIAL COLLEGE LONDON   (United Kingdom)

Author keywords

Chondrocyte; Inflammatory response; MAP kinase; Matrix metalloproteinase; NF B; Osteoarthritis; Protein kinase; Protein kinase inhibitor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; ACETYLSALICYLIC ACID; ANTHRA[1,9 CD]PYRAZOL 6(2H) ONE; AS 600292; AS 601245; AS 602868; BENZOTHIAZOLE DERIVATIVE; BENZYLOXYCARBONYLLEUCYLLEUCYLLEUCINAL; BETA CARBOLINE DERIVATIVE; BMS 345541; CYTOKINE; I KAPPA B KINASE INHIBITOR; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; LACTACYSTIN; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; MITOGEN ACTIVATED PROTEIN KINASE P38 INHIBITOR; NONSTEROID ANTIINFLAMMATORY AGENT; PD 198306; PEPTIDE DERIVATIVE; PROSTAGLANDIN SYNTHASE; PROTEINASE; S 1627; SC 514; STRESS ACTIVATED PROTEIN KINASE INHIBITOR; TRANSFORMING GROWTH FACTOR BETA; U 0162; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ARTICULAR CARTILAGE; CARTILAGE CELL; CARTILAGE DEGENERATION; CLINICAL TRIAL; DRUG RESEARCH; DRUG SPECIFICITY; DRUG TARGETING; GENE ACTIVATION; GENE EXPRESSION REGULATION; HUMAN; IN VITRO STUDY; INFLAMMATION; NONHUMAN; OSTEOARTHRITIS; PATHOGENESIS; REVIEW; SIGNAL TRANSDUCTION;

CHONDROCYTES; GENE EXPRESSION; HUMANS; INFLAMMATION; INFLAMMATION MEDIATORS; MAP KINASE SIGNALING SYSTEM; NF-KAPPA B; OSTEOARTHRITIS; SIGNAL TRANSDUCTION;

EID: 33847219960     PISSN: 13894501     EISSN: None     Source Type: Journal    
DOI: 10.2174/138945007779940115     Document Type: Review

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