Ctgf/hcs24 induces chondrocyte differentiation through a p38 mitogen-activated protein kinase (p38mapk), and proliferation through a p44/42 mapk/extracellular-signal regulated kinase (erk)

European Journal of Biochemistry

Volumn 268, Issue 23, 2001, Pages 6058-6065

  Yosimichi, Gen ^a,b   Nakanishi, Tohru ^a   Nishida, Takashi ^a,b   Hattori, Takako ^a   Takano Yamamoto, Teruko ^b   Takigawa, Masaharu ^a,b  

^a OKAYAMA UNIVERSITY   (Japan)

^b OKAYAMA UNIVERSITY   (Japan)

Author keywords

Chondrocyte; Connective tissue growth factor; Hypertrophic chondrocyte specific gene product (CTGF Hcs24); MAPK; MAPK inhibitor; Signal transduction

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 4 (4 FLUOROPHENYL) 2 (4 METHYLSULFINYLPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CONNECTIVE TISSUE GROWTH FACTOR; MITOGEN ACTIVATED PROTEIN KINASE; PROTEIN P42; PROTEIN P44; PROTEOGLYCAN; SYNAPTOPHYSIN; TRANSCRIPTION FACTOR;

ANIMAL CELL; ARTICLE; CARTILAGE CELL; CELL DIFFERENTIATION; CELL LINE; CELL PROLIFERATION; CONCENTRATION RESPONSE; CONTROLLED STUDY; DNA SYNTHESIS INHIBITION; DRUG EFFECT; ENZYME ASSAY; ENZYME INDUCTION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; ENZYME REPRESSION; HUMAN; HUMAN CELL; IMMUNOBLOTTING; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS INHIBITION; RABBIT;

ANIMALS; CELL DIFFERENTIATION; CELL DIVISION; CELL LINE; CHONDROCYTES; DNA; FLAVONOIDS; GENES, REPORTER; GROWTH SUBSTANCES; HUMANS; IMIDAZOLES; IMMEDIATE-EARLY PROTEINS; INTERCELLULAR SIGNALING PEPTIDES AND PROTEINS; LUCIFERASES; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; MITOGEN-ACTIVATED PROTEIN KINASES; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROTEOGLYCANS; PYRIDINES; RABBITS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION;

EID: 0035207024     PISSN: 00142956     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0014-2956.2001.02553.x     Document Type: Article

References (46)

1. Connective tissue growth factor: A cysteine-rich mitogen secreted by human vascular endothelial cells is related to the SRC-induced immediate early gene product CEF-10
2. The architecture of a new family of growth regulators related to connective tissue growth factor
3. The CCN family of angiogenic regulators: The integrin connection
4. The connective tissue growth factor/cysteine-rich 61/nephroblastoma overexpressed (CCN) family
5. Physiological roles of connective tissue growth factor (CTGF/Hcs24): Promotion of endochondral ossifica-tion, angiogenesis and tissue remodeling
6. Identification of rCop-1, a new member of the CCN protein family, as a negative regulator for cell transformation
7. Expression of the Elm1 gene, a novel gene of the CCN (connective tissue growth factor. Cyr61/Cef10, and neuroblastoma over-expressed gene) family, suppresses in vivo tumor growth and metastasis of K-1735 murine melanoma cells
8. Mutations in the CCN gene family member WISP3 cause progressive pseudorheumatoid dysplasia
9. Identification and cloning of a connective tissue growth factor-like cDNA from human osteoblasts encoding a novel regulator of osteoblast functions
10. Establishment of a clonal human chondrosarcoma cell line with cartilage phenotypes
11. Establishment from a human chondrosarcoma of a new immortal cell line with high tumorigenicity in vivo, which is able to form proteoglycan- rich cartilage-like nodules and to respond to insulin in vitro
12. Cloning of a mRNA preferentially expressed in chondrocytes by differential display-PCR from a human chondrocytic cell line that is identical with connective tissue growth factor (CTGF) mRNA
13. Effects of CTGF/ Hcs24, a product of a hypertrophic chondrocyte-specific gene, on the proliferation and differentiation of chondrocytes in culture
14. Demonstration of receptors specific for connective tissue growth factor on a human chondrocytic cell line (HCS-2/8)
15. Effects of CTGF/Hcs24, a hypertrophic chondrocyte-specific gene product, on the proliferation and differentiation of osteoblastic cells in vitro
16. Regulation of connective tissue growth factor gene expression in human skin fibroblasts and during wound repair
17. Inhibition of endogenous expression of connective tissue growth factor by its antisense oligonucleotide and antisense RNA suppresses proliferation and migration of vascular endothelial cells
18. Connective tissue growth factor induces the p4roliferation, migration, and tube formation of vascular endothelial cells in vitro, and angiogenesis in vivo
19. Connective tissue growth factor induces apoptosis in human breast cancer cell line MCF-7
20. Fisp12/mouse connective tissue growth factor mediates endothelial cell adhesion and migration through integrin alphavbeta3, promotes endothelial cell survival, and induces angiogenesis in vivo
21. Activation-dependent adhesion of human platelets to Cyr61 and Fisp12/mouse connective tissue growth factor is mediated through integrin alpha (IIb) beta (3)
22. The angiogenic factors Cyr61 and CTGF induce adhesive signaling in primary human skin fibroblasts
23. Identification of an RNA element that confers post-transcriptional repression of connective tissue growth factor/hypertrophic chondrocyte specific 24 (ctgf/ hcs24) gene: Similarities to retroviral RNA-protein interactions
24. Novel intracellular effects of human connective tissue growth factor expressed in COS-7 cells
25. Epidermal growth factor negatively regulates chondrogenesis of mesenchymal cells by modulating the protein kinase C-alpha, Erk-1, and p38 MAPK signaling pathways
26. Inhibition of MAP kinase kinase blocks the differentiation of PC-12 cells induced by nerve growth factor
27. Up-regulation of the chondrogenic Sox9 gene by fibroblast growth factors is mediated by the mitogen-activated protein kinase pathway
28. Transforming growth factor-beta stimulates articular chondrocyte cell growth through p44/42 MAP kinase (ERK) activation
29. Activation of specific MEK-ERK cascade is necessary for TGF beta signaling and crosstalk with PKA and PKC pathways in cultured rat articular chondrocytes
30. elk-1 proteins interact with MAP kinases
31. Characterization of the structure and function of a new mitogen- activated protein kinase (p38beta)
32. Signal transduction by the JNK group of MAP kinases
33. Transcriptional regulation by extracellular signals: Mechanisms and specificity
34. A novel kinase cascade madiated by mitogen-activated protein kinase kinase 6 and MKK3
35. PD 098059 is a specific inhibitor of the activation of mitogen-activated protein kinase kinase in vitro and in vivo
36. A synthetic inhibitor of the mitogen-activated protein kinase cascade
37. SB 203580 is a specific inhibitor of a MAP kinase homologue which is stimulated by cellular stresses and interleukin-1
38. Endothelin-1 stimulates heat shock protein 27 induction in osteoblasts: Involvement of p38 MAP kinase
39. Nitric oxide mediates interleukin-1-induced matrix degradation and basic fibroblast growth factor release in cultured rabbit articular chondrocytes: A possible mechanism of pathological neovascularization in arthritis
40. Nitric oxide mediates interleukin-1-induced gene expression of matrix metalloproteinases and basic fibroblast growth factor in cultured rabbit articular chondrocytes
41. Mitogen-activated protein kinase p38 mediates regulation of chondrocyte differentiation by parathyroid hormone
42. p38 mitogen-activated protein kinase functionally contributes to chondrogenesis induced by growth/ differentiation factor-5 in ATDC5 cells
43. Nephro-blastoma overexpressed gene (NOV) codes for a growth factor that induces protein tyrosine phosphorylation
44. Mitogen-activated protein (MAP) kinases are involved in interleukin-1 (IL-1)-induced IL-6 synthesis in osteoblasts: Modulation not of p38 MAP kinase, but of p42/p44 MAP kinase by IL-1-activated protein kinase C
45. Independent human MAP kinase signal transduction pathways defined by MEK and MKK isoforms
46. Selective activation of p38 mitogen-activated protein (MAP) kinase isoforms by the MAP kinase kinase MKK3 and MKK6