Chondrocyte death in experimental osteoarthritis is mediated by MEK 1/2 and p38 pathways: Role of cyclooxygenase-2 and inducible nitric oxide synthase

Journal of Rheumatology

Volumn 28, Issue 11, 2001, Pages 2509-2519

  Pelletier, J P ^a   Fernandes, J C ^a   Jovanovic, D V ^a   Reboul, P ^a   Martel Pelletier, J ^a  

^a NOTRE DAME HOSPITAL   (Canada)

Author keywords

Apoptosis; Chondrocyte death; Mitogen activated protein kinases; Osteoarthritis

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 3 NITROTYROSINE; 4 (4 FLUOROPHENYL) 2 (4 HYDROXYPHENYL) 5 (4 PYRIDYL)IMIDAZOLE; CASPASE 3; CASPASE INHIBITOR; CYCLOOXYGENASE 2; CYCLOOXYGENASE 2 INHIBITOR; I KAPPA B; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; INDUCIBLE NITRIC OXIDE SYNTHASE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE KINASE; N (2 CYCLOHEXYLOXY 4 NITROPHENYL)METHANESULFONAMIDE; N IMINOETHYLLYSINE; NITRIC OXIDE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE INHIBITOR; PROSTAGLANDIN E2; SYNAPTOPHYSIN; UNCLASSIFIED DRUG;

ANIMAL MODEL; ANIMAL TISSUE; ANTERIOR CRUCIATE LIGAMENT; ARTICLE; AUTOREGULATION; CARTILAGE CELL; CELL DEATH; CONTROLLED STUDY; DOG; ENZYME INHIBITION; MORPHOMETRICS; NICK END LABELING; NONHUMAN; OSTEOARTHRITIS; PRIORITY JOURNAL; PROTEIN EXPRESSION;

ANIMALS; APOPTOSIS; CARRIER PROTEINS; CARTILAGE, ARTICULAR; CASPASES; CHONDROCYTES; CYCLOOXYGENASE 2; DOGS; ENZYME INHIBITORS; IN SITU NICK-END LABELING; ISOENZYMES; KNEE JOINT; MAP KINASE KINASE 1; MAP KINASE KINASE 2; MITOGEN-ACTIVATED PROTEIN KINASE KINASES; NF-KAPPA B; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; OSTEOARTHRITIS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PROSTAGLANDIN-ENDOPEROXIDE SYNTHASES; PROTEIN-SERINE-THREONINE KINASES; PROTEIN-TYROSINE KINASES;

EID: 0034767499     PISSN: 0315162X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

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